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Abstract An iced suspension bridge hanger has an altered aerodynamic shape, potentially causing various types of wind-induced vibrations. A wind tunnel experiment was performed, based on the DenHartog galloping theory, to study the wake galloping of the iced suspension bridge hangers at different hanger spacings. The results revealed that, for iced pin joint hangers, the pneumatic characteristics of the leeward hanger are more stable when the hanger spacing is in the 4.8D ≤ L ≤ 6.2D range. The range of wind attack angle corresponding to the negative value of the DenHartog coefficient increased gradually with the increase in hanger spacing. For iced straddling hangers, the effect of lift must be considered when the static wind load of iced straddling hangers is calculated. The DenHartog coefficients of iced hangers under different hanger spacings all exceeded the -1.0 specified in the code for Wind Resistance Design of Highway Bridges (JTG/T3360-01–2018). The aerodynamic characteristics of iced leeward hangers were more stable when the hanger spacing was A × B = 8D × 4D. Therefore, measures should be taken to increase the rigid vibration-damping frame and improve the critical wind speed of the hangers to avoid vibration in iced hangers.

The objective of this study was to examine the effect of rosehip (Rosa rugosa Thunb.) ethanol extract (RRE) on liver fibrosis in mice and the underlying molecular mechanisms. RRE has no acute oral toxicity, and the MTD in mice is 46.14 g/kg. Histopathological analysis showed that RRE significantly ameliorated inflammation, necrosis, and apoptosis of hepatocytes and collagen deposition caused by CCl4. Further assays indicated that RRE significantly suppressed the production of MDA while markedly increasing the levels of SOD and GSH in the liver. The AST, ALT, IL-6, IL-1β, TNF-α, HA, LN, PCIII, and IVC levels in serum were decreased by RRE. Transcriptome analysis shows that RRE significantly upregulates the PPAR signaling pathway. The RT-q PCR results further confirmed the RRE up-regulating Pparγ, Rxrα, and Plin5 in the PPAR signaling pathway. The Western blot and immunohistochemical results indicate that RRE upregulated PPARγ, RXRα, and Perilipin 5 while downregulating α-SMA and COL1A1 expression. The results indicate that RRE can ameliorate liver fibrosis in mice by upregulating the PPAR signaling pathway.

Abstract To scavenge energy from imperceptible vibrations, this paper investigates the broadband response and output performance of a microvibrational piezoelectric energy harvesting system with mechanical stopper. The energy harvesting system comprises a cantilever beam made of piezoelectric material, which is affixed with a coil at its unbound end and a mechanical stopper. The coil is placed in a magnetic field to provide an ultra‐low level excitation. The electromechanical model is derived according to force integration method (FIM) and Hertz's contact theory, and numerical simulations are undertaken to evaluate the influence of the excitation level, and the gap on the performance. For the linear counterpart without stopper, experimental results indicate the system generates a peak power of 24.12 μW with matched resistance under excitation with a level of 0.003 N and a frequency of 200.3 Hz. When a polydimethylsiloxane (PDMS) stopper is introduced, the vibration of the piezoelectric beam exhibits an obvious nonlinearity with an amplitude of micron scale. Increasing the excitation level and decreasing the gap could efficiently broaden the response bandwidth. Experimental results demonstrate that a copper stopper with larger elastic modulus results in a wider response frequency range, and the half‐power bandwidth could reach 37.1 Hz under excitation with a level of 0.003 N.

Background: In recent years, numerous studies have suggested that the gut microbiota and its metabolites are closely related to myocardial infarction. Utilizing insights from these research findings may be advantageous in the prevention, treatment, and prognosis of myocardial infarction. We have employed bibliometric methodology to summarize the progress made in this research area over the past 20 years, identify the hotspots, and highlight the developmental tendencies, providing a reference for future research in this field. Methods: We searched the content related to this field in the Web of Science Core Collection database, with a time range from 2001 to 2023. We used VOSviewer, CiteSpace, and Scimago Graphica software to visualize the search results. Results: We included 889 reports in this study. The country with the most publications was China, while the country with the greatest influence was the United States. An analysis of institutions showed that the Chinese Academy of Medical Sciences had the largest volume of publications, whereas the Cleveland Clinic had the most influential ones. An author analysis showed Stanley L Hazen to have published the most and to also have been the most influential researcher. An analysis of all the journals publishing articles related to the search terms showed that PLoS One journal had the highest number of publications (18 articles), while Atherosclerosis journal had the most influential articles. The results of our reference analysis showed a strong association between Trimethylamine N-oxide and myocardial infarction. We found that increased intestinal permeability may be related to the progression of cardiovascular diseases, a high-fiber diet may help in the prevention of diseases such as myocardial infarction, and populations with a high intake of red meat may have an increased risk of myocardial infarction. Keyword analysis suggested that ‘cardiac fibrosis’ and ‘major bleeding’ were promising research directions in the future, and supplementing food intake with short-chain fatty acids was looked upon as a promising approach to treating coronary heart disease. Conclusion: The gut microbiota are closely related to myocardial infarction, and investigating this relationship is crucial for the prevention and treatment of myocardial infarction, where interdisciplinary research and international cooperation are indispensable.

Objective Lead-zinc mineralization is widely distributed in southwestern Hubei Province, but no large deposits have been found thus far, and there is a lack of systematic studies on metallogenic systems. Methods The C-H-O-S-Pb isotope analysis and the homogenization temperature of fluid inclusions of lead-zinc-fluorite ore in the Geleche area of Laifeng were conducted. Results The results show that the homogenization temperature of fluid inclusions in fluorite and calcite is concentrated between 137-170℃, and the variation range of salinity is 11.46%-16.89%. It is a NaCl-H2O system with low temperature and medium and low salinity. The main source may be metamorphic dehydration of rock formations containing sedimentary sulfate (marine sediments). The δ34S content ranges from 9.5‰ to 11.8‰, with an average of 10.92‰. 206Pb/204Pb < 18.20, 207Pb/204Pb>15.60, and 208Pb/204Pb < 39.00, and the floating ratio is small and high μ and high ω. Conclusion The sulfur and lead sources are mainly from the Ordovician and Cambrian ore-bearing strata in the Paleozoic sedimentary basin of the upper crust. Syngenetic sedimentary diagenesis and epigenetic medium- and low-temperature hydrothermal transformation are the dominant genetic types of the Geleche mining area. Compared with the typical lead-zinc deposits in the Yangtze Platform of West Hubei and Hunan, they have great similarity and obvious differences in metallogenic fluid, Paleozoic sedimentary environment and tectonic background.

The pure rotational Raman (PRR) lidar technique relies on calibration functions (CFs) to extract temperature information from raw detection data. The choice of CF significantly impacts the accuracy of the retrieved temperature. In this study, we propose a method that combines multiple Monte Carlo simulation experiments with a statistical analysis, and we first conduct simulated comparisons of the calibration effects of different CFs while considering the impact of noise. We categorized ten common CFs into four groups based on their functional form and the number of calibration coefficients. Based on functional form, specifically, we defined 1/T = f(lnQ) as a forward calibration function (FCF) and lnQ = g(1/T) as a backward calibration function (BCF). Here, T denotes temperature, and Q denotes the signal intensity ratio. Their performance within and outside the calibration interval is compared across different integration times, smoothing methods, and reference temperature ranges. The results indicate that CFs of the same category exhibit similar calibration effects, while those of different categories exhibit notable differences. Within the calibration interval, the FCF performs better, especially with more coefficients. However, outside the calibration interval, the linear calibration function (which can be considered a two-coefficient FCF) has an obvious advantage. Conclusions based on the simulation results are validated with actual data, and the factors influencing calibration errors are discussed. Utilizing these findings to guide CF selection can enhance the accuracy and stability of PRR lidar detection.

The inclination angle of the spacecraft seat is related to the astronaut’s reentry angle, which in turn affects the safety of the astronauts. This study quantitatively analyzed the effects of different seat inclination angles on astronauts’ lumbar spine injuries using the finite element method during the Lunar-Earth reentry. Firstly, a finite element model of the astronaut’s lumbar spine was constructed based on reverse engineering technology, and the effectiveness of the model was verified through mesh sensitivity, vertebral range of motion, and spinal impact experiments. Then, simulation calculations were carried out for different seat inclination angles (0°, 10°, 20°, and 30°) under the typical reentry return loads of Chang’e 5T1 (CE-5T1) and Apollo 10, and the prediction and evaluation of lumbar spine injuries were conducted in conjunction with the biological tissue injury criteria. The results indicated that the stress on the vertebrae and annulus fibrosus increased under both reentry loads with the rise of the seat inclination angle, but the increasing rates decreased. When the acceleration peak of CE-5T1 approached 9G, the risk of tissue injury was higher under the seat angle exceeded 20°. According to the Multi-Axis Dynamic Response Criteria for spinal injury, neither of the two load conditions would directly cause injury to the astronauts’ lumbar spine when the seat inclination angle was below 30°. The study findings provide a numerical basis for designing and improving the spacecraft’s inclination angle in crewed lunar missions, ensuring the safety of astronauts.

Quickly localizing the identified white dwarf (WD) binaries is the basic requirement for the space-based gravitational wave (GW) detection. In fact, the amplitude of GW signals are modulated by the periodic motion of GW detectors on the solar orbit. The intensity of the observed signals is enhanced according to the observation time beyond a year to enhance a high signal to noise ratio (SNR). As data gap exists, the completeness of the data observed for a long time depends on filling gaps in the data. Actually, in a year period, the GW sources have a best observation orbit position of GW detectors, where the intensity of GW is maximum. Thus, the best positions can be searched for the verified GW sources of the sky map to enhance SNR too, which avoids filling data gaps. For the three arms response intensity of the GW signals changing more clearly with the location of the GW sources relative to the detector, the noises and the suppression of noise by time delay interferometer are ignored. As a verification case, the four WD binaries are chosen, whose best observation orbit positions of the GW detectors are related to the direction of WD binaries perpendicular to the detection arms. The two verification binaries: J0806 and V407 Vul are observed at the best orbit positions by TAIJI for the short time of 2 and 3 days respectively. The corresponding intensities of GWs are above the values of the TAIJI sensitivity curve, significantly. Location parameter estimation of the verification WD binaries are performed using the Metropolis–Hastings MCMC method. The confidence level of the parameters obtained in the best position is significantly several times higher than that in the worst position where the direction of WD binaries are almost parallel to the detection arms. Compared with a single detector, the network of two detectors improve slightly the accuracy of location of the verification binaries. These results imply that the searching of GW signals and parameter estimation of GW sources from the experimental data of the space-based mission do not ignore the orbit positions relevant to GW sources.

Based on an analysis of the extant literature, this paper summarizes the research progress on the mechanical properties and long-term behavior of corrugated steel web (CSW) box girder bridges. First, the research results of CSW box girder bridges in terms of the shear buckling performance (local shear buckling, overall shear buckling, and interaction buckling), bending performance, bending capacity, torsional capacity, and coefficient of internal force increase are summarized, along with the main factors affecting the mechanical performance of CSW box girder bridges. Second, based on research on the self-oscillation characteristics and dynamic response of CSW box girder bridges, the influence of structural parameters on the self-oscillation characteristics is analyzed. Finally, the long-term mechanical behavior of the CSW box girder bridges is analyzed in terms of fatigue, creep, and temperature effects. The existing research results demonstrate that there still exist deficiencies in the mechanical properties and long-term behavior of CSW box girder bridges, and this paper thus suggests a future research focus on CSW box girder bridges to provide a reference for further improving their basic theoretical system.

The vehicle load on a bridge is a critical and dynamic variable. It adversely affects bridges, especially when overloading occurs. Bridges are prone to fatigue damage or collapse. Therefore, identifying the size and type of dynamic vehicle loads on bridges is critical for theoretical studies and practical applications, such as health monitoring, daily maintenance, safety assessment, and traffic planning. The paper proposes a method for identifying the dynamic load parameters based on a convolutional neural network (CNN) and dynamic strain data. The model is implemented in MATLAB. An initial finite-element model of a three-span precast beam bridge is established in the software ABAQUS and modified by combining the modal and experimental data derived from a segmental girder bridge. The dynamic strain response of the bridge under a moving vehicle load is simulated under different working conditions. The results are used as the training data of the CNN to identify the vehicle’s position, speed, and load on the bridge. The high prediction accuracy indicates the proposed model’s suitability for identifying the dynamic load parameters.

Haze aerosols have a profound impact on air quality and pose serious health risks to the public. Due to its geographical location, Beijing experienced haze events in the spring of 2024. Lidar is an active remote sensing technology with a high spatiotemporal resolution and the ability to classify aerosols, and it is essential for effective haze monitoring. This study utilizes fluorescence–Raman–Mie polarization lidar with an emission wavelength of 355 nm, employing the δp-Gf method based on the particle depolarization ratio at 355 nm (δp355) and the fluorescence capacity (Gf), and combines meteorological data and backward-trajectory analysis to observe and classify low-altitude haze aerosols in Beijing during the spring of 2024. Notably, a mining dust event with strong fluorescence backscatter was detected. The haze aerosols were categorized into three types: pollution aerosols, desert dust, and mining dust. Their optical properties were summarized and compared. Desert dust showed a particle depolarization ratio range of 0.23–0.39 and a fluorescence capacity range from 0.18 × 10−4 to 0.63 × 10−4. Pollution aerosols had a larger fluorescence capacity but a lower depolarization ratio compared to desert dust, with a fluorescence capacity ranging from 0.55 × 10−4 to 1.10 × 10−4 and a depolarization ratio ranging from 0.10 to 0.17. Mining dust shared similar depolarization characteristics with desert dust but had a larger fluorescence capacity, ranging from 0.71 × 10−4 to 1.23 × 10−4, with a depolarization ratio range of 0.30–0.39. This study validates the effectiveness of the δp355-Gf method in classifying low-altitude haze aerosols in Beijing. Additionally, it offers a new perspective for more detailed dust classification using lidar. Furthermore, utilizing the δp355-Gf classification method and the δp355-Gf distributions of three typical aerosol samples, we developed a set of equations for the analysis of mixed aerosols. This method facilitates the separation and fraction analysis of aerosol components under various mixing scenarios. It enables the characterization of variations in the three types of haze aerosols at different altitudes and times, offering valuable insights into the interactions between desert dust, mining dust, and pollution aerosols in Beijing.

The safety of crews is the primary concern in the manned lunar landing project, particularly during re-entry as the manned spacecraft returns from a direct Lunar-Earth trajectory. This paper analyzed the crew’s chest biomechanical response to assess potential injuries caused by acceleration loads during the re-entry phase. Initially, a sophisticated finite element model of the chest was constructed, whose effectiveness was verified by experiments involving vertebral range of motion, rib lateral rupture, and chest frontal impact. The model was then subjected to the return re-entry loads simulating the Apollo and Chang’e 5 T1 (CE-5T1) test returner to specifically analyze the correlation between the acceleration load and the injury of the crew’s chest tissues and organs. The results indicate that the biomechanical response of crew chest bone tissue under the two return missions is within the threshold value and will not directly cause damage. Compared to the Apollo mission, the CE-5T1 mission’s load poses a higher risk to internal organs. These findings can enhance the crew’s safety and provide reliable assurance for future space exploration.

Summary: The incidence of premature myocardial infarction (PMI) has been rising and acute kidney injury (AKI) occurring in PMI patients severely impacts prognosis. This study aimed to develop and validate a prediction model for AKI specific to PMI patients. The MIMIC-Ⅲ-CV and MIMIC-Ⅳ databases were utilized for model derivation of PMI patients. Single-center data served for external validation. There were 571 and 182 AKI patients in the training set (n = 937) and external validation set (n = 292) cohorts, respectively. Finally, a 7-variable model consisting of: Sequential Organ Failure Assessment (SOFA) score, coronary artery bypass grafting (CABG), ICU stay time, loop diuretics, estimated glomerular filtration rate (eGFR) HCO3- and Albumin was developed, achieving an AUC of 0.85 (95% CI: 0.83–0.88) in the training set. External validation also confirmed model robustness. This model may assist clinicians in the early identification of patients at elevated risk for PMI. Further validation is warranted before clinical application.

Abstract Nuclear magnetic resonance (NMR) has shown good applications in engineering fields such as well logging and rubber material ageing assessment. However, due to the low magnetic field strength of NMR sensors and the complex working conditions of engineering sites, the signal-to-noise ratio (SNR) of NMR signals is low, and it is usually necessary to increase the number of repeated measurements to improve the SNR, which means a longer measurement time. Therefore, it is especially important to set the measurement parameters appropriately for onsite NMR. In this paper, we propose a stochastic simulation using Monte Carlo methods to predict the measurement curves of $${\mathrm{T}}_{1}$$ T 1 and $${\mathrm{D}}_{0}$$ D 0 and correct the measurement parameters of the next step according to the previous measurement results. The method can update the measurement parameters in real time and perform automatic measurements. At the same time, this method greatly reduces the measurement time. The experimental results show that the method is suitable for the measurement of the self-diffusion coefficient D0 and longitudinal relaxation time T1, which are frequently used in NMR measurements.

The grouting quality of prestressed pipelines directly affects the safety and durability of prestressed reinforced concrete bridge structures, attracting wide attention from the engineering community. Based on the principles of the scattering wave method, this paper designs and manufactures a large-scale model to simulate the actual construction testing environment. Several sets of design defects with significantly distributed spans in the prestressing ducts were pre-set, and the Engineering Geophysical Instrument System–Pipeline Grouting Profile (EGS-PGP) equipment developed was used to detect the grouting quality of the prestressed pipelines under different conditions, obtaining the frequency attenuation values at defect locations. The study shows that stability of the peak frequency throughout the test can indicate compact grouting, while a large fluctuation in the peak frequency range with no regular changes can indicate non-compact grouting; a sudden increase or decrease in peak frequency can effectively indicate the location of grouting defects along the pipeline. The number of sudden changes in frequency can indicate the number of gaps inside the pipeline. The chirp signal, compared to the hammer impact signal, shows greater stability and engineering application value in detecting defects using the scatter wave method. This study provides technical support for the detection of grouting quality in prestressed pipelines based on chirp signals.

The plant microbiota can affect plant health and fitness by promoting methylmercury (MeHg) production in paddy soil. Although most well-known mercury (Hg) methylators are observed in the soil, it remains unclear how rice rhizosphere assemblages alter MeHg production. Here, we used network analyses of microbial diversity to identify bulk soil (BS), rhizosphere (RS) and root bacterial networks during rice development at Hg gradients. Hg gradients greatly impacted the niche-sharing of taxa significantly relating to MeHg/THg, while plant development had little effect. In RS networks, Hg gradients increased the proportion of MeHg-related nodes in total nodes from 37.88% to 45.76%, but plant development enhanced from 48.59% to 50.41%. The module hub and connector in RS networks included taxa positively (Nitrososphaeracea, Vicinamibacteraceae and Oxalobacteraceae) and negatively (Gracilibacteraceae) correlating with MeHg/THg at the blooming stage. In BS networks, Deinococcaceae and Paludibacteraceae were positively related to MeHg/THg, and constituted the connector at the reviving stage and the module hub at the blooming stage. Soil with an Hg concentration of 30 mg kg−1 increased the complexity and connectivity of root microbial networks, although microbial community structure in roots was less affected by Hg gradients and plant development. As most frequent connector in root microbial networks, Desulfovibrionaceae did not significantly correlate with MeHg/THg, but was likely to play an important role in the response to Hg stress.

Nano-targeted delivery systems have been widely used for breast tumor drug delivery. Estrogen receptors are considered to be significant drug delivery target receptors due to their overexpression in a variety of tumor cells. However, targeted ligands have a significant impact on the safety and effectiveness of active delivery systems, limiting the clinical transformation of nanoparticles. Phytoestrogens have shown good biosafety characteristics and some affinity with the estrogen receptor. In the present study, molecular docking was used to select tanshinone IIA (Tan IIA) among phytoestrogens as a target ligand to be used in nanodelivery systems with some modifications. Modified Tan IIA (Tan-NH2) showed a good biosafety profile and demonstrated tumor-targeting, anti-tumor and anti-tumor metastasis effects. Moreover, the ligand was utilized with the anti-tumor drug Dox-loaded mesoporous silica nanoparticles via chemical modification to generate a nanocomposite Tan-Dox-MSN. Tan-Dox-MSN had a uniform particle size, good dispersibility and high drug loading capacity. Validation experiments in vivo and in vitro showed that it also had a better targeting ability, anti-tumor effect and lower toxicity in normal organs. These results supported the idea that phytoestrogens with high affinity for the estrogen receptor could improve the therapeutic efficacy of nano-targeted delivery systems in breast tumors.

This research focuses on the impact of smoke exhaust volume and smoke vent layout, which are two crucial factors affecting the smoke control efficiency in tunnels, on the smoke exhaust effect in tunnel fires. Numerical simulation methods are employed to investigate the impact of changing the smoke exhaust volume and the smoke vent number on the smoke exhaust performance in a curved tunnel with a ceiling centralized smoke exhaust system. This research primarily examines the length of the smoke distribution, the smoke temperature under the ceiling, the vertical visibility, and the exhausted smoke mass flow rate. The findings indicate that, in a tunnel with a single-side ceiling centralized smoke exhaust mode, an imbalance in smoke distribution occurs between the upstream and downstream of the fire source. The upstream area experiences a higher amount of smoke, while the downstream area has thinner smoke. Increasing the smoke exhaust volume yielded positive effects on smoke control, as evident in the reduced the smoke spread range, and improved the smoke exhaust efficiency. The influence of changing smoke vent number on the smoke exhaust effect was dependent on the smoke exhaust volume. When the smoke exhaust volume was excessive, altering the number of smoke vents had a minimal impact on smoke exhaust, while in cases with small smoke exhaust volumes, changes in smoke vent numbers obviously influenced the smoke control effect. Therefore, selecting an appropriate smoke exhaust volume and raising the smoke vent number can effectively optimize the performance of the ceiling centralized smoke exhaust system.

Abstract Background Poor in vivo targeting of tumors by chemotherapeutic drugs reduces their anti-cancer efficacy in the clinic. The discovery of over-expressed components on the tumor cell surface and their specific ligands provide a basis for targeting tumor cells. However, the differences in the expression levels of these receptors on the tumor cell surface limit the clinical application of anti-tumor preparations modified by a single ligand. Meanwhile, toxicity of chemotherapeutic drugs leads to poor tolerance to anti-tumor therapy. The discovery of natural active products antagonizing these toxic side effects offers an avenue for relieving cancer patients’ pain during the treatment process. Since the advent of nanotechnology, interventions, such as loading appropriate drug combinations into nano-sized carriers and multiple tumor-targeting functional modifications on the carrier surface to enhance the anti-tumor effect and reduce toxic and side effects, have been widely used for treating tumors. Results Nanocarriers containing doxorubicin hydrochloride (DOX) and salvianolic acid A (Sal A) are spherical with a diameter of about 18 nm; the encapsulation efficiency of both DOX and salvianolic acid A is greater than 80%. E-[c(RGDfK)2]/folic acid (FA) co-modification enabled nanostructured lipid carriers (NLC) to efficiently target a variety of tumor cells, including 4T1, MDA-MB-231, MCF-7, and A549 cells in vitro. Compared with other preparations (Sal A solution, NLC-Sal A, DOX solution, DOX injection, Sal A/DOX solution, NLC-DOX, NLC-Sal A/DOX, and E-[c(RGDfK)2]/FA-NLC-Sal A/DOX) in this experiment, the prepared E-[c(RGDfK)2]/FA-NLC-Sal A/DOX had the best anti-tumor effect. Compared with the normal saline group, it had the highest tumor volume inhibition rate (90.72%), the highest tumor weight inhibition rate (83.94%), led to the highest proportion of apoptosis among the tumor cells (61.30%) and the lowest fluorescence intensity of proliferation among the tumor cells (0.0083 ± 0.0011). Moreover, E-[c(RGDfK)2]/FA-NLC-Sal A/DOX had a low level of nephrotoxicity, with a low creatinine (Cre) concentration of 52.58 μmoL/L in the blood of mice, and no abnormalities were seen on pathological examination of the isolated kidneys at the end of the study. Sal A can antagonize the nephrotoxic effect of DOX. Free Sal A reduced the Cre concentration of the free DOX group by 61.64%. In NLC groups, Sal A reduced the Cre concentration of the DOX group by 42.47%. The E-[c(RGDfK)2]/FA modification reduced the side effects of the drug on the kidney, and the Cre concentration was reduced by 46.35% compared with the NLC-Sal A/DOX group. These interventions can potentially improve the tolerance of cancer patients to chemotherapy. Conclusion The E-[c(RGDfK)2]/FA co-modified DOX/Sal A multifunctional nano-drug delivery system has a good therapeutic effect on tumors and low nephrotoxicity and is a promising anti-cancer strategy. Graphical Abstract

Abstract Although nanomedicine have greatly developed and human life span has been extended, we have witnessed the soared incidence of central nervous system (CNS) diseases including neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease), ischemic stroke, and brain tumors, which have severely damaged the quality of life and greatly increased the economic and social burdens. Moreover, partial small molecule drugs and almost all large molecule drugs (such as recombinant protein, therapeutic antibody, and nucleic acid) cannot cross the blood–brain barrier. Therefore, it is especially important to develop a drug delivery system that can effectively deliver therapeutic drugs to the central nervous system for the treatment of central nervous system diseases. Cell penetrating peptides (CPPs) provide a potential strategy for the transport of macromolecules through the blood–brain barrier. This study analyzed and summarized the progress of CPPs in CNS diseases from three aspects: CPPs, the conjugates of CPPs and drug, and CPPs modified nanoparticles to provide scientific basis for the application of CPPs for CNS diseases.

Background: Heart failure (HF) patients in intensive care units (ICUs) are rather poorly studied based on varying left ventricular ejection fraction (LVEF) classification. Characteristics and prognosis of patients in ICUs with HF with mildly reduced ejection fraction (HFmrEF), HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF) require further clarification. Methods: Data involving clinical information and 4-year follow-up records of HF patients were extracted and integrated from the Medical Information Mart for Intensive Care III (MIMIC-III) database. Tests were carried out to identity differences among these three HF subtypes. Prognostic analyses were performed using Kaplan-Meier survival analysis and Cox proportional-hazards regression modeling. To develop a novel prediction nomogram, forward selection was used as the best-fit model. Prognostic heterogeneity of the subgroups prespecified by stratification factors in pairwise comparisons was presented using forest plots. Results: A total of 4150 patients were enrolled in this study. HFmrEF had the lowest all-cause mortality rate during the 4-year follow-up, which was significantly different from HFrEF and HFpEF (Log-Rank p < 0.001). The Cox proportional-hazards regression model also showed that a comparison of HFrEF versus HFmrEF indicated a hazard ratio (HR) of 0.76 (95% CI 0.61–0.94, p = 0.011) and HFrEF versus HFpEF indicated a HR 0.93 (95% CI 0.82–1.07, p = 0.307). Following a multivariable analysis, 13 factors were confirmed as independent. A new nomogram was established and quantified with a concordance index (C-index) of 0.70 (95% CI 0.67–0.73), and the internal validation indicated the accuracy of the model. Stratification factors such as a history of coronary artery bypass grafting (CABG) and comorbidity of chronic obstructive pulmonary disease (COPD) induced prognostic heterogeneity among the three subtypes. Conclusions: Clinical characteristics and prognosis significantly varied among the three subtypes of HF patients in ICUs, with HFmrEF patients achieving the best prognosis. The novel prediction model, tailored for this population, showed a satisfying prediction ability.

In this study, an optimized unilateral magnetic resonance sensor with a three-magnet array is presented for assessing the aging of composite insulators in power grids. The sensor’s optimization involved enhancing the static magnetic field strength and the homogeneity of the RF field while maintaining a constant gradient in the direction of the vertical sensor surface and maximizing homogeneity in the horizontal direction. The center layer of the target area was positioned 4 mm from the coil’s upper surface, resulting in a magnetic field strength of 139.74 mT at the center point of the area, with a gradient of 2.318 T/m and a corresponding hydrogen atomic nuclear magnetic resonance frequency of 5.95 MHz. The magnetic field uniformity over a 10 mm × 10 mm range on the plane was 0.75%. The sensor measured 120 mm × 130.5 mm × 76 mm and weighed 7.5 kg. Employing the optimized sensor, magnetic resonance assessment experiments were conducted on composite insulator samples utilizing the CPMG (Carr–Purcell–Meiboom–Gill) pulse sequence. The T2 distribution provided visualizations of the T2 decay in insulator samples with different degrees of aging.

Abstract. Background:. Clinical features and outcomes of heart failure (HF) with mid-range ejection fraction (HFmrEF) remain controversial. Thus, we systematically reviewed literatures of clinical research to assess and analyze characteristics and prognosis of patients with HFmrEF. Methods:. PubMed, Embase, and Web of Science were searched for cohort studies up to April 23, 2019. Clinical features and multivariate adjusted hazard ratios (HRs) of endpoints of short-term all-cause mortality (SAM), long-term all-cause mortality (LAM), long-term cardiovascular death (LCD) and long-term HF rehospitalization (LHR) among patients with HFmrEF and HF with preserved ejection fraction (HFpEF), HF with reduced ejection fraction (HFrEF) were well addressed. The primary outcome was LAM. Results:. Totally 19 studies were included in this study with 164,678 patients enrolled. The follow-up time of LAM was 3.6 ± 2.5 years. HRs of LAM, SAM, LCD, LHR indicated that the risks of patients with HFmrEF were higher than HFpEF patients but lower than HFrEF patients, as for LAM, HFmrEF:HFpEF (reference) HR: 1.07, 95% confidence interval (CI): 1.00–1.15 (I2 = 63%, P = 0.0005); HFmrEF:HFrEF (reference) HR: 0.80, 95% CI: 0.73–0.88 (I2 = 70%, P

Radioactive aerosol will transport in the containment and also will leak into the environment under a severe nuclear accident. Thus, it is of great significance for predicting the behavior of aerosol under a severe nuclear accident. In order to analyze the aerosol behavior, an improved multi-component sectional model is developed, which improves section numbers and updates the aerosol particle density at each time step. The model’s dependability is confirmed to use benchmark and experimental values. An excellent agreement can be observed between simulation and benchmark. On this premise, the LBLOCA accident is chosen to explore the behavior of radioactive aerosol in the containment. The finding shows that the aerosol is mostly deposited on the structure’s surface due to gravity in the LBLOCA accident. According to a comparison of the influence of aerosol natural deposition mechanisms on the distribution of diameter particles, Brownian diffusion, thermophoresis, diffusiophoresis, and gravity all have an effect on aerosol in the range of 0.01 μm–0.03 μm particles, and the deposition of 2 μm–20 μm particles is mainly due to gravity. After comparing and evaluating the influence of aerosol density in the containment, it can be inferred that changed aerosol particle density leads aerosol particles coagulate into larger particles.

We demonstrate an ultrafast humidity micro-fiber sensor based on molybdenum disulfide (MoS2) cladding with three dimensional network structure. The high surface-to-volume rations and porous mesh structure improve the interaction of between MoS2 and water molecules, further enhancing the performance of the humidity sensor. The results demonstrated that the sensor can perform in a wide relative humidity (RH) range between 10%RH to 90%RH with rapid dynamic behavior (response and recovery time are 0.090 and 0.130 s respectively). The sum of response and recovery time (total time) is 0.220 s, which is the fastest in the reported MoS2-based humidity sensors. The sensitivity of this sensor is up to -1.501 dB/%RH in the RH range (77%RH–90%RH). Such a high performance RH sensor will have a wide range of application potential in chemical processing, various medical diagnostics, and so on.

This paper built a three-dimensional layered structure model of semirigid base asphalt pavement with single and double transverse reflective cracks based on the Extended Finite Element Method and fatigue fracture theory. The effects of the number of cracks, crack spacing, and crack length on the stress intensity factors (KI, KII, and Keff) under moving vehicle loads were studied. The fracture life of the asphalt pavement structure was calculated based on the Pairs formula. The results demonstrate that reflective cracks in semirigid asphalt pavement are composite cracks of type I and type II under moving vehicle loads, and shear fracture is the main reason for the failure of the base. The damage to the pavement base will be accelerated with the increase in the number of cracks and the length of the cracks. As the distance between the two reflection fractures is closer, the interaction between the cracks has a superimposed enhancement effect on the crack propagation. Compared with the single nonpenetrating crack model, the fatigue life of the nonpenetrating reflective crack in the double crack pavement structure with a crack spacing of 30 cm is reduced by 46.87%. The research on the propagation mechanism of reflective cracks in this paper provides the essential theoretical and numerical basis for the design, construction, working condition evaluation, and maintenance of pavement structures.

BackgroundDuring the past years, clinical and epidemiological studies have indicated a close relationship between Alzheimer's disease (AD) and other mental disorders like major depressive disorder (MDD). At the same time, a number of genes genetically associated with AD or MDD have been detected. However, our knowledge on the mechanisms that link the two disorders is still incomplete, and controversies exist. In such a situation, a systematic analysis on these genes could provide clues to understand the molecular features of two disorders and their comorbidity.MethodsIn this study, we compiled the genes reported to be associated with AD or MDD by a comprehensive search of human genetic studies and genes curated in disease-related database. Then, we investigated the features of the shared genes between AD and MDD using the functional enrichment analysis. Furthermore, the major biochemical pathways enriched in the AD- or MDD-associated genes were identified, and the cross talks between the pathways were analyzed. In addition, novel candidate genes related to AD and MDD were predicted in the context of human protein-protein interactome.ResultsWe obtained 650 AD-associated genes, 447 MDD-associated genes, and 77 shared genes between AD and MDD. The functional analysis revealed that biological processes involved in cognition, neural development, synaptic transmission, and immune-related processes were enriched in the common genes, indicating a complex mechanism underlying the comorbidity of the two diseases. In addition, we conducted the pathway enrichment analysis and found 102 shared pathways between AD and MDD, which involved in neuronal development, endocrine, cell growth, and immune response. By using the pathway cross-talk analysis, we found that these pathways could be roughly clustered into four modules, i.e., the immune response-related module, the neurodevelopmental module, the cancer or cell growth module, and the endocrine module. Furthermore, we obtained 37 novel candidate genes potentially related to AD and MDD with node degrees > 5.0 by mapping the shared genes to human protein-protein interaction network (PPIN). Finally, we found that 37 novel candidate genes are significantly expressed in the brain.ConclusionThese results indicated shared biological processes and pathways between AD and MDD and provided hints for the comorbidity of AD and MDD.

As a natural compound, gambogic acid (GA) emerged a shining multi-target antitumor activity in a variety of tumors. Whereas its poor solubility and non-specific effect to tumor blocked the clinical application of this drug. Herein, we reported a simple and effective strategy to construct liposome modified with nuclear targeted peptide CB5005N (VQRKRQKLMPC) via polyethylene glycol (PEG) linker to decrease the inherent limitations of GA and promote its anti-tumor activity. In this study, liposomes were prepared by thin film hydration method. The characterization of formulations contained particle size, Zeta potential, morphology and encapsulation efficiency. Further, in vitro cytotoxicity and uptake tests were investigated by 4T1 and MDA-MB-231 cells, and nuclear targeting capability was performed on MDA-MB-231 cells. In addition, the in vivo antitumor effect and biological distribution of formulations were tested in BALB/c female mice. The GA-loaded liposome modified by CB5005N showed small size, good uniformity, better targeting, higher anti-tumor efficiency, better tumor inhibition rate and lower toxicity to normal tissues than other groups. In vitro and in vivo research proved that CB5005N-GA-liposome exhibited excellent anti-tumor activity and significantly reduced toxicities. As a result, CB5005N-GA-liposome nano drug delivery system enhanced the tumor targeting and antitumor effects of GA, which provided a basis for its clinical application.

Structured light fields carrying orbital angular momentum (OAM) have been widely studied, and a variety of applications have been found. The exploration of the generation of the structured light beams with higher purity, order, and efficiency has become an inevitable trend. In early years, structured light beams are normally generated with the extra-cavity methods, as it is simpler in principle. However, the intra-cavity generation of the structured light has a better beam purity and higher light conversion efficiency. Here, the current advance in the production of structured light directly from lasers based on spatial light modulators (SLMs), metasurfaces, and microrings is reviewed.

Silicone rubber insulators (SRIs) are widely used in high-voltage power grids. Due to high-voltage fields and harsh environmental conditions, SRIs eventually deteriorate with use in the power grid, decreasing their insulating performance and operational life and contributing to transmission line failures. Therefore, quantitatively assessing the aging status of SRIs is crucial. In this study, we evaluated the viability of the magnetic resonance method for assessing the age of SRIs at the level of chemical structure; we built and made a portable magnetic resonance sensor, and evaluated the sensor’s functionality. By measuring the SRI sheds at various service times, it was discovered that the equivalent transverse relaxation time, T2eff, can describe the degree of aging of the SRIs. The results of the magnetic resonance measurements were also compared with those of the static contact angle method, and the two measurement methods yielded the same conclusions. However, the magnetic resonance method was more sensitive than the one using the static contact angle method.

Summary: The sluggish oxygen reduction reaction (ORR) has becoming the bottleneck of largescale implementation of proton exchange membrane fuel cells. However, when it comes to the ORR activity assessing of platinum group metals (PGMs) with rotating disk electrode, the corresponding potential conversion vs. reversible hydrogen electrode, test protocols, and activity calculation processes are still in chaos in many published literatures. In this work, two standard calculation processes for PGM ORR activities are demonstrated, followed by a specification for the usage of reference electrodes. Then a 4-fold discrepancy in ORR activities obtained via different test protocols is found for the same Pt/C, and an average adsorption model and the “coverage effects” are proposed to illustrate the hysteresis loop between negative and positive-going ORR polarization plots. Finally, four motions over appropriate assessment of PGM ORR activity are emphasized, hoping to bring a fair communication platform for researchers from different groups.

Labrasol, as a non-ionic surfactant, can enhance the permeation and absorption of drugs, and is extensively used in topical, transdermal, and oral pharmaceutical preparations as an emulsifier and absorption enhancer. Recent studies in our laboratory have indicated that labrasol has a strong absorption enhancing effect on different types of drugs in vitro and in vivo. This study was performed to further elucidate the action mechanism of labrasol on the corneal penetration. In this research, the fluorescein sodium, a marker of passive paracellular transport of tight junction, was selected as the model drug to assess the effect of labrasol on in vitro corneal permeability. To investigate the continuous and real-time influence of labrasol on the membrane permeability and integrity, the Ussing chamber system was applied to monitor the electrophysiological parameters. And, furthermore, we elucidated the effect of labrasol on excised cornea at the molecular level by application of RT-PCR, Western blot, and immunohistochemical staining. The results indicated that labrasol obviously enhance the transcorneal permeability of fluorescein sodium, and the enhancement was realized by interacting with and down-regulating the associated proteins, such as F-actin, claudin-1 and β-catenin, which were contributed to cell-cell connections, respectively. Keywords: Enhanced corneal permeation, Tight junctions associated proteins, Labrasol, Ussing chamber, Western blot, Immunohistochemistry

Baicalein (BE) is one of the main active flavonoids representing the variety of pharmacological effects including anticancer, anti-inflammatory and cardiovascular protective activities, but it's very low solubility, dissolution rate and poor oral absorption limit the therapeutic applications. In this work, a nano-cocrystal strategy was successfully applied to improve the dissolution rate and bioavailability of BE. Baicalein-nicotinamide (BE-NCT) nano-cocrystals were prepared by high pressure homogenization and evaluated both in vitro and in vivo. Physical characterization results including scanning electron microscopy, dynamic light scattering, powder X-ray diffraction and differential scanning calorimetry demonstrated that BE-NCT nano-cocrystals were changed into amorphous state with mean particle size of 251.53 nm. In the dissolution test, the BE-NCT nano-cocrystals performed 2.17-fold and 2.54-fold enhancement than BE coarse powder in FaSSIF-V2 and FaSSGF. Upon oral administration, the integrated AUC0 − t of BE-NCT nano-cocrystals (6.02-fold) was significantly higher than BE coarse powder (1-fold), BE-NCT cocrystals (2.87-fold) and BE nanocrystals (3.32-fold). Compared with BE coarse powder, BE-NCT cocrystals and BE nanocrystals, BE-NCT nano-cocrystals possessed excellent performance both in vitro and in vivo evaluations. Thus, it can be seen that nano-cocrystal is an appropriate novel strategy for improving dissolution rate and bioavailability of poor soluble natural products such as BE. Keywords: Baicalein, Nano-cocrystals, Cocrystals, Bioavailability

The probabilistic short-circuit current (PSCC) of photovoltaic generation is determined by the voltage sag at the grid connection and the low voltage ride-through of the unit during the grid fault, while the voltage sag and the low voltage ride-through are both stochastic. According to short-circuit current characteristics and Thevenin equivalent circuit in the transient state, this paper analyzes the changing trajectory of the equivalent internal potential of photovoltaic generation during the period of low voltage ride-through. To deal with the uncertainty of low voltage ride-through, the probability density function by the maximum entropy method is used to characterize the stochastic process of low voltage disconnection of photovoltaic generation. Based on the fault information, the calculation method of PSCC in active distribution network considering the uncertainty of low voltage ride-through of photovoltaic generation is proposed. Two cases of 9-node and 34-node distribution network are used to verify the effectiveness of the method. The obtained PSCC results can reasonably reflect the actual short-circuit current level of the active distribution network.

It is of great importance to elucidate the mechanism of mercury (Hg) migration in the forest litterfall so as to clearly understand global Hg deposition. However, it is still unclear for the migration and transformation of Hg in different forest litters during long-term decomposition. Therefore, the dynamics of total Hg (THg), methylmercury (MeHg), carbon, nitrogen, microbial biomass carbon and nitrogen in the litterfall of the evergreen broadleaf (EB) and mixed broadleaf-conifer (MBC) forests, southwest China were investigated, aiming to understand the migration characteristics of Hg in the two-year decomposing litterfall. Results showed that carbon decreased, while nitrogen accumulated slightly in the process of litterfall decomposition. THg levels in the second year of the EB and MBC forests decreased by 16.9% and 11.3%, while MeHg levels reduced by 141.4% and 210.7% respectively comparing with those in the first year. The total percentage of hydrochloric acid-soluble mercury (Hg-h) and water-soluble mercury (Hg-w) had a significant impact on the migration of THg and MeHg in the two forest stands. The C/N ratio in the EB forest bore a positive correlation with THg and MeHg levels, whereas that in the MBC forest was adverse. Besides, microbial biomass C and N were positively related with THg and MeHg levels in both the EB and MBC forests. It is proposed that THg and MeHg accumulation in the second year drastically decreased probably due to finite nutritional conditions, which implies that Hg accumulation risks alleviate with degradation time.

The fatigue performance of the bridge deck significantly affects the safety and durability of the overall steel-concrete composite beam bridge. Based on the vehicle flow information of the highway within 10 years, the fatigue performance of a two-way four-lane steel-concrete composite continuous beam bridge deck is studied in this research. The results indicate that the effect of the wheel track position is negligible for two-way four-lane bridge when the wheel track sways laterally, and the fatigue stress of bridge deck concrete is the most unfavorable while the loading position is 7.0 m away from the bridge center line. The fatigue damage decreases by 30%–40% when the centerline of the lane deviates from the most unfavorable stress position by 1 m. The punching fatigue of the concrete is more sensitive to the changes in slab thickness, and the thickness of the deck concrete slab is recommended to be ≥35 cm.

Complexly distributed aerosol particles have significant impacts on climate and environmental changes. As one of the vital atmospheric power sources, the wind field deeply affects the distribution and transport of aerosol particles. For a more comprehensive investigation of the aerosols flux and transport mechanism, two retrieval methods of aerosol optical properties (backscatter coefficient and extinction coefficient at 1550 nm) from coherent Doppler lidar (CDL) observation are proposed in this paper. The first method utilizes the calculated aerosol backscatter coefficient (532 nm) from Mie-scattering lidar datasets and the iterative Fernald method to retrieve aerosol optical property profiles during joint measurements with CDL and Mie-scattering lidar. After verifying the correctness of the first method compared with AERONET datasets, we proposed the second retrieval method. Using the forward integral Fernald method with near-ground reference aerosol extinction coefficient calculated by atmospheric visibility, aerosol optical properties at 1550 nm could be obtained. Thirty-six-day joint measurements with two lidars were specially designed and conducted to verify the correctness of these retrieval methods. The validation results of these two methods indicate great performances, where the mean relative errors are 0.0272 and 0.1656, and the correlation coefficients are 0.9306 and 0.9197, respectively. In conclusion, the feasibility of these two retrieval methods extends the capability of CDL to detect aerosol optical properties and also provides a possibility to observe the aerosol distribution and transport process comprehensively, which is a great promotion of aerosol transport studies development.

This paper presents a modified time discontinuous Galerkin finite element method (MDGFEM) for transient acoustic wave propagation problem of multilayered pavement. The pavement consists of cement concrete pavement, semi-rigid base, and natural soil. The multilayered pavement is modeled as poroelastic mediums and assumed to be water-saturated. The well-known generalized Biot’s theory is employed to describe the wave propagation problem. The present MDGFEM, based on the artificial damping scheme, employs the Hermite (P3) functions and the linear (P1) shape functions to interpolate the global nodal vector and its temporal gradient respectively in a time step. Numerical results of 1D and 2D problems show that the MDGFEM can filter out spurious numerical oscillations before and after waves, boundaries of the hole, and the interface between the layers more effectively for the propagation of acoustic waves in multilayered pavement. Compared with widely used time-continuous methods such as the Newmark method, the method proposed in this paper presents better capabilities in the fluid–structure interaction behavior of multilayer pavements and provides a more accurate solution, which contributes to the further development of non-destructive testing of multilayer pavement structures.

Based on the general Biot theory of saturated porous media, a modified time-discontinuous Galerkin finite element method (MDGFEM) is presented to simulate the structural dynamics and wave propagation problems of gas-saturated coal subjected to impact loading. Numerical results of one dimension and two dimensions show that the present MDGFEM possesses better abilities and provides much more accurate solutions than the traditional Newmark method and previous DGFEM for the impact problem. It can effectively capture the discontinuities of the wave and filter out the effects of spurious numerical oscillation induced by high-frequency impulsive load. The results can provide a technological basis for the research of the prevention of coal and gas dynamic disasters under deep mining. And the method could be useful for the further numerical research of coal-rock-gas coupling problems and coal-gas-heat coupling problems subjected to impact loading.

In order to reveal the influence of freezing and thawing on fatigue properties of the prestressed concrete beam, a kind of novel freeze-thaw test method for large concrete structure components was proposed, and the freeze-thaw experiments and fatigue failure test of prestressed concrete hollow beams were performed in this paper. Firstly, the compressive strength and dynamic elastic modulus of standard specimens subjected to different numbers of freeze-thaw cycles (0, 50, 75, and 100) were determined. Then, the static and dynamic experiments were performed for prestressed concrete beams under different freeze-thaw cycles. Depending on the static failure test results, the fatigue load for the prestressed concrete beam model was carried out, the fatigue tests for prestressed concrete beam under freezing and thawing cycles were done, and the influence of fatigue loading times on dynamic and static characteristics of prestressed concrete beam was also studied. Finally, the relation between fatigue characteristics and numbers of freeze-thaw cycles was established, and the fatigue life prediction formulas of prestressed concrete beams under freeze-thaw cycles were developed. The research shows that the freezing and thawing cycles had obvious influence on fatigue life, and the freezing and thawing cycles should be taken into account for life prediction and quality evaluation of prestressed concrete beams.

Although the effect of high temperature on the performance of organic solar cells has been widely investigated, it is inevitably influenced by the associated annealing effect (which usually leads to film morphology change and variation in electrical properties), which makes the discussion more sophisticated. In this study, we simplified the issue and investigated the influence of low temperatures (from room temperature to 77 K) on the photocurrent and internal/external quantum efficiency of a CuPc/C60 based solar cell. We found that besides the charge dynamic process (charge transport), one or more of the exciton dynamic processes, such as exciton diffusion and exciton dissociation, also play a significant role in affecting the photocurrent of organic solar cells at different temperatures. Additionally, the results showed that the temperature had negligible influence on the absorption of the CuPc film as well as the exciton generation process, but obviously influenced the other two exciton dynamic processes (exciton diffusion and exciton dissociation).

The remote sensing of water clouds is useful for studying their spatial and temporal variations and constraining physical processes in climate and weather prediction models. However, radar-only detection provides inadequate information for the cloud droplet size distribution. Here, we propose a novel lookup-table method, which combines lidar (1064, 532 nm) and radar (8.6 mm) to retrieve profiles of cloud optical (backscatter coefficient and extinction coefficient) and microphysical properties (effective diameter and liquid water content). Through the iteration of the extinction-to-backscatter ratio, more continuous cloud optical characteristics can be obtained. Sensitivity analysis shows that a 10% error of the lidar constant will lead to a retrieval error of up to 30%. The algorithm performed precise capture of the ideal cloud signal at a specific height and at full height and the maximum relative error of the backscatter coefficients at 1064 nm and 532 nm were 6% and 4%, respectively. With the application of the algorithm in the two observation cases on single or multiple cloud layers, the results indicate that the microphysical properties mostly agree with the empirical radar measurements but are slightly different when larger particles cause signal changes of different extents. Consequently, the synergetic algorithm is capable of computing the cloud droplet size distribution. It provides continuous profiles of cloud optical properties and captures cloud microphysical properties well for water cloud studies.

The transiting test method is a new approach for structural wind resistance research. However, traffic on the test road inevitably influences test results. In this study, the symmetrical CAARC standard tall building model was used to investigate the influence of a small vehicle near the test vehicle. A small vehicle was set up as an interference vehicle to drive around the test vehicle under different cases during the test. Results indicate that the mean wind pressure coefficient during the overtaking period is higher than that during the no overtaking period. The enlarged relative velocity and the small test vehicle velocity increase the overtaking interference and the data calculation time required to eliminate the overtaking influence. The overtaking influence only occurs if the test vehicle is overtaken by the small vehicle in the adjacent lane. The influence of the overtaking behavior of a small vehicle can be eliminated after the data calculation time exceeds 26 s. Moreover, the wake of small interference vehicle no longer influences the transiting test results after the spacing reaches 24 m.

A bridge structure is subjected to different external loads and environmental effects during its operation, which results in different types and degrees of damage to the structure during its service life. Reinforcement is often required to maintain regular operation and extend its service life. However, a reinforced bridge structure continues to be subjected to vehicle loads and environmental erosion. Therefore, research on the durability deterioration mechanisms and fatigue life decay of reinforced structures is key to ensuring the long service lives of bridge structures. To study the influence of freeze–thaw cycle erosion on the basic mechanical properties and fatigue characteristics of a bridge structure and a strengthened structure, 2 m long prestressed hollow slab beams were designed and fabricated based on the principle of a similarity ratio and subsequently pre-cracked by fatigue failure. The prestressed hollow slab beams were strengthened after fatigue damage by two methods: pasting steel plates and pasting carbon fiber cloths. After this, a freeze–thaw cycle test was conducted to study the dynamic and static mechanical index changes and the attenuation of the fatigue characteristics of the prestressed strengthened hollow slab beams under freeze–thaw cycle erosion. Meanwhile, a numerical model for reinforced structures was established based on the ABAQUS software to study the mechanisms governing the attenuation of the fatigue life of the prestressed hollow slab beams with different freeze–thaw cycles. The results showed that the deflections and strains observed for the two methods were less than those prior to reinforcement. For instance, the deflection in the span decreased by 14–15%, and the compressive strain decreased by 5.2% to 6%. Under the fatigue load, the prestressed hollow slab beams strengthened by the two methods could withstand a fatigue load cycle of 2 million, and the reinforced components exhibited good fatigue resistance. Under cyclic erosion and fatigue loading, the deflections and strains in the reinforced prestressed hollow slab beams were increased by varying degrees, such as a 30–40% increase in the tensile strain and a 65–70% increase in the span. The fatigue life of the reinforced hollow slab beams decreased with the increasing number of freeze–thaw cycles, and the decay rate of the fatigue life was accelerated.

To coordinate the supply chain risk caused by demand uncertainty, this paper proposed a flexible return strategy under demand uncertainty, in which the retailer can choose return quantity independently by put option after the selling season, while the return quantity is usually determined by the supplier in the classical return strategy. In our novel return strategy, the exercise price is not fixed, and we developed the base model of this strategy, named the selective buyback contracts model. We have solved the optimal pricing and ordering strategies of supply chain members. Numerical studies demonstrated that the contracts can coordinate a supply chain with one retailer and one supplier, and the supplier can adjust the profit distribution of the supply chain by adjusting the option exercise price. Compared with other return strategies, the selective buyback contracts give the retailer more power of choice, and the supplier receives risk compensation from the put options.

The force integration method (FIM) and the methods based on the mode transfer principle are the frequently used choices for solving the vibro-impact problem of continuum. Notably, there are different solving options such as numerical and semianalytical procedures. In this paper, a new modeling method based on the mode transfer principle, called the relative mode transfer method (RMTM), is proposed, and its semianalytical solution is obtained. A typical vibro-impact problem of continuum beam is studied. The time-history response under periodic excitation is obtained using the FIM, mode transfer method (MTM) through numerical procedure, and the RMTM through numerical procedure and semianalytical procedure. The effects of the method on the system steady-state response, amplitude-frequency response, and sticking motion are discussed. The impact type is divided into “hard impact” and “soft impact” when obtaining the results.

Although it is quite challenging to image and analyze the spatial distribution of bioaerosols in a confined space, a three-dimensional (3D) modeling system based on the planar laser-induced fluorescence (PLIF) technique is proposed in this paper, which is designed to analyze the temporal and spatial variations of bioaerosol particles in a confined chamber. The system employs a continuous planar laser source to excite the fluoresce, and a scientific complementary metal oxide semiconductor (sCMOS) camera to capture images of 2048 × 2048 pixels at a frame rate of 12 Hz. While a sliding platform is moving back and forth on the track, a set of images are captured at different positions for 3D reconstruction. In this system, the 3D reconstruction is limited to a maximum measurement volume of about 50 cm × 29.7 cm × 42 cm, with a spatial resolution of about 0.58 mm × 0.82 mm × 8.33 mm, and a temporal resolution of 5 s. Experiments were carried out to detect the PLIF signals from fluorescein aerosols in the chamber, and then 3D reconstruction was used to visualize and analyze the diffusion of aerosol particles. The results prove that the system can be applied to clearly reconstruct the 3D distribution and record the diffusion process of aerosol particles in a confined space.