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Background Methods Results Conclusion Inverted papilloma (IP) is a benign tumor characterized by epithelial proliferation, which has the potential for malignant transformation. However, the mechanisms driving this transformation are poorly defined. Matrix metalloproteinase‐11 (MMP‐11), a regulator of the tumor microenvironment that degrades extracellular matrix, is upregulated in IP with dysplasia. Here, we aim to investigate the role of MMP‐11 in IP epithelial migration and invasion.Human IP and contralateral normal sinus mucosa (control) samples were obtained. IP‐derived epithelial cultures and normal mucosa‐derived epithelial cultures were grown in air‒liquid interface, followed by immunostaining to assess MMP‐11 expression in IP. Migration and invasion assays were used to evaluate the role of an anti‐MMP‐11 antibody on IP and control epithelial cultures.IP‐derived cultures demonstrated strong MMP‐11 expression compared to controls. Treatment with anti‐MMP‐11 blocking antibody significantly reduced epithelial migration only in IP‐derived cells compared to non‐treated IP cells, as seen by incomplete wound closure and reduced transepithelial resistance. In addition, inhibition of MMP‐11 reduced IP epithelia's ability to invade through collagen‐coated transwells, suggesting that MMP‐11 plays a role in invasion.We established an in vitro model to study IP‐derived epithelial cells. MMP‐11 is uniquely expressed in IP epithelial cultures compared to control epithelial cultures. Inhibition of MMP‐11 limits IP epithelial migration and invasion to levels similar to that of normal sinus mucosa. MMP‐11 does not appear to have a functional role in normal sinus epithelium, suggesting that MMP‐11 has a role in malignant transformation of IP. [ABSTRACT FROM AUTHOR]

Objective: To characterize adverse events, provide a safety profile, and understand patient outcomes after complications arising from LigaSure and Harmonic use in the head and neck region. Methods: Retrospective analysis of adverse events from the Manufacturer and User Facility Device Experience (MAUDE) between January 2013 and 2023. Results: A total of 158 LigaSure and 159 Harmonic events were extracted. There were significantly more reports of Harmonic device overheating (6.9% vs. 0.6%, p = 0.003) and spontaneous self‐activation (4.4% vs. 0%, p = 0.032). Although intra‐operative and post‐operative complications were similar among both groups, there were significantly more intra‐operative bleeding events for LigaSure as compared to Harmonic (8.2% vs. 0.0%, p = 0.001). Conclusion: Understanding technical complications and adverse events attributable to LigaSure and Harmonic devices enables the development of clinically relevant risk mitigation strategies. Surgeons should avoid improper use by remaining vigilant of device functionality and temperature changes. [ABSTRACT FROM AUTHOR]

A study published in the journal Laryngoscope discusses the use of a combined transnasal, transoral approach for the removal of odontogenic cysts. The study found that this approach resulted in reduced recurrence rates and favorable sinonasal outcomes compared to traditional transoral-only approaches. The study included a retrospective review of patients who underwent the combined approach and collected data on demographic information, clinical history, and sinonasal outcomes. The results showed a low recurrence rate and improvement in sinonasal symptoms. The study recommends considering this approach for the management of odontogenic cysts involving the maxillary sinus. [Extracted from the article]

Background: Management of the neck in laryngeal squamous cell carcinoma (LSCC) is essential to oncologic control and survival. We aim to describe patterns and rates of clinical/pathologic lymph node disease, elective neck dissection (END), and occult lymph node metastasis (LNM) in patients with surgically‐managed LSCC. Methods: Retrospective cohort study of patients in the National Cancer Database (NCDB) diagnosed with LSCC between January 2004 and December 2016 who underwent primary surgery. Results: Seven thousand eight hundred and seventy‐six patients met inclusion criteria. For cN0 patients, the rates of END and occult LNM both increased with tumor stage and were highest for supraglottic tumors. Predictors of occult LNM included supraglottic site, pathologic T3 and T4 stage, positive margins, and presence of lymphovascular invasion (p < 0.05). Conclusions: The propensity for cervical LNM in surgically‐managed LSCC varies based on primary tumor site and stage, and a variety of disease factors increase risk of occult LNM. [ABSTRACT FROM AUTHOR]

Introduction: Chronic rhinosinusitis (CRS) can be associated with tumors involving the maxillary sinus, but outcomes after undergoing maxillectomy with free flap reconstruction remain unclear., Methods: A retrospective analysis of medical records was performed to evaluate evidence of CRS in patients who underwent maxillectomy with free flap reconstruction at a single tertiary care academic institution from 2013 through 2020., Results: Eighty-four patients were assessed. Nineteen (22.6%) patients were diagnosed with CRS after surgery, 23 (27.4%) patients were treated for sinus symptoms, and 49 (58.3%) had radiographic evidence of sinus inflammation for more than 6 months. Risk factors for requiring sinus treatment included adjuvant or neoadjuvant chemotherapy (p = 0.002) and pre-operative use of sinus medication (p &lt; 0.001). Radiographic evidence of sinusitis 6 months after surgery is also closely associated with sinusitis treatment (p = 0.051)., Conclusions: CRS may be underdiagnosed in patients undergoing maxillectomy with microvascular reconstruction. Further evaluation into patient sinus disease and symptoms following neoplastic surgery may lead to a higher quality of life in some long-term survivors., (© 2024 S. Karger AG, Basel.)