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32 results on '"Pandey, Arjun K"'

8. Aldosterone and aldosterone synthase inhibitors in cardiorenal disease

Author

Verma, Subodh, primary, Pandey, Avinash, additional, Pandey, Arjun K., additional, Butler, Javed, additional, Lee, John S., additional, Teoh, Hwee, additional, Mazer, C. David, additional, Kosiborod, Mikhail N., additional, Cosentino, Francesco, additional, Anker, Stefan D., additional, Connelly, Kim A., additional, and Bhatt, Deepak L., additional

Published
2024
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10. Efficacy of sodium–glucose cotransporter 2 inhibitors and angiotensin receptor–neprilysin inhibitors for heart failure in black patients: a systematic review and meta‐analysis of randomized controlled trials

Author

Pandey, Arjun K., primary, Dhingra, Nitish K., additional, Pandey, Avinash, additional, Puar, Pankaj, additional, Ahmed, Shamon, additional, Verma, Raj, additional, Mazer, C. David, additional, Butler, Javed, additional, Badiwala, Mitesh, additional, Yau, Terrence M., additional, Yanagawa, Bobby, additional, Bhatt, Deepak L., additional, and Verma, Subodh, additional

Published
2023
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12. Mechanisms of benefits of sodium-glucose cotransporter 2 inhibitors in heart failure with preserved ejection fraction.

Author

Pandey, Arjun K, Bhatt, Deepak L, Pandey, Avinash, Marx, Nikolaus, Cosentino, Francesco, Pandey, Ambarish, and Verma, Subodh

Subjects
SODIUM-glucose cotransporter 2 inhibitors, CANAGLIFLOZIN, HEART failure, VENTRICULAR ejection fraction, GLUCOSE transporters, IRON in the body, HEART fibrosis
Abstract

For decades, heart failure with preserved ejection fraction (HFpEF) proved an elusive entity to treat. Sodium-glucose cotransporter 2 (SGLT2) inhibitors have recently been shown to reduce the composite of heart failure hospitalization or cardiovascular death in patients with HFpEF in the landmark DELIVER and EMPEROR-Preserved trials. While improvements in blood sugar, blood pressure, and attenuation of kidney disease progression all may play some role, preclinical and translational research have identified additional mechanisms of these agents. The SGLT2 inhibitors have intriguingly been shown to induce a nutrient-deprivation and hypoxic-like transcriptional paradigm, with increased ketosis, erythropoietin, and autophagic flux in addition to altering iron homeostasis, which may contribute to improved cardiac energetics and function. These agents also reduce epicardial adipose tissue and alter adipokine signalling, which may play a role in the reductions in inflammation and oxidative stress observed with SGLT2 inhibition. Emerging evidence also indicates that these drugs impact cardiomyocyte ionic homeostasis although whether this is through indirect mechanisms or via direct, off-target effects on other ion channels has yet to be clearly characterized. Finally, SGLT2 inhibitors have been shown to reduce myofilament stiffness as well as extracellular matrix remodelling/fibrosis in the heart, improving diastolic function. The SGLT2 inhibitors have established themselves as robust, disease-modifying therapies and as recent trial results are incorporated into clinical guidelines, will likely become foundational in the therapy of HFpEF. [ABSTRACT FROM AUTHOR]

Published
2023
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13. The impact of statins on post-discharge atrial fibrillation after cardiac surgery: Secondary analysis from a randomized trial

Author

Hibino, Makoto, primary, Verma, Subodh, additional, Pandey, Arjun K., additional, Bisleri, Gianluigi, additional, Yanagawa, Bobby, additional, Verma, Raj, additional, Puar, Pankaj, additional, Quan, Adrian, additional, Teoh, Hwee, additional, Yau, Terrence M., additional, Verma, Atul, additional, Ha, Andrew C.T., additional, and Mazer, C. David, additional

Published
2022
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22. Sodium‐Glucose Co‐Transporter Inhibitors and Atrial Fibrillation: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Author

Pandey, Arjun K., primary, Okaj, Iva, additional, Kaur, Hargun, additional, Belley‐Cote, Emilie P., additional, Wang, Jia, additional, Oraii, Alireza, additional, Benz, Alexander P., additional, Johnson, Linda S. B., additional, Young, Jack, additional, Wong, Jorge A., additional, Verma, Subodh, additional, Conen, David, additional, Gerstein, Hertzel, additional, Healey, Jeff S., additional, and McIntyre, William F., additional

Published
2021
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24. Lower versus Standard INR Targets in Atrial Fibrillation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Author

Pandey, Arjun K., additional, Xu, Ke, additional, Zhang, Li, additional, Gupta, Saurabh, additional, Eikelboom, John, additional, Cook, Olivia, additional, McIntyre, William F., additional, Lopes, Renato D., additional, Crowther, Mark, additional, Belley-Côté, Emilie P., additional, and Whitlock, Richard P., additional

Published
2020
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25. Ambient temperature and aortic dissection: do pipes burst in freezing weather?

Author

Hibino, Makoto, Yanagawa, Bobby, Pandey, Arjun K, and Verma, Subodh

Subjects
AORTIC dissection, TEMPERATURE, CARDIOVASCULAR diseases, BLOOD pressure, TREADMILL exercise
Abstract

The article presents the discussion on low ambient temperature and temperature dropping between neighbouring days and acute aortic dissection. Topics include exposure to cold temperatures being associated with acute and chronic changes in several cardiovascular risk factors including blood pressure, heart rate, haematocrit, and platelet count; and myocardial and aerobic demands elicited by heavy snow shovelling rival maximal treadmill exercise and blood pressure.

Published
2022
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31. Vascular Regenerative Cell Deficiencies in South Asian Adults.

Author

Krishnaraj, Aishwarya, Bakbak, Ehab, Teoh, Hwee, Pan, Yi, Firoz, Irene N., Pandey, Arjun K., Terenzi, Daniella C., Verma, Raj, Bari, Basel, Bakbak, Asaad I., Kunjummar, Shakkeela Padanilathu, Yanagawa, Bobby, Connelly, Kim A., Mazer, C. David, Rotstein, Ori D., Quan, Adrian, Bhatt, Deepak L., McGuire, Darren K., Hess, David A., and Verma, Subodh

Subjects
*SOUTH Asians, *ASIANS, *ALDEHYDE dehydrogenase, *PROGENITOR cells, *GLYCOSYLATED hemoglobin
Abstract

South Asian individuals shoulder a disproportionate burden of cardiometabolic diseases. The purpose of this study was to determine if vascular regenerative cell content varies significantly between South Asian and White European people. Between January 2022 and January 2023, 60 South Asian and 60 White European adults with either documented cardiovascular disease or established diabetes with ≥1 other cardiovascular risk factor were prospectively enrolled. Vascular regenerative cell content in venous blood was enumerated using a flow cytometry assay that is based on high aldehyde dehydrogenase (ALDHhi) activity and cell surface marker phenotyping. The primary outcome was the difference in frequency of circulating ALDHhi progenitor cells, monocytes, and granulocytes between the 2 groups. Compared with White European participants, those of South Asian ethnicity were younger (69 ± 10 years vs 66 ± 9 years; P < 0.05), had lower weight (88 ± 19 kg vs 75 ± 13 kg; P < 0.001), and exhibited a greater prevalence of type 2 diabetes (62% vs 92%). South Asian individuals had markedly lower circulating frequencies of pro-angiogenic ALDHhiSSClowCD133+ progenitor cells (P < 0.001) and ALDHhiSSCmidCD14+CD163+ monocytes with vessel-reparative capacity (P < 0.001), as well as proportionally more ALDHhi progenitor cells with high reactive oxygen species content (P < 0.05). After correction for sex, age, body mass index, and glycated hemoglobin, South Asian ethnicity was independently associated with lower ALDHhiSSClowCD133+ cell count. South Asian people with cardiometabolic disease had less vascular regenerative and reparative cells suggesting compromised vessel repair capabilities that may contribute to the excess vascular risk in this population. (The Role of South Asian vs European Origins on Circulating Regenerative Cell Exhaustion [ORIGINS-RCE]; NCT05253521) [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2024
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