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Background: The transitional state between normal aging and dementia is known as Cognitive impairment (CI) where a person has memory complaints and objective evidence of CI but no evidence of dementia. With the globe undergoing a "demographic transition," the magnitude of neurodegenerative disorders is rising. In India, 27.3% of older persons with comorbidities had CI. Early identification of CI will likely help initiate proper remedial intervention, leading to better overall outcomes. In order to determine the prevalence of CI in older persons and whether it is associated with co-morbid conditions, this study was designed. Methods: A descriptive cross-sectional study was conducted among 350 older adults aged ≥60 residing in rural areas of Lucknow, selected using multistage cluster sampling. The Hindi Mental State Examination (HMSE) scale was used to assess cognitive function. A pretested semi-structured questionnaire was used to collect information on sociodemographic characteristics and comorbidity status. Results: Among 350 participants, with mean ± SD age 70.66 ± 9.53 years, the prevalence of CI as per HMSE (<23) was 24.9%. Overall, the mean HMSE score was less in individuals with (25.2) than without (27.19) comorbidities. Those with comorbidities had significantly lower mean scores in all individual domains of HMSE. Conclusion: CI affects one-fourth of the older adult population. Risk increases with the presence of comorbidities. Hence, screening, and early treatment are recommended. [ABSTRACT FROM AUTHOR]

Background: Despite being in temperate zone, India is endemic to nutritional rickets. However, very little has been studied on knowledge, perception and cultural practices of Indian communities, towards calcium and vitamin-D deficiency in children. Aim & Objective: The study aimed to develop and validate a questionnaire in Hindi language for the assessment of knowledge, attitude, and practices of parents towards calcium and vitamin D deficiency among children. Methodology: We searched electronic databases for item generation. The questionnaire was developed in Hindi language by five experts in the field of pediatrics, pediatric orthopaedics and community medicine using Delphi method. After language correction from Hindi language experts, a convenient sample of 30 participants filled the questionnaire and tested for internal consistency and test-retest reliability. Results: The overall Cronbach's alpha value for the finalized 46-item scale indicated an acceptable reliability (alpha = 0.91). The internal consistency reliability for six domains created was acceptable. The results revealed 'high' test-retest reliability, and there was no statistically significant difference noted between any of the first test and re-test corresponding values (p>0.05). Conclusion: The present questionnaire developed in Hindi Language to assess knowledge, attitude and practices (KAP) of parents towards Calcium & Vitamin-D deficiency in children, has a good validity and reliability. This newly developed instrument could prove its use to highlight the gaps that may exist among parents. The use of this tool may help clinicians, health educators and policy makers to identify key areas of intervention with regards to Calcium & Vitamin-D deficiency in children. [ABSTRACT FROM AUTHOR]

Background: Neonatal septicemia remains a significant healthcare challenge, particularly in resource-limited settings, with both early-onset neonatal septicemia (EONS) and late-onset neonatal septicemia (LONS) presentations contributing to morbidity and mortality. This study aimed to characterize the clinico-etiological profile and antibiotic susceptibility patterns of neonatal septicemia in a tertiary care setting in north India., Methodology: An analytical cross-sectional study was conducted from March 2021 to February 2022, encompassing neonates admitted to the Department of Pediatrics with suspected neonatal septicemia, confirmed by positive blood cultures., Results: A total of 96 neonates were included, predominantly male (71.9%). Gram-negative bacteria constituted 61.6% of isolates, and the most common organism isolated was non-lactose fermenter group (38.4%) followed by coagulase-negative staphylococci (CoNS) (33.4%). Non-lactose fermenter group bacteria were prominent in EONS cases (44.6%), while CoNS predominated in LONS cases (51.6%). Birthplace, birth weight, and perinatal score were significantly associated with both EONS and LONS. Linezolid exhibited high efficacy against gram-positive bacteria, while ciprofloxacin and meropenem demonstrated effectiveness against various gram-negative pathogens. Methicillin-resistant Staphylococcus aureus (MRSA) strains exhibited resistance to all the antibiotics used in the study except for linezolid., Conclusion: These findings underscore the importance of tailored empirical therapy guided by local epidemiological data to optimize clinical outcomes and mitigate antimicrobial resistance., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Institutional Ethics Committee, Indira Gandhi Medical College, Shimla issued approval HFW(MC-2)B(12)ETHICS/2021/14453 dated January 2021. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Sharma et al.)