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Keith L Davis,1 Wenhui Wei,2 Juliana L Meyers,1 Brett S Kilpatrick,3 Naushira Pandya4 1RTI Health Solutions, Research Triangle Park, NC, USA; 2Sanofi US, Inc, Bridgewater, NJ, USA; 3AnalytiCare, LLC, Glenview, IL, USA; 4Nova Southeastern University College of Osteopathic Medicine, Fort Lauderdale, FL, USA Background: The management of type 2 diabetes mellitus in long-term care (LTC) settings can be complex as a result of age-related complications. Despite guideline recommendations, sliding scale insulin remains commonplace in the LTC setting and data on basal insulin use are lacking.Methods: This retrospective study used medical chart data and the Minimum Data Set from elderly LTC facility patients who received basal insulin (insulin glargine, insulin detemir, or neutral protamine Hagedorn insulin) for the treatment of diabetes, to investigate the practice patterns and associated clinical outcomes.Results: A total of 2,096 elderly, insulin-treated patients in LTC were identified, with 59.5% of them (N=1,247) receiving basal insulin. Of these, more than 50% of patients received sliding scale insulin in co-administration with basal insulin. Despite its ease of use, insulin pen use was very low, at 14.6%. Significant differences were observed between the basal insulin groups for glycated hemoglobin level and dosing frequency. Hypoglycemia was uncommon -17.2% of patients experienced at least one event, and there was no significant difference in the prevalence of hypoglycemia between the groups.Conclusion: These data suggest the underutilization of basal insulin in the LTC setting and worryingly high combinational use with sliding scale insulin. Differences in glycated hemoglobin and dosing frequencies between types of basal insulin warrant further comparative effectiveness studies. Keywords: long-term care, nursing homes, type 2 diabetes mellitus, insulin detemir, insulin glargine, NPH insulin

Gregory Reardon,1 Naushira Pandya,2 Robert A Bailey31Informagenics, LLC and The Ohio State University College of Pharmacy, Columbus, OH, USA; 2Department of Geriatrics, Nova Southeastern University College of Osteopathic Medicine, Ft Lauderdale, FL, USA; 3Janssen Scientific Affairs, LLC, Horsham, PA, USAPurpose: Falls are common among nursing home residents and have potentially severe consequences, including fracture and other trauma. Recent evidence suggests anemia may be independently related to these falls. This study explores the relationship between the use of anemia-related pharmacotherapies and falls among nursing home residents.Methods: Forty nursing homes in the United States provided data for analysis. All incidents of falls over the 6-month post-index follow-up period were used to identify the outcomes of falls (≥1 fall) and recurrent falls (>1 fall). Logistic regression was used to analyze the relationship between falls and recurrent falls with each of the anemia pharmacotherapies after adjusting for potential confounders.Results: A total of 632 residents were eligible for analysis. More than half (57%) of residents were identified as anemic (hemoglobin < 12 g/dL females, or

The present paper reports a comprehensive first-principles calculation of the structural, electronic and thermophysical properties of B1, B2 and B3 phases of AlSi (Silumine) alloy using plane-wave pseudopotential density functional theory (DFT). PAW type pseudopotential with the exchange correlation of Perdew-Burke-Ernzerhof (PBE) are used to compute properties of B1, B2 and B3 phases of AlSi alloy. Our computed equilibrium lattice constants are in excellent agreement with the reported results. To investigate the structural phase transitions beween different phases of AlSi alloy, volume dependence of energy and pressure dependence of enthaply are studied for B1, B2 and B3 phases of AlSi alloy. Further, the electronic band structure along with the total electronic density of states of B1, B2 and B3 phases of AlSi alloy are calculated at the ground states. Behaviour of the total electronic density of states of B1, B2 and B3 phases of AlSi is also studied with the increase in pressure up to 100 GPa. In addition, various finite temperature/pressure thermophysical properties such as the room temperature thermal equation of state, isothermal bulk modulus, coefficient of thermal expansion, heat capacity at constant volume and pressure, Debye temperature and Grüneisen parameter are computed for B1, B2 and B3 phases of AlSi alloy using quasi harmonic Debye model. Conclusions based on the structural, electronic and thermophysical properties of B1, B2 and B3 phases of AlSi alloy are summarized. [ABSTRACT FROM AUTHOR]

Physics of Earth’s core is crucial to give insight into the origin and behavior of the Earth and other terrestrial planets. In order to interpret the behavior of tetrataenite L10 FeNi at Earth’s inner core boundary and Earth’s center conditions, we report electronic properties namely electronic charge density and Fermi surface of tetrataenite L10 FeNi using the first-principles plane wave self-consistent method under the framework of density functional theory. For structural and electronic properties of tetrataenite L10 FeNi at the Earth’s core conditions, we used spin polarization and ultrasoft pseudopotential with the exchange correlation of Perdew-Burke-Ernzerhof (PBE). Variable cell optimization (VC-relax) calculation using Wentzcovitch dynamics as implemented in Quantum ESPRESSO code is used for estimating equilibrium lattice constant of tetrataenite phase of L10 FeNi at 0 K. Bonding character between Fe-Fe, Ni-Ni and Fe- Ni metal atoms is discussed at 0 K and extreme Earth’s core conditions. The complicated shape of comprehensive Fermi surface is observed which occurred from the merging of all individual Fermi surfaces due to corresponding band crossing at Fermi level EF in the electronic band structure. Relation between crossing of each band in the electronic band structure with high symmetrical points of the Brillouin zone and the corresponding shape of Fermi surfaces are discussed. Conclusions based on the electronic charge density plot and Fermi surface topology of tetrataenite L10 FeNi at Earth’s core conditions are summarized. [ABSTRACT FROM AUTHOR]