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In recent years, immune checkpoint molecules have made breakthroughs in the fields of inducing graft tolerance, tumor immune escape and preventing autoimmunity. These immunoregulatory factors, when combined with ligand, can transduce the inhibitory signal into cells to negatively regulate the immune response, which brings new enlightenment for the immune research of pregnancy and pregnancy complications. In this review, we reviewed the immunomodulatory effects of CTLA-4, PD-1 and Tim-3 in pregnancy, in order to evaluate their potential effects in pregnancy, and to provide a new direction for the immunotherapy of pregnancy complications. [ABSTRACT FROM AUTHOR]