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Background/objectives Numerous clinical trials have confirmed that supplementation with purified anthocyanins has favorable effects on metabolic diseases, but the dose-response of dyslipidemia to anthocyanin supplementation remains unclear. This study aimed to investigate the effect of anthocyanin supplementation in different doses on lipid profile. Subjects/methods We randomly assigned 176 dyslipidemic subjects aged 35-70 to three purified anthocyanin groups (40 mg/day, n = 45; 80 mg/day, n = 42; 320 mg/day, n = 43) and a placebo group (n = 46). Anthropometric parameters, serum lipid profiles, and cholesterol efflux capacity (CEC) were measured at baseline, and at the end of 6 and 12 weeks. Results After 12 weeks of supplementation, significant differences in CEC (P = 0.033), high-density lipoprotein cholesterol (HDL-C) (P = 0.043), and apolipoprotein A-I (ApoA-I) (P = 0.022) were observed between four groups. Compared with placebo, 320 mg/day anthocyanin significantly increased CEC (35.8%, 95% CI: 11.5-60.2%; P = 0.004), HDL-C (0.07 mmol/L, 95% CI: 0.01-0.14; P = 0.003), and ApoA-I (0.07 g/L, 95% CI: 0.01-0.12; P = 0.008). Linear trend analysis showed that anthocyanin supplementation has a strong dose-response relationship with CEC (P = 0.002), HDL-C (P = 0.038), and ApoA-I (P = 0.023). Moreover, the enhancement of CEC showed positive correlations with the increase in HDL-C (r = 0.215, P < 0.01) and APOA-I (r = 0.327, P < 0.01). Conclusions Anthocyanin supplementation at 0-320 mg/day for 12 weeks enhances CEC in a dose-response manner in dyslipidemic subjects. Anthocyanin supplementation doses of 80-320 mg/day can improve serum HDL-C levels and HDL-induced CEC., Author(s): Zhongliang Xu [sup.1] [sup.2] , Jiewen Xie [sup.1] [sup.2] , Hanyue Zhang [sup.1] [sup.2] , Juan Pang [sup.1] [sup.2] , Qing Li [sup.1] [sup.2] , Xu Wang [sup.1] [sup.2] [...]

Resveratrol (RES) has been reported to prevent hyperuricemia (HUA); however, its effect on intestinal uric acid metabolism remains unclear. This study evaluated the impact of RES on intestinal uric acid metabolism in mice with HUA induced by a high-fat diet (HFD). Moreover, we revealed the underlying mechanism through metagenomics, fecal microbiota transplantation (FMT), and 16S ribosomal RNA analysis. We demonstrated that RES reduced the serum uric acid, creatinine, urea nitrogen, and urinary protein levels, and improved the glomerular atrophy, unclear renal tubule structure, fibrosis, and renal inflammation. The results also showed that RES increased intestinal uric acid degradation. RES significantly changed the intestinal flora composition of HFD-fed mice by enriching the beneficial bacteria that degrade uric acid, reducing harmful bacteria that promote inflammation, and improving microbial function via the upregulation of purine metabolism. The FMT results further showed that the intestinal microbiota is essential for the effect of RES on HUA, and that Lactobacillus may play a key role in this process. The present study demonstrated that RES alleviates HFD-induced HUA and renal injury by regulating the gut microbiota composition and the metabolism of uric acid. [ABSTRACT FROM AUTHOR]

Traditional hydrogel sensors can easily freeze or evaporate under extreme conditions, resulting in their performance degradation. At the same time, the low strength/toughness and high resistance of hydrogels hinder their practical applications in different fields. In this work, we report a simple and effective strategy to prepare mechanically strong and conductive nanocomposite hydrogels by covalent interaction of acidified carbon fibers and various ions. In this paper, a wearable strain sensor with high sensitivity and flexibility and self-healing, anti-freezing and anti-drying properties was prepared using polyacrylic acid, sodium alginate and acidified carbon fibers as raw materials. The hydrogel has an interpenetrating cross-linked network structure. The interpenetrating cross-linking structure makes the hydrogel sensor exhibit excellent ductility, remarkable repeatability and stable sensing performance. The hydrogel can be used as a human strain sensor for the real-time detection of human movement, including joint movement and speech. The hydrogel strain sensor shows low strain detection limit (3% strain), fast response time (∼100 ms), high sensitivity factor and excellent stability. The hydrogel has good self-adhesion with various substrates (such as copper, glass, plastic and skin). The hydrogel has good strain sensing performance at different strains (1–200%). In addition, the hydrogel can maintain excellent flexibility, extensibility and conductivity in a wide temperature range from −20 °C to 50 °C, effectively improving the practicability and durability of the hydrogel in practical applications. Therefore, the hydrogel has a good application prospect in wearable devices, soft robot systems and health monitoring applications. [ABSTRACT FROM AUTHOR]