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2. The Acute Effect of the Antioxidant Drug U-74389G on Red Blood Cell Distribution Width Levels During Hypoxia Reoxygenation Injury in Rats

Author

Tsompos Constantinos, Panoulis Constantinos, Toutouzas Konstantinos, Zografos George, and Papalois Apostolos

Subjects
hypoxia, U-74389G, red blood cell distribution width, reoxygenation, Medicine
Abstract

The AIM of this experimental study was to evaluate the effect of the antioxidant drug “U-74389G” in a rat model of hypoxia reoxygenation (HR) using the previously established protocol. Effects of treatment were evaluated by mean red blood cell distribution width (RDW) levels. MATERIALS AND METHODS: 40 rats of a mean weight of 231.875 g were employed in the study. RDW levels were determined at 60 min (groups A and C) and at 120 min (groups B and D) after starting the reoxygenation. Groups A and B received no drugs, whereas rats from groups C and D were administered with U-74389G. RESULTS: demonstrated that U-74389G administration significantly decreased the RDW levels by 4.96% + 2.27% (p = 0.0175). Reoxygenation time non-significantly decreased the RDW levels by 0.27% + 2.41% (p = 0.8889). Together, U-74389G administration and reoxygenation time non-significantly decreased the RDW levels by 2.54% + 1.39% (p = 0.0679). CONCLUSIONS: U-74389G administration particulary in concert without reperfusion declines the RDW levels even within the short - time context of 1.5 hours reperfusion.

Published
2015
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4. The Effect of the Antioxidant Drug 'U-74389G' on Haemoglobin Levels Following a Hypoxemia/ Re-oxygenation Protocol in Rats

Author

Tsompos Constantinos, Panoulis Constantinos, Toutouzas Konstantinos, Zografos George, and Papalois Apostolos

Subjects
hypoxia, haemoglobin, u-74389g, re-oxygenation, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Critically ill patients usually present with circulatory hypoxemia and this is associated with a poorer prognosis. The aim of this experimental study was to examine the effect of U-74389G with specific regard to a hypoxemia/re-oxygenation protocol, on mean blood haemoglobin (Hgb) levels in rats.

Published
2015
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5. The Rat Ovaries after Erythropoietin Process.

Author

Tsompos, Constantinos, Panoulis, Constantinos, Triantafyllou, Aggeliki, Zografos, George C., Gerakis, Evripidis, Gerakis, Stergios, and Papalois, Apostolos

Subjects
*ERYTHROPOIETIN, *OVARIES, *LABORATORY rats, *RATS, *NUCLEAR fragmentation
Abstract

Background: This article presents an experimental model for assessment of Erythropoietin (Epo) effects produced upon post-ischemic damage of ovarian tissue. The results of study were expressed as a combined index calculated from individual pathologic scores of experimental ovarian damages. The panel included 4 distinct histologic variables, those of Ovarian Epithelium edema (OE), Ovarian Congestion (OC), Ovarian epithelium Karyorrhexis (OK) and Oophoritis (OO). Final conclusions were based on the data from 2 independent experimental series with acute ischemia-reperfusion of ovaries produced in female rats, assessing the effects of locally injected Erythropoietin (Epo). Moreover, the proinflammatory cytokine (TNFa) and Malonic Dialdehyde (MDA) were also assayed as biomarkers of oxidative stress. Materials and Methods: The study was performed in young Wistar rats. Ovarian ischemia was induced by clapping inferior aorta for 45 min after the laparotomy. Two experimental time points were chosen for assessing the OE, OC and OK, OO and TNFa, MDA scores, i.e., 60 and 120 min after starting the ovarian reperfusion. The groups A and B were served as controls, whereas the groups C and D were administered Epo intravenously. Results: The first experimental series showed that Epo has a non-significant enhancing effect for the OE and OC indexes (p-values=0.94) in a subgroup with the histologically "unchanged" state, at a grade of 0.009 [-0.258-+0.276]. The second study showed that Epo treatment was associated with a moderate, however, non-significant increase of OK and OO within the animals with "unchanged" state, grade 0.027 [-0.055-0.110] (p-values=0.50). These two studies were co-evaluated since they were obtained in the same experimental setting. Separate calculations were performed for TNFa and MDA scores showing some marginal unspecified effects of Epo. Conclusion: Epo administration was associated with a trend for enhancement of the 4 histologic variables within the "unchanged" grade group at the score of 0.018 [-0.128-+0.165] (p-value=0.80), along with some reduction of the TNFa levels by 22.89% [+15.05%] (p-value=0.12), and non-significant increase of MDA levels by 27.05% [+29.63%] (p-value=0.35). This minimal antioxidant effects should be interpreted with caution. Very likely, the antioxidant effects will be more pronounced at later observation terms. [ABSTRACT FROM AUTHOR]

Published
2023
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8. Endosalpingeal karyorrhexis ve salpingitis 'nin eritropoietin etkisinin ardından ortak değerlendirilmesi

Author

Maria Karamperi, Papalois Apostolos, Kalliopi Tsarea, Toutouzas Konstantinos, Panoulis Constantinos, Tsompos Constantinos, Triantafyllou Aggeliki, and C. Zografos George

Subjects
i̇skemi, medicine.medical_specialty, Medicine (General), RD1-811, Ischemia,Erythropoietin,Endosalpingeal karyorrhexis,Salpingitis,Reperfusion, ischemia, R5-920, salpenjit, salpingitis, medicine, eritropoietin, Cerrahi, Gynecology, business.industry, Karyorrhexis, Salpingitis, medicine.disease, İskemi,Eritropoietin,Endosalpingeal karyorrhexis,Salpenjit,Reperfüzyon, reperfüzyon, reperfusion, Erythropoietin, Medicine, Surgery, endosalpingeal karyorrhexis, erythropoietin, business, Reperfusion injury, medicine.drug
Abstract

Aim: This studyco-evaluated the 2 quoted histologic variables after the cytokine erythropoietin (Epo) administration. The calculation was based on the results of 2preliminary studies, each one evaluating a respective histologic variable of endosalpingeal karyorrhexis (EK) or salpingitis (S) in an induced ischemiareperfusion (IR) animal experiment.Methods: The 2 main experimental endpoints at which the EKand S scores were evaluated, were thereperfusion 60thmin(for A & C groups) and thereperfusion 120thmin (for B & D groups). Specially, the groups A and B wereprocessed without drugs, whereas the groups CandD after Epo administration. Results: Thefirst preliminary study showed that Epo hardly non significantly increased theEK scores by the grade “without lesions” 0.0181818 [-0.0679319 - +0.1042955](p-value=0.6715). The other preliminary study found that Epo did not influence theS scores (p-value=1.0000). Both studies were co-estimated since they belong tothe same experimental setting. This study co-evaluated the combined diagnosticvalues of both variables together. Conclusions: Epoagain hardly non significantly increased both scores for these histologicparameters at the grade of “withoutlesions” 0.0090909 [-0.0339659 - +0.0521478] (p-value=0.6715) since they wereco-evaluated together., Amaç: Bu çalışma sitokin eritropoietin (EPO) uygulamasından sonra 2 atfedilen histolojik değişkenleri ortaklaşa değerlendirdi. Hesaplama, her biri endosalpingeal karyorrhexis (EK) veya salpingitis (S) bir indüklenen iskemi reperfüzyonu (IR) hayvan denemesi içinde ilgili histolojik değişken değerlendiren 2 ön çalışmanın sonuçlarını temel aldı.Yöntemler: EK ve S puanlarının değerlendirilmesi gereken 2 ana deneysel uç noktası reperfüzyon 60 dk (A & C grupları için) ve reperfüzyon 120 dk (B & D grupları için) idi. Özel olarak, A ve B grupları ilaç olmadan işlendi, oysa C ve D EPO uygulamasından sonra işlendi. Bulgular: İlk ön çalışmada EPO çok önemli ölçüde anlamlı "lezyonlar olmadan" 0,0181818 [-0,0679319-+ 0,1042955] (p-değer = 0,6715) notu tarafından ek puanları artış gösterdi. Diğer ön çalışmada EPO, S puanlarını etkilemez bulundu (p-değer = 1,0000). Her iki çalışmada aynı deneysel ayarlara sahip olduğundan birlikte tahmin edilmiştir. Bu çalışma her iki değişkenin kombine tanı değerlerini birlikte değerlendirir. Sonuç: EPO yine de çok önemli ölçüde bu histolojik parametreler için "lezyonlar olmadan" 0,0090909 [-0,0339659-+ 0,0521478] (p-değer = 0,6715) sınıfında birlikte değerlendirildiğinde her iki skoru artmıştır.

Published
2018

13. Comparison of the Hyponatremic Effects of Erythropoietin and U-74389G

Author

Karamperi Maria, Papalois Apostolos, Triantafyllou Aggeliki, Zografos George C, Toutouzas Konstantinos, Tsarea Kalliopi, Tsompos Constantinos, and Panoulis Constantinos

Subjects
Drug, Antioxidant, business.industry, medicine.medical_treatment, media_common.quotation_subject, Sodium, Ischemia, chemistry.chemical_element, U 74389g, Pharmacology, medicine.disease, Drug usage, chemistry, Erythropoietin, medicine, business, After treatment, media_common, medicine.drug
Abstract

This study calculated the effects on serum sodium (Na) levels, after treatment with either of 2 drugs: The erythropoietin (Epo) and the antioxidant lazaroid (L) drug U-74389G. The calculation was based on the results of 2 preliminary studies, each one of which estimated the certain influence, after the respective drug usage in an induced ischemia reperfusion (IR) animal experiment.

Published
2019

17. The Rat Uterus after U-74389G Process

Author

Tsompos, Constantinos, primary, Panoulis, Constantinos, additional, Toutouzas, Konstantinos, additional, Triantafyllou, Aggeliki, additional, C Zografos, George, additional, Tsarea, Kalliopi, additional, Karamperi, Maria, additional, and Papalois, Apostolos, additional

Published
2019
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19. The effect of the antioxidant drug 'U-74389G' on alkaline phosphatase levels during ischemia reperfusion injury in rats

Author

TSOMPOS, Constantinos, PANOULİS, Constantinos, TOUTOUZAS, Konstantinos, ZOGRAFOS, George, and PAPALOİS, Apostolos

Subjects
Alkaline phosphatase levels, ischemia, reperfusion, U-74389G, General Medicine, General Biochemistry, Genetics and Molecular Biology
Abstract

The aim of this experimental study was to examine the effect of the antioxidant drug “U-74389G”, on rat model and particularly in a liver ischemia reperfusion (IR) protocol. The beneficial effect or non effectiveness of that molecule were studied biochemically using mean blood alkaline phosphatase levels (ALP). Forty rats of mean weight 231.875 gr were used in the study. ALP levels were measured 60 min after reperfusion (groups A and C) and 120 min after reperfusion (groups B and D) with administration of the drug U-74389G in groups C and D. U-74389G administration non significantly increased the ALP levels by 19.76%±15.06% (p=0.1784), but by 31.91%±7.69% (p=0.0001) for predicted values. Reperfusion time non-significantly decreased the ALP levels by 25.21%±14.83% (p=0.0675), also by 6.38%±9.30% (p=0.3650) for predicted values. However, U-74389G administration and reperfusion time together non-significantly increased the ALP levels by 8.08%±9.19% (p=0.3696), but also by 17.75%±4.79% (p=0.0005) for predicted values. This study indicates that U-74389G administration and its interaction with reperfusion time non significantly increased short-term effects on ALP levels. However, the predicted ALP values adjusted for rats weight, kept significantly increased ones, which stand for the restorating effects of U-74389G, that are slower than it seems.

Published
2014

25. THE ACUTE EFFECT OF ERYTHROPOIETIN ON GLUCOSE LEVELS DURING ISCHEMIA REPERFUSION INJURY IN RATS

Author

Tsompos, Constantinos, Panoulis, Constantinos, Toutouzas, Konstantinos, Zografos, George, Papalois, Apostolos, Tsompos, Constantinos, Panoulis, Constantinos, Toutouzas, Konstantinos, Zografos, George, and Papalois, Apostolos

Abstract

The aim of this experimental study was to examine the effect of erythropoietin on rat model and particularly in an ischemia reperfusion (HR) protocol. The effect of that molecule was studied biochemically using blood mean glucose (Gl) levels. Materials and methods: 40 rats of mean weight 247.7 g were used in the study. Gl levels were measured at 60 min (groups A and C) and at 120 min (groups B and D) of reperfusion. Erythropoietin was administered only in groups C and D. Results were that Epo administration non-significantly increased the gl levels by 5.59% +6.46% (p=0.3208). Reperfusion time non-significantly increased the gl levels by 5.63%+6.45% (p=0.4098). However, erythropoietin administration and reperfusion time together produced a non significant combined effect in increasing the gl levels by 4.94%+3.81% (p= 0.1892). Conclusions: Results of this study indicate that erythropoietin administration, reperfusion time, or their interaction non-significantly increase the blood glucose levels in short-term. Opposite bibliographic data are considered more reliable, until a greater sample provide clearer results.

Published
2017

31. Comparison of the excretory capacities of erythropoietin and U-74389G concerning serum creatinine levels

Author

Tsompos, Constantinos, Panoulis, Constantinos, Toutouzas, Konstantinos, Triantafyllou, Aggeliki, Zografos, George, and Papalois, Apostolos

Abstract

This study compared the excretory effects, the erythropoietin (Epo) and antioxidant drug U-74389G exert on serum creatinine levels through kidneys. 2 preliminary studies were used for this purpose including respectively one drug used in a renal ischemia–reperfusion (IR) protocol of an animal model. The preliminary studies are part of the present work. The subjects were pretreated in preliminary studies but the results of the same subjects were simply compared in the current work.

Published
2024
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32. Acute effect of the antioxidant drug U-74389G on hematocrit levels during hypoxia and reoxygenation injury in rats

Author

Tsompos, Constantinos, Panoulis, Constantinos, Toutouzas, Konstantinos, Triantafyllou, Aggeliki, Zografos, George, Papalois, Apostolos, Tsompos, Constantinos, Panoulis, Constantinos, Toutouzas, Konstantinos, Triantafyllou, Aggeliki, Zografos, George, and Papalois, Apostolos

Abstract

Aims: This experimental study evaluated the effect of the antioxidant drug U-74389G on hematocrit levels using a rat model of hypoxia and reoxygenation following an established protocol. Methods: Forty rats with a mean weight of 231.875 g were employed in the study. Hematocrit levels were determined at 60 min (groups A and C) and at 120 min (groups B and D) after starting reoxygenation. Groups A and B received no drugs, whereas U-74389G was administered to rats from groups C and D. Results: U-74389G administration significantly increased hematocrit levels by 4.73%±2.25% (p=0.0435). Reoxygenation time increased hematocrit levels non significantly by 3.96%±2.29% (p=0.1025). U-74389G administration combined with reoxygenation time significantly increased hematocrit levels by 3.16%±1.33% (p=0.0196). Conclusions: U-74389G administration, whether it interacted or not with reoxygenation time, significantly increased hematocrit levels in the short term in a rat model of hypoxia and reoxygenation.

Published
2016

39. Thyroid function and autoimmunity are associated with the risk of vertebral fractures in postmenopausal women

Author

Lambrinoudaki, Irene, primary, Armeni, Eleni, additional, Pliatsika, Paraskevi, additional, Rizos, Demetrios, additional, Kaparos, George, additional, Augoulea, Areti, additional, Alexandrou, Andreas, additional, Flokatoula, Maria, additional, Creatsa, Maria, additional, Panoulis, Constantinos, additional, Triantafyllou, Nikolaos, additional, and Papacharalambous, Xenofon, additional

Published
2016
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46. The effect of erythropoietin on ?-glutamyltransferase during ischemia reperfusion injury in rats

Author

Tsompos, Constantinos, Panoulis, Constantinos, Toutouzas, Konstantinos, Zografos, George, Papalois, Apostolos, Tsompos, Constantinos, Panoulis, Constantinos, Toutouzas, Konstantinos, Zografos, George, and Papalois, Apostolos

Abstract

The aim of this experimental study was to examine the effect of erythropoietin on rat model and particularly in an ischemia reperfusion (IR) protocol. The effect of that molecule was studied biochemically using blood mean ?-glutamyltransferase (?GT) levels. Materials and methods: 40 rats of mean weight 247.7 g were used in the study. ?GT levels were measured at 60 min (groups A and C) and at 120 min (groups B and D) of reperfusion. Erythropoietin was administered only in groups C and D. Results were that Epo administration non-significantly decreased the ?GT levels by 12.70% +13.11% results of paired t-test (p= 0.3541). Reperfusion time kept non-significantly increased the ?GT levels by 6.35%+13.24% (P=0.6264). However, erythropoietin administration and reperfusion time together produced a non-significant combined effect in keeping decreased the ?GT levels by 4.62%+7.97% (P= 0.5534). Conclusions are that erythropoietin administration interacted or not with reperfusion time have non significant short term decreasing effects on ?GT levels.

Published
2015

47. The effect of the antioxidant drug 'U-74389G' on amylase during ischemia reperfusion injury in rats

Author

Zografos C. George, Panoulis Constantinos, Triantafyllou Aggeliki, Toutouzas Konstantinos, Papalois Apostolos, and Tsompos Constantinos

Subjects
Drug, medicine.medical_specialty, Antioxidant, biology, business.industry, media_common.quotation_subject, medicine.medical_treatment, Rat model, Amylase levels, Ischemia, General Medicine, U 74389g, medicine.disease, Endocrinology, Anesthesia, Internal medicine, biology.protein, Medicine, Amylase, business, Reperfusion injury, media_common
Abstract

Background: This experimental study examined the effect of the antioxidant drug U-74389G on a rat model and particularly in an ischemia-reperfusion protocol. Settings and Design: The beneficial effect or noneffectiveness of that molecule was studied biochemically using blood mean amylase (A) levels. Materials and Methods: Forty rats of mean weight 231.875 g were used in the study. The levels were measured at 60 min of reperfusion (Groups A and C) and at 120 min of reperfusion (Groups B and D) with the administration of the drug U-74389G in Groups C and D. Results: U-74389G administration significantly decreased the predicted A levels by 8.40 ± 2.02% ( P = 0.0001). Reperfusion time kept nonsignificantly increased the predicted A levels by 1.68 ± 2.44% ( P = 0.4103). However, U-74389G administration and reperfusion time together produced a significant combined effect in keeping decreased the predicted A levels by 4.67 ± 1.26% ( P = 0.0005). Conclusions: U-74389G administration whether it interacted or not with reperfusion time has a significant decreasing beneficial restoring short-term effect on amylase levels.

Published
2016

49. Association of sex hormones and glucose metabolism with the severity of multiple sclerosis

Author

Triantafyllou, Nikolaos, primary, Thoda, Pinelopi, additional, Armeni, Eleni, additional, Rizos, Demetrios, additional, Kaparos, George, additional, Augoulea, Areti, additional, Alexandrou, Andreas, additional, Creatsa, Maria, additional, Tsivgoulis, Georgios, additional, Artemiades, Artemios, additional, Panoulis, Constantinos, additional, and Lambrinoudaki, Irene, additional

Published
2015
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50. Stress urinary incontinence and endogenous sex steroids in postmenopausal women

Author

Augoulea, Areti, primary, Sioutis, Dimos, additional, Rizos, Demetrios, additional, Panoulis, Constantinos, additional, Triantafyllou, Nikolaos, additional, Armeni, Eleni, additional, Deligeoroglou, Efthymios, additional, Chrelias, Charalambos, additional, Creatsa, Maria, additional, Liapis, Angelos, additional, and Lambrinoudaki, Irene, additional

Published
2015
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