Search

Your search keyword '"Paolillo, Joshua M."' showing total 10 results
Start Over Author "Paolillo, Joshua M."
10 results on '"Paolillo, Joshua M."'

1. Development of a Scalable Synthesis toward a KRAS G12C Inhibitor Building Block Bearing an All-Carbon Quaternary Stereocenter, Part 2: Asymmetric Synthesis via Shi Epoxidation

Author

Tan, Zhulin, primary, Ju, Xuan, additional, Wu, Hao, additional, Dong, Weitong, additional, Leung, Joyce C., additional, Hou, Xiaowen, additional, Lee, Heewon, additional, Granger, Alice, additional, Paolillo, Joshua M., additional, DiMeo, Susan V., additional, Chen, Chengsheng, additional, Wu, Linglin, additional, Lorenz, Jon C., additional, Sarvestani, Max, additional, Buono, Frederic, additional, Frutos, Rogelio, additional, Tampone, Thomas G., additional, Huang, Xiaojun, additional, Zhang, Gulin, additional, Wang, Yuwen, additional, Spinelli, Earl, additional, Lei, Zhen, additional, and Song, Jinhua J., additional

Published
2024
Full Text
View/download PDF

6. Scalable copper‐catalyzed preparation of imidazopyridinones from iodopyridinyl ureas.

Author

Rugg, Kyle W., Balk, Regina C., Paolillo, Joshua M., Yerkozhanov, Dauzhan, Tampone, Thomas G., Holan, Martin, Buono, Frederic G., and Reeves, Jonathan T.

Subjects
MANUFACTURING processes, UREA
Abstract

The efficient copper‐catalyzed construction of imidazopyridinones is described. Beginning from iodopyridinyl ureas, Ullmann coupling provides imidazopyridinones in good yield. Manufacturing by this process is described on 473 kg scale; the scope and limitations of substrates is also detailed. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

10. Anaerobic Hydroxylation of C(sp 3 )-H Bonds Enabled by the Synergistic Nature of Photoexcited Nitroarenes.

Author

Paolillo JM, Duke AD, Gogarnoiu ES, Wise DE, and Parasram M

Abstract

A photoexcited-nitroarene-mediated anaerobic C-H hydroxylation of aliphatic systems is reported. The success of this reaction is due to the bifunctional nature of the photoexcited nitroarene, which serves as the C-H bond activator and the oxygen atom source. Compared to previous methods, this approach is cost- and atom-economical due to the commercial availability of the nitroarene, the sole mediator of the reaction. Because of the anaerobic conditions of the transformation, a noteworthy expansion in substrate scope can be obtained compared to prior reports. Mechanistic studies support that the photoexcited nitroarenes engage in successive hydrogen atom transfer and radical recombination events with hydrocarbons, leading to N -arylhydroxylamine ether intermediates. Spontaneous fragmentation of these intermediates leads to the key oxygen atom transfer products.

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results