137 results on '"Paonessa G"'
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2. Development of Humanized Mice for the Study of Hepatitis C Virus Infection
3. High circulating levels of biologically inactive IL-6/SIL-6 receptor complexes in systemic juvenile idiopathic arthritis: evidence for serum factors interfering with the binding to gp130
4. Identification of novel multi-stage histone deacetylase (HDAC) inhibitors that impair Schistosoma mansoni viability and egg production
5. 'Use of Perhexiline'
6. Polymorphism of rat seminal vesicle secretory proteins: Characterization of svp-1 and svp-2 and their identification with the major secretory proteins IV and V
7. Ciliary Neurotrophic Factor Corrects Obesity and Diabetes Associated with Leptin Deficiency and Resistance
8. Chimpanzee DNA profiles on trial
9. Human IL-6 receptor super-antagonists with high potency and wide spectrum on multiple myeloma cells
10. Definition of a complex binding site for gp130 in human interleukin-6
11. GENERATION OF IL-6 ANTAGONISTS BY SUBSTITUTING RESIDUES IN HELIX-A
12. Chimpanzee DNA profile on trial
13. Chimpanzee DNA profiles on trial
14. Identification of ciliary neurotrophic factor (CNTF) residues essential for leukemia inhibitory factor receptor binding and generation of CNTF receptor antagonists.
15. Human interleukin-6 receptor super-antagonists with high potency and wide spectrum on multiple myeloma cells
16. Six different cytokines that share GP130 as a receptor subunit, induce serum amyloid A and potentiate the induction of interleukin-6 and the activation of the hypothalamus-pituitary-adrenal axis by interleukin-1
17. The Molecular Design of Human IL‐6 Receptor Antagonistsa
18. Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling.
19. Nonradioactive Receptor Binding Assay for Ciliary Neurotrophic Factor
20. Oncostatin M binds directly to gp130 and behaves as interleukin-6 antagonist on a cell line expressing gp130 but lacking functional oncostatin M receptors
21. Generation of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation.
22. Chimpanzee DNA profiles on trial
23. The 11S rat seminal vesicle mRNA directs the in vitro synthesis of two precursors of the major secretory protein IV.
24. Potent Inhibitors of Subgenomic Hepatitis C Virus RNA Replication through Optimization of Indole-N-Acetamide Allosteric Inhibitors of the Viral NS5B Polymerase
25. Cis- and trans-acting elements responsible for the cell-specific expression of the human Ą1-antitrypsin gene
26. Structural analysis of the X‐linked gene encoding human glucose 6‐phosphate dehydrogenase.
27. Purification of a NF1‐like DNA‐binding protein from rat liver and cloning of the corresponding cDNA.
28. Cis‐ and trans‐acting elements responsible for the cell‐specific expression of the human alpha 1‐antitrypsin gene.
29. Two distinct factors interact with the promoter regions of several liver‐specific genes.
30. Agonistic and antagonistic variants of ciliary neurotrophic factor (CNTF) reveal functional differences between membrane-bound and soluble CNTF alpha-receptor.
31. Functional expression of soluble human interleukin-11 (IL-11) receptor alpha and stoichiometry of in vitro IL-11 receptor complexes with gp130.
32. Monovalent phage display of human interleukin (hIL)-6: selection of superbinder variants from a complex molecular repertoire in the hIL-6 D-helix
33. Interleukin-6 (IL-6) antagonism by soluble IL-6 receptor alpha mutated in the predicted gp130-binding interface.
34. Down-regulation of interleukin 6 receptor alpha chain in interleukin 6 transduced melanoma cells causes selective resistance to interleukin 6 but not to oncostatin M
35. Liver specific expression of cloned human genes
36. Human interleukin-6 receptor super-antagonists with high potency and wide spectrum on multiple myeloma cells
37. Two distinct and independent sites on IL-6 trigger gp130 dimer formation and signalling
38. Down-Regulation of Interleukin 6 Receptor a Chain in Interleukin 6 Transduced Melanoma Cells Causes Selective Resistance to Interleukin 6 but not to Oncostatin M
39. The 11S rat seminal vesicle mRNA directs thein vitrosynthesis of two precursors of the major secretory protein IV
40. Optimization of 2-(1H-imidazo-2-yl)piperazines series of Trypanosoma brucei growth inhibitors as potential treatment for the second stage of HAT
41. Generation of IL-6 receptor antagonist and super-antagonist by molecular modelling and site-directed mutagenesis
42. Discovery of 2-(1H-imidazo-2-yl)piperazines as a new class of potent and non-cytotoxic inhibitors of Trypanosoma brucei growth in vitro
43. Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs
44. Production and structural characterization of amino terminally histidine tagged human oncostatin M in E. Coli
45. Role of scavenger receptor class B type I in hepatitis C virus entry: kinetics and molecular determinants
46. High-avidity monoclonal antibodies against the human scavenger class B type I receptor efficiently block hepatitis C virus infection in the presence of high-density lipoprotein
47. Induction of interleukin-6 (IL-6) autoantibodies through vaccination with an engineered IL-6 receptor antagonist
48. Transglutaminase-Mediated Modifications of the Rat Sperm Surface in Vitro
49. Purification of a NF1-like DNA-binding protein from rat liver and cloning of the corresponding cDNA
50. Two distinct factors interact with the promoter regions of several liver-specific genes
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