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11 results on '"Papa, F. R."'

1. Design and expected performances of the large acceptance calorimeter for the HERD space mission

Author

Pacini, L., Adriani, O., Bai, Y. -L., Bao, T. -W., Berti, E., Bottai, S., Cao, W. -W., Casaus, J., Cui, X. -Z., D’Alessandro, R., Formato, V., Gao, J. -R., Li, R., Liu, X., Lorusso, L., Lyu, L. -W., Marin, J., Martinez, G., Pizzolotto, C., Qin, J. -J., Quan, Z., Shi, D. -L., Starodubtsev, O., Tang, Z. -C., Tiberio, A., Vagelli, V., Velasco, M. A., Wang, B., Wang, Hongmei, R. -J., Z. -G., Xu, M., Yang, Y., Zhang, L., Zheng, J. -K., Alemanno, F., Aloisio, R., Altomare, G., Ambrosi, G., An, Q., Antonelli, M., Azzarello, P., Bai, L., Bai, Y. L., Bao, T. W., Barbanera, M., Barbato, F. C. T., Bernardini, P., Berti, B., Bertucci, B., X. J., Bi, Bigongiari, G., Bongi, M., Bonvicini, V., Bordas, P., Bosch-Ramon, V., Brogi, P., Cadoux, F., Campana, D., Cao, W. W., Cao, Z., Catanzani, E., Cattaneo, P. W., Chang, J., Chang, Y. H., Chen, G. M., Chen, F., Cianetti, F., Comerma, A., Cortis, D., Cui, X. H., Cui, X. Z., Dai, C., Dai, Z. G., Gaetanoe, De, Mitri, De, Palma, De, Felice, Di, Giovanni, Di, Santo, Di, Venere, Di, Dong, L., Dong, J. N., Donvito, Y. W., Duranti, G., D’Urso, M., Evoli, D., Fang, C., Fariña, K., Favre, L., Feng, Y., Feng, C. Q., Feng, H., Feng, H. B., Finetti, Z. K., Formato, N., Frieden, V., Fusco, J. M., Gao, P., Gargano, J. R., Gascon-Fora, F., Gasparrini, D., Giglietto, D., Giovacchini, N., Gomez, F., Gong, S., Gou, K., Guida, Q. B., Guo, R., Guo, D. Y., Guo, J. H., Y. Q., He, H. H., Hu, H. B., Hu, J. Y., Hu, Hu, P., Huang, Y. M., Huang, G. S., Huang, J., Huang, W. H., Huang, X. T., Huang, Y. B., Ionica, Y. F., Jouvin, M., Kotenko, L., Kyratzis, A., Marra, La, Li, D., M. J., Li, Q. Y., Li, S. L., Li, Li, T., Li, X., Li, Z., Liang, Z. H., Liang, E. W., Liao, M. J., Licciulli, C. L., Lin, F., Liu, S. J., Liu, D., Liu, H. B., Liu, H., Liu, J. B., Liu, S. B., Liu, X. W., Loparco, Y. Q., Loporchio, F., Lu, S., Lyu, X., Lyu, J. G., Maestro, L. W., Mancini, E., Manera, E., Marin, R., Marrocchesi, J., Marsella, P. S., Marzullo, M., Mauricio, D., Mocchiutti, J., Morettini, G., Mori, G., Mussolin, L., Nicola, Mazziotta, Oliva, M., Orlandi, A., Osteria, D., Pacini, G., Panico, L., Pantalei, B., Papa, F. R., Papini, S., Paredes, P., Parenti, J. M., Pauluzzi, A., Pearce, M., Peng, M., Perfetto, W. X., Perrina, F., Perrotta, C., Pillera, G., Pizzolotto, R., Qiao, C., Qin, R., Quadrani, J. J., Quan, L., Rappoldi, Z., Raselli, A., Ren, G., Renno, X. X., Ribo, F., Rico, M., Rossella, J., Ryde, M., Sanmukh, F., Scotti, A., Serini, V., Shi, D., Shi, D. L., Silveri, Q. Q., Starodubtsev, L., Su, O., D. T., Su, Sukhonos, M., Suma, D., Sun, A., Sun, X. L., Surdo, Z. T., Tang, A., Tiberio, Z. C., Tykhonov, A., Vagelli, A., Vannuccini, V., Velasco, E., Walter, M., Wang, R., Wang, A. Q., Wang, J. C., Wang, J. M., Wang, J. J., Wang, L., Wang, M., Wang, R. J., Wang, S., Wang, X. Y., Wang, X. L., Wei, Z. G., Wei, D. M., J. J., Wu, B. B., Wu, Wu, J., L. B., Wu, Wu, X., Xin, X. F., Y. L., Xu, Yan, Z. Z., Yang, H. R., Yin, Y., P. F., Yu, Yuan, Y. W., Zampa, Q., Zampa, G., Zha, N., Zhang, M., Zhang, C., Zhang, F. Z., Zhang, L. F., Zhang, S. N., Zhang, Y., Zhao, Y. L., Zheng, Z. G., Zhou, J. K., Zhu, Y. L., Zhu, F. R., and K. J.

Subjects
Space experiments, Energy, Scintillating fiber, Performance, Monte Carlo methods, Measurements of, Space stations, Space missions, Cosmology, Cosmic rays, Intelligent systems, Scintillation counters, Silicon detectors, Charge detectors, Fiber trackers, Radiation detection, Read out systems, Calorimeters
Published
2022

2. Gamma-ray performance study of the HERD payload

Author

Adriani, O., Alemanno, F., Aloisio, R., Altomare, C., Ambrosi, G., An, Q., Antonelli, M., Azzarello, P., Bai, L., Bai, Y. L., Bao, T. W., Barbanera, M., Barbato, F. C. T., Bernardini, P., Berti, E., Bertucci, B., X. J., Bi, Bigongiari, G., Bongi, M., Bonvicini, V., Bordas, P., Bosch-Ramon, V., Bottai, S., Brogi, P., Cadoux, F., Campana, D., Cao, W. W., Cao, Z., Casaus, J., Catanzani, E., Cattaneo, P. W., Chang, J., Chang, Y. H., Chen, G. M., Chen, Y., Cianetti, F., Comerma, A., Cortis, D., Cui, X. H., Cui, X. Z., Dai, C., Dai, Z. G., D'Alessandro, R., Gaetano, De, Mitri, De, Palma, De, Felice, Di, Giovanni, Di, Santo, Di, Venere, Di, Dong, L., Dong, J. N., Donvito, Y. W., Duranti, G., D'Urso, M., Evoli, D., Fang, C., Fariña, K., Favre, L., Feng, Y., Feng, C. Q., Feng, H., Feng, H. B., Finetti, Z. K., Formato, N., Frieden, V., Fusco, J. M., Gao, P., Gargano, J. R., Gascon-Fora, F., Gasparrini, D., Giglietto, D., Giovacchini, N., Gomez, F., Gong, S., Gou, K., Guida, Q. B., Guo, R., Guo, D. Y., Guo, J. H., Y. Q., He, H. H., Hu, H. B., Hu, J. Y., Hu, Hu, P., Huang, Y. M., Huang, G. S., Huang, J., Huang, W. H., Huang, X. T., Huang, Y. B., Ionica, Y. F., Jouvin, M., Kotenko, L., Kyratzis, A., Marra, La, Li, D., M. J., Li, Q. Y., Li, Li, R., S. L., Li, Li, T., Li, X., Li, Z., Liang, Z. H., Liang, E. W., Liao, M. J., Licciulli, C. L., Lin, F., Liu, S. J., Liu, D., Liu, H. B., Liu, H., Liu, J. B., Liu, S. B., Liu, X., Liu, X. W., Loparco, Y. Q., Loporchio, F., Lu, S., Lyu, X., Lyu, J. G., Maestro, L. W., Mancini, E., Manera, E., Marin, R., Marrocchesi, J., Marsella, P. S., Martinez, G., Marzullo, M., Mauricio, D., Mocchiutti, J., Morettini, G., Mori, G., Mussolin, L., Nicola, Mazziotta, Oliva, M., Orlandi, A., Osteria, D., Pacini, G., Panico, L., Pantaleo, B., Papa, F. R., Papini, S., Paredes, P., Parenti, J. M., Pauluzzi, A., Pearce, M., Peng, M., Perfetto, W. X., Perrina, F., Perrotta, C., Pillera, G., Pizzolotto, R., Qiao, C., Qin, R., Quadrani, J. J., Quan, L., Rappoldi, Z., Raselli, A., Ren, G., Renno, X. X., Ribo, F., Rico, M., Rossella, J., Ryde, M., Sanmukh, F., Scotti, A., Serini, V., Shi, D., Shi, D. L., Silveri, Q. Q., Starodubtsev, L., Su, O., D. T., Su, Sukhonos, M., Suma, D., Sun, A., Sun, X. L., Surdo, Z. T., Tang, A., Tiberio, Z. C., Tykhonov, A., Vagelli, A., Vannuccini, V., Velasco, E., Walter, M., Wang, R., Wang, A. Q., Wang, B., Wang, J. C., Wang, J. M., Wang, J. J., Wang, L., Wang, M., Wang, R. J., Wang, S., Wang, X. Y., Wang, X. L., Wei, Z. G., Wei, D. M., J. J., Wu, B. B., Wu, Wu, J., L. B., Wu, Wu, X., Xin, X. F., Y. L., Xu, Xu, M., Yan, Z. Z., Yang, H. R., Yin, Y., P. F., Yu, Yuan, Y. W., Zampa, Q., Zampa, G., Zha, N., Zhang, M., Zhang, C., Zhang, F. Z., Zhang, L., Zhang, L. F., Zhang, S. N., Zhang, Y., Zhao, Y. L., Zheng, Z. G., Zhou, J. K., Zhu, Y. L., Zhu, F. R., and K. J.

Subjects
Energy, Performance, Cosmology, Gamma rays, Optical transfer function, Space stations, Dark matter searches, Detector geometry, Full simulations, Gamma-rays, Knee energy, Performance study, Radiation detection, Space astronomy, Cosmic rays
Published
2022

3. The High Energy cosmic-Radiation Detector (HERD) Trigger System

Author

Velasco, M. A., Bao, T., Berti, E., Bonvicini, V., Casaus, J., Giovacchini, F., Liu, X., Marco, R., Marín, J., Martínez, G., Mori, N., Oliva, A., Pacini, L., Quan, Z., Tang, Z., Xu, M., Zampa, G., Zampa, N., Adriani, O., Alemanno, F., Aloisio, R., Altomare, G., Ambrosi, G., An, Q., Antonelli, M., Azzarello, P., Bai, L., Bai, Y. L., Bao, T. W., Barbanera, M., Barbato, F. C. T., Bernardini, B., Bertucci, B., X. J., Bi, Bigongiari, G., Bongi, M., Bordas, P., Bosch-Ramon, V., Bottai, S., Brogi, P., Cadoux, F., Campana, D., Cao, W. W., Cao, Z., Catanzani, E., Cattaneo, P. W., Chang, J., Chang, Y. H., Chen, G. M., Chen, F., Cianetti, F., Comerma, A., Cortis, D., Cui, X. H., Cui, X. Z., Dai, C., Dai, Z. G., D'Alessandro, R., Gaetanoe, De, Mitri, De, Palma, De, Felice, Di, Giovanni, Di, Santo, Di, Venere, Di, Dong, L., Dong, J. N., Donvito, Y. W., Duranti, G., D'Urso, M., Evoli, D., Fang, C., Fariña, K., Favre, L., Feng, Y., Feng, C. Q., Feng, H., Feng, H. B., Finetti, Z. K., Formato, N., Frieden, V., Fusco, J. M., Gao, P., Gargano, J. R., Gascon-Fora, F., Gasparrini, D., Giglietto, D., Gomez, N., Gong, S., Gou, K., Guida, Q. B., Guo, R., Guo, D. Y., Guo, J. H., Y. Q., He, H. H., Hu, H. B., Hu, J. Y., Hu, Hu, P., Huang, Y. M., Huang, G. S., Huang, J., Huang, W. H., Huang, X. T., Huang, Y. B., Ionica, Y. F., Jouvin, M., Kotenko, L., Kyratzis, A., Marra, La, Li, D., M. J., Li, Q. Y., Li, Li, R., S. L., Li, Li, T., Li, X., Li, Z., Liang, Z. H., Liang, E. W., Liao, M. J., Licciulli, C. L., Lin, F., Liu, S. J., Liu, D., Liu, H. B., Liu, H., Liu, J. B., Liu, S. B., Liu, X. W., Loparco, Y. Q., Loporchio, F., Lu, S., Lyu, X., Lyu, J. G., Maestro, L. W., Mancini, E., Manera, E., Marrocchesi, R., Marsella, P. S., Martinez, G., Marzullo, M., Mauricio, D., Mocchiutti, J., Morettini, G., Mussolin, L., Nicola, Mazziotta, Orlandi, M., Osteria, D., Panico, G., Pantalei, B., Papa, F. R., Papini, S., Paredes, P., Parenti, J. M., Pauluzzi, A., Pearce, M., Peng, M., Perfetto, W. X., Perrina, F., Perrotta, C., Pillera, G., Pizzolotto, R., Qiao, C., Qin, R., Quadrani, J. J., Rappoldi, L., Raselli, A., Ren, G., Renno, X. X., Ribo, F., Rico, M., Rossella, J., Ryde, M., Sanmukh, F., Scotti, A., Serini, V., Shi, D., Shi, D. L., Silveri, Q. Q., Starodubtsev, L., Su, O., D. T., Su, Sukhonos, M., Suma, D., Sun, A., Sun, X. L., Surdo, Z. T., Tang, A., Tiberio, Z. C., Tykhonov, A., Vagelli, A., Vannuccini, V., Velasco, E., Walter, M., Wang, R., Wang, A. Q., Wang, B., Wang, J. C., Wang, J. M., Wang, J. J., Wang, L., Wang, M., Wang, R. J., Wang, S., Wang, X. Y., Wang, X. L., Wei, Z. G., Wei, D. M., J. J., Wu, B. B., Wu, Wu, J., L. B., Wu, Wu, X., Xin, X. F., Y. L., Xu, Yan, Z. Z., Yang, H. R., Yin, Y., P. F., Yu, Yuan, Y. W., Zha, Q., Zhang, M., Zhang, C., Zhang, F. Z., Zhang, L., Zhang, L. F., Zhang, S. N., Zhang, Y., Zhao, Y. L., Zheng, Z. G., Zhou, J. K., Zhu, Y. L., Zhu, F. R., and K. J.

Subjects
Cosmology, Gamma rays, Intelligent systems, Monte Carlo methods, Space stations, Tellurium compounds, Topology, Dark matter, Electron spectrum, Energy, Fundamental physics, Measurements of, Plastic scintillator detector, Precise measurements, Radiation detection, Space-borne, Trigger systems, Cosmic rays
Published
2022

7. FIT: the scintillating fiber tracker of the HERD space mission

Author

Perrina, C., Azzarello, P., Cadoux, F., Favre, Y., Frieden, J. M., Marra, La, Sukhonos, D., Wu, D., Adriani, X., Alemanno, O., Aloisio, F., Altomare, R., Ambrosi, G., An, G., Antonelli, Q., Azzarello, M., Bai, P., Bai, L., Bao, Y. L., Barbanera, T. W., Barbato, M., Bernardini, F. C. T., Berti, P., Bertucci, B., Bi, B., Bigongiari, X. J., Bongi, G., Bonvicini, M., Bordas, V., Bosch-Ramon, P., Bottai, V., Brogi, S., Cadoux, P., Campana, F., Cao, D., Cao, W. W., Casaus, Z., Catanzani, J., Cattaneo, E., Chang, P. W., Chang, J., Chen, Y. H., Chen, G. M., Cianetti, F., Comerma, F., Cortis, A., Cui, D., Cui, X. H., Dai, X. Z., Dai, C., D’Alessandro, Z. G., Gaetano, De, Mitri, De, Palma, De, Felice, Di, Giovanni, Di, Santo, Di, Venere, Di, Dong, L., Dong, J. N., Donvito, Y. W., Duranti, G., D’Urso, M., Evoli, D., Fang, C., Fariña, K., Favre, L., Feng, Y., Feng, C. Q., Feng, H., Feng, H. B., Finetti, Z. K., Formato, N., Frieden, V., Fusco, J. M., Gao, P., Gargano, J. R., Gascon-Fora, F., Gasparrini, D., Giglietto, D., Giovacchini, N., Gomez, F., Gong, S., Gou, K., Guida, Q. B., Guo, R., Guo, D. Y., Guo, J. H., Y. Q., He, H. H., Hu, H. B., Hu, J. Y., Hu, Hu, P., Huang, Y. M., Huang, G. S., Huang, J., Huang, W. H., Huang, X. T., Huang, Y. B., Ionica, Y. F., Jouvin, M., Kotenko, L., Kyratzis, A., Li, D., M. J., Li, Q. Y., Li, Li, R., S. L., Li, Li, T., Li, X., Li, Z., Liang, Z. H., Liang, E. W., Liao, M. J., Licciulli, C. L., Lin, F., Liu, S. J., Liu, D., Liu, H. B., Liu, H., Liu, J. B., Liu, S. B., Liu, X., Liu, X. W., Loparco, Y. Q., Loporchio, F., Lu, S., Lyu, X., Lyu, J. G., Maestro, L. W., Mancini, E., Manera, E., Marin, R., Marrocchesi, J., Marsella, P. S., Martinez, G., Marzullo, M., Mauricio, D., Mocchiutti, J., Morettini, G., Mori, G., Mussolin, N., Mazziotta, L., Oliva, M. N., Orlandi, A., Osteria, D., Pacini, G., Panico, L., Pantaleo, B., Papa, F. R., Papini, S., Paredes, P., Parenti, J. M., Pauluzzi, A., Pearce, M., Peng, M., Perfetto, W. X., Perrina, F., Perrotta, C., Pillera, G., Pizzolotto, R., Qiao, C., Qin, R., Quadrani, J. J., Quan, L., Rappoldi, Z., Raselli, A., Ren, G., Renno, X. X., Ribo, F., Rico, M., Rossella, J., Ryde, M., Sanmukh, F., Scotti, A., Serini, V., Shi, D., Shi, D. L., Silveri, Q. Q., Starodubtsev, L., Su, O., D. T., Su, Sukhonos, M., Suma, D., Sun, A., Sun, X. L., Surdo, Z. T., Tang, A., Tiberio, Z. C., Tykhonov, A., Vagelli, A., Vannuccini, V., Velasco, E., Walter, M., Wang, R., Wang, A. Q., Wang, B., Wang, J. C., Wang, J. M., Wang, J. J., Wang, L., Wang, M., Wang, R. J., Wang, S., Wang, X. Y., Wang, X. L., Wei, Z. G., Wei, D. M., J. J., Wu, B. B., Wu, Wu, J., L. B., Wu, Wu, X., Xin, X. F., Y. L., Xu, Xu, M., Yan, Z. Z., Yang, H. R., Yin, Y., P. F., Yu, Yuan, Y. W., Zampa, Q., Zampa, G., Zha, N., Zhang, M., Zhang, C., Zhang, F. Z., Zhang, L., Zhang, L. F., Zhang, S. N., Zhang, Y., Zhao, Y. L., Zheng, Z. G., Zhou, J. K., Zhu, Y. L., Zhu, F. R., and K. J.

Subjects
Energy, Scintillating fiber, Gamma rays, Direct-detection, Space stations, Space missions, Cosmology, Spectra's, Scintillation, Dark matter, Fiber trackers, Gamma-rays, Indirect detection, Radiation detection, Cosmic rays

8. Interaction of the Doa4 deubiquitinating enzyme with the yeast 26S proteasome.

Author

Papa FR, Amerik AY, and Hochstrasser M

Subjects
Amino Acid Sequence, Cysteine Endopeptidases genetics, Endopeptidases genetics, Endopeptidases metabolism, Endosomal Sorting Complexes Required for Transport, Fungal Proteins chemistry, Fungal Proteins genetics, Molecular Sequence Data, Multienzyme Complexes genetics, Proteasome Endopeptidase Complex, Recombinant Proteins genetics, Recombinant Proteins metabolism, Sequence Homology, Amino Acid, Structure-Activity Relationship, Ubiquitin Thiolesterase, Yeasts genetics, Cysteine Endopeptidases metabolism, Fungal Proteins metabolism, Multienzyme Complexes metabolism, Saccharomyces cerevisiae Proteins, Yeasts metabolism
Abstract

e Saccharomyces cerevisiae Doa4 deubiquitinating enzyme is required for the rapid degradation of protein substrates of the ubiquitin-proteasome pathway. Previous work suggested that Doa4 functions late in the pathway, possibly by deubiquitinating (poly)-ubiquitin-substrate intermediates associated with the 26S proteasome. We now provide evidence for physical and functional interaction between Doa4 and the proteasome. Genetic interaction is indicated by the mutual enhancement of defects associated with a deletion of DOA4 or a proteasome mutation when the two mutations are combined. Physical association of Doa4 and the proteasome was investigated with a new yeast 26S proteasome purification procedure, by which we find that a sizeable fraction of Doa4 copurifies with the protease. Another yeast deubiquitinating enzyme, Ubp5, which is related in sequence to Doa4 but cannot substitute for it even when overproduced, does not associate with the proteasome. DOA4-UBP5 chimeras were made by a novel PCR/yeast recombination method and used to identify an N-terminal 310-residue domain of Doa4 that, when appended to the catalytic domain of Ubp5, conferred Doa4 function, consistent with Ubp enzymes having a modular architecture. Unlike Ubp5, a functional Doa4-Ubp5 chimera associates with the proteasome, suggesting that proteasome binding is important for Doa4 function. Together, these data support a model in which Doa4 promotes proteolysis through removal of ubiquitin from proteolytic intermediates on the proteasome before or after initiation of substrate breakdown.

Published
1999
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9. An evolutionarily conserved gene on human chromosome 5q33-q34, UBH1, encodes a novel deubiquitinating enzyme.

Author

Hansen-Hagge TE, Janssen JW, Hameister H, Papa FR, Zechner U, Seriu T, Jauch A, Becke D, Hochstrasser M, and Bartram CR

Subjects
Amino Acid Sequence, Animals, Base Sequence, Caenorhabditis elegans enzymology, Caenorhabditis elegans genetics, Chromosome Mapping, Chromosomes, Human, Pair 14, Conserved Sequence, DNA Primers, Endopeptidases biosynthesis, Endopeptidases chemistry, Humans, In Situ Hybridization, Leukemia genetics, Mice, Molecular Sequence Data, Multigene Family, Nervous System embryology, Nervous System metabolism, Neurons enzymology, Polymerase Chain Reaction, Saccharomyces cerevisiae enzymology, Saccharomyces cerevisiae genetics, Sequence Alignment, Sequence Homology, Amino Acid, Transcription, Genetic, Translocation, Genetic, Ubiquitin Thiolesterase, Chromosomes, Human, Pair 5, Endopeptidases genetics, Evolution, Molecular, Pseudogenes
Abstract

While cloning breakpoint sequences of a leukemia patient exhibiting a t(5; 14) translocation, we identified a pseudogenic variant of a novel multigene family in proximity to the breakpoint. Chromosomal in situ hybridization suggested that the gene family is clustered on human chromosome 5q33-q34. The gene family is evolutionarily conserved. Northern blot analysis of mouse tissues revealed low-level expression of a functional member of this gene family in almost all samples. Marked levels of transcripts were detected by in situ hybridization in the retina, the olfactory epithelium, the peripheral neuronal ganglia, and distinct areas of the gut. The predicted protein displays striking similarity to a hypothetical protein of Caenorhabditis elegans (R10E11.3.) and to two yeast deubiquitinating enzymes, Ubp9 and Ubp13, albeit to a lesser extent. We expressed the putative coding region of the human gene in Escherichia coli and demonstrated that it indeed bears deubiquitinating activity based on its ability to cleave ubiquitin from a ubiquitin-beta-galactosidase fusion protein. This new deubiquitinating enzyme has been named UBH1, for ubiquitin hydrolyzing enzyme 1.

Published
1998
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10. The DOA pathway: studies on the functions and mechanisms of ubiquitin-dependent protein degradation in the yeast Saccharomyces cerevisiae.

Author

Hochstrasser M, Papa FR, Chen P, Swaminathan S, Johnson P, Stillman L, Amerik AY, and Li SJ

Subjects
Amino Acid Sequence, Conserved Sequence, Cysteine Endopeptidases chemistry, Cysteine Endopeptidases genetics, Cysteine Endopeptidases metabolism, Endosomal Sorting Complexes Required for Transport, Fungal Proteins genetics, Genes, Fungal, Homeodomain Proteins metabolism, Humans, Models, Molecular, Molecular Sequence Data, Multienzyme Complexes chemistry, Multienzyme Complexes genetics, Multienzyme Complexes metabolism, Mutation, Oncogene Proteins, Fusion genetics, Oncogene Proteins, Fusion metabolism, Proteasome Endopeptidase Complex, Proto-Oncogene Proteins, Repressor Proteins metabolism, Saccharomyces cerevisiae genetics, Sequence Homology, Amino Acid, Ubiquitin Thiolesterase, Endopeptidases, Fungal Proteins metabolism, Oncogene Proteins, Saccharomyces cerevisiae metabolism, Saccharomyces cerevisiae Proteins, Ubiquitins metabolism
Published
1995
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11. The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene.

Author

Papa FR and Hochstrasser M

Subjects
Amino Acid Sequence, Animals, Base Sequence, Endosomal Sorting Complexes Required for Transport, Fungal Proteins metabolism, Humans, Mice, Mice, Nude, Molecular Sequence Data, Mutation, Oncogene Proteins, Fusion genetics, Open Reading Frames, Phenotype, Proto-Oncogene Proteins, Recombinant Fusion Proteins metabolism, Saccharomyces cerevisiae enzymology, Sequence Homology, Amino Acid, Ubiquitin Thiolesterase, Endopeptidases, Fungal Proteins genetics, Genes, Fungal, Oncogene Proteins, Oncogenes, Saccharomyces cerevisiae genetics, Saccharomyces cerevisiae Proteins, Ubiquitins metabolism
Abstract

Modification of specific intracellular proteins by ubiquitin targets them for degradation. We describe a yeast enzyme, Doa4, that is integral to the degradation of ubiquitinated proteins and is required in diverse physiological processes. Doa4 appears to function late in the proteolytic pathway by cleaving ubiquitin from substrate remnants still bound to protease. The human tre-2 oncogene encodes a deubiquitinating enzyme similar to Doa4, indicating a role for the ubiquitin system in mammalian growth control.

Published
1993
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