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288 results on '"Papadatou, B"'

4. Transition of inflammatory bowel disease patients from pediatric to adult care: an observational study on a joint-visits approach

Author

Corsello, Andrea, Pugliese, Daniela, Bracci, Francesca, Knafelz, D., Papadatou, B., Aloi, M., Cucchiara, S., Guidi, Luisa, Gasbarrini, Antonio, Armuzzi, Alessandro, Corsello A., Pugliese D., Bracci F., Guidi L. (ORCID:0000-0003-3320-7094), Gasbarrini A. (ORCID:0000-0002-7278-4823), Armuzzi A. (ORCID:0000-0003-1572-0118), Corsello, Andrea, Pugliese, Daniela, Bracci, Francesca, Knafelz, D., Papadatou, B., Aloi, M., Cucchiara, S., Guidi, Luisa, Gasbarrini, Antonio, Armuzzi, Alessandro, Corsello A., Pugliese D., Bracci F., Guidi L. (ORCID:0000-0003-3320-7094), Gasbarrini A. (ORCID:0000-0002-7278-4823), and Armuzzi A. (ORCID:0000-0003-1572-0118)

Abstract

Background: Transition from pediatric to adult care of patients affected by Inflammatory Bowel Disease (IBD) is a critical step that needs specific care and multidisciplinary involvement. The aim of our study was to evaluate the outcome of the transition process of a cohort of IBD patients, exploring their readiness and the possible impact on quality of life. Methods: This observational study followed transitioned IBD patients from pediatric to adult care. Transition was carried-out through combined visits, jointly performed by the pediatrician and the adult gastroenterologist. Clinical data were collected before and after transition. A subgroup of patients was submitted to an anonymous online questionnaire of 38 items based on the validated questionnaires TRAQ and SIBDQ within the first 6 months from the beginning of the transition process. Results: Eighty-two patients with IBD were enrolled, with a mean age at transition of 20.2±2.7 years. Before transition, 40.2% of patients already had major surgery and 64.6% started biologics. At transition, 24% of patients were in moderate to severe active phase of their disease and 40% of them had already been treated with ≥ 2 biologics. The mean score of the TRAQ questionnaires collected is 3.4±1.5 and the mean score of SIBDQ is 53.9±9.8. A significant association was found between a TRAQ mean score > 3 and a SIBDQ > 50 (p=0.0129). Overall, 75% of patients had a positive opinion of the transition model adopted. Conclusions: A strong association has been found between TRAQ and SIBDQ questionnaires, showing how transition readiness has a direct impact on the quality of life of the young adult with IBD.

Published
2021

6. Diagnostic approach to monogenic inflammatory bowel disease in clinical practice: a 10-year multi-centric experience

Author

Lega, S, Pin, A, Arrigo, S, Cifaldi, C, Girardelli, M, Bianco, A, Malamisura, M, Angelino, G, Faraci, S, Romeo, E F, Papadatou, B, Miano, M, Aloi, M, Magazzù, G, Romano, C, Calvo, P, Barabino, A, Martelossi, S, Tommasini, A, Di Matteo, G, Cancrini, C, De Angelis, P, Finocchi, A, Bramuzzo, M, Lega, S, Pin, A, Arrigo, S, Cifaldi, C, Girardelli, M, Bianco, A, Malamisura, M, Angelino, G, Faraci, S, Romeo, E F, Papadatou, B, Miano, M, Aloi, M, Magazzù, G, Romano, C, Calvo, P, Barabino, A, Martelossi, S, Tommasini, A, Di Matteo, G, Cancrini, C, De Angelis, P, Finocchi, A, and Bramuzzo, M

Subjects
next generation sequencing, monogenic IBD, very early onset IBD
Abstract

Background and aims Multiple monogenic disorders present as very early onset inflammatory bowel disease (VEO-IBD) or as IBD with severe and atypical features. Establishing a genetic diagnosis may change patients’ management and prognosis. In this study, we describe the diagnostic approach to suspected monogenic IBD in a real clinical setting, discussing genetic and phenotypic findings and therapeutic implications of molecular diagnosis. Methods Information of patients with VEO-IBD and early onset IBD with severe/atypical phenotypes (EO-IBD s/a) managed between 2008–2017 who underwent a genetic workup were collected. Results Ninety-three patients were included, and 12 (13%) reached a genetic diagnosis. Candidate sequencing (CS) was performed in 47 patients (50%), and next generation sequencing (NGS) was performed in 84 patients (90%). Candidate sequencing had a good diagnostic performance only when guided by clinical features specific for known monogenic diseases, whereas NGS helped finding new causative genetic variants and would have anticipated one monogenic diagnosis (XIAP) and consequent bone marrow transplant (BMT). Patients with monogenic IBD more frequently were male (92% vs 54%; P = 0.02), had extraintestinal findings (100% vs 34%; P < 0.001), and had disease onset ≤1 month of life (25% vs 1%; P = 0.006). Genetic diagnosis impacted patient management in 11 patients (92%), 7 of whom underwent BMT. Conclusion A genetic diagnosis can be established in a significant proportion of suspected monogenic IBD and has an impact on patients’ management. Candidate sequencing may be deployed when clinical findings orientate toward a specific diagnosis. Next generation sequencing should be preferred in patients with nonspecific phenotypes.

Published
2019

14. P212 Diagnostic approach to monogenic inflammatory bowel disease in clinical practice: a 10-year multi-centric experience

Author

Lega, S, primary, Pin, A, additional, Arrigo, S, additional, Cifaldi, C, additional, Girardelli, M, additional, Bianco, A, additional, Malamisura, M, additional, Angelino, G, additional, Faraci, S, additional, Romeo, E F, additional, Papadatou, B, additional, Miano, M, additional, Aloi, M, additional, Magazzù, G, additional, Romano, C, additional, Calvo, P, additional, Barabino, A, additional, Martelossi, S, additional, Tommasini, A, additional, Di Matteo, G, additional, Cancrini, C, additional, De Angelis, P, additional, Finocchi, A, additional, and Bramuzzo, M, additional

Published
2019
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19. I polimorfismi del gene IRGM sono associati al comportamento fistolizzante della malattia di Crohn

Author

Latiano, A, Palmieri, O, Valvano, MR, D’Incà, R, Cucchiara, S, Castro, M, Corritore, G, Dallapiccola, B, Vieni, G, Staiano, AM, Guariso, G, De Angelis, GL, Romano, C, Lionetti, P, Barabino, A, Papadatou, B, Annese, V., ACCOMANDO, Salvatore, Latiano, A, Palmieri, O, Valvano, MR, D’Incà, R, Cucchiara, S, Castro, M, Corritore, G, Dallapiccola, B, Vieni, G, Staiano, AM, Guariso, G, Accomando, S, De Angelis, GL, Romano, C, Lionetti, P, Barabino, A, Papadatou, B, and Annese, V

Subjects
SNP, Malattia di Crohn
Published
2008

21. Changing therapeutic strategy according to trough level of infliximab and antibodies in children affected by inflammatory bowel disease

Author

Bracci, F., primary, Tolusso, B., additional, Tomarchio, S., additional, Papadatou, B., additional, Knafelz, D., additional, Di Sante, G., additional, Basso, M.S., additional, Liccardo, D., additional, Candusso, M., additional, Pietrobattista, A., additional, Gremese, E., additional, and Torre, G., additional

Published
2016
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32. Are food intolerances and allergies increasing in immigrant children coming from developing countries? ( Review )

Author

Cataldo, F, Accomando, S, Fragapane, Ml, Montaperto, D, Carlucci, A, Baldassarre, M, Intini, Ac, Corvaglia, L, Masi, M, Spina, M, Bombace, V, Lodin, D, Gentile, T, Montesanti, M, Corona, G, Galizzi, R, Bonarrigo, A, Cassone, R, Magazzù, G, Sferlazzas, C, Prampolini, L, Fredella, C, Barera, G., Frison, E, Pitter, M, Amarri, S, Balli, F, Zaffaroni, M, Oderda, G, Bona, G, Guariso, Graziella, Greco, P, Pitarresi, N, Amato, Gm, DE ANGELIS GL, Bizzarri, B, Fornalori, F, Ughi, C, Zanacca, C, Castro, M, Diamanti, A, Ferretti, F, Papadatou, B, Gambara, M, Bonamico, M, Guido, M, Fusco, P, Musumeci, S, and Martellossi, S.

Published
2006

34. Epidemiological and clinical features in immigrant children with coeliac disease: An Italian multicentre study

Author

Cataldo, F, Pitarresi, N, Accomando, S, Greco, L, Carlucci, A, Baldassarre, M, Intini, Ac, Corvaglia, L, Masi, M, Spina, M, Bombace, V, Lodin, D, Gentile, T, Montesanti, M, Corona, G, Galizzi, R, Bonarrigo, A, Cassone, R, Sferlazzas, C, Magazzù, G, Prampolini, L, Fredella, C, Barera, G, Frison, E, Pitter, M, Amarri, S, Balli, F, Zaffaroni, M, Oderda, G, Bona, G, Guariso, Graziella, Fragapane, Ml, Greco, P, Montaperto, D, Amato, Gm, DE ANGELIS GL, Bizzarri, B, Fornalori, F, Ughi, C, Zanacca, C, Castro, M, Diamanti, A, Ferretti, F, Papadatou, B, Gambara, M, Bonamico, M, Guido, M, and Fusco, P.

Published
2004

43. P101 LONG-TERM TREATMENT WITH AUTOLOGOUS RED BLOOD CELLS LOADED WITH DEXAMETHASONE 21-PHOSPHATE IN PEDIATRIC PATIENTS AFFECTED BY STEROID-DEPENDENT CROHN DISEASE AND ULCERATIVE COLITIS

Author

Papadatou, B., primary, Rossi, L., additional, Bracci, F., additional, Knafelz, D., additional, Noto, C., additional, Diamanti, A., additional, Filoni, A., additional, Rossi, M., additional, Ferretti, F., additional, Magnani, M., additional, and Castro, M., additional

Published
2009
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44. ASSOCIATION BETWEEN PREVIOUSLY IDENTIFIED DISEASE LOCI AT CHR21Q22 AND MHC AND UC IN ITALIAN POPULATION

Author

Palmieri, O., primary, Latiano, A., additional, Valvano, M.R., additional, Bossa, F., additional, Corritore, G., additional, D'Incà, R., additional, Vecchi, M., additional, Vieni, G., additional, Accomando, S., additional, de Angelis, G.L., additional, Lombardi, G., additional, Romano, C., additional, Pastore, M., additional, Cucchiara, S., additional, Castro, M., additional, Ferraris, A., additional, Staiano, A., additional, Papadatou, B., additional, Bascietto, C., additional, Ardizzone, S., additional, and Annese, V., additional

Published
2009
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45. P221 - Lack of association of previously identified disease loci 10q12, 11p15, and 20q13 in IBD

Author

Latiano, A., primary, Colombo, E., additional, Palmieri, O., additional, Valvano, M.R., additional, Latiano, T., additional, Corritore, G., additional, D'Incà, R., additional, Vecchi, M., additional, Caprilli, R., additional, Ardizzone, S., additional, Nobile, S., additional, De Venuto, D., additional, Sferlazzas, C., additional, Staiano, A., additional, Lodde, V., additional, Iacono, G., additional, Bascietto, C., additional, Papadatou, B., additional, Marseglia, A., additional, Castro, M., additional, Cucchiara, S., additional, and Annese, V., additional

Published
2009
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