202 results on '"Papadopoulos Orfanos, Dimitri"'
Search Results
2. Assessing general versus specific liability for externalizing problems in adolescence: Concurrent and prospective prediction of symptoms of conduct disorder, ADHD, and substance use.
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Perkins, Emily, Foell, Jens, Drislane, Laura, Brislin, Sarah, Frick, Paul, Yancey, James, Soto, Elia, Ganley, Colleen, Keel, Pamela, Sica, Claudio, Flor, Herta, Nees, Frauke, Banaschewski, Tobias, Bokde, Arun, Desrivières, Sylvane, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Paillère Martinot, Marie-Laure, Artiges, Eric, Papadopoulos Orfanos, Dimitri, Poustka, Luise, Hohmann, Sarah, Fröhner, Juliane, Smolka, Michael, Walter, Henrik, Whelan, Robert, Schumann, Gunter, Patrick, Christopher, and Joyner, Keanan
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Adolescent ,Alcoholism ,Attention Deficit Disorder with Hyperactivity ,Conduct Disorder ,Female ,Humans ,Male ,Prospective Studies ,Substance-Related Disorders - Abstract
This study explored the generality versus specificity of two trait-liability factors for externalizing problems-disinhibition and callousness-in the concurrent and prospective prediction of symptoms of conduct disorder, attention-deficit/hyperactivity disorder (ADHD), and substance use (i.e., alcohol use disorder and history of illicit substance use). Disinhibition involves an impulsive, unrestrained cognitive-behavioral style; callousness entails a dispositional lack of social-emotional sensitivity. Participants were European adolescents from the multisite IMAGEN project who completed questionnaires and clinical interviews at ages 14 (N = 1,504, Mage = 14.41, 51.13% female) and 16 (N = 1,407, Mage = 16.46, 51.88% female). Disinhibition was related concurrently and prospectively to greater symptoms of conduct disorder, ADHD, and alcohol use disorder; higher scores on a general externalizing factor; and greater likelihood of having tried an illicit substance. Callousness was selectively related to greater conduct disorder symptoms. These findings indicate disinhibition confers broad liability for externalizing spectrum disorders, perhaps due to its affiliated deficits in executive function. In contrast, callousness appears to represent more specific liability for antagonistic (aggressive/exploitative) forms of externalizing, as exemplified by antisocial behavior. Results support the utility of developmental-ontogenetic and hierarchical-dimensional models of psychopathology and have important implications for early assessment of risk for externalizing problems. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
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- 2022
3. Temporo-basal sulcal connections: a manual annotation protocol and an investigation of sexual dimorphism and heritability
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de Matos, Kevin, Cury, Claire, Chougar, Lydia, Strike, Lachlan T., Rolland, Thibault, Riche, Maximilien, Hemforth, Lisa, Martin, Alexandre, Banaschewski, Tobias, Bokde, Arun L. W., Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Brühl, Rüdiger, Martinot, Jean-Luc, Paillère Martinot, Marie-Laure, Artiges, Eric, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Lemaitre, Herve, Paus, Tomáš, Poustka, Luise, Hohmann, Sarah, Millenet, Sabina, Fröhner, Juliane H., Smolka, Michael N., Vaidya, Nilakshi, Walter, Henrik, Whelan, Robert, Schumann, Gunter, Frouin, Vincent, Bach Cuadra, Meritxell, Colliot, Olivier, and Couvy-Duchesne, Baptiste
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- 2023
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4. Adolescents’ pain-related ontogeny shares a neural basis with adults’ chronic pain in basothalamo-cortical organization
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Heukamp, Nils Jannik, Banaschewski, Tobias, Bokde, Arun L.W., Desrivières, Sylvane, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Kandić, Mina, Brühl, Rüdiger, Martinot, Jean-Luc, Paillère Martinot, Marie-Laure, Artiges, Eric, Papadopoulos Orfanos, Dimitri, Lemaitre, Herve, Löffler, Martin, Poustka, Luise, Hohmann, Sarah, Millenet, Sabina, Fröhner, Juliane H., Smolka, Michael N., Usai, Katrin, Vaidya, Nilakshi, Walter, Henrik, Whelan, Robert, Schumann, Gunter, Flor, Herta, and Nees, Frauke
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- 2024
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5. Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group
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Jia, Tianye, Chu, Congying, Liu, Yun, van Dongen, Jenny, Papastergios, Evangelos, Armstrong, Nicola J, Bastin, Mark E, Carrillo-Roa, Tania, den Braber, Anouk, Harris, Mathew, Jansen, Rick, Liu, Jingyu, Luciano, Michelle, Ori, Anil PS, Roiz Santiañez, Roberto, Ruggeri, Barbara, Sarkisyan, Daniil, Shin, Jean, Sungeun, Kim, Tordesillas Gutiérrez, Diana, van’t Ent, Dennis, Ames, David, Artiges, Eric, Bakalkin, Georgy, Banaschewski, Tobias, Bokde, Arun LW, Brodaty, Henry, Bromberg, Uli, Brouwer, Rachel, Büchel, Christian, Burke Quinlan, Erin, Cahn, Wiepke, de Zubicaray, Greig I, Ehrlich, Stefan, Ekström, Tomas J, Flor, Herta, Fröhner, Juliane H, Frouin, Vincent, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Hoare, Jacqueline, Ittermann, Bernd, Jahanshad, Neda, Jiang, Jiyang, Kwok, John B, Martin, Nicholas G, Martinot, Jean-Luc, Mather, Karen A, McMahon, Katie L, McRae, Allan F, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Sämann, Philipp G, Schofield, Peter R, Smolka, Michael N, Stein, Dan J, Strike, Lachlan T, Teeuw, Jalmar, Thalamuthu, Anbupalam, Trollor, Julian, Walter, Henrik, Wardlaw, Joanna M, Wen, Wei, Whelan, Robert, Apostolova, Liana G, Binder, Elisabeth B, Boomsma, Dorret I, Calhoun, Vince, Crespo-Facorro, Benedicto, Deary, Ian J, Hulshoff Pol, Hilleke, Ophoff, Roel A, Pausova, Zdenka, Sachdev, Perminder S, Saykin, Andrew, Wright, Margaret J, Thompson, Paul M, Schumann, Gunter, and Desrivières, Sylvane
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Biological Psychology ,Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences ,Psychology ,Mental Health ,Neurosciences ,Genetics ,Human Genome ,Diabetes ,Neurodegenerative ,2.1 Biological and endogenous factors ,Aetiology ,Neurological ,Mental health ,CpG Islands ,DNA Methylation ,Epigenesis ,Genetic ,Epigenome ,Genome-Wide Association Study ,Humans ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry ,Clinical sciences ,Biological psychology ,Clinical and health psychology - Abstract
DNA methylation, which is modulated by both genetic factors and environmental exposures, may offer a unique opportunity to discover novel biomarkers of disease-related brain phenotypes, even when measured in other tissues than brain, such as blood. A few studies of small sample sizes have revealed associations between blood DNA methylation and neuropsychopathology, however, large-scale epigenome-wide association studies (EWAS) are needed to investigate the utility of DNA methylation profiling as a peripheral marker for the brain. Here, in an analysis of eleven international cohorts, totalling 3337 individuals, we report epigenome-wide meta-analyses of blood DNA methylation with volumes of the hippocampus, thalamus and nucleus accumbens (NAcc)-three subcortical regions selected for their associations with disease and heritability and volumetric variability. Analyses of individual CpGs revealed genome-wide significant associations with hippocampal volume at two loci. No significant associations were found for analyses of thalamus and nucleus accumbens volumes. Cluster-based analyses revealed additional differentially methylated regions (DMRs) associated with hippocampal volume. DNA methylation at these loci affected expression of proximal genes involved in learning and memory, stem cell maintenance and differentiation, fatty acid metabolism and type-2 diabetes. These DNA methylation marks, their interaction with genetic variants and their impact on gene expression offer new insights into the relationship between epigenetic variation and brain structure and may provide the basis for biomarker discovery in neurodegeneration and neuropsychiatric conditions.
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- 2021
6. Anxiety onset in adolescents: a machine-learning prediction
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Chavanne, Alice V., Paillère Martinot, Marie Laure, Penttilä, Jani, Grimmer, Yvonne, Conrod, Patricia, Stringaris, Argyris, van Noort, Betteke, Isensee, Corinna, Becker, Andreas, Banaschewski, Tobias, Bokde, Arun L. W., Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Brühl, Rüdiger, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Hohmann, Sarah, Millenet, Sabina, Fröhner, Juliane H., Smolka, Michael N., Walter, Henrik, Whelan, Robert, Schumann, Gunter, Martinot, Jean-Luc, and Artiges, Eric
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- 2023
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7. Trees for brains: Current residential tree cover density and its association with brain structure in young adults
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Kühn, Simone, Banaschewski, Tobias, Bokde, Arun L.W., Büchel, Christian, Burke Quinlan, Erin, Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Paillère Martinot, Marie Laure, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Millenet, Sabina, Fröhner, Juliane H., Smolka, Michael N., Walter, Henrik, Whelan, Robert, Schumann, Gunter, Vaidya, Nilakshi, Meyer-Lindenberg, Andreas, and Gallinat, Jürgen
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- 2023
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8. Chronotype, Longitudinal Volumetric Brain Variations Throughout Adolescence, and Depressive Symptom Development
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Vulser, Hélène, Lemaître, Hervé S., Guldner, Stella, Bezivin-Frère, Pauline, Löffler, Martin, Sarvasmaa, Anna S., Massicotte-Marquez, Jessica, Artiges, Eric, Paillère Martinot, Marie-Laure, Filippi, Irina, Miranda, Ruben, Stringaris, Argyris, van Noort, Betteke Maria, Penttilä, Jani, Grimmer, Yvonne, Becker, Andreas, Banaschewski, Tobias, Bokde, Arun L.W., Desrivières, Sylvane, Fröhner, Juliane H., Garavan, Hugh, Grigis, Antoine, Gowland, Penny A., Heinz, Andreas, Papadopoulos Orfanos, Dimitri, Poustka, Luise, Smolka, Michael N., Spechler, Philip A., Walter, Henrik, Whelan, Robert, Schumann, Gunter, Flor, Herta, Martinot, Jean-Luc, and Nees, Frauke
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- 2023
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9. Population clustering of structural brain aging and its association with brain development
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Duan, Haojing, primary, Shi, Runye, additional, Kang, Jujiao, additional, Banaschewski, Tobias, additional, Bokde, Arun LW, additional, Büchel, Christian, additional, Desrivières, Sylvane, additional, Flor, Herta, additional, Grigis, Antoine, additional, Garavan, Hugh, additional, Gowland, Penny A, additional, Heinz, Andreas, additional, Brühl, Rüdiger, additional, Martinot, Jean-Luc, additional, Martinot, Marie-Laure Paillère, additional, Artiges, Eric, additional, Nees, Frauke, additional, Papadopoulos Orfanos, Dimitri, additional, Paus, Tomas, additional, Poustka, Luise, additional, Hohmann, Sarah, additional, Holz, Nathalie, additional, Fröhner, Juliane, additional, Smolka, Michael N, additional, Vaidya, Nilakshi, additional, Walter, Henrik, additional, Whelan, Robert, additional, Schumann, Gunter, additional, Lin, Xiaolei, additional, and Feng, Jianfeng, additional
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- 2024
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10. Neuroimaging evidence for structural correlates in adolescents resilient to polysubstance use: A five-year follow-up study
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Filippi, Irina, Galinowski, André, Lemaître, Hervé, Massot, Christian, Zille, Pascal, Frère, Pauline, Miranda-Marcos, Rubén, Trichard, Christian, Guldner, Stella, Vulser, Hélène, Paillère-Martinot, Marie-Laure, Quinlan, Erin Burke, Desrivieres, Sylvane, Gowland, Penny, Bokde, Arun, Garavan, Hugh, Heinz, Andreas, Walter, Henrik, Daedelow, Laura, Büchel, Christian, Bromberg, Uli, Conrod, Patricia J., Flor, Herta, Banaschewski, Tobias, Nees, Frauke, Heintz, Stefan, Smolka, Michael, Vetter, Nora C., Papadopoulos-Orfanos, Dimitri, Whelan, Robert, Poustka, Louise, Paus, Tomas, Schumann, Gunter, Artiges, Eric, and Martinot, Jean-Luc
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- 2021
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11. Residual effects of cannabis-use on neuropsychological functioning
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Wendel, Lena Kristin, Daedelow, Laura, Kaminski, Jakob, Banaschewski, Tobias, Millenet, Sabina, Bokde, Arun L.W., Quinlan, Erin Burke, Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Brühl, Rüdiger, Martinot, Jean-Luc, Artiges, Eric, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Fröhner, Juliane H., Smolka, Michael N., Whelan, Robert, Schumann, Gunter, and Walter, Henrik
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- 2021
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12. Are psychotic-like experiences related to a discontinuation of cannabis consumption in young adults?
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Daedelow, Laura S., Banaschewski, Tobias, Berning, Moritz, Bokde, Arun L.W., Brühl, Rüdiger, Burke Quinlan, Erin, Curran, H. Valerie, Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Hardon, Anita, Kaminski, Jakob, Martinot, Jean-Luc, Paillère Martinot, Marie-Laure, Artiges, Eric, Murray, Hayley, Nees, Frauke, Oei, Nicole Y.L., Papadopoulos Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Hohmann, Sarah, Millenet, Sabina, Rosenthal, Annika, Fröhner, Juliane H., Smolka, Michael N., Walter, Henrik, Whelan, Robert, Wiers, Reinout W., Schumann, Gunter, and Heinz, Andreas
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- 2021
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13. Nonlinear functional mapping of the human brain
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Allgaier, Nicholas, Banaschewski, Tobias, Barker, Gareth, Bokde, Arun L. W., Bongard, Josh C., Bromberg, Uli, Büchel, Christian, Cattrell, Anna, Conrod, Patricia J., Danforth, Christopher M., Desrivières, Sylvane, Dodds, Peter S., Flor, Herta, Frouin, Vincent, Gallinat, Jürgen, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Mackey, Scott, Martinot, Jean-Luc, Murphy, Kevin, Nees, Frauke, Papadopoulos-Orfanos, Dimitri, Poustka, Luise, Smolka, Michael N., Walter, Henrik, Whelan, Robert, Schumann, Gunter, Garavan, Hugh, and Consortium, IMAGEN
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Quantitative Biology - Neurons and Cognition ,Computer Science - Neural and Evolutionary Computing - Abstract
The field of neuroimaging has truly become data rich, and novel analytical methods capable of gleaning meaningful information from large stores of imaging data are in high demand. Those methods that might also be applicable on the level of individual subjects, and thus potentially useful clinically, are of special interest. In the present study, we introduce just such a method, called nonlinear functional mapping (NFM), and demonstrate its application in the analysis of resting state fMRI from a 242-subject subset of the IMAGEN project, a European study of adolescents that includes longitudinal phenotypic, behavioral, genetic, and neuroimaging data. NFM employs a computational technique inspired by biological evolution to discover and mathematically characterize interactions among ROI (regions of interest), without making linear or univariate assumptions. We show that statistics of the resulting interaction relationships comport with recent independent work, constituting a preliminary cross-validation. Furthermore, nonlinear terms are ubiquitous in the models generated by NFM, suggesting that some of the interactions characterized here are not discoverable by standard linear methods of analysis. We discuss one such nonlinear interaction in the context of a direct comparison with a procedure involving pairwise correlation, designed to be an analogous linear version of functional mapping. We find another such interaction that suggests a novel distinction in brain function between drinking and non-drinking adolescents: a tighter coupling of ROI associated with emotion, reward, and interoceptive processes such as thirst, among drinkers. Finally, we outline many improvements and extensions of the methodology to reduce computational expense, complement other analytical tools like graph-theoretic analysis, and allow for voxel level NFM to eliminate the necessity of ROI selection., Comment: 21 pages, 12 figures, and 1 table
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- 2015
14. Sex effects on structural maturation of the limbic system and outcomes on emotional regulation during adolescence
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Frere, Pauline Bezivin, Vetter, Nora C., Artiges, Eric, Filippi, Irina, Miranda, Rubén, Vulser, Hélène, Paillère-Martinot, Marie-Laure, Ziesch, Veronika, Conrod, Patricia, Cattrell, Anna, Walter, Henrik, Gallinat, Jurgen, Bromberg, Uli, Jurk, Sarah, Menningen, Eva, Frouin, Vincent, Papadopoulos Orfanos, Dimitri, Stringaris, Argyris, Penttilä, Jani, van Noort, Betteke, Grimmer, Yvonne, Schumann, Gunter, Smolka, Michael N., Martinot, Jean-Luc, and Lemaître, Hervé
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- 2020
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15. Low Smoking Exposure, the Adolescent Brain, and the Modulating Role of CHRNA5 Polymorphisms
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Mann, Karl, Struve, Maren, Rietschel, Marcella, Spanagel, Rainer, Fauth-Bühler, Mira, Millenet, Sabina, Grimmer, Yvonne, Ivanov, Nikolay, Strache, Nicole, Rapp, Michael, Ströhle, Andreas, Reuter, Jan, Barbot, Alexis, Thyreau, Benjamin, Schwartz, Yannick, Lalanne, Christophe, Bricaud, Zuleima, Briand, Fanny Gollier, Lemaitre, Hervé, Massicotte, Jessica, Vulser, Helene, Pentillä, Jani, Galinowski, André, Jia, Tianye, Werts, Helen, Topper, Lauren, Reed, Laurence, Andrew, Chris, Mallik, Catherine, Ruggeri, Barbara, Nymberg, Charlotte, Smith, Lindsay, Loth, Eva, Havatzias, Stephanie, Stueber, Kerstin, Stringaris, Argyris, Constant, Patrick, Brühl, Ruediger, Ihlenfeld, Albrecht, Walaszek, Bernadeta, Hübner, Thomas, Müller, Kathrin, Ripke, Stephan, Rodehacke, Sarah, Mennigen, Eva, Schmidt, Dirk, Vetter, Nora, Ziesch, Veronika, Jones, Jennifer, Poline, Jean-Baptiste, Fadai, Tahmine, Yacubian, Juliana, Schneider, Sophia, Lawrence, Claire, Newman, Craig, Head, Kay, Heym, Nadja, Pausova, Zdenka, Tahmasebi, Amir, Chaarani, Bader, Kan, Kees-Jan, Mackey, Scott, Spechler, Philip A., Potter, Alexandra, Orr, Catherine, D’Alberto, Nicholas, Hudson, Kelsey E., Banaschewski, Tobias, Bokde, Arun L.W., Bromberg, Uli, Büchel, Christian, Cattrell, Anna, Conrod, Patricia J., Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Gallinat, Jürgen, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Nees, Frauke, Papadopoulos-Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Smolka, Michael N., Walter, Henrik, Whelan, Robert, Higgins, Stephen T., Schumann, Gunter, Althoff, Robert R., Stein, Elliot A., and Garavan, Hugh
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- 2019
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16. Interplay of early negative life events, development of orbitofrontal cortical thickness and depression in young adulthood.
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Backhausen, Lea L., Granzow, Jonas, Fröhner, Juliane H., Artiges, Eric, Paillère‐Martinot, Marie‐Laure, Lemaître, Hervé, Sticca, Fabio, Banaschewski, Tobias, Desrivières, Sylvane, Grigis, Antoine, Heinz, Andreas, Brühl, Rüdiger, Papadopoulos‐Orfanos, Dimitri, Poustka, Luise, Hohmann, Sarah, Robinson, Lauren, Walter, Henrik, Winterer, Jeanne, Schumann, Gunter, and Martinot, Jean‐Luc
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LIFE change events ,YOUNG adults ,CENTER for Epidemiologic Studies Depression Scale - Abstract
Background: Early negative life events (NLE) have long‐lasting influences on neurodevelopment and psychopathology. Reduced orbitofrontal cortex (OFC) thickness was frequently associated with NLE and depressive symptoms. OFC thinning might mediate the effect of NLE on depressive symptoms, although few longitudinal studies exist. Using a complete longitudinal design with four time points, we examined whether NLE during childhood and early adolescence predict depressive symptoms in young adulthood through accelerated OFC thinning across adolescence. Methods: We acquired structural MRI from 321 participants at two sites across four time points from ages 14 to 22. We measured NLE with the Life Events Questionnaire at the first time point and depressive symptoms with the Center for Epidemiologic Studies Depression Scale at the fourth time point. Modeling latent growth curves, we tested whether OFC thinning mediates the effect of NLE on depressive symptoms. Results: A higher burden of NLE, a thicker OFC at the age of 14, and an accelerated OFC thinning across adolescence predicted young adults' depressive symptoms. We did not identify an effect of NLE on OFC thickness nor OFC thickness mediating effects of NLE on depressive symptoms. Conclusions: Using a complete longitudinal design with four waves, we show that NLE in childhood and early adolescence predict depressive symptoms in the long term. Results indicate that an accelerated OFC thinning may precede depressive symptoms. Assessment of early additionally to acute NLEs and neurodevelopment may be warranted in clinical settings to identify risk factors for depression. [ABSTRACT FROM AUTHOR]
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- 2024
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17. Adolescent to young adult longitudinal development of subcortical volumes in two European sites with four waves.
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Backhausen, Lea L., Fröhner, Juliane H., Lemaître, Hervé, Artiges, Eric, Martinot, Marie‐Laure Palillère, Herting, Megan M., Sticca, Fabio, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L. W., Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Brühl, Rüdiger, Nees, Frauke, Papadopoulos‐Orfanos, Dimitri, and Poustka, Luise
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YOUNG adults ,ADULT development ,TEENAGERS ,ADOLESCENT development ,TEENAGE boys - Abstract
Adolescent subcortical structural brain development might underlie psychopathological symptoms, which often emerge in adolescence. At the same time, sex differences exist in psychopathology, which might be mirrored in underlying sex differences in structural development. However, previous studies showed inconsistencies in subcortical trajectories and potential sex differences. Therefore, we aimed to investigate the subcortical structural trajectories and their sex differences across adolescence using for the first time a single cohort design, the same quality control procedure, software, and a general additive mixed modeling approach. We investigated two large European sites from ages 14 to 24 with 503 participants and 1408 total scans from France and Germany as part of the IMAGEN project including four waves of data acquisition. We found significantly larger volumes in males versus females in both sites and across all seven subcortical regions. Sex differences in age‐related trajectories were observed across all regions in both sites. Our findings provide further evidence of sex differences in longitudinal adolescent brain development of subcortical regions and thus might eventually support the relationship of underlying brain development and different adolescent psychopathology in boys and girls. [ABSTRACT FROM AUTHOR]
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- 2024
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18. Trajectories of cortical structures associated with stress across adolescence: a bivariate latent change score approach
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Nweze, Tochukwu, Banaschewski, Tobias, Ajaelu, Cyracius, Okoye, Chukwuemeka, Ezenwa, Michael, Whelan, Robert, Papadopoulos Orfanos, Dimitri, Bokde, Arun LW, Desrivières, Sylvane, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Brühl, Rüdiger, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Artiges, Eric, Nees, Frauke, Paus, Tomáš, Poustka, Luise, Hohmann, Sarah, Millenet, Sabina, Fröhner, Juliane H, Smolka, Michael N, Walter, Henrik, Schumann, Gunter, Hanson, Jamie L, IMAGEN Consortium, and Apollo - University of Cambridge Repository
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Adult ,Cerebral Cortex ,Adolescent ,Sexually Transmitted Diseases ,bivariate latent change score model ,longitudinal models ,Stress ,Magnetic Resonance Imaging ,cognitive functioning ,Young Adult ,longitudinal mediation analysis ,Cross-Sectional Studies ,Humans ,cortical development ,Longitudinal Studies - Abstract
Funder: Cambridge Trust (University of Cambridge); Id: http://dx.doi.org/10.13039/501100000735, Funder: National Institute for Health Research (NIHR) Biomedical Research Centre at South London, Funder: Maudsley NHS Foundation Trust and King's College London, Funder: Medical Research Foundation; Id: http://dx.doi.org/10.13039/501100009187, Funder: Mission Interministérielle de Lutte‐contre‐les‐Drogues‐et‐les‐Conduites‐Addictives (MILDECA), Funder: Assistance‐Publique‐Hôpitaux‐de‐Paris and INSERM, Funder: Paris Sud University IDEX 2012, Funder: Fédération pour la Recherche sur le Cerveau; Id: http://dx.doi.org/10.13039/501100006424, BACKGROUND: Stress exposure in childhood and adolescence has been linked to reductions in cortical structures and cognitive functioning. However, to date, most of these studies have been cross-sectional, limiting the ability to make long-term inferences, given that most cortical structures continue to develop through adolescence. METHODS: Here, we used a subset of the IMAGEN population cohort sample (N = 502; assessment ages: 14, 19, and 22 years; mean age: 21.945 years; SD = 0.610) to understand longitudinally the long-term interrelations between stress, cortical development, and cognitive functioning. To these ends, we first used a latent change score model to examine four bivariate relations - assessing individual differences in change in the relations between adolescent stress exposure and volume, surface area, and cortical thickness of cortical structures, as well as cognitive outcomes. Second, we probed for indirect neurocognitive effects linking stress to cortical brain structures and cognitive functions using rich longitudinal mediation modeling. RESULTS: Latent change score modeling showed that greater baseline adolescence stress at age 14 predicted a small reduction in the right anterior cingulate volume (Std. β = -.327, p = .042, 95% CI [-0.643, -0.012]) and right anterior cingulate surface area (Std. β = -.274, p = .038, 95% CI [-0.533, -0.015]) across ages 14-22. These effects were very modest in nature and became nonsignificant after correcting for multiple comparisons. Our longitudinal analyses found no evidence of indirect effects in the two neurocognitive pathways linking adolescent stress to brain and cognitive outcomes. CONCLUSION: Findings shed light on the impact of stress on brain reductions, particularly in the prefrontal cortex that have consistently been implicated in the previous cross-sectional studies. However, the magnitude of effects observed in our study is smaller than that has been reported in past cross-sectional work. This suggests that the potential impact of stress during adolescence on brain structures may likely be more modest than previously noted.
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- 2023
19. Coupled changes between ruminating thoughts and resting-state brain networks during the transition into adulthood
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Marchitelli, Rocco, Paillère Martinot, Marie-Laure, Trouvé, Alain, Banaschewski, Tobias, Bokde, Arun L. W., Desrivières, Sylvane, Flor, Herta, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Brühl, Rüdiger, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Hohmann, Sarah, Holz, Nathalie, Vaidya, Nilakshi, Fröhner, Juliane H., Smolka, Michael N., Walter, Henrik, Whelan, Robert, Schumann, Gunter, Martinot, Jean-Luc, and Artiges, Eric
- Abstract
Perseverative negative thoughts, known as rumination, might arise from emotional challenges and preclude mental health when transitioning into adulthood. Due to its multifaceted nature, rumination can take several ruminative response styles, that diverge in manifestations, severity, and mental health outcomes. Still, prospective ruminative phenotypes remain elusive insofar. Longitudinal study designs are ideal for stratifying ruminative response styles, especially with resting-state functional MRI whose setup naturally elicits people’s ruminative traits. Here, we considered self-rated questionnaires on rumination and psychopathology, along with resting-state functional MRI data in 595 individuals assessed at age 18 and 22 from the IMAGEN cohort. We conducted independent component analysis to characterize eight single static resting-state functional networks in each subject and session and furthermore conducted a dynamic analysis, tackling the time variations of functional networks during the entire scanning time. We then investigated their longitudinal mediation role between changes in three ruminative response styles (reflective pondering, brooding, and depressive rumination) and changes in internalizing and co-morbid externalizing symptoms. Four static and two dynamic networks longitudinally differentiated these ruminative styles and showed complemental sensitivity to internalizing and co-morbid externalizing symptoms. Among these networks, the right frontoparietal network covaried with all ruminative styles but did not play any mediation role towards psychopathology. The default mode, the salience, and the limbic networks prospectively stratified these ruminative styles, suggesting that maladaptive ruminative styles are associated with altered corticolimbic function. For static measures, only the salience network played a longitudinal causal role between brooding rumination and internalizing symptoms. Dynamic measures highlighted the default-mode mediation role between the other ruminative styles and co-morbid externalizing symptoms. In conclusion, we identified the ruminative styles’ psychometric and neural outcome specificities, supporting their translation into applied research on young adult mental healthcare.
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- 2024
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20. The Brainomics/Localizer database
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Papadopoulos Orfanos, Dimitri, Michel, Vincent, Schwartz, Yannick, Pinel, Philippe, Moreno, Antonio, Le Bihan, Denis, and Frouin, Vincent
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- 2017
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21. Neurocognitive Analysis of Low-level Arsenic Exposure and Executive Function Mediated by Brain Anomalies Among Children, Adolescents, and Young Adults in India
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Vaidya, Nilakshi, Holla, Bharath, Heron, Jon, Sharma, Eesha, Zhang, Yuning, Fernandes, Gwen, Iyengar, Udita, Spiers, Alex, Yadav, Anupa, Das, Surajit, Roy, Sanjit, Ahuja, Chirag K, Barker, Gareth J, Basu, Debasish, Bharath, Rose Dawn, Hickman, Matthew, Jain, Sanjeev, Kalyanram, Kartik, Kartik, Kamakshi, Krishna, Murali, Krishnaveni, Ghattu, Kumaran, Kalyanaraman, Kuriyan, Rebecca, Murthy, Pratima, Papadopoulos Orfanos, Dimitri, Purushottam, Meera, Kurpad, Sunita Simon, Singh, Lenin, Singh, Roshan, Subodh, B N, Toledano, Mireille, Walter, Henrik, Desrivières, Sylvane, Chakrabarti, Amit, Benegal, Vivek, and Schumann, Gunter
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Male ,Cohort Studies ,Young Adult ,Executive Function ,Brain Diseases ,Cross-Sectional Studies ,Adolescent ,Humans ,Brain/pathology ,Child ,Arsenic - Abstract
IMPORTANCE: Arsenic, a contaminant of groundwater and irrigated crops, is a global public health hazard. Exposure to low levels of arsenic through food extends well beyond the areas with high arsenic content in water.OBJECTIVE: To identify cognitive impairments following commonly prevalent low-level arsenic exposure and characterize their underlying brain mechanisms.DESIGN, SETTING, AND PARTICIPANTS: This multicenter population-based cohort study analyzed cross-sectional data of the Indian Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA) cohort, recruited between November 4, 2016, and May 4, 2019. Participants aged 6 to 23 years were characterized using deep phenotyping measures of behavior, neuropsychology, psychopathology, brain neuroimaging, and exposure to developmental adversities and environmental neurotoxins. All analyses were performed between June 1, 2020, and December 31, 2021.EXPOSURE: Arsenic levels were measured in urine as an index of exposure.MAIN OUTCOMES AND MEASURES: Executive function measured using the cVEDA neuropsychological battery, gray matter volume (GMV) from T1-weighted magnetic resonance imaging, and functional network connectivity measures from resting state functional magnetic resonance imaging.RESULTS: A total of 1014 participants aged 6 to 23 years (589 male [58.1%]; mean [SD] age, 14.86 [4.79] years) were included from 5 geographic locations. Sparse-partial least squares analysis was used to describe a negative association of arsenic exposure with executive function (r = -0.12 [P = 5.4 × 10-4]), brain structure (r = -0.20 [P = 1.8 × 10-8]), and functional connectivity (within network, r = -0.12 [P = 7.5 × 10-4]; between network, r = -0.23 [P = 1.8 × 10-10]). Alterations in executive function were partially mediated by GMV (b = -0.004 [95% CI, -0.007 to -0.002]) and within-network functional connectivity (b = -0.004 [95% CI, -0.008 to -0.002]). Socioeconomic status and body mass index moderated the association between arsenic and GMV, such that the association was strongest in participants with lower socioeconomic status and body mass index.CONCLUSIONS AND RELEVANCE: The findings of this cross-sectional study suggest that low-level arsenic exposure was associated with alterations in executive functioning and underlying brain correlates. These results indicate potential detrimental consequences of arsenic exposure that are below the currently recommended guidelines and may extend beyond endemic risk areas. Precision medicine approaches to study global mental health vulnerabilities highlight widespread but potentially modifiable risk factors and a mechanistic understanding of the impact of low-level arsenic exposure on brain development.
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- 2023
22. Genetic variants associated with longitudinal changes in brain structure across the lifespan
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Brouwer, Rachel M, Klein, Marieke, Kremen, William S, Guimaraes, Joao P O F T, Homuth, Georg, Hottenga, Jouke-Jan, Knol, Maria J, Kwok, John B J, Le Hellard, Stephanie, Mather, Karen A, Milaneschi, Yuri, Morris, Derek W, Nöthen, Markus M., Panizzon, Matthew S, Papiol, Sergi, Rietschel, Marcella, Santoro, Marcos L, Steen, Vidar M, Stein, Jason L, Streit, Fabian, Tankard, Rick M, Teumer, Alexander, van 't Ent, Dennis, van der Meer, Dennis, Olde Loohuis, Loes M, van Eijk, Kristel R, Vassos, Evangelos, Vázquez-Bourgon, Javier, Witt, Stephanie H, Consortium, IMAGEN, Adams, Hieab H H, Agartz, Ingrid, Ames, David, Amunts, Katrin, Andreassen, Ole A, Whelan, Christopher D, Arango, Celso, Banaschewski, Tobias, Baune, Bernhard T, Belangero, Sintia I, Bokde, Arun L W, Boomsma, Dorret I, Bressan, Rodrigo A, Brodaty, Henry, Buitelaar, Jan K, Cahn, Wiepke, Aghajani, Moji, Caspers, Svenja, Cichon, Sven, Crespo-Facorro, Benedicto, Cox, Simon R, Dannlowski, Udo, Elvsåshagen, Torbjørn, Espeseth, Thomas, Falkai, Peter, Fisher, Simon E, Flor, Herta, Alloza, Clara, Fullerton, Janice M, Garavan, Hugh, Gowland, Penny A, Grabe, Hans, Hahn, Tim, Heinz, Andreas, Hillegers, Manon, Hoare, Jacqueline, Hoekstra, Pieter J, Ikram, Mohammad A, Alnæs, Dag, Jackowski, Andrea P, Jansen, Andreas, Jönsson, Erik G, Kahn, Rene S, Kircher, Tilo, Korgaonkar, Mayuresh S, Krug, Axel, Lemaitre, Herve, Malt, Ulrik F, Martinot, Jean-Luc, Artiges, Eric, McDonald, Colm, Mitchell, Philip B, Muetzel, Ryan L, Murray, Robin M, Nees, Frauke, Nenadić, Igor, Oosterlaan, Jaap, Ophoff, Roel A, Pan, Pedro M, Penninx, Brenda W J H, Ayesa-Arriola, Rosa, Poustka, Luise, Sachdev, Perminder S, Salum, Giovanni A, Schofield, Peter R, Schumann, Gunter, Shaw, Philip, Sim, Kang, Smolka, Michael N, Stein, Dan J, Trollor, Julian N, Barker, Gareth J, van den Berg, Leonard H, Veldink, Jan H, Walter, Henrik, Westlye, Lars T, Whelan, Robert, White, Tonya, Wright, Margaret J, Medland, Sarah E, Franke, Barbara, Thompson, Paul M, Grasby, Katrina L, Bastin, Mark E, Hulshoff Pol, Hilleke E, Brühl, Rüdiger, Papadopoulos Orfanos, Dimitri, Paus, Tomáš, Millenet, Sabina, Blok, Elisabet, Bøen, Erlend, Breukelaar, Isabella A, Bright, Joanna K, Buimer, Elizabeth E L, Bülow, Robin, Cannon, Dara M, Ciufolini, Simone, Crossley, Nicolas A, Schnack, Hugo G, Damatac, Christienne G, Dazzan, Paola, de Mol, Casper L, de Zwarte, Sonja M C, Desrivières, Sylvane, Díaz-Caneja, Covadonga M, Doan, Nhat Trung, Dohm, Katharina, Fröhner, Juliane H, Goltermann, Janik, Jahanshad, Neda, Grigis, Antoine, Grotegerd, Dominik, Han, Laura K M, Harris, Mathew, Hartman, Catharina A, Heany, Sarah J, Heindel, Walter, Heslenfeld, Dirk J., Hohmann, Sarah, Ittermann, Bernd, Teeuw, Jalmar, Jansen, Philip R, Janssen, Joost, Jia, Tianye, Jiang, Jiyang, Jockwitz, Christiane, Karali, Temmuz, Keeser, Daniel, Koevoets, Martijn G J C, Lenroot, Rhoshel K, Malchow, Berend, Thomopoulos, Sophia I, Mandl, René C W, Medel, Vicente, Meinert, Susanne, Morgan, Catherine A, Mühleisen, Thomas W, Nabulsi, Leila, Opel, Nils, de la Foz, Víctor Ortiz-García, Overs, Bronwyn J, Paillère Martinot, Marie-Laure, Sprooten, Emma, Redlich, Ronny, Marques, Tiago Reis, Repple, Jonathan, Roberts, Gloria, Roshchupkin, Gennady V, Setiaman, Nikita, Shumskaya, Elena, Stein, Frederike, Sudre, Gustavo, Takahashi, Shun, Franz, Carol E, Thalamuthu, Anbupalam, Tordesillas-Gutiérrez, Diana, van der Lugt, Aad, van Haren, Neeltje E M, Wardlaw, Joanna M, Wen, Wei, Westeneng, Henk-Jan, Wittfeld, Katharina, Zhu, Alyssa H, Zugman, Andre, Gogtay, Nitin, Armstrong, Nicola J, Bonfiglio, Gaia, Bralten, Janita, Dalvie, Shareefa, Davies, Gail, Di Forti, Marta, Ding, Linda, Donohoe, Gary, Forstner, Andreas J, Gonzalez-Peñas, Javier, Child and Adolescent Psychiatry / Psychology, Erasmus MC other, Anesthesiology, Epidemiology, Radiology & Nuclear Medicine, Clinical Genetics, Psychiatry, the IMAGEN Consortium, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Human genetics, Amsterdam Neuroscience - Complex Trait Genetics, Pediatric surgery, APH - Aging & Later Life, APH - Mental Health, APH - Digital Health, European Commission, European Research Council, Comunidad de Madrid, Instituto de Salud Carlos III, Fundación Mutua Madrileña, Fundación Alicia Koplowitz, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Clinical Cognitive Neuropsychiatry Research Program (CCNP), Psychiatry 2, RS: MHeNs - R2 - Mental Health, Psychiatrie & Neuropsychologie, Complex Trait Genetics, Cognitive Psychology, Biological Psychology, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, APH - Methodology, Clinical Neuropsychology, IBBA, General Paediatrics, ARD - Amsterdam Reproduction and Development, and Paediatrics
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Neuroinformatics ,EXPRESSION ,Aging ,SUSCEPTIBILITY LOCI ,Longevity ,SURFACE-AREA ,INDIVIDUAL-DIFFERENCES ,All institutes and research themes of the Radboud University Medical Center ,SDG 3 - Good Health and Well-being ,Aging/genetics ,Humans ,ddc:610 ,GENOME-WIDE ASSOCIATION ,METAANALYSIS ,RISK ,Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] ,General Neuroscience ,220 Statistical Imaging Neuroscience ,Longevity/genetics ,Brain ,Magnetic Resonance Imaging ,genetics [Aging] ,VOLUME ,RELIABILITY ,sense organs ,CORTICAL THICKNESS ,genetics [Longevity] ,Genome-Wide Association Study - Abstract
et al., Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and aging., The ENIGMA-Plasticity Working Group is part of the ENIGMA World Aging Center, funded by NIA grants R56 AG058854 and R01 AG058854. The ENIGMA Consortium core funding was supported by NIH Consortium Grant U54 EB020403, supported by a cross-NIH alliance that funds Big Data to Knowledge Centers of Excellence. 1000BRAINS: 1000BRAINS is a population-based cohort based on the Heinz-Nixdorf Recall Study and is supported, in part, by the German National Cohort. We thank the Heinz Nixdorf Foundation (Germany) for their generous support in terms of the Heinz Nixdorf Study. The authors are supported by the Initiative and Networking Fund of the Helmholtz Association (Svenja Caspers) and the European Union’s Horizon 2020 Research and Innovation Programme under grant agreements 785907 (Human Brain Project SGA2; Svenja Caspers, Sven Cichon and Katrin Amunts). This work was further supported by the German Federal Ministry of Education and Research (BMBF) through the Integrated Network IntegraMent (Integrated Understanding of Causes and Mechanisms in Mental Disorders) under the auspices of the e:Med Program (grant 01ZX1314A; Sven Cichon) and by the Swiss National Science Foundation (SNSF, grant 156791; Sven Cichon). The authors acknowledge grants supporting their work from the European Union’s Horizon 2020 Research and Innovation Programme (H2020/2014–2020) under grant agreements 667302 (CoCA), 728018 (Eat2beNICE), 785907 (HBP SGA2) and 772376 (EScORIAL) and the Netherlands ALS Foundation.Additional support is received from the European Community’s Seventh Framework Programme (FP7/2007—2013) under grant agreements n° 602805 (Aggressotype), n° 603016 (MATRICS), n° 602450 (IMAGEMEND) and n° 278948 (TACTICS) and from the European Community’s Horizon 2020 Programme (H2020/2014—2020) under grant agreements n° 643051 (MiND) and n° 667302 (CoCA). FP7 Ideas: the European Research Council (ERC-230374 to D.B.). This work was supported by Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III (SAM16PE07CP1, PI16/02012 and PI19/024), co-financed by ERDF Funds from the European Commission, ‘A way of making Europe’, CIBERSAM; Madrid Regional Government (B2017/BMD-3740 AGES-CM-2), European Union Structural Funds; European Union Seventh Framework Program under grant agreements FP7- HEALTH-2013-2.2.1-2-603196 (Project PSYSCAN) and European Union H2020 Program under the Innovative Medicines Initiative 2 Joint Undertaking (grant agreement 115916, Project PRISM and grant agreement 777394, Project AIMS-2-TRIALS), Fundación Familia Alonso, Fundación Alicia Koplowitz and Fundación Mutua Madrileña. The Horizon 2020 funded ERC Advanced Grant ‘STRATIFY’ (Brain network based stratification of reinforcement-related disorders) (695313). The FP7 project MATRICS (603016). The research leading to these results also received support from the European Community’s Seventh Framework Programme (FP7/2007-2013) under grant agreement 278948 (TACTICS), 602805 (Aggressotype), 603016 (MATRICS) and 602450 (Imagemend) and the Innovation Medicine Initiative grants 115300 (EU-AIMS) and 777394 (AIMS-2-TRIALS).PAFIP: PAFIP was supported by the Instituto de Salud Carlos III (PI14/00639, PI14/00918 and PI17/01056) and Fundación Instituto de Investigación Marqués de Valdecilla (NCT0235832 and NCT025KG Jebsen Stiftelsen and H2020 CoMorMent (847776).34363). European Union Marie Curie Research Training Network (MRTN-CT-2006-035987).
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- 2022
23. Longitudinal associations between adolescent catch-up sleep, white-matter maturation and internalizing problems
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Guldner, Stella, primary, Sarvasmaa, Anna S., additional, Lemaître, Hervé, additional, Massicotte, Jessica, additional, Vulser, Hélène, additional, Miranda, Ruben, additional, Bezivin – Frère, Pauline, additional, Filippi, Irina, additional, Penttilä, Jani, additional, Banaschewski, Tobias, additional, Barker, Gareth J, additional, Bokde, Arun LW, additional, Bromberg, Uli, additional, Büchel, Christian, additional, Conrod, Patricia J, additional, Desrivières, Sylvane, additional, Flor, Herta, additional, Frouin, Vincent, additional, Gallinat, Jürgen, additional, Garavan, Hugh, additional, Gowland, Penny, additional, Heinz, Andreas, additional, Nees, Frauke, additional, Papadopoulos-Orfanos, Dimitri, additional, Smolka, Michael N, additional, Schumann, Gunter, additional, Artiges, Eric, additional, Martinot, Marie-Laure Paillère, additional, and Martinot, Jean-Luc, additional
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- 2023
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24. Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative
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Scott, Jan, Hidalgo-Mazzei, Diego, Strawbridge, Rebecca, Young, Allan, Resche-Rigon, Matthieu, Etain, Bruno, Andreassen, Ole A., Bauer, Michael, Bennabi, Djamila, Blamire, Andrew M., Boumezbeur, Fawzi, Brambilla, Paolo, Cattane, Nadia, Cattaneo, Annamaria, Chupin, Marie, Coello, Klara, Cointepas, Yann, Colom, Francesc, Cousins, David A., Dubertret, Caroline, Duchesnay, Edouard, Ferro, Adele, Garcia-Estela, Aitana, Goikolea, Jose, Grigis, Antoine, Haffen, Emmanuel, Høegh, Margrethe C., Jakobsen, Petter, Kalman, Janos L., Kessing, Lars V., Klohn-Saghatolislam, Farah, Lagerberg, Trine V., Landén, Mikael, Lewitzka, Ute, Lutticke, Ashley, Mazer, Nicolas, Mazzelli, Monica, Mora, Cristina, Muller, Thorsten, Mur-Mila, Estanislao, Oedegaard, Ketil Joachim, Oltedal, Leif, Pålsson, Erik, Papadopoulos Orfanos, Dimitri, Papiol, Sergi, Perez-Sola, Victor, Reif, Andreas, Ritter, Philipp, Rossi, Roberto, Schulze, Thomas, Senner, Fanny, Smith, Fiona E., Squarcina, Letizia, Steen, Nils Eiel, Thelwall, Pete E., Varo, Cristina, Vieta, Eduard, Vinberg, Maj, Wessa, Michele, Westlye, Lars T., and Bellivier, Frank
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- 2019
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25. Pubertal maturation and sex effects on the default-mode network connectivity implicated in mood dysregulation
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Ernst, Monique, Benson, Brenda, Artiges, Eric, Gorka, Adam X., Lemaitre, Herve, Lago, Tiffany, Miranda, Ruben, Banaschewski, Tobias, Bokde, Arun L. W., Bromberg, Uli, Brühl, Rüdiger, Büchel, Christian, Cattrell, Anna, Conrod, Patricia, Desrivières, Sylvane, Fadai, Tahmine, Flor, Herta, Grigis, Antoine, Gallinat, Juergen, Garavan, Hugh, Gowland, Penny, Grimmer, Yvonne, Heinz, Andreas, Kappel, Viola, Nees, Frauke, Papadopoulos-Orfanos, Dimitri, Penttilä, Jani, Poustka, Luise, Smolka, Michael N., Stringaris, Argyris, Struve, Maren, van Noort, Betteke M., Walter, Henrik, Whelan, Robert, Schumann, Gunter, Grillon, Christian, Martinot, Marie-Laure Paillère, Martinot, Jean-Luc, and for the IMAGEN Consortium
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- 2019
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26. The Role of Empathy in Alcohol Use of Bullying Perpetrators and Victims: Lower Personal Empathic Distress Makes Male Perpetrators of Bullying More Vulnerable to Alcohol Use.
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Prignitz, Maren, Banaschewski, Tobias, Bokde, Arun L. W., Desrivières, Sylvane, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Martinot, Jean-Luc, Paillère Martinot, Marie-Laure, Artiges, Eric, Papadopoulos Orfanos, Dimitri, Poustka, Luise, Hohmann, Sarah, Fröhner, Juliane H., Robinson, Lauren, Smolka, Michael N., Walter, Henrik, Winterer, Jeanne M., and Whelan, Robert
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- 2023
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27. Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex
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Guadalupe, Tulio, Mathias, Samuel R., vanErp, Theo G. M., Whelan, Christopher D., Zwiers, Marcel P., Abe, Yoshinari, Abramovic, Lucija, Agartz, Ingrid, Andreassen, Ole A., Arias-Vásquez, Alejandro, Aribisala, Benjamin S., Armstrong, Nicola J., Arolt, Volker, Artiges, Eric, Ayesa-Arriola, Rosa, Baboyan, Vatche G., Banaschewski, Tobias, Barker, Gareth, Bastin, Mark E., Baune, Bernhard T., Blangero, John, Bokde, Arun L.W., Boedhoe, Premika S.W., Bose, Anushree, Brem, Silvia, Brodaty, Henry, Bromberg, Uli, Brooks, Samantha, Büchel, Christian, Buitelaar, Jan, Calhoun, Vince D., Cannon, Dara M., Cattrell, Anna, Cheng, Yuqi, Conrod, Patricia J., Conzelmann, Annette, Corvin, Aiden, Crespo-Facorro, Benedicto, Crivello, Fabrice, Dannlowski, Udo, de Zubicaray, Greig I., de Zwarte, Sonja M.C., Deary, Ian J., Desrivières, Sylvane, Doan, Nhat Trung, Donohoe, Gary, Dørum, Erlend S., Ehrlich, Stefan, Espeseth, Thomas, Fernández, Guillén, Flor, Herta, Fouche, Jean-Paul, Frouin, Vincent, Fukunaga, Masaki, Gallinat, Jürgen, Garavan, Hugh, Gill, Michael, Suarez, Andrea Gonzalez, Gowland, Penny, Grabe, Hans J., Grotegerd, Dominik, Gruber, Oliver, Hagenaars, Saskia, Hashimoto, Ryota, Hauser, Tobias U., Heinz, Andreas, Hibar, Derrek P., Hoekstra, Pieter J., Hoogman, Martine, Howells, Fleur M., Hu, Hao, Hulshoff Pol, Hilleke E., Huyser, Chaim, Ittermann, Bernd, Jahanshad, Neda, Jönsson, Erik G., Jurk, Sarah, Kahn, Rene S., Kelly, Sinead, Kraemer, Bernd, Kugel, Harald, Kwon, Jun Soo, Lemaitre, Herve, Lesch, Klaus-Peter, Lochner, Christine, Luciano, Michelle, Marquand, Andre F., Martin, Nicholas G., Martínez-Zalacaín, Ignacio, Martinot, Jean-Luc, Mataix-Cols, David, Mather, Karen, McDonald, Colm, McMahon, Katie L., Medland, Sarah E., Menchón, José M., Morris, Derek W., Mothersill, Omar, Maniega, Susana Munoz, Mwangi, Benson, Nakamae, Takashi, Nakao, Tomohiro, Narayanaswaamy, Janardhanan C., Nees, Frauke, Nordvik, Jan E., Onnink, A. Marten H., Opel, Nils, Ophoff, Roel, Paillère Martinot, Marie-Laure, Papadopoulos Orfanos, Dimitri, Pauli, Paul, Paus, Tomáš, Poustka, Luise, Reddy, Janardhan YC., Renteria, Miguel E., Roiz-Santiáñez, Roberto, Roos, Annerine, Royle, Natalie A., Sachdev, Perminder, Sánchez-Juan, Pascual, Schmaal, Lianne, Schumann, Gunter, Shumskaya, Elena, Smolka, Michael N., Soares, Jair C., Soriano-Mas, Carles, Stein, Dan J., Strike, Lachlan T., Toro, Roberto, Turner, Jessica A., Tzourio-Mazoyer, Nathalie, Uhlmann, Anne, Hernández, Maria Valdés, van den Heuvel, Odile A., van der Meer, Dennis, van Haren, Neeltje E.M ., Veltman, Dick J., Venkatasubramanian, Ganesan, Vetter, Nora C., Vuletic, Daniella, Walitza, Susanne, Walter, Henrik, Walton, Esther, Wang, Zhen, Wardlaw, Joanna, Wen, Wei, Westlye, Lars T., Whelan, Robert, Wittfeld, Katharina, Wolfers, Thomas, Wright, Margaret J., Xu, Jian, Xu, Xiufeng, Yun, Je-Yeon, Zhao, JingJing, Franke, Barbara, Thompson, Paul M., Glahn, David C., Mazoyer, Bernard, Fisher, Simon E., and Francks, Clyde
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- 2016
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28. Brain structural covariance network differences in adults with alcohol dependence and heavy-drinking adolescents
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Albaugh, Matthew D., Cao, Zhipeng, Cupertino, Renata B., Schwab, Nathan, Spechler, Phillip A., Allen, Nicholas, Artiges, Eric, Banaschewski, Tobias, Bokde, Arun L. W., Burke Quinlan, Erin, Orr, Catherine, Cousijn, Janna, Flor, Herta, Foxe, John J., Goudriaan, Anna E., Gowland, Penny, Grigis, Antoine, Heinz, Andreas, Hester, Robert, Hutchison, Kent, Li, Chiang?Shan R., London, Edythe D., Lorenzetti, Valentina, Luijten, Maartje, Nees, Frauke, Martin?Santos, Rocio, Martinot, Jean?Luc, Millenet, Sabina, Momenan, Reza, Papadopoulos Orfanos, Dimitri, Paulus, Martin P., Poustka, Luise, Schmaal, Lianne, Schumann, Gunter, Sinha, Rajita, Smolka, Michael N., Solowij, Nadia, Stein, Dan J., Stein, Elliot A., Uhlmann, Anne, Holst, Ruth J., Veltman, Dick J., Walter, Henrik, Whelan, Robert, Wiers, Reinout W., Zhang, Sheng, Jahanshad, Neda, Thompson, Paul M., Conrod, Patricia, Mackey, Scott, and Garavan, Hugh
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Psychiatry and Mental health ,Sir Peter Mansfield Imaging Centre (SPMIC) ,Medicine (miscellaneous) - Abstract
BACKGROUND AND AIMS: Graph theoretic analysis of structural covariance networks (SCN) provides an assessment of brain organization that has not yet been applied to alcohol dependence (AD). We estimated whether SCN differences are present in adults with AD and heavy-drinking adolescents at age 19 and age 14, prior to substantial exposure to alcohol. DESIGN: Cross-sectional sample of adults and a cohort of adolescents. Correlation matrices for cortical thicknesses across 68 regions were summarized with graph theoretic metrics. SETTING AND PARTICIPANTS: A total of 745 adults with AD and 979 non-dependent controls from 24 sites curated by the Enhancing NeuroImaging Genetics through Meta Analysis (ENIGMA)-Addiction consortium, and 297 hazardous drinking adolescents and 594 controls at ages 19 and 14 from the IMAGEN study, all from Europe. MEASUREMENTS: Metrics of network segregation (modularity, clustering coefficient and local efficiency) and integration (average shortest path length and global efficiency). FINDINGS: The younger AD adults had lower network segregation and higher integration relative to non-dependent controls. Compared with controls, the hazardous drinkers at age 19 showed lower modularity [area-under-the-curve (AUC) difference?=?-0.0142, 95% confidence interval (CI)?=?-0.1333, 0.0092; P-value?=?0.017], clustering coefficient (AUC difference?=?-0.0164, 95% CI?=?-0.1456, 0.0043; P-value?=?0.008) and local efficiency (AUC difference?=?-0.0141, 95% CI?=?-0.0097, 0.0034; P-value?=?0.010), as well as lower average shortest path length (AUC difference?=?-0.0405, 95% CI?=?-0.0392, 0.0096; P-value?=?0.021) and higher global efficiency (AUC difference?=?0.0044, 95% CI?=?-0.0011, 0.0043; P-value?=?0.023). The same pattern was present at age 14 with lower clustering coefficient (AUC difference?=?-0.0131, 95% CI?=?-0.1304, 0.0033; P-value?=?0.024), lower average shortest path length (AUC difference?=?-0.0362, 95% CI?=?-0.0334, 0.0118; P-value?=?0.019) and higher global efficiency (AUC difference?=?0.0035, 95% CI?=?-0.0011, 0.0038; P-value?=?0.048). CONCLUSIONS: Cross-sectional analyses indicate that a specific structural covariance network profile is an early marker of alcohol dependence in adults. Similar effects in a cohort of heavy-drinking adolescents, observed at age 19 and prior to substantial alcohol exposure at age 14, suggest that this pattern may be a pre-existing risk factor for problematic drinking.
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- 2022
29. Multisubject Non-rigid Registration of Brain MRI Using Intensity and Geometric Features
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Cachier, Pascal, Mangin, Jean-François, Pennec, Xavier, Rivière, Denis, Papadopoulos-Orfanos, Dimitri, Régis, Jean, Ayache, Nicholas, Goos, Gerhard, editor, Hartmanis, Juris, editor, van Leeuwen, Jan, editor, Niessen, Wiro J., editor, and Viergever, Max A., editor
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- 2001
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30. Autistic traits and alcohol use in adolescents within the general population
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Pijnenburg, Lisa J, Kaplun, Anais, de Haan, Lieuwe, Janecka, Magdalena, Smith, Lauren, Reichenberg, Abraham, Banaschewski, Tobias, Bokde, Arun L W, Quinlan, Erin Burke, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Poustka, Luise, Hohmann, Sarah, Millenet, Sabina, Smolka, Michael N, Walter, Henrik, Whelan, Robert, Schumann, Gunter, Velthorst, Eva, and IMAGEN Consortium
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Psychiatry and Mental health ,Pediatrics, Perinatology and Child Health ,Developmental and Educational Psychology ,General Medicine - Abstract
It has been suggested that autistic traits are associated with less frequent alcohol use in adolescence. Our study seeks to examine the relationship between autistic traits and alcohol use in a large adolescent population. Leveraging data from the IMAGEN cohort, including 2045 14-year-old adolescents that were followed-up to age 18, we selected items on social preference/skills and rigidity from different questionnaires. We used linear regression models to (1) test the effect of the sum scores on the prevalence of alcohol use (AUDIT-C) over time, (2) explore the relationship between autistic traits and alcohol use patterns, and (3) explore the specific effect of each autistic trait on alcohol use. Higher scores on the selected items were associated with trajectories of less alcohol use from the ages between 14 and 18 (b = ? 0.030; CI 95% = ? 0.042, ? 0.017; p < 0.001). Among adolescents who used alcohol, those who reported more autistic traits were also drinking less per occasion than their peers and were less likely to engage in binge drinking. We found significant associations between alcohol use and social preference (p < 0.001), nervousness for new situations (p = 0.001), and detail orientation (p < 0.001). Autistic traits (social impairment, detail orientation, and anxiety) may buffer against alcohol use in adolescence.
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- 2022
31. Brain substrates of reward processing and the μ-opioid receptor: a pathway into pain?
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Nees, Frauke, Becker, Susanne, Millenet, Sabina, Banaschewski, Tobias, Poustka, Luise, Bokde, Arun, Bromberg, Uli, Büchel, Christian, Conrod, Patricia J., Desrivières, Sylvane, Frouin, Vincent, Gallinat, Jürgen, Garavan, Hugh, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Papadopoulos Orfanos, Dimitri, Paus, Tomáš, Smolka, Michael N., Walter, Henrik, Whelan, Rob, Schumann, Gunter, and Flor, Herta
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- 2017
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32. Automatic Recognition of Cortical Sulci Using a Congregation of Neural Networks
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Rivière, Denis, Mangin, Jean-François, Papadopoulos-Orfanos, Dimitri, Martinez, Jean-Marc, Frouin, Vincent, Régis, Jean, Goos, Gerhard, editor, Hartmanis, Juris, editor, van Leeuwen, Jan, editor, Delp, Scott L., editor, DiGoia, Anthony M., editor, and Jaramaz, Branislav, editor
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- 2000
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33. Differential predictors for alcohol use in adolescents as a function of familial risk
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Tschorn, Mira, Lorenz, Robert C., O’Reilly, Paul F., Reichenberg, Abraham, Quinlan, Erin B., Flor, Herta, Grigis, Antoine, Garavan, Hugh, Ittermann, Bernd, Papadopoulos Orfanos, Dimitri, Poustka, Luise, Millenet, Sabina, Smolka, Michael N., Whelan, Robert, Schumann, Gunter, Rapp, Michael A., Robbins, Trevor, Dalley, Jeffrey, Subramaniam, Naresh, Theobald, David, Mann, Karl, Bach, Christiane, Struve, Maren, Banaschewski, Tobias, Rietschel, Marcella, Spanagel, Rainer, Nees, Frauke, Fauth-Bühler, Mira, Grimmer, Yvonne, Lathrop, Mark, Heinz, Andreas, Albrecht, Lisa, Ivanov, Nikolay, Strache, Nicole, Rapp, Michael, Ströhle, Andreas, Reuter, Jan, Gallinat, Jürgen, Walter, Henrik, Gemmeke, Isabel, Genauck, Alexander, Parchetka, Caroline, Weiß, Katharina, Kruschwitz, Johann, Raffaelli, Bianca, Isci, Alev, Daedelow, Laura, Barbot, Alexis, Thyreau, Benjamin, Schwartz, Yannick, Lalanne, Christophe, Frouin, Vincent, Orfanos, Dimitri Papadopoulos, Rogers, John, Ireland, James, Lanzerath, Dirk, Feng, Jianfeng, Martinot, Jean-Luc, Bricaud, Zuleima, Briand, Fanny Gollier, LemaÎtre, Hervé, Miranda, Ruben, Artiges, Eric, Massicotte, Jessica, Martinot, Marie-Laure Paillère, Vulser, Helene, Pentillä, Jani, Filippi, Irina, Galinowski, André, Bezivin, Pauline, Cattrell, Anna, Jia, Tianye, Desrivières, Sylvane, Werts, Helen, Topper, Lauren, Reed, Laurence, Andrew, Chris, Mallik, Catherine, Ruggeri, Barbara, Nymberg, Charlotte, Barker, Gareth, Conrod, Patricia J., Smith, Lindsay, Loth, Eva, Havatzias, Stephanie, Shekarrizi, Sheyda, Kitson, Emily, Robinson, Alice, Hall, Deborah, Rubino, Chiara, Wright, Hannah, Stueber, Kerstin, Hanratty, Eanna, Kennedy, Eleanor, De Carvahlo, Fabiana Mesquita, Stringaris, Argyris, Robert, Gabriel, Ing, Alex, Macare, Christine, Xu, Bing, Yu, Tao, Quinlan, Erin Burke, Constant, Patrick, Aydin, Semiha, Brühl, Ruediger, Ihlenfeld, Albrecht, Walaszek, Bernadeta, Smolka, Michael, Hübner, Thomas, Müller, Kathrin, Ripke, Stephan, Jurk, Sarah, Mennigen, Eva, Schmidt, Dirk, Vetter, Nora, Ziesch, Veronika, Fröhner, Juliane H., Bokde, Arun L. W., Carter, Daniel, Walsh, Emily, O’Driscoll, Susanne, Agan, Maria Leonora Fatimah, McMorrow, Mairead, Nugent, Sinead, Connolly, Colm, Dooley, Eoin, Cremen, Clodagh, Jones, Jennifer, O’Keefe, John, O’Connor, Martin, Poline, Jean-Baptiste, Büchel, Christian, Bromberg, Uli, Fadai, Tahmine, Yacubian, Juliana, Schneider, Sophia, Lobatchewa, Maria, Lawrence, Claire, Newman, Craig, Head, Kay, Heym, Nadja, Gowland, Penny, Stedman, Alicia, Kaviani, Mehri, Taplin, Susannah, Stephens, Dai, Paus, Tomáš, Pausova, Zdenka, Tahmasebi, Amir, Banaschewski, Tobias [0000-0003-4595-1144], Bokde, Arun L. W. [0000-0003-0114-4914], Quinlan, Erin B. [0000-0003-2927-1632], Desrivières, Sylvane [0000-0002-9120-7060], Gowland, Penny [0000-0002-4900-4817], Martinot, Jean-Luc [0000-0002-0136-0388], Artiges, Eric [0000-0003-4461-7646], Nees, Frauke [0000-0002-7796-8234], Papadopoulos Orfanos, Dimitri [0000-0002-1242-8990], Fröhner, Juliane H. [0000-0002-8493-6396], Smolka, Michael N. [0000-0001-5398-5569], Walter, Henrik [0000-0002-9403-6121], Heinz, Andreas [0000-0001-5405-9065], Rapp, Michael A. [0000-0003-0106-966X], and Apollo - University of Cambridge Repository
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631/208 ,article ,59/36 ,45/23 ,631/378 ,631/477 ,692/699/476/5 - Abstract
Traditional models of future alcohol use in adolescents have used variable-centered approaches, predicting alcohol use from a set of variables across entire samples or populations. Following the proposition that predictive factors may vary in adolescents as a function of family history, we used a two-pronged approach by first defining clusters of familial risk, followed by prediction analyses within each cluster. Thus, for the first time in adolescents, we tested whether adolescents with a family history of drug abuse exhibit a set of predictors different from adolescents without a family history. We apply this approach to a genetic risk score and individual differences in personality, cognition, behavior (risk-taking and discounting) substance use behavior at age 14, life events, and functional brain imaging, to predict scores on the alcohol use disorders identification test (AUDIT) at age 14 and 16 in a sample of adolescents (N = 1659 at baseline, N = 1327 at follow-up) from the IMAGEN cohort, a longitudinal community-based cohort of adolescents. In the absence of familial risk (n = 616), individual differences in baseline drinking, personality measures (extraversion, negative thinking), discounting behaviors, life events, and ventral striatal activation during reward anticipation were significantly associated with future AUDIT scores, while the overall model explained 22% of the variance in future AUDIT. In the presence of familial risk (n = 711), drinking behavior at age 14, personality measures (extraversion, impulsivity), behavioral risk-taking, and life events were significantly associated with future AUDIT scores, explaining 20.1% of the overall variance. Results suggest that individual differences in personality, cognition, life events, brain function, and drinking behavior contribute differentially to the prediction of future alcohol misuse. This approach may inform more individualized preventive interventions.
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- 2021
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34. Brain structural covariance network differences in adults with alcohol dependence and heavy drinking adolescents
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Ottino‐Gonzalez, Jonatan, primary, Albaugh, Matthew D., additional, Cao, Zhipeng, additional, Cupertino, Renata B., additional, Schwab, Nathan, additional, Spechler, Phillip A., additional, Allen, Nicholas, additional, Artiges, Eric, additional, Banaschewski, Tobias, additional, Bokde, Arun L. W., additional, Burke Quinlan, Erin, additional, Brühl, Rüdiger, additional, Orr, Catherine, additional, Cousijn, Janna, additional, Desrivières, Sylvane, additional, Flor, Herta, additional, Foxe, John J., additional, Fröhner, Juliane H., additional, Goudriaan, Anna E., additional, Gowland, Penny, additional, Grigis, Antoine, additional, Heinz, Andreas, additional, Hester, Robert, additional, Hutchison, Kent, additional, Li, Chiang‐Shan R., additional, London, Edythe D., additional, Lorenzetti, Valentina, additional, Luijten, Maartje, additional, Nees, Frauke, additional, Martin‐Santos, Rocio, additional, Martinot, Jean‐Luc, additional, Millenet, Sabina, additional, Momenan, Reza, additional, Paillère Martinot, Marie‐Laure, additional, Papadopoulos Orfanos, Dimitri, additional, Paulus, Martin P., additional, Poustka, Luise, additional, Schmaal, Lianne, additional, Schumann, Gunter, additional, Sinha, Rajita, additional, Sjoerds, Zsuzsika, additional, Smolka, Michael N., additional, Solowij, Nadia, additional, Stein, Dan J., additional, Stein, Elliot A., additional, Uhlmann, Anne, additional, Holst, Ruth J., additional, Veltman, Dick J., additional, Walter, Henrik, additional, Whelan, Robert, additional, Wiers, Reinout W., additional, Yücel, Murat, additional, Zhang, Sheng, additional, Jahanshad, Neda, additional, Thompson, Paul M., additional, Conrod, Patricia, additional, Mackey, Scott, additional, and Garavan, Hugh, additional
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- 2021
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35. Immune-Related Genetic Overlap Between Regional Gray Matter Reductions and Psychiatric Symptoms in Adolescents, and Gene-Set Validation in a Translational Model
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Penninck, Lukas, Artiges, Eric, Gorgievski, Victor, Farley, Severine, Filippi, Irina, de Macedo, Carlos E. A., Belzeaux, Raoul, Banaschewski, Tobias, Bokde, Arun L. W., Quinlan, Erin Burke, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Poustka, Luise, Smolka, Michael N., Walter, Henrik, Whelan, Robert, Grenier, Julien, Schumann, Gunter, Tzavara, Eleni T., and Martinot, Jean-Luc
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Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Cognitive Neuroscience ,Neuroscience (miscellaneous) - Abstract
Adolescence is a period of vulnerability for the maturation of gray matter (GM) and also for the onset of psychiatric disorders such as major depressive disorder (MDD), bipolar disorder and schizophrenia. Chronic neuroinflammation is considered to play a role in the etiology of these illnesses. However, the involvement of neuroinflammation in the observed link between regional GM volume reductions and psychiatric symptoms is not established yet. Here, we investigated a possible common immune-related genetic link between these two phenomena in european adolescents recruited from the community. Hippocampal and medial prefrontal cortex (mPFC) were defined a priori as regions of interest (ROIs). Their GM volumes were extracted in 1,563 14-year-olds from the IMAGEN database. We found a set of 26 SNPs that correlated with the hippocampal volumes and 29 with the mPFC volumes at age 14. We formed two ROI-Related Immune-gene scores (RRI) with the inflammation SNPs that correlated to hippocampal GM volume and to mPFC GM volume. The predictive ability of both RRIs with regards to the presence of psychiatric symptoms at age 18 was investigated by correlating the RRIs with psychometric questionnaires obtained at age 18. The RRIs (but not control scores constructed with random SNPs) correlated with the presence of depressive symptoms, positive psychotic symptoms, and externalizing symptoms in later adolescence. In addition, the effect of childhood maltreatment, one of the major environmental risk factors for depression and other mental disorders, interacted with the RRI effect. We next sought to validate this finding by investigating our set of inflammatory genes in a translational animal model of early life adversity. Mice were subjected to a protocol of maternal separation at an early post-natal age. We evaluated depressive behaviors in separated and non-separated mice at adolescence and their correlations with the concomitant expression of our genes in whole blood samples. We show that in mice, early life adversity affected the expression of our set of genes in peripheral blood, and that levels of expression correlated with symptoms of negative affect in adolescence. Overall, our translational findings in adolescent mice and humans provide a novel validated gene-set of immune-related genes for further research in the early stages of mood disorders.
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- 2021
36. The role of the cannabinoid receptor in adolescents′ processing of facial expressions
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Ewald, Anais, Becker, Susanne, Heinrich, Angela, Banaschewski, Tobias, Poustka, Luise, Bokde, Arun, Büchel, Christian, Bromberg, Uli, Cattrell, Anna, Conrod, Patricia, Desrivières, Sylvane, Frouin, Vincent, Papadopoulos-Orfanos, Dimitri, Gallinat, Jürgen, Garavan, Hugh, Heinz, Andreas, Walter, Henrik, Ittermann, Bernd, Gowland, Penny, Paus, Tomáš, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Smolka, Michael N., Vetter, Nora, Whelan, Rob, Schumann, Gunter, Flor, Herta, Nees, Frauke, and OʼDoherty, John
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- 2016
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37. Association of Cannabis Use During Adolescence With Neurodevelopment
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Albaugh, Matthew D., Ottino-Gonzalez, Jonatan, Sidwell, Amanda, Lepage, Claude, Juliano, Anthony, Owens, Max M., Chaarani, Bader, Spechler, Philip, Fontaine, Nicholas, Rioux, Pierre, Lewis, Lindsay, Jeon, Seun, Evans, Alan, Radhakrishnan, Rajiv, Banaschewski, Tobias, Bokde, Arun L. W., Quinlan, Erin Burke, Conrod, Patricia, Flor, Herta, Grigis, Antoine, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Poustka, Luise, Millenet, Sabina, Smolka, Michael N., Walter, Henrik, Whelan, Robert, Schumann, Gunter, Potter, Alexandra, and Garavan, Hugh
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Psychiatry and Mental health - Abstract
IMPORTANCE Animal studies have shown that the adolescent brain is sensitive to disruptions in endocannabinoid signaling, resulting in altered neurodevelopment and lasting behavioral effects. However, few studies have investigated ties between cannabis use and adolescent brain development in humans.OBJECTIVE To examine the degree to which magnetic resonance (MR) imaging–assessed cerebral cortical thickness development is associated with cannabis use in a longitudinal sample of adolescents.DESIGN, SETTING, AND PARTICIPANTS Data were obtained from the community-based IMAGEN cohort study, conducted across 8 European sites. Baseline data used in the present study were acquired from March 1, 2008, to December 31, 2011, and follow-up data were acquired from January 1, 2013, to December 31, 2016. A total of 799 IMAGEN participants were identified who reported being cannabis naive at study baseline and had behavioral and neuroimaging data available at baseline and 5-year follow-up. Statistical analysis was performed from October 1, 2019, to August 31, 2020.MAIN OUTCOMES AND MEASURES Cannabis use was assessed at baseline and 5-year follow-up with the European School Survey Project on Alcohol and Other Drugs. Anatomical MR images were acquired with a 3-dimensional T1-weighted magnetization prepared gradient echo sequence. Quality-controlled nativeMR images were processed through the CIVET pipeline, version 2.1.0.RESULTS The study evaluated 1598 MR images from 799 participants (450 female participants [56.3%]; mean [SD] age, 14.4 [0.4] years at baseline and 19.0 [0.7] years at follow-up). At 5-year follow-up, cannabis use (from 0 to >40 uses) was negatively associated with thickness in left prefrontal (peak: t785 = –4.87, cluster size = 1558 vertices; P = 1.10 × 10−6, random field theory cluster corrected) and right prefrontal (peak: t785 = –4.27, cluster size = 1551 vertices; P = 2.81 × 10−5, random field theory cluster corrected) cortices. There were no significant associations between lifetime cannabis use at 5- year follow-up and baseline cortical thickness, suggesting that the observed neuroanatomical differences did not precede initiation of cannabis use. Longitudinal analysis revealed that age-related cortical thinning was qualified by cannabis use in a dose-dependent fashion such that greater use, from baseline to follow-up, was associated with increased thinning in left prefrontal (peak: t815.27 = –4.24, cluster size = 3643 vertices; P = 2.28 × 10−8, random field theory cluster corrected) and right prefrontal (peak: t813.30 = –4.71, cluster size = 2675 vertices; P = 3.72 × 10−8, random field theory cluster corrected) cortices. The spatial pattern of cannabis-related thinning was associated with age-related thinning in this sample (r = 0.540; P less than< .001), and a positron emission tomography–assessed cannabinoid 1 receptor–binding map derived from a separate sample of participants (r = −0.189; P less than .001). Analysis revealed that thinning in right prefrontal cortices, from baseline to follow-up, was associated with attentional impulsiveness at follow-up.CONCLUSIONS AND RELEVANCE Results suggest that cannabis use during adolescence is associated with altered neurodevelopment, particularly in cortices rich in cannabinoid 1 receptors and undergoing the greatest age-related thickness change in middle to late adolescence.
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- 2021
38. Bayesian Causal Network Modeling Suggests Adolescent Cannabis Use Promotes Accelerated Prefrontal Cortical Thinning
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Owens, Max Michael, primary, Albaugh, Matthew, additional, Allgaier, Nicholas, additional, Yuan, Dekang, additional, Robert, Gabriel, additional, Cupertino, Renata B., additional, Spechler, Philip A., additional, Juliano, Anthony, additional, Hahn, Sage, additional, Banaschewski, Tobias, additional, Bokde, Arun L.W., additional, Quinlan, Erin Burke, additional, Desrivieres, Sylvane, additional, Flor, Herta, additional, Grigis, Antoine, additional, Gowland, Penny, additional, Heinz, Andreas, additional, Brühl, Rüdiger, additional, Martinot, Jean-Luc, additional, Martinot, Marie-Laure Paillère, additional, Artiges, Eric, additional, Nees, Frauke, additional, Papadopoulos Orfanos, Dimitri, additional, Lemaitre, Herve, additional, Paus, Tomáš, additional, Poustka, Luise, additional, Millenet, Sabina, additional, Fröhner, Juliane Hilde, additional, Smolka, Michael N., additional, Walter, Henrik, additional, Whelan, Robert, additional, Schumann, Gunter, additional, and Garavan, Hugh, additional
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- 2021
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39. Irregular sleep habits, regional grey matter volumes, and psychological functioning in adolescents
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the IMAGEN consortium, Lapidaire, Winok, Urrila, Anna S., Artiges, Eric, Miranda, Ruben, Vulser, Helene, Bezivin-Frere, Pauline, Lemaitre, Herve, Penttilä, Jani, Banaschewski, Tobias, Bokde, Arun L.W., Bromberg, Uli, Buchel, Christian, Conrod, Patricia J., Desrivières, Sylvane, Frouin, Vincent, Gallinat, Jurgen, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Papadopoulos-Orfanos, Dimitri, Paus, Tomas, Smolka, Michael N., Schumann, Gunter, Martinot, Marie Laure Paillere, Martinot, Jean Luc, Fauth-Buhler, M., Poutska, L., Nees, F., Grimmer, Y., Struve, M., Strohle, A., Kappel, V., Van Noort, B. M., Bordas, N., Bricaud, Z., Filippi, I., Galinowski, A., Gollier-Briant, F., Menard, Vincent, Cattrell, A., Goodman, R., Stringaris, A., Nymberg, C., Reed, L., Ittermann, B., Bruhl R, R., Hubner, T., Muller, K., Bromberg, U., CB - Centre Borelli - UMR 9010 (CB), Service de Santé des Armées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Ecole Normale Supérieure Paris-Saclay (ENS Paris Saclay)-Université Paris Cité (UPCité), Adolescent psychopathology and Medicine, Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Departamento de Fisica de la Materia Condensada [Madrid] (FMC), Facultad de Ciencas [Madrid], Universidad Autónoma de Madrid (UAM)-Universidad Autónoma de Madrid (UAM), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Tampere University Hospital, Heidelberg University, Trinity College Dublin, University Hospital Hamburg-Eppendorf, Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), CHU Sainte Justine [Montréal], Institute of Psychiatry, Psychology & Neuroscience, King's College London, King‘s College London, Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], University of Nottingham, UK (UON), University of Toronto, Technische Universität Dresden = Dresden University of Technology (TU Dresden), Service de Psychiatrie de l'Enfant et de l'Adolescent [CHU Pitié-Salpêtrière] (SPEA), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), ANR-19-CE37-0017,GeBra,Approches translationelles, profilage transcriptomique, et imagerie cérébrale: vers des nouveaux biomarqueurs et réseaux biologiques dans la resilience au stress(2019), ANR-18-NEUR-0002,ADORe,TARGETING ADOLESCENT NEUROCOGNITIVE PROCESSES IN DEPRESSION TO PROMOTE INTERVENTION RESPONSE(2018), Gestionnaire, HAL Sorbonne Université 5, Approches translationelles, profilage transcriptomique, et imagerie cérébrale: vers des nouveaux biomarqueurs et réseaux biologiques dans la resilience au stress - - GeBra2019 - ANR-19-CE37-0017 - AAPG2019 - VALID, ERANET NEURON - TARGETING ADOLESCENT NEUROCOGNITIVE PROCESSES IN DEPRESSION TO PROMOTE INTERVENTION RESPONSE - - ADORe2018 - ANR-18-NEUR-0002 - ERAnet NEURON - VALID, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Tampere University, Clinical Medicine, Staff Services, HUS Children and Adolescents, Nuorisopsykiatria, University of Helsinki, Helsinki University Hospital Area, HYKS erva, Päijät-Häme Welfare Consortium, Service de Santé des Armées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Ecole Normale Supérieure Paris-Saclay (ENS Paris Saclay)-Université de Paris (UP), and Universidad Autonoma de Madrid (UAM)-Universidad Autonoma de Madrid (UAM)
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Central Nervous System ,Male ,Physiology ,Emotions ,[SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health ,Social Sciences ,Adolescents ,Nervous System ,Hippocampus ,3124 Neurology and psychiatry ,Families ,Habits ,0302 clinical medicine ,Cognition ,Learning and Memory ,3123 Gynaecology and paediatrics ,Medicine and Health Sciences ,Psychology ,Gray Matter ,Prefrontal cortex ,Children ,education.field_of_study ,Multidisciplinary ,05 social sciences ,Brain ,Strengths and Difficulties Questionnaire ,Amygdala ,medicine.anatomical_structure ,Memory, Short-Term ,Medicine ,Female ,medicine.symptom ,Anatomy ,Psychopathology ,Clinical psychology ,Research Article ,Adolescent ,515 Psychology ,Cognitive Neuroscience ,Science ,Population ,education ,Prefrontal Cortex ,Grey matter ,Impulsivity ,050105 experimental psychology ,03 medical and health sciences ,Memory ,medicine ,Humans ,0501 psychology and cognitive sciences ,Working Memory ,Behavior ,Working memory ,Biology and Life Sciences ,Age Groups ,[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health ,People and Places ,Impulsive Behavior ,Cognitive Science ,Population Groupings ,Physiological Processes ,Sleep ,030217 neurology & neurosurgery ,Neuroscience ,Follow-Up Studies - Abstract
Changing sleep rhythms in adolescents often lead to sleep deficits and a delay in sleep timing between weekdays and weekends. The adolescent brain, and in particular the rapidly developing structures involved in emotional control, are vulnerable to external and internal factors. In our previous study in adolescents at age 14, we observed a strong relationship between weekend sleep schedules and regional medial prefrontal cortex grey matter volumes. Here, we aimed to assess whether this relationship remained in this group of adolescents of the general population at the age of 16 (n = 101; mean age 16.8 years; 55% girls). We further examined grey matter volumes in the hippocampi and the amygdalae, calculated with voxel-based morphometry. In addition, we investigated the relationships between sleep habits, assessed with self-reports, and regional grey matter volumes, and psychological functioning, assessed with the Strengths and Difficulties Questionnaire and tests on working memory and impulsivity. Later weekend wake-up times were associated with smaller grey matter volumes in the medial prefrontal cortex and the amygdalae, and greater weekend delays in wake-up time were associated with smaller grey matter volumes in the right hippocampus and amygdala. The medial prefrontal cortex region mediated the correlation between weekend wake up time and externalising symptoms. Paying attention to regular sleep habits during adolescence could act as a protective factor against the emergence of psychopathology via enabling favourable brain development. publishedVersion
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- 2021
40. Global and Regional Structural Differences and Prediction of Autistic Traits during Adolescence.
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Nees, Frauke, Banaschewski, Tobias, Bokde, Arun L. W., Desrivières, Sylvane, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Grimmer, Yvonne, Heinz, Andreas, Brühl, Rüdiger, Isensee, Corinna, Becker, Andreas, Martinot, Jean-Luc, Paillère Martinot, Marie-Laure, Artiges, Eric, Papadopoulos Orfanos, Dimitri, Lemaître, Hervé, Stringaris, Argyris, van Noort, Betteke, and Paus, Tomáš
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REGIONAL differences ,ADOLESCENCE ,NEURAL development - Abstract
Background: Autistic traits are commonly viewed as dimensional in nature, and as continuously distributed in the general population. In this respect, the identification of predictive values of markers such as subtle autism-related alterations in brain morphology for parameter values of autistic traits could increase our understanding of this dimensional occasion. However, currently, very little is known about how these traits correspond to alterations in brain morphology in typically developing individuals, particularly during a time period where changes due to brain development processes do not provide a bias. Therefore, in the present study, we analyzed brain volume, cortical thickness (CT) and surface area (SA) in a cohort of 14–15-year-old adolescents (N = 285, female: N = 162) and tested their predictive value for autistic traits, assessed with the social responsiveness scale (SRS) two years later at the age of 16–17 years, using a regression-based approach. We found that autistic traits were significantly predicted by volumetric changes in the amygdala (r = 0.181), cerebellum (r = 0.128) and hippocampus (r = −0.181, r = −0.203), both in boys and girls. Moreover, the CT of the superior frontal region was negatively correlated (r = −0.144) with SRS scores. Furthermore, we observed a significant association between the SRS total score and smaller left putamen volume, specifically in boys (r = −0.217), but not in girls. Our findings suggest that neural correlates of autistic traits also seem to lie on a continuum in the general population, are determined by limbic–striatal neuroanatomical brain areas, and are partly dependent on sex. As we imaged adolescents from a large population-based cohort within a small age range, these data may help to increase the understanding of autistic-like occasions in otherwise typically developing individuals. [ABSTRACT FROM AUTHOR]
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- 2022
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41. Structural differences in adolescent brainscan predict alcohol misuse.
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Prakash Rane, Roshan, de Man, Evert Ferdinand, Kim, JiHoon, Görgen, Kai, Tschorn, Mira, Rapp, Michael A., Banaschewski, Tobias, Bokde, Arun LW, Desrivieres, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny A., Brühl, Rüdiger, Martinot, Jean-Luc, Paillere Martinot, Marie-Laure, Artiges, Eric, Nees, Frauke, Papadopoulos Orfanos, Dimitri, and Lemaitre, Herve
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- 2022
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42. Longitudinal Trajectory of the Link Between Ventral Striatum and Depression in Adolescence.
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Pan, Pedro Mario, Sato, João R., Paillère Martinot, Marie-Laure, Martinot, Jean-Luc, Artiges, Eric, Penttilä, Jani, Grimmer, Yvonne, van Noort, Betteke M., Becker, Andreas, Banaschewski, Tobias, Bokde, Arun L. W., Desrivières, Sylvane, Flor, Herta, Garavan, Hugh, Ittermann, Bernd, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Poustka, Luise, Fröhner, Juliane H., and Whelan, Robert
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ANHEDONIA ,MAGNETIC resonance imaging ,TELENCEPHALON ,REWARD (Psychology) ,MENTAL depression ,RESEARCH funding - Abstract
Objective: Research in adolescent depression has found aberrant intrinsic functional connectivity (iFC) among the ventral striatum (VS) and several brain regions implicated in reward processing. The present study probes this question by taking advantage of the availability of data from a large youth cohort, the IMAGEN Consortium.Methods: iFC data from 303 adolescents (48% of them female) were used to examine associations of VS connectivity at baseline (at age 14) with depressive disorders at baseline and at 2-year (N=250) and 4-year (N=219) follow-ups. Eleven regions of interest, key nodes of the reward system, were used to probe the reward network and calculate the connectivity strength of the VS within this network (VS connectivityrw). The main analyses assessed associations of VS connectivityrw with depressive disorders, anhedonia, and low mood using logistic regression. Autoregressive models accounting for carryover effects over time were conducted to further evaluate these brain-behavior associations.Results: Higher right VS connectivityrw was associated with higher probability of depressive disorders at baseline (odds ratio=2.65, 95% CI=1.40, 5.05). This finding was confirmed in the autoregressive model, adjusting for carryover effects of the depressive disorders across the three time points. VS connectivityrw was not predictive of depressive disorders at follow-up assessments. Longitudinal associations between VS connectivityrw and anhedonia emerged in the structural equation model: left VS connectivityrw was associated with anhedonia at 2 years (odds ratio=2.20, 95% CI=1.54, 3.14), and right VS connectivityrw was linked to anhedonia at 4 years (odds ratio=1.87, 95% CI=1.09, 3.21). VS connectivityrw did not predict low mood at any time point in the structural equation model.Conclusions: The connectivity strength of the VS within the reward network showed distinct patterns of association with depressive disorders and anhedonia from mid to late adolescence, suggesting that the role of this circuitry in depression changes with age. This study replicates, in an independent sample, the association between the VS and depression previously reported in younger adolescents. The findings suggest a role of VS connectivityrw in anhedonia but not in low mood. [ABSTRACT FROM AUTHOR]- Published
- 2022
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43. Orbitofrontal cortex volume links polygenic risk for smoking with tobacco use in healthy adolescents.
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Li, Jin, Liu, Bing, Banaschewski, Tobias, Bokde, Arun L.W., Quinlan, Erin Burke, Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Artiges, Eric, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Hohmann, Sarah, and Fröhner, Juliane H.
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PREFRONTAL cortex ,RESEARCH ,SINGLE nucleotide polymorphisms ,SELF-evaluation ,RISK assessment ,GENOMICS ,SMOKING ,TOBACCO products ,PATH analysis (Statistics) ,NEURORADIOLOGY ,ADOLESCENCE - Abstract
Background: Tobacco smoking remains one of the leading causes of preventable illness and death and is heritable with complex underpinnings. Converging evidence suggests a contribution of the polygenic risk for smoking to the use of tobacco and other substances. Yet, the underlying brain mechanisms between the genetic risk and tobacco smoking remain poorly understood. Methods: Genomic, neuroimaging, and self-report data were acquired from a large cohort of adolescents from the IMAGEN study (a European multicenter study). Polygenic risk scores (PGRS) for smoking were calculated based on a genome-wide association study meta-analysis conducted by the Tobacco and Genetics Consortium. We examined the interrelationships among the genetic risk for smoking initiation, brain structure, and the number of occasions of tobacco use. Results: A higher smoking PGRS was significantly associated with both an increased number of occasions of tobacco use and smaller cortical volume of the right orbitofrontal cortex (OFC). Furthermore, reduced cortical volume within this cluster correlated with greater tobacco use. A subsequent path analysis suggested that the cortical volume within this cluster partially mediated the association between the genetic risk for smoking and the number of occasions of tobacco use. Conclusions: Our data provide the first evidence for the involvement of the OFC in the relationship between smoking PGRS and tobacco use. Future studies of the molecular mechanisms underlying tobacco smoking should consider the mediation effect of the related neural structure. [ABSTRACT FROM AUTHOR]
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- 2022
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44. Associations of delay discounting and drinking trajectories from ages 14 to 22.
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Fröhner, Juliane H., Ripke, Stephan, Jurk, Sarah, Li, Shu‐Chen, Banaschewski, Tobias, Bokde, Arun L.W., Quinlan, Erin Burke, Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Heinz, Andreas, Brühl, Rüdiger, Martinot, Jean‐Luc, Paillère Martinot, Marie‐Laure, Artiges, Eric, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Poustka, Luise, and Hohmann, Sarah
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ANALYSIS of variance ,DELAY discounting (Psychology) ,BRAIN mapping ,ALCOHOL drinking ,QUESTIONNAIRES ,REPEATED measures design ,LONGITUDINAL method - Abstract
Background: While drinking alcohol, one must choose between the immediate rewarding effects and the delayed reward of a healthier lifestyle. Individuals differ in their devaluation of a delayed reward based on the time required to receive it, i.e., delay discounting (DD). Previous studies have shown that adolescents discount more steeply than adults and that steeper DD is associated with heavier alcohol use in both groups. Methods: In a large‐scale longitudinal study, we investigated whether higher rates of DD are an antecedent or a consequence of alcohol use during adolescent development. As part of the IMAGEN project, 2220 adolescents completed the Monetary Choice Questionnaire as a DD measure, the Alcohol Use Disorders Identification Test, and the Timeline Follow Back interview at ages 14, 16, 18, and 22. Bivariate latent growth curve models were applied to investigate the relationship between DD and drinking. To explore the consequences of drinking, we computed the cumulative alcohol consumption and correlated it with the development of discounting. A subsample of 221 participants completed an intertemporal choice task (iTeCh) during functional magnetic resonance imaging at ages 14, 16, and 18. Repeated‐measures ANOVA was used to differentiate between high‐risk and low‐risk drinkers on the development of neural processing during intertemporal choices. Results: Overall, high rates of DD at age 14 predicted a greater increase in drinking over 8 years. In contrast, on average, moderate alcohol use did not affect DD from ages 14 to 22. Of note, we found indicators for less brain activity in top‐down control areas during intertemporal choices in the participants who drank more. Conclusions: Steep DD was shown to be a predictor rather than a consequence of alcohol use in low‐level drinking adolescents. Important considerations for future longitudinal studies are the sampling strategies to be used and the reliability of the assessments. [ABSTRACT FROM AUTHOR]
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- 2022
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45. Examination of the neural basis of psychotic-like experiences in adolescenceduring processing of emotional faces
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Papanastasiou, Evangelos, Mouchlianitis, Elias, Joyce, Daniel, McGuire, Philip, Boussebaa, Celia, Banaschewski, Tobias, Bokde, Arun L.W., Büchel, Christian, Quinlan, Erin, Desrivieres, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Spechler , Philip, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Paillère Martinot, Marie-Laure, Artiges, Eric, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Millenet, Sabina, Fröhner, Juliane H., Smolka, Michael N., Walter, Henrik, Whelan, Robert, Schumann, Gunter, and Shergill, Sukhi
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nervous system ,behavioral disciplines and activities ,psychological phenomena and processes - Abstract
Contemporary theories propose that dysregulation of emotional perception is involved in the aetiology of psychosis. 298 healthy adolescents were assessed at age 14- and 19-years using fMRI while performing a facial emotion task. Psychotic-like experiences (PLEs) were assessed with the CAPE-42 questionnaire at age 19. The high PLEs group at age 19 years exhibited an enhanced response in right insular cortex and decreased response in right prefrontal, right parahippocampal and left striatal regions; also, a gradient of decreasing response to emotional faces with age, from 14 to 19 years, in the right parahippocampal region and left insular cortical area. The right insula demonstrated an increasing response to emotional faces with increasing age in the low PLEs group, and a decreasing response over time in the high PLEs group. The change in parahippocampal / amygdala and insula responses during the perception of emotional faces in adolescents with high PLEs between the ages of 14 and 19 suggests a potential ‘aberrant’ neurodevelopmental trajectory for critical limbic areas. Our findings emphasize the role of the frontal and limbic areas in the aetiology of psychotic symptoms, in subjects without the illness phenotype and the confounds introduced by antipsychotic medication.
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- 2020
46. Classification based on cortical folding patterns
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Duchesnay, Edouard, Cachia, Arnaud, Roche, Alexis, Riviere, Denis, Cointepas, Yann, Papadopoulos-Orfanos, Dimitri, Zilbovicius, Monica, Martinot, Jean-Luc, Regis, Jean, and Mangin, Jean-Francois
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Object recognition (Computers) -- Analysis ,Pattern recognition -- Analysis ,Business ,Electronics ,Electronics and electrical industries ,Health care industry - Abstract
We describe here a classification system based on automatically identified cortical sulci. Multivariate recognition methods are required for the detection of complex brain patterns with a spatial distribution. However, such methods may face the well-known issue of the curse of dimensionality--the risk of overfitting the training dataset in high-dimensional space. We overcame this problem, using a classifier pipeline with one- or two-stage of descriptor selection based on machine-learning methods, followed by a support vector machine classifier or linear discriminant analysis. We compared alternative designs of the pipeline on two different datasets built from the same database corresponding to 151 brains. The first dataset dealt with cortex asymmetry and the second dealt with the effect of the subject's sex. Our system successfully (98%) distinguished between the left and right hemispheres on the basis of sulcal shape (size, depth, etc.). The sex of the subject could be determined with a success rate of 85%. These results highlight the attractiveness of multivariate recognition models combined with appropriate descriptor selection. The sulci selected by the pipeline are consistent with previous whole-brain studies on sex effects and hemispheric asymmetries. Index Terms--Feature selection, pattern recognition, sulcal morphometry.
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- 2007
47. Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability?
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Kaminski, Jakob A., Schlagenhauf, Florian, Rapp, Michael, Awasthi, Swapnil, Ruggeri, Barbara, Deserno, Lorenz, Banaschewski, Tobias, Bokde, Arun L. W., Bromberg, Uli, Büchel, Christian, Quinlan, Erin Burke, Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Garavan, Hugh, Gowland, Penny, Ittermann, Bernd, Martinot, Jean-Luc, Paillère Martinot, Marie-Laure, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Smolka, Michael N., Fröhner, Juliane H., Walter, Henrik, Whelan, Robert, Ripke, Stephan, Schumann, Gunter, Heinz, Andreas, and The IMAGEN Consortium
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lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,lcsh:RC321-571 - Abstract
Genetic and environmental factors both contribute to cognitive test performance. A substantial increase in average intelligence test results in the second half of the previous century within one generation is unlikely to be explained by genetic changes. One possible explanation for the strong malleability of cognitive performance measure is that environmental factors modify gene expression via epigenetic mechanisms. Epigenetic factors may help to understand the recent observations of an association between dopamine-dependent encoding of reward prediction errors and cognitive capacity, which was modulated by adverse life events. The possible manifestation of malleable biomarkers contributing to variance in cognitive test performance, and thus possibly contributing to the "missing heritability" between estimates from twin studies and variance explained by genetic markers, is still unclear. Here we show in 1475 healthy adolescents from the IMaging and GENetics (IMAGEN) sample that general IQ (gIQ) is associated with (1) polygenic scores for intelligence, (2) epigenetic modification of DRD2 gene, (3) gray matter density in striatum, and (4) functional striatal activation elicited by temporarily surprising reward-predicting cues. Comparing the relative importance for the prediction of gIQ in an overlapping subsample, our results demonstrate neurobiological correlates of the malleability of gIQ and point to equal importance of genetic variance, epigenetic modification of DRD2 receptor gene, as well as functional striatal activation, known to influence dopamine neurotransmission. Peripheral epigenetic markers are in need of confirmation in the central nervous system and should be tested in longitudinal settings specifically assessing individual and environmental factors that modify epigenetic structure., Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe, 950
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- 2018
48. Neuroimaging evidence for right orbitofrontal cortex differences in adolescents with emotional and behavioral dysregulation
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Spechler, Philip A., Chaarani, Bader, Orr, Catherine, Mackey, Scott, Higgins, Stephen T., Banaschewski, Tobias, Bokde, Arun L.W., Bromberg, Uli, Burke Quinlan, Erin, Conrod, Patricia J., Flor, Herta, Frouin, Vincent, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Poustka, Luise, Smolka, Michael N., Walter, Henrik, Whelan, Robert, Schumann, Gunter, Garavan, Hugh, Althoff, Robert R., and IMAGEN Consortium
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Psychiatry and Mental health ,Developmental and Educational Psychology - Abstract
Objective: To characterize the structural and functional neurobiology of a large group of adolescents exhibiting a behaviorally and emotionally dysregulated phenotype.Methods: Age 14 adolescents from the IMAGEN study were investigated. Latent class analysis (LCA) on the Strengths and Difficulties Questionnaire (SDQ) was used to identify a class of individuals with elevated behavioral and emotional difficulties (“dysregulated”; N=233) who were compared to a matched sample from a low symptom class (controls, N=233). Whole-brain gray matter volume (GMV) images were compared using a general linear model with 10,000 random label permutations. Regional GMV findings were then probed for functional differences from three fMRI tasks. Significant brain features then informed mediation path models linking the likelihood of psychiatric disorders (DSM-IV) with dysregulation.Results: Whole-brain differences were found in the right orbitofrontal cortex (R.OFC; p less than .05; k=48), with dysregulated individuals exhibiting lower GMV. The dysregulated group also exhibited higher activity in this region during successful inhibitory control (F1,429=7.53, p less than .05). Path analyses indicated significant direct effects between the likelihood of psychopathologies and dysregulation. Modeling the R.OFC as a mediator returned modest partial effects, suggesting the path linking the likelihood of an anxiety or conduct disorder diagnoses to dysregulation is partially explained by this anatomical feature.Conclusion: A large sample of dysregulated adolescents exhibited lower GMV in the R.OFC relative to controls. Dysregulated individuals also exhibited higher regional activations when exercising inhibitory control at performance levels comparable to controls. These findings suggest a neurobiological marker of dysregulation, and highlight the role of the R.OFC in impaired emotional and behavioral control.
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- 2019
49. Cognitive and brain development is independently influenced by socioeconomic status and polygenic scores for educational attainment
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Judd, Nicholas, primary, Sauce, Bruno, additional, Wiedenhoeft, John, additional, Tromp, Jeshua, additional, Chaarani, Bader, additional, Schliep, Alexander, additional, van Noort, Betteke, additional, Penttilä, Jani, additional, Grimmer, Yvonne, additional, Insensee, Corinna, additional, Becker, Andreas, additional, Banaschewski, Tobias, additional, Bokde, Arun L. W., additional, Quinlan, Erin Burke, additional, Desrivières, Sylvane, additional, Flor, Herta, additional, Grigis, Antoine, additional, Gowland, Penny, additional, Heinz, Andreas, additional, Ittermann, Bernd, additional, Martinot, Jean-Luc, additional, Paillère Martinot, Marie-Laure, additional, Artiges, Eric, additional, Nees, Frauke, additional, Papadopoulos Orfanos, Dimitri, additional, Paus, Tomáš, additional, Poustka, Luise, additional, Hohmann, Sarah, additional, Millenet, Sabina, additional, Fröhner, Juliane H., additional, Smolka, Michael N., additional, Walter, Henrik, additional, Whelan, Robert, additional, Schumann, Gunter, additional, Garavan, Hugh, additional, and Klingberg, Torkel, additional
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- 2020
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50. Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group
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Jia, Tianye, primary, Chu, Congying, additional, Liu, Yun, additional, van Dongen, Jenny, additional, Papastergios, Evangelos, additional, Armstrong, Nicola J., additional, Bastin, Mark E., additional, Carrillo-Roa, Tania, additional, den Braber, Anouk, additional, Harris, Mathew, additional, Jansen, Rick, additional, Liu, Jingyu, additional, Luciano, Michelle, additional, Ori, Anil P. S., additional, Roiz Santiañez, Roberto, additional, Ruggeri, Barbara, additional, Sarkisyan, Daniil, additional, Shin, Jean, additional, Sungeun, Kim, additional, Tordesillas Gutiérrez, Diana, additional, van’t Ent, Dennis, additional, Ames, David, additional, Artiges, Eric, additional, Bakalkin, Georgy, additional, Banaschewski, Tobias, additional, Bokde, Arun L. W., additional, Brodaty, Henry, additional, Bromberg, Uli, additional, Brouwer, Rachel, additional, Büchel, Christian, additional, Burke Quinlan, Erin, additional, Cahn, Wiepke, additional, de Zubicaray, Greig I., additional, Ehrlich, Stefan, additional, Ekström, Tomas J., additional, Flor, Herta, additional, Fröhner, Juliane H., additional, Frouin, Vincent, additional, Garavan, Hugh, additional, Gowland, Penny, additional, Heinz, Andreas, additional, Hoare, Jacqueline, additional, Ittermann, Bernd, additional, Jahanshad, Neda, additional, Jiang, Jiyang, additional, Kwok, John B., additional, Martin, Nicholas G., additional, Martinot, Jean-Luc, additional, Mather, Karen A., additional, McMahon, Katie L., additional, McRae, Allan F., additional, Nees, Frauke, additional, Papadopoulos Orfanos, Dimitri, additional, Paus, Tomáš, additional, Poustka, Luise, additional, Sämann, Philipp G., additional, Schofield, Peter R., additional, Smolka, Michael N., additional, Stein, Dan J., additional, Strike, Lachlan T., additional, Teeuw, Jalmar, additional, Thalamuthu, Anbupalam, additional, Trollor, Julian, additional, Walter, Henrik, additional, Wardlaw, Joanna M., additional, Wen, Wei, additional, Whelan, Robert, additional, Apostolova, Liana G., additional, Binder, Elisabeth B., additional, Boomsma, Dorret I., additional, Calhoun, Vince, additional, Crespo-Facorro, Benedicto, additional, Deary, Ian J., additional, Hulshoff Pol, Hilleke, additional, Ophoff, Roel A., additional, Pausova, Zdenka, additional, Sachdev, Perminder S., additional, Saykin, Andrew, additional, Wright, Margaret J., additional, Thompson, Paul M., additional, Schumann, Gunter, additional, and Desrivières, Sylvane, additional
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- 2019
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