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179 results on '"Papatriantafyllou, John"'

1. The Assessment of the Socioemotional Disorder in Neurodegenerative Diseases with the Revised Self-Monitoring Scale (RSMS)

Author

Dimitriou, Tatiana, Parthimos, Theodore, Kamtsadeli, Vasiliki, Tsinia, Niki, Hatzopoulou, Maria, Lykou, Evi, Chatziantoniou, Lina, Papatriantafyllou, Olga, Tzavara, Chara, Zikos, Panagiotis, Papageorgiou, Sokratis, Miller, Bruce, Rankin, Kate, and Papatriantafyllou, John

Subjects
Biomedical and Clinical Sciences, Brain Disorders, Neurosciences, Behavioral and Social Science, Acquired Cognitive Impairment, Neurodegenerative, Clinical Research, Alzheimer's Disease, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Mental Health, Dementia, Aging, Neurological, RSMS, differential diagnosis, neurodegenerative dementias, socioemotional cognition, theory of mind, Clinical Sciences, Biomedical and clinical sciences
Abstract

BackgroundSocial cognition helps people to understand their own and others' behavior and to modulate the way of thinking and acting in different social situations. Rapid and accurate diagnoses of neurodegenerative diseases are essential, as social cognition is affected by these diseases. The Revised Self-Monitoring Scale (RSMS) is a scale that detects social-emotional cognition deficits.AimThe aim of the current study is to examine how socioemotional parameters are affected by neurodegenerative diseases and whether the RSMS can discern these disorders based on the socioemotional parameters in the Greek population.Methods/designA total of 331 dementia subjects were included. Mini Mental State Examination (MMSE) and Addenbrooke's Cognitive Examination (Revised, ACE-R) measurements were used in order to assess the cognitive deficits. The Neuropsychiatric Inventory (NPI) was used for the evaluation of the neuropsychiatric symptoms. The RSMS and its two subscales was used in order to detect the socioemotional deficits.ResultsThe RSMS and its two subscales (RSMS_EX and RSMS_SP) can effectively detect neurodegenerative diseases. The RSMS can detect bvFTD in Alzheimer's Disease (AD), AD in a healthy cohort, behavioral variant Frontotemporal Dementia (bvFTD) in a healthy cohort, bvFTD in Parkinson's Disease (PD) and Frontotemporal Semantic Dementia (FTD/SD) in a healthy cohort. It is a useful tool in order to detect frontotemporal dementias. RSMS correlated negatively with the NPI questionnaire total and the subcategories of apathy, disinhibition and eating disorders. The RSMS results are associated with the ACE-R score (specifically verbal fluency).ConclusionsThe RSMS is a helpful tool in order to identify socioemotional deficits in neurodegenerative dementias. It is also a useful scale that can discern bvFTD and svPPA in AD patients. A worse RSMS score correlates with a worse ACE-R and NPI. It seems to be a useful scale that can reliably measure social behavior in non-reversible neurodegenerative disorders, such as AD, FTD (bvFTD, svPPA), PDD and PD. The results also apply to the Greek population.

Published
2022

2. Frequency of the TREM2 R47H Variant in Various Neurodegenerative Disorders

Author

Ayer, Ariane H, Wojta, Kevin, Ramos, Eliana Marisa, Dokuru, Deepika, Chen, Jason A, Karydas, Anna M, Papatriantafyllou, John D, Agiomyrgiannakis, Dimitrios, Kamtsadeli, Vasiliki, Tsinia, Niki, Sali, Dimitra, Gylys, Karen H, Agosta, Federica, Filippi, Massimo, Small, Gary W, Bennett, David A, Gearing, Marla, Juncos, Jorge L, Kramer, Joel, Lee, Suzee E, Yokoyama, Jennifer S, Mendez, Mario F, Chui, Helena, Zarow, Chris, Ringman, John M, Kilic, Ulkan, Babacan-Yildiz, Gülsen, Levey, Allan, DeCarli, Charles S, Cotman, Carl W, Boxer, Adam L, Miller, Bruce L, and Coppola, Giovanni

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Clinical Sciences, Neurosciences, Psychology, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Alzheimer's Disease Related Dementias (ADRD), Neurodegenerative, Brain Disorders, Alzheimer's Disease, Acquired Cognitive Impairment, Dementia, Rare Diseases, Frontotemporal Dementia (FTD), Aging, Aetiology, 2.1 Biological and endogenous factors, Neurological, Aged, Alzheimer Disease, Amyotrophic Lateral Sclerosis, Cognitive Dysfunction, Cohort Studies, Female, Frontotemporal Dementia, Genetic Predisposition to Disease, Genetic Variation, Genotype, Humans, Internationality, Male, Membrane Glycoproteins, Neurodegenerative Diseases, Receptors, Immunologic, Alzheimer disease, frontotemporal dementia, genetics, TREM2, progressive supranuclear palsy, mild cognitive impairment, corticobasal syndrome, amyotrophic lateral sclerosis, association study, Cognitive Sciences, Geriatrics, Clinical sciences, Biological psychology
Abstract

ObjectiveA rare variant in TREM2 (p.R47H, rs75932628) has been consistently reported to increase the risk for Alzheimer disease (AD), while mixed evidence has been reported for association of the variant with other neurodegenerative diseases. Here, we investigated the frequency of the R47H variant in a diverse and well-characterized multicenter neurodegenerative disease cohort.MethodsWe examined the frequency of the R47H variant in a diverse neurodegenerative disease cohort, including a total of 3058 patients clinically diagnosed with AD, frontotemporal dementia spectrum syndromes, mild cognitive impairment, progressive supranuclear palsy syndrome, corticobasal syndrome, or amyotrophic lateral sclerosis and 5089 control subjects.ResultsWe observed a significant association between the R47H variant and AD, while no association was observed with any other neurodegenerative disease included in this study.ConclusionsOur results support the consensus that the R47H variant is significantly associated with AD. However, we did not find evidence for association of the R47H variant with other neurodegenerative diseases.

Published
2019

3. Neurological Examination via Telemedicine: An Updated Review Focusing on Movement Disorders

Author

Angelopoulou, Efthalia, primary, Koros, Christos, additional, Stanitsa, Evangelia, additional, Stamelos, Ioannis, additional, Kontaxopoulou, Dionysia, additional, Fragkiadaki, Stella, additional, Papatriantafyllou, John D., additional, Smaragdaki, Evangelia, additional, Vourou, Kalliopi, additional, Pavlou, Dimosthenis, additional, Bamidis, Panagiotis D., additional, Stefanis, Leonidas, additional, and Papageorgiou, Sokratis G., additional

Published
2024
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5. Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study

Author

Heller, Carolin, Convery, Rhian S, Woollacott, Ione OC, Shafei, Rachelle M, Graff-Radford, Jonathan, Jones, David T, Dheel, Christina M, Savica, Rodolfo, Lapid, Maria I, Baker, Matt, Fields, Julie A, Gavrilova, Ralitza, Domoto-Reilly, Kimiko, Poos, Jackie M, Van der Ende, Emma L, Panman, Jessica L, Donker Kaat, Laura, Seelaar, Harro, Richardson, Anna, Frisoni, Giovanni, Mega, Anna, Fostinelli, Silvia, Chiang, Huei-Hsin, Alberici, Antonella, Arighi, Andrea, Fenoglio, Chiara, Heuer, Hilary, Miller, Bruce, Karydas, Anna, Fong, Jamie, João Leitão, Maria, Santiago, Beatriz, Duro, Diana, Ferreira, Carlos, Gabilondo, Alazne, De Arriba, Maria, Tainta, Mikel, Zulaica, Miren, Ferreira, Catarina, Semler, Elisa, Ludolph, Albert, Landwehrmeyer, Bernhard, Volk, Alexander E, Miltenberger, Gabriel, Verdelho, Ana, Afonso, Sónia, Tartaglia, Maria Carmela, Freedman, Morris, Rogaeva, Ekaterina, Ferrari, Camilla, Piaceri, Irene, Bessi, Valentina, Lombardi, Gemma, St-Onge, Frédéric, Doré, Marie-Claire, Bruffaerts, Rose, Vandenbulcke, Mathieu, Van den Stock, Jan, Mesulam, M Marsel, Bigio, Eileen, Koros, Christos, Papatriantafyllou, John, Kroupis, Christos, Stefanis, Leonidas, Shoesmith, Christien, Robertson, Erik, Coppola, Giovanni, Da Silva Ramos, Eliana Marisa, Geschwind, Daniel, Moore, Katrina M, Nicholas, Jennifer, Grossman, Murray, McMillan, Corey T, Irwin, David J, Massimo, Lauren, Van Deerlin, Vivianna M, Warren, Jason D, Fox, Nick C, Rossor, Martin N, Mead, Simon, Bocchetta, Martina, Boeve, Bradley F, Knopman, David S, Graff-Radford, Neill R, Forsberg, Leah K, Rademakers, Rosa, Wszolek, Zbigniew K, van Swieten, John C, Jiskoot, Lize C, Meeter, Lieke H, Dopper, Elise GP, Papma, Janne M, Snowden, Julie S, Saxon, Jennifer, Jones, Matthew, Pickering-Brown, Stuart, Le Ber, Isabelle, Camuzat, Agnès, Brice, Alexis, Caroppo, Paola, Ghidoni, Roberta, Pievani, Michela, Benussi, Luisa, Binetti, Giuliano, Dickerson, Bradford C, Lucente, Diane, Krivensky, Samantha, Graff, Caroline, Öijerstedt, Linn, Fallström, Marie, Thonberg, Håkan, Ghoshal, Nupur, Morris, John C, Borroni, Barbara, Benussi, Alberto, Padovani, Alessandro, Galimberti, Daniela, Scarpini, Elio, Fumagalli, Giorgio G, Mackenzie, Ian R, Hsiung, Ging-Yuek R, Sengdy, Pheth, Boxer, Adam L, Rosen, Howie, Taylor, Joanne B, Synofzik, Matthis, Wilke, Carlo, Sulzer, Patricia, Hodges, John R, Halliday, Glenda, Kwok, John, Sanchez-Valle, Raquel, Lladó, Albert, Borrego-Ecija, Sergi, Santana, Isabel, Almeida, Maria Rosário, Tábuas-Pereira, Miguel, Moreno, Fermin, Barandiaran, Myriam, Indakoetxea, Begoña, Levin, Johannes, Danek, Adrian, Rowe, James B, Cope, Thomas E, Otto, Markus, Anderl-Straub, Sarah, de Mendonça, Alexandre, Maruta, Carolina, Masellis, Mario, Black, Sandra E, Couratier, Philippe, Lautrette, Geraldine, Huey, Edward D, Sorbi, Sandro, Nacmias, Benedetta, Laforce, Robert, Jr, Tremblay, Marie-Pier L, Vandenberghe, Rik, Damme, Philip Van, Rogalski, Emily J, Weintraub, Sandra, Gerhard, Alexander, Onyike, Chiadi U, Ducharme, Simon, Papageorgiou, Sokratis G, Ng, Adeline Su Lyn, Brodtmann, Amy, Finger, Elizabeth, Guerreiro, Rita, Bras, Jose, and Rohrer, Jonathan D

Published
2020
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6. Perceptions of Patients, Caregivers, and Healthcare Professionals toward Telemedicine Use for Cognitive and Movement Disorders in the Aegean Islands, Greece: A Pilot Study of the SI4CARE European Project

Author

Angelopoulou, Efthalia, primary, Kontaxopoulou, Dionysia, additional, Fragkiadaki, Stella, additional, Stanitsa, Evangelia, additional, Pavlou, Dimosthenis, additional, Papatriantafyllou, John, additional, Koros, Christos, additional, Dimovski, Vlado, additional, Šemrov, Darja, additional, and Papageorgiou, Sokratis G., additional

Published
2023
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8. Big 5 Personality Changes in Greek bvFTD, AD, and MCI Patients

Author

Lykou, Evdoxia, Rankin, Katherine P, Chatziantoniou, Lina, Boulas, Chrysanthos, Papatriantafyllou, Olga, Tsaousis, Ioannis, Neuhaus, John, Karageorgiou, Clementine, Miller, Bruce L, and Papatriantafyllou, John D

Subjects
Psychology, Social and Personality Psychology, Applied and Developmental Psychology, Frontotemporal Dementia (FTD), Neurosciences, Brain Disorders, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Acquired Cognitive Impairment, Behavioral and Social Science, Alzheimer's Disease, Alzheimer's Disease Related Dementias (ADRD), Dementia, Aging, Neurodegenerative, 2.1 Biological and endogenous factors, Neurological, Aged, Alzheimer Disease, Cognitive Dysfunction, Female, Frontotemporal Lobar Degeneration, Humans, Male, Neuropsychological Tests, Personality Disorders, personality, frontotemporal dementia, Alzheimer disease, mild cognitive impairment, Big 5, Clinical Sciences, Cognitive Sciences, Geriatrics, Clinical sciences, Biological psychology
Abstract

Patients with neurodegenerative disease show distinct patterns of personality change, some of which may be traced to focal neurological damage, whereas others may be mediated by cultural reactions to functional impairment. Although such changes are early and pervasive in behavioral variant frontotemporal dementia (bvFTD), and milder changes are seen in Alzheimer disease (AD), no study has examined all Big 5 factors of personality in mild cognitive impairment (MCI) patients. In addition, the influence of culture and ethnicity on disease-related personality changes has seldom been examined. Premorbid and current personality were measured in 47 Greek patients with bvFTD, AD, and MCI on the basis of informant reports using the Traits Personality Questionnaire 5, a 5-factor inventory in the Greek language that accounts for Greek cultural factors. bvFTDs showed greater decreases in conscientiousness compared with ADs and MCIs. ADs and MCIs showed increased neuroticism, whereas the bvFTD patients were rated as having become much less neurotic in the course of their disease. The pattern of personality change in MCIs was very similar to that of ADs, supporting recent evidence that personality changes occur as early as the MCI disease stage. In all the groups, personality changes were similar to those previously described in non-Mediterranean cultures, supporting the hypothesis that they may result directly from disease-specific neurological processes.

Published
2013

12. How Well Did the Healthcare System Respond to the Healthcare Needs of Older People with and without Dementia during the COVID-19 Pandemic? The Perception of Healthcare Providers and Older People from the SI4CARE Project in the ADRION Region

Author

Fragkiadaki, Stella, primary, Kontaxopoulou, Dionysia, additional, Stanitsa, Evangelia, additional, Angelopoulou, Efthalia, additional, Pavlou, Dimosthenis, additional, Šemrov, Darja, additional, Colnar, Simon, additional, Lustrek, Mitja, additional, Blažica, Bojan, additional, Vučica, Inga, additional, Matković, Roberta, additional, Vukojevic, Katarina, additional, Jelicic, Ana, additional, Guzzi, Pietro Hiram, additional, Martinović, Vlatka, additional, Medina, Amina Pekmez, additional, Piccoli, Guido, additional, Menon, Margherita, additional, Kozetinac, Srdjan, additional, Miljković, Miodrag, additional, Kiskini, Chrysanthi, additional, Kokorotsikos, Themis, additional, Zilidou, Vasiliki, additional, Radević, Ivan, additional, Papatriantafyllou, John, additional, Thireos, Eleftherios, additional, Tsouros, Agis, additional, Dimovski, Vlado, additional, and Papageorgiou, Sokratis G., additional

Published
2023
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13. APOE Allele Frequency in Southern Greece: Exploring the Role of Geographical Gradient in the Greek Population

Author

Papastefanopoulou, Vasiliki, primary, Stanitsa, Evangelia, additional, Koros, Christos, additional, Simoudis, Aimilios, additional, Florou-Hatziyiannidou, Chryseis, additional, Beratis, Ion, additional, Antonelou, Roubina, additional, Andronas, Nikolaos, additional, Voskou, Panagiota, additional, Angelopoulou, Efthalia, additional, Papatriantafyllou, John D., additional, Stefanis, Leonidas, additional, Kroupis, Christos, additional, and Papageorgiou, Sokratis G., additional

Published
2022
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14. LANGaware: Robust Multimodal Machine Learning Methods for the Early Detection of Neurodegenerative and Psychiatric Diseases

Author

Rentoumi, Vassiliki, primary, Vassiliou, Evangelos, additional, Pittaras, Nikiforos, additional, Demiraj, Admir, additional, Alexandridou, Martha, additional, Danezi, Maria, additional, Hatzopoulou, Maria, additional, Kamtsadeli, Vassiliki, additional, Papatriantafyllou, John D, additional, and Paliouras, George, additional

Published
2022
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15. How Telemedicine Can Improve the Quality of Care for Patients with Alzheimer’s Disease and Related Dementias? A Narrative Review

Author

Angelopoulou, Efthalia, primary, Papachristou, Nikolaos, additional, Bougea, Anastasia, additional, Stanitsa, Evangelia, additional, Kontaxopoulou, Dionysia, additional, Fragkiadaki, Stella, additional, Pavlou, Dimosthenis, additional, Koros, Christos, additional, Değirmenci, Yıldız, additional, Papatriantafyllou, John, additional, Thireos, Eleftherios, additional, Politis, Antonios, additional, Tsouros, Agis, additional, Bamidis, Panagiotis, additional, Stefanis, Leonidas, additional, and Papageorgiou, Sokratis, additional

Published
2022
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17. Non-Pharmacological Interventions for the Hallucinations in Patients with Dementia. A Cross-Over Randomized Controlled Trial

Author

Dimitriou, Tatiana-Danai, Papatriantafyllou, John, Konsta, Anastasia, Kazis, Dimitrios, Athanasiadis, Loukas, Ioannidis, Panagiotis, Koutsouraki, Efrosini, Tegos, Thomas, and Tsolaki, Magda

Abstract

Hallucinations is a core characteristic symptom in Lewy Body Dementia (DLB) and Parkinson's Dementia (PDD). It may also appear at the late stages of Alzheimer's disease (AD). They are not easily managed, and they are associated with cognitive decline, earlier institutionalization, increased mortality, and increased caregivers' burden.This is a cross-over RCT. The participants were randomly assigned in 6 different groups of 10 patients each.60 dementia patients (different types and stages of dementia).The three non-pharmacological interventions used are: A) Validation therapy (VT) in a Psycho-educational program, B) Reminiscence therapy (RT) and C) Music therapy (MT). Each intervention lasted for 5 days and there was an interval of two days, as a wash-out period (all the interventions had a duration of 3 weeks).The measurements which were used at baseline were: MMSE, ACE-R, GDS, FRSDD and NPI questionnaire at baseline and after each intervention.The most effective combination for the reduction of the hallucinations is: VT/Psycho-educational program (p = 0.005), MT (p = 0.007) and RT (p = 0.022). The same combination applies for the caregivers' distress: VT/Psychoeducational program (p = 0.010) - MT (p = 0.023) - RT (p = 0.036).VT/Psycho-educational program followed by MT, followed by RT is an effective combination of non-pharmacological interventions that can reduce hallucinations in patients with dementia and caregivers' burden. Non-pharmacological interventions should be further examined as an effective alternative for the reduction of the hallucinations in dementia.

Published
2022

18. Frontotemporal dementia spectrum: first genetic screen in a Greek cohort

Author

Ramos, Eliana Marisa, Koros, Christos, Dokuru, Deepika Reddy, Van Berlo, Victoria, Kroupis, Christos, Wojta, Kevin, Wang, Qing, Andronas, Nikolaos, Matsi, Stavroula, Beratis, Ion N., Huang, Alden Y., Lee, Suzee E., Bonakis, Anastasios, Florou-Hatziyiannidou, Chryseis, Fragkiadaki, Stella, Kontaxopoulou, Dionysia, Agiomyrgiannakis, Dimitrios, Kamtsadeli, Vasiliki, Tsinia, Niki, Papastefanopoulou, Vasiliki, Stamelou, Maria, Miller, Bruce L., Stefanis, Leonidas, Papatriantafyllou, John D., Papageorgiou, Sokratis G., and Coppola, Giovanni

Published
2019
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19. NON-PHARMACOLOGICAL INTERVENTIONS FOR DEPRESSIVE SYMPTOMS IN DEMENTIA. A CROSS-OVER RCT

Author

Papatriantafyllou John, Tsolaki Magdalini, Konsta Anastasia, Dimitriou TatianaDanai, Tegos Thomas, Kazis Dimitrios, Ioannidis Panagiotis, Koutsouraki Efrosini, and Athanasiadis Loukas

Subjects
Cross over, medicine.medical_specialty, Non pharmacological interventions, business.industry, medicine.disease, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, medicine, Dementia, 030212 general & internal medicine, business, Psychiatry, 030217 neurology & neurosurgery, Depressive symptoms
Abstract

Background: Depression is accompanied by the early stages of Alzheimer’s disease (AD) and other forms of dementia. Depression can influence the daily functioning of the patients with dementia (PwD) and their cognitive abilities. Sometimes it is hard to diagnose because it may seem like apathy. The current pharmacological treatment can manage depressive symptoms, however the side effects of the drugs are severe. Methods: Sixty (60) PwD randomly assigned in six (6) different groups of 10 participants each. They received three non-pharmacological interventions: a) Reminiscence Therapy (RT), b) Body Exercise (BE) and c) Music Therapy (MT). The study is a cross-over randomized controlled trial including patients with different types of dementia and at different stages of dementia. The neuropsychological examination before the interventions included: MMSE, ACE-R, GDS, FRSSD and NPI Questionnaire (sub-questions only for depression). The interventions lasted for 5 days and there were 2 days off as a washout period. There was no drop-out rate. Results: The combination of MT (p=0.012)- BE (p=0.020)- RT (p=0.041) is the sequence of the interventions that can reduce depression. For the caregivers, we had the same combination with the best results as well: MT (p=0.002)- BE (p=0.006)- RT (p=0.012). Conclusions: There is a combination of non-pharmacological interventions that can reduce statistically significant the depression in patients with dementia (PwD) and their caregivers.

Published
2021

20. Assess of Combinations of Non-Pharmacological Interventions for the Reduction of Irritability in Patients with Dementia and their Caregivers: A Cross-Over RCT

Author

Dimitriou, Tatiana, primary, Papatriantafyllou, John, additional, Konsta, Anastasia, additional, Kazis, Dimitrios, additional, Athanasiadis, Loukas, additional, Ioannidis, Panagiotis, additional, Koutsouraki, Efrosini, additional, Tegos, Thomas, additional, and Tsolaki, Magda, additional

Published
2022
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21. Anosognosia in Dementia: Evaluation of Perfusion Correlates Using 99mTc-HMPAO SPECT and Automated Brodmann Areas Analysis

Author

Valotassiou, Varvara, primary, Sifakis, Nikolaos, additional, Tzavara, Chara, additional, Lykou, Evi, additional, Tsinia, Niki, additional, Kamtsadeli, Vasiliki, additional, Sali, Dimitra, additional, Angelidis, George, additional, Psimadas, Dimitrios, additional, Theodorou, Eudoxia, additional, Tsougos, Ioannis, additional, Papageorgiou, Sokratis G., additional, Georgoulias, Panagiotis, additional, and Papatriantafyllou, John, additional

Published
2022
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22. How telemedicine can improve the quality of care for patients with alzheimer’s disease and related dementias? A narrative review

Author

Angelopoulou, Efthalia, Papachristou, Nikolaos, Bougea, Anastasia, Stanitsa, Evangelia, Kontaxopoulou, Dionysia, Fragkiadaki, Stella, Pavlou, Dimosthenis, Koros, Christos, Değirmenci, Yıldız, Papatriantafyllou, John, Thireos, Eleftherios, Politis, Antonios, Tsouros, Agis, Bamidis, Panagiotis, Stefanis, Leonidas, and Papageorgiou, Sokratis

Subjects
COVID-19, Alzheimer’s Disease (AD), World Health Organization (WHO), Telemedicine
Abstract

Background and Objectives: Dementia affects more than 55 million patients worldwide, with a significant societal, economic, and psychological impact. However, many patients with Alzheimer’s disease (AD) and other related dementias have limited access to effective and individualized treatment. Care provision for dementia is often unequal, fragmented, and inefficient. The COVID-19 pandemic accelerated telemedicine use, which holds promising potential for addressing this important gap. In this narrative review, we aim to analyze and discuss how telemedicine can improve the quality of healthcare for AD and related dementias in a structured manner, based on the seven dimensions of healthcare quality defined by the World Health Organization (WHO), 2018: effectiveness, safety, people-centeredness, timeliness, equitability, integrated care, and efficiency. Materials and Methods: MEDLINE and Scopus databases were searched for peer-reviewed articles investigating the role of telemedicine in the quality of care for patients with dementia. A narrative synthesis was based on the seven WHO dimensions. Results: Most studies indicate that telemedicine is a valuable tool for AD and related dementias: it can improve effectiveness (better access to specialized care, accurate diagnosis, evidence-based treatment, avoidance of preventable hospitalizations), timeliness (reduction of waiting times and unnecessary transportation), patient-centeredness (personalized care for needs and values), safety (appropriate treatment, reduction of infection risk),integrated care (interdisciplinary approach through several dementia-related services), efficiency (mainly cost-effectiveness) and equitability (overcoming geographical barriers, cultural diversities). However, digital illiteracy, legal and organizational issues, as well as limited awareness, are significant potential barriers. Conclusions: Telemedicine may significantly improve all aspects of the quality of care for patients with dementia. However, future longitudinal studies with control groups including participants of a wide educational level spectrum will aid in our deeper understanding of the real impact of telemedicine in quality care for this population.

Published
2022

24. Alzheimer's disease research progress in the Mediterranean region: The Alzheimer's Association International Conference Satellite Symposium

Author

Sexton, Claire, primary, Solis, Michele, additional, Aharon‐Peretz, Judith, additional, Alexopoulos, Panagiotis, additional, Apostolova, Liana G., additional, Bayen, Eléonore, additional, Birkenhager, Betty, additional, Cappa, Stefano, additional, Constantinidou, Fofi, additional, Fortea, Juan, additional, Gerritsen, Debby L., additional, Hassanin, Hany I., additional, Ibanez, Agustin, additional, Ioannidis, Panagiotis, additional, Karageorgiou, Elissaios, additional, Korczyn, Amos, additional, Leroi, Iracema, additional, Lichtwarck, Bjorn, additional, Logroscino, Giancarlo, additional, Lynch, Chris, additional, Mecocci, Patrizia, additional, Molinuevo, Jose Luis, additional, Papatriantafyllou, John, additional, Papegeorgiou, Sokratis, additional, Politis, Antonis, additional, Raman, Rema, additional, Ritchie, Karen, additional, Sanchez‐Juan, Pascual, additional, Sano, Mary, additional, Scarmeas, Nikolas, additional, Spiru, Luiza, additional, Stathi, Afroditi, additional, Tsolaki, Magda, additional, Yener, Görsev, additional, Zaganas, Ioannis, additional, Zygouris, Stelios, additional, and Carrillo, Maria, additional

Published
2022
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26. LANGaware: Introducing the right solution for the early detection of neurodegenerative and psychiatric diseases

Author

Rentoumi, Vassiliki, primary, Vassiliou, Evangelos, additional, Demiraj, Admir, additional, Pittaras, Nikiforos, additional, Mandalis, Petros, additional, Alexandridou, Martha, additional, Kemp, Hollie, additional, Eleftheriou, Ioanna, additional, Danezi, Maria, additional, Hatzopoulou, Maria, additional, Kamtsadeli, Vasiliki, additional, Paliouras, George, additional, and Papatriantafyllou, John D, additional

Published
2021
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27. LANGaware: Leveraging machine learning on natural language for the early detection of neurodegenerative and psychiatric diseases

Author

Rentoumi, Vassiliki, primary, Vassiliou, Evangelos, additional, Demiraj, Admir, additional, Pittaras, Nikiforos, additional, Mandalis, Petros, additional, Alexandridou, Martha, additional, Kemp, Hollie, additional, Eleftheriou, Ioanna, additional, Danezi, Maria, additional, Hatzopoulou, Maria, additional, Kamtsadeli, Vasiliki, additional, Paliouras, George, additional, and Papatriantafyllou, John D, additional

Published
2021
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28. Effect of Apolipoprotein E4 on the Driving Behavior of Patients with Amnestic Mild Cognitive Impairment or Mild Alzheimer’s Disease Dementia

Author

Stanitsa, Evangelia, primary, Economou, Alexandra, additional, Beratis, Ion, additional, Kontaxopoulou, Dionysia, additional, Fragkiadaki, Stella, additional, Papastefanopoulou, Vicky, additional, Pavlou, Dimosthenis, additional, Papantoniou, Panagiotis, additional, Kroupis, Christos, additional, Papatriantafyllou, John, additional, Stefanis, Leonidas, additional, Yannis, George, additional, and Papageorgiou, Sokratis G., additional

Published
2021
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29. Eating Disorders in Frontotemporal Dementia and Alzheimer’s Disease: Evaluation of Brain Perfusion Correlates Using 99mTc-HMPAO SPECT with Brodmann Areas Analysis

Author

Valotassiou, Varvara, primary, Sifakis, Nikolaos, additional, Tzavara, Chara, additional, Lykou, Evi, additional, Tsinia, Niki, additional, Kamtsadeli, Vasiliki, additional, Sali, Dimitra, additional, Angelidis, George, additional, Psimadas, Dimitrios, additional, Tsougos, Ioannis, additional, Papageorgiou, Sokratis G., additional, Georgoulias, Panagiotis, additional, and Papatriantafyllou, John, additional

Published
2021
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30. Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau

Author

Darwich, Nabil F., primary, Phan, Jessica M., additional, Kim, Boram, additional, Suh, EunRan, additional, Papatriantafyllou, John D., additional, Changolkar, Lakshmi, additional, Nguyen, Aivi T., additional, O’Rourke, Caroline M., additional, He, Zhuohao, additional, Porta, Sílvia, additional, Gibbons, Garrett S., additional, Luk, Kelvin C., additional, Papageorgiou, Sokratis G., additional, Grossman, Murray, additional, Massimo, Lauren, additional, Irwin, David J., additional, McMillan, Corey T., additional, Nasrallah, Ilya M., additional, Toro, Camilo, additional, Aguirre, Geoffrey K., additional, Van Deerlin, Vivianna M., additional, and Lee, Edward B., additional

Published
2020
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31. Differences of apathy perfusion correlates between Alzheimer’s disease and frontotemporal dementia. A 99mTc-HMPAO SPECT study with automated Brodmann areas analysis

Author

Valotassiou, Varvara, primary, Sifakis, Nikolaos, additional, Tzavara, Chara, additional, Lykou, Evi, additional, Tsinia, Niki, additional, Kamtsadeli, Vasiliki, additional, Sali, Dimitra, additional, Angelidis, George, additional, Psimadas, Dimitrios, additional, Tsougos, Ioannis, additional, Papageorgiou, Sokratis G., additional, Georgoulias, Panagiotis, additional, and Papatriantafyllou, John, additional

Published
2020
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32. The impact of COVID‐19 pandemic on people with mild cognitive impairment/dementia and on their caregivers

Author

Tsapanou, Angeliki, primary, Papatriantafyllou, John D., additional, Yiannopoulou, Konstantina, additional, Sali, Dimitra, additional, Kalligerou, Fedra, additional, Ntanasi, Eva, additional, Zoi, Panagiota, additional, Margioti, Eleni, additional, Kamtsadeli, Vasiliki, additional, Hatzopoulou, Maria, additional, Koustimpi, Maria, additional, Zagka, Athina, additional, Papageorgiou, Sokratis G., additional, and Sakka, Paraskeui, additional

Published
2020
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35. Differences of apathy perfusion correlates between Alzheimer's disease and frontotemporal dementia. A 99mTc-HMPAO SPECT study with automated Brodmann areas analysis.

Author

Valotassiou, Varvara, Sifakis, Nikolaos, Tzavara, Chara, Lykou, Evi, Tsinia, Niki, Kamtsadeli, Vasiliki, Sali, Dimitra, Angelidis, George, Psimadas, Dimitrios, Tsougos, Ioannis, Papageorgiou, Sokratis G., Georgoulias, Panagiotis, and Papatriantafyllou, John

Subjects
ALZHEIMER'S disease diagnosis, APATHY, RESEARCH, FRONTAL lobe, LIMBIC system, RADIONUCLIDE imaging, SINGLE-photon emission computed tomography, STATISTICAL correlation, FRONTOTEMPORAL dementia, PERFUSION
Abstract

To explore differences of apathy perfusion correlates between Alzheimer's disease (AD) and Frontotemporal dementia (FTD) using perfusion SPECT. We studied 75 FTD and 66 AD patients. We evaluated apathy using Neuropsychiatric Inventory (NPI). We compared perfusion of BAs on left (L) and right (R) hemisphere in AD and FTD. Apathy in AD was significantly and negatively correlated with dorsolateral prefrontal cortex bilaterally, right anterior prefrontal cortex, inferior frontal cortex bilaterally, especially on the right, orbital part of inferior frontal gyrus bilaterally, left dorsal anterior cingulate cortex, right primary and secondary visual cortex, and with bilateral anterior and dorsolateral prefrontal cortex, inferior frontal cortex and orbital part of inferior frontal gyrus, bilaterally, bilateral anterior -ventral and dorsal- cingulate cortex, left posterior ventral cingulate cortex, right inferior, middle and anterior temporal gyri, entorhinal and parahippocampal cortex in FTD. Significant overlapping of apathy perfusion correlates between AD and FTD is seen in frontal areas and anterior cingulate. Right occipital cortex is also involved in AD, while right temporal cortex and left posterior cingulate are involved in FTD. Nuclear imaging could be a useful biomarker for revealing apathy underlying mechanisms, resulting in directed treatments. Underlying neural networks and clinical manifestation of apathy may differ between AD and FTD. Apathy in AD is correlated with hypoperfusion in bilateral frontal areas, more prominent on the right, left anterior cingulate and right occipital cortex. Apathy in FTD is correlated with hypoperfusion in bilateral frontal areas, bilateral anterior cingulate, left posterior cingulate and right temporal cortex. Brain perfusion SPECT with automated BAs analysis and comparison with normal healthy subjects may provide significant information for apathy mechanisms in neurodegenerative disorders, affecting patients' treatment. [ABSTRACT FROM AUTHOR]

Published
2022
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38. Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study

Author

Moore, Katrina M, primary, Nicholas, Jennifer, additional, Grossman, Murray, additional, McMillan, Corey T, additional, Irwin, David J, additional, Massimo, Lauren, additional, Van Deerlin, Vivianna M, additional, Warren, Jason D, additional, Fox, Nick C, additional, Rossor, Martin N, additional, Mead, Simon, additional, Bocchetta, Martina, additional, Boeve, Bradley F, additional, Knopman, David S, additional, Graff-Radford, Neill R, additional, Forsberg, Leah K, additional, Rademakers, Rosa, additional, Wszolek, Zbigniew K, additional, van Swieten, John C, additional, Jiskoot, Lize C, additional, Meeter, Lieke H, additional, Dopper, Elise GP, additional, Papma, Janne M, additional, Snowden, Julie S, additional, Saxon, Jennifer, additional, Jones, Matthew, additional, Pickering-Brown, Stuart, additional, Le Ber, Isabelle, additional, Camuzat, Agnès, additional, Brice, Alexis, additional, Caroppo, Paola, additional, Ghidoni, Roberta, additional, Pievani, Michela, additional, Benussi, Luisa, additional, Binetti, Giuliano, additional, Dickerson, Bradford C, additional, Lucente, Diane, additional, Krivensky, Samantha, additional, Graff, Caroline, additional, Öijerstedt, Linn, additional, Fallström, Marie, additional, Thonberg, Håkan, additional, Ghoshal, Nupur, additional, Morris, John C, additional, Borroni, Barbara, additional, Benussi, Alberto, additional, Padovani, Alessandro, additional, Galimberti, Daniela, additional, Scarpini, Elio, additional, Fumagalli, Giorgio G, additional, Mackenzie, Ian R, additional, Hsiung, Ging-Yuek R, additional, Sengdy, Pheth, additional, Boxer, Adam L, additional, Rosen, Howie, additional, Taylor, Joanne B, additional, Synofzik, Matthis, additional, Wilke, Carlo, additional, Sulzer, Patricia, additional, Hodges, John R, additional, Halliday, Glenda, additional, Kwok, John, additional, Sanchez-Valle, Raquel, additional, Lladó, Albert, additional, Borrego-Ecija, Sergi, additional, Santana, Isabel, additional, Almeida, Maria Rosário, additional, Tábuas-Pereira, Miguel, additional, Moreno, Fermin, additional, Barandiaran, Myriam, additional, Indakoetxea, Begoña, additional, Levin, Johannes, additional, Danek, Adrian, additional, Rowe, James B, additional, Cope, Thomas E, additional, Otto, Markus, additional, Anderl-Straub, Sarah, additional, de Mendonça, Alexandre, additional, Maruta, Carolina, additional, Masellis, Mario, additional, Black, Sandra E, additional, Couratier, Philippe, additional, Lautrette, Geraldine, additional, Huey, Edward D, additional, Sorbi, Sandro, additional, Nacmias, Benedetta, additional, Laforce, Robert, additional, Tremblay, Marie-Pier L, additional, Vandenberghe, Rik, additional, Damme, Philip Van, additional, Rogalski, Emily J, additional, Weintraub, Sandra, additional, Gerhard, Alexander, additional, Onyike, Chiadi U, additional, Ducharme, Simon, additional, Papageorgiou, Sokratis G, additional, Ng, Adeline Su Lyn, additional, Brodtmann, Amy, additional, Finger, Elizabeth, additional, Guerreiro, Rita, additional, Bras, Jose, additional, Rohrer, Jonathan D, additional, Heller, Carolin, additional, Convery, Rhian S, additional, Woollacott, Ione OC, additional, Shafei, Rachelle M, additional, Graff-Radford, Jonathan, additional, Jones, David T, additional, Dheel, Christina M, additional, Savica, Rodolfo, additional, Lapid, Maria I, additional, Baker, Matt, additional, Fields, Julie A, additional, Gavrilova, Ralitza, additional, Domoto-Reilly, Kimiko, additional, Poos, Jackie M, additional, Van der Ende, Emma L, additional, Panman, Jessica L, additional, Donker Kaat, Laura, additional, Seelaar, Harro, additional, Richardson, Anna, additional, Frisoni, Giovanni, additional, Mega, Anna, additional, Fostinelli, Silvia, additional, Chiang, Huei-Hsin, additional, Alberici, Antonella, additional, Arighi, Andrea, additional, Fenoglio, Chiara, additional, Heuer, Hilary, additional, Miller, Bruce, additional, Karydas, Anna, additional, Fong, Jamie, additional, João Leitão, Maria, additional, Santiago, Beatriz, additional, Duro, Diana, additional, Ferreira, Carlos, additional, Gabilondo, Alazne, additional, De Arriba, Maria, additional, Tainta, Mikel, additional, Zulaica, Miren, additional, Ferreira, Catarina, additional, Semler, Elisa, additional, Ludolph, Albert, additional, Landwehrmeyer, Bernhard, additional, Volk, Alexander E, additional, Miltenberger, Gabriel, additional, Verdelho, Ana, additional, Afonso, Sónia, additional, Tartaglia, Maria Carmela, additional, Freedman, Morris, additional, Rogaeva, Ekaterina, additional, Ferrari, Camilla, additional, Piaceri, Irene, additional, Bessi, Valentina, additional, Lombardi, Gemma, additional, St-Onge, Frédéric, additional, Doré, Marie-Claire, additional, Bruffaerts, Rose, additional, Vandenbulcke, Mathieu, additional, Van den Stock, Jan, additional, Mesulam, M Marsel, additional, Bigio, Eileen, additional, Koros, Christos, additional, Papatriantafyllou, John, additional, Kroupis, Christos, additional, Stefanis, Leonidas, additional, Shoesmith, Christien, additional, Robertson, Erik, additional, Coppola, Giovanni, additional, Da Silva Ramos, Eliana Marisa, additional, and Geschwind, Daniel, additional

Published
2020
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39. QUANTITATIVE CONNECTED SPEECH ANALYSIS IN A CASE OF NON-FLUENT/AGRAMMATIC PRIMARY PROGRESSIVE APHASIA

Author

Karpathiou, Nomiki, Kambanaros, Maria, Potamianou, Dimitra, Papatriantafyllou, John, and Sakka, Paraskevi

Subjects
Speech deficits, Clinical Medicine, Nonfluent/agrammatic variant, Medical and Health Sciences, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, lcsh:RC321-571
Abstract

OBJECTIVE: Primary progressive aphasia (PPA) is a neurodegenerative syndrome characterized by a selective loss of language functions. In the nonfluent/agrammatic variant (nfvPPA), speech is slow and hesitant. Utterances are shorter, less complex and contain grammatical errors. Single word production deficits in PPA have been extensively examined. However, connected speech analysis has only recently begun to be systematically studied. The aim of the present study was to investigate connected speech deficits in a Greek-speaking person with nfvPPA. MATERIAL - METHOD: Participant LJ is a 60-year-old right-handed man, with 6 years of formal education. At the time of the study, he had a FTLD-modified CDR score of 9 (MMSE=17/30). A narrative sample was collected using the “cookie theft” picture from BDAE and analyzed following the procedures described by Saffran et al. (1989) for quantitative production analysis (QPA). QPA summary measures, percentages of dysfluent variables and counts of errors were computed. LJ’s scores were compared to a healthy control group included in a study by Varkanitsa (2012). T-values were calculated using the Crawford and Howell’s method (Crawford and Garthwaite, 2012). RESULTS: Speech rate was 40.37 words per minute. Dysfluencies included silent pauses, filled pauses, false starts, sound distortions and repetitions (23%, 20%, 3%, 2% and 1% of total words produced). LJ produced less nouns (p

Published
2018

40. The impact of COVID‐19 pandemic on people with mild cognitive impairment/dementia and on their caregivers.

Author

Tsapanou, Angeliki, Papatriantafyllou, John D., Yiannopoulou, Konstantina, Sali, Dimitra, Kalligerou, Fedra, Ntanasi, Eva, Zoi, Panagiota, Margioti, Eleni, Kamtsadeli, Vasiliki, Hatzopoulou, Maria, Koustimpi, Maria, Zagka, Athina, Papageorgiou, Sokratis G., and Sakka, Paraskeui

Subjects
*COVID-19 pandemic, *DEMENTIA, *CAREGIVERS, *MILD cognitive impairment, *COVID-19
Abstract

Background: The novel coronavirus disease (COVID‐19) was first detected in Mainland China in December 2019, and soon it spread throughout the world, with multiple physical and psychological consequences across the affected populations. Aims: The aim of the current study was to analyze the impact of COVID‐19 pandemic on older adults with mild cognitive impairment (MCI)/dementia and their caregivers as well. Materials and Methods: Two hundred and four caregivers took part in the study, completing a self‐reported questionnaire about the person with MCI/dementia and their own, since the lockdown period which started in February and ended in May of 2020 in Greece. Results: Results indicated a significant overall decline of the people with MCI/dementia. Further, the domains in which people with MCI/dementia were mostly affected were: communication, mood, movement and compliance with the new measures. Caregivers also reported a great increase in their psychological and physical burden during this period, where the available support sources were limited. Discussion: The pandemic threatens to disrupt the basic routines that promote mental and physical health of both people with MCI/dementia and t heir caregivers. Conclusion: Further measures to protect and provide support to people who suffer and their families are needed. [ABSTRACT FROM AUTHOR]

Published
2021
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43. A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction

Author

Lopez, Ana, Lee, Suzee E., Wojta, Kevin, Ramos, Eliana Marisa, Klein, Eric, Chen, Jason, Boxer, Adam L., Gorno-Tempini, Maria Luisa, Geschwind, Daniel H., Schlotawa, Lars, Ogryzko, Nikolay V., Bigio, Eileen H., Rogalski, Emily, Weintraub, Sandra, Mesulam, Marsel M., Fleming, Angeleen, Coppola, Giovanni, Miller, Bruce L., Rubinsztein, David C., Agosta, Federica, Alberici, Antonella, Babacan-Yildiz, GÜLSEN, Bennett, David A., Bilguvar, Kaya, Borroni, Barbara, Caglayan, Ahmet O., Combarros, Onofre, Comi, Giancarlo, Cortés, Etty P., Ferrer, Isidre, Genç, Şermin, Gunel, Murat, Gylys, Karen H., Indakoetxea, Begoña, Karageorgiou, Clementine E., Karydas, Anna, Kilic, Ulkan, De Munain, Adolfo Lopez, Magnani, Giuseppe, Mahley, Robert W., Boneschi, Filippo Martinelli, Martinez, Jacqueline, Mazzeo, Salvatore, Moreno, Fermin, Padovani, Alessandro, Papatriantafyllou, John, Rogaeva, Ekaterina, Sanchez-Juan, Pascual, Santangelo, Roberto, Small, Gary W., Tarawneh, Rawan, Tartaglia, Maria Carmela, Vonsattel, Jean Paul G., Yener, Gorsev, and BABACAN YILDIZ, GÜLSEN

Subjects
autophagy, proteasome, tauopathy, neurodegeneration
Published
2017

45. Correlation of Neuropsychiatric Symptoms in Dementia with Brain Perfusion: A 99mTc-SPECT-HMPAO Study with Brodmann Areas Analysis

Author

Valotassiou, Varvara, Sifakis, Nikolaos, Tzavara, Chara, Lykou, Evi, Tsinia, Niki, Kamtsadeli, Vasiliki, Sali, Dimitra, Angelidis, George, Psimadas, Dimitrios, Tsougos, Ioannis, Papageorgiou, Sokratis G., Georgoulias, Panagiotis, and Papatriantafyllou, John

Abstract

Background: Neuropsychiatric symptoms (NPSs) are common in dementia. Their evaluation is based on Neuropsychiatric Inventory (NPI). Neuroimaging studies have tried to elucidate the underlying neural circuits either in isolated NPSs or in specific forms of dementia. Objective: The objective of this study is to evaluate the correlation of NPS in the NPI with Brodmann areas (BAs) perfusion, for revealing BAs involved in the pathogenesis of NPSs in dementia of various etiologies. Methods: We studied 201 patients (82 with Alzheimer's disease, 75 with Frontotemporal dementia, 27 with Corticobasal Syndrome, 17 with Parkinson Disease/Lewy Body Dementia). Exploratory factor analysis was carried out to evaluate underlying groups of BAs, and Principal Component analysis was chosen as extraction method using Varimax rotation. Partial correlation coefficients were computed to explore the association of factors obtained from analysis and NPI items controlling for age, educational yeas, and ACE-R. Results: We found 6 BAs Factors(F); F1 (BAs 8,9,10,11,24,32,44,45,46,47, bilaterally), F2 (BAs 4,5,6,7,23,31, bilaterally), F3 (BAs 19,21,22,37,39,40, bilaterally), F4 (BAs 20,28,36,38, bilaterally), F5 (BAs 25, bilaterally) and F6 (BAs 17,18, bilaterally). Significant and negative correlation was found between NPI1 (delusions) and F3,F6, NPI2 (hallucinations) and F6, NPI7 (apathy) and F1,F4,F5, NPI3 (agitation) - NPI10 (aberrant motor behavior) - NPI12 (eating disorders) and F1. We did not find any significant correlation for NPI4,5,6,8,9,11 (depression, anxiety, euphoria, disinhibition, irritability, sleep disorders, respectively). Conclusion: Several NPSs share the same BAs among different types of dementia, while the manifestation of the rest may be attributed to different neural networks. These findings may have an impact on patients treatment.

Published
2021
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46. Cognition and driving behavior in neurodegenerative disorders

Author

Beratis Ion, Papatriantafyllou John, Papageorgiou Sokratis, Pavlou Dimosthenis, and Economou Alexandra

Subjects
03 medical and health sciences, Behavioral Neuroscience, Psychiatry and Mental health, 0302 clinical medicine, Neuropsychology and Physiological Psychology, Neurology, Cognition, Psychology, Neuroscience, 030217 neurology & neurosurgery, Biological Psychiatry, 030227 psychiatry
Published
2016

49. Defining Neuropsychiatric Inventory scale differences across frontotemporal dementia syndromes.

Author

Yiannopoulou, Konstantina G., Papatriantafyllou, John D., Ghika, Apostolia, Tsinia, Niki, Lykou, Eudoxia, Hatziantoniou, Evaggelia, Agiomyrgiannakis, Dimitrios, Kyrozis, Andreas, and Papageorgiou, Sokratis G.

Subjects
*APATHY, *APHASIA, *COGNITION disorders, *RESEARCH methodology, *MOTOR ability, *FRONTOTEMPORAL dementia, *DESCRIPTIVE statistics
Abstract

Aim: The aim of this study was to assess the ability of Neuropsychiatric Inventory (NPI) scale profiles to differentiate between distinct frontotemporal dementia (FTD) subtypes. Methods: The NPI was used to assess 311 older patients who had been clinically diagnosed with FTD. FTD subtypes included behavioural variant FTD (bvFTD, n = 121), primary progressive aphasia (semantic variant (n = 69), non‐fluent agrammatic variant (n = 31), and logopenic variant (n = 0)), FTD‐motor neuron disease (n = 4), progressive supranuclear palsy (n = 43), and corticobasal syndrome (n = 43). Total NPI score and scores for each NPI item were correlated across the distinct FTD subtypes. Results: Patients with bvFTD showed significantly greater impairment on their total NPI score than patients with corticobasal syndrome (P < 0.001), non‐fluent agrammatic variant primary progressive aphasia (P < 0.001), progressive supranuclear palsy (P = 0.002), and semantic variant primary progressive aphasia (P = 0.010). Aggressiveness, euphoria, apathy, disinhibition, irritability, aberrant motor behaviours, and appetite disturbance were significantly higher in bvFTD than in the other subgroups. The lowest NPI scores were generally shown among those with CBS. However, NPI total and specific item values overlapped among the subtypes. Conclusions: Patients with bvFTD showed significantly greater neuropsychiatric dysfunction than those with the other FTD subtypes, as measured by the NPI scale. In contrast, patients with corticobasal syndrome had a comparatively healthier profile. Therefore, differential diagnosis among the FTD subtypes may be guided by the NPI, although the subtype is unlikely to be confirmed on the basis of NPI alone. [ABSTRACT FROM AUTHOR]

Published
2019
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