Search

Your search keyword '"Papoian, Thomas"' showing total 23 results
Start Over Author "Papoian, Thomas"
23 results on '"Papoian, Thomas"'

4. Chemical Effects in Biological Systems—Data Dictionary (CEBS-DD): A Compendium of Terms for the Capture and Integration of Biological Study Design Description, Conventional Phenotypes, and ‘Omics Data

Author

Fostel, Jennifer, Choi, Danielle, Zwickl, Craig, Morrison, Norman, Rashid, Asif, Hasan, Atif, Bao, Wenjun, Richard, Ann, Tong, Weida, Bushel, Pierre R., Brown, Roger, Bruno, Maribel, Cunningham, Michael L., Dix, David, Eastin, William, Frade, Carlos, Garcia, Alex, Heinloth, Alexandra, Irwin, Rick, Madenspacher, Jennifer, Merrick, B. Alex, Papoian, Thomas, Paules, Richard, Rocca-Serra, Philippe, Sansone, Assunta-Susanna, Stevens, James, Tomer, Kenneth, Yang, Chihae, and Waters, Michael

Published
2005

14. Genomics and drug toxicity

Author

Lord, Peter G. and Papoian, Thomas

Subjects
Genomics -- Research -- Methods, Pharmaceutical research -- Methods -- Research, Science and technology, Research, Methods
Abstract

As genomics has revolutionized the study of biology, so has it affected how drugs are discovered. Pharmaceutical companies have also realized another major application: how drugs are assessed for safety. [...]

Published
2004

18. Molecular mechanisms of heart muscle disease

Author

Lewis, William and Papoian, Thomas

Subjects
Heart diseases -- Physiological aspects, Doxorubicin -- Physiological aspects, Cardiomyopathy -- Physiological aspects, Health, Physiological aspects
Abstract

Molecular Mechanisms of Heart Muscle Disease SUBCELLULAR MECHANISMS of dilated heart muscle disease (congestive cardiomyopathy) are poorly understood. With the development of techniques of molecular biology, some causal events in [...]

Published
1991

19. Absence of Down-Regulation of Insulin Receptors in Human Breast Cancer Cells (MCF-7) Cultured in Serum-Free Medium: Comparison with Epidermal Growth Factor

Author

Hwang, David, Papoian, Thomas, Barseghian, Gegham, Josefsberg, Zeev, and Lev-ran, Arye

Abstract

MCF-7 cells were cultured either in RPM1-1640 medium containing 10% fetal calf serum (FCS) or in a serum-free (SF) medium supplemented with insulin, epidermal growth factor (EGF) and transferrin. Binding studies were performed with 125I-insulin or 125I-EGF. In the FCS containing culture, down-regulation was seen for insulin receptors (47%), and for the EGF receptors (75%). Using cells grown in the serum-free medium we could not demonstrate down-regulation of the insulin receptors, while the EGF receptors were down-regulated to the same extent (74%). The number of binding sites per cell was about twice as much in cells cultured in FCS as that in SF medium. No significant differences were observed for receptor affinity of insulin or EGF in cells grown in both media. The rate of internalization of insulin or EGF into cells was similar in both culture conditions. The mechanism in which only EGF but not insulin demonstrated receptor down-regulation in SF medium remains unknown.

Published
1985
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results