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26. Topical small molecule granzyme B inhibitor improves remodeling in a murine model of impaired burn wound healing

Author

Shen, Yue, Zeglinski, Matthew R., Turner, Christopher T., Raithatha, Sheetal A., Wu, Zhenguo, Russo, Valerio, Oram, Cameron, Hiroyasu, Sho, Nabai, Layla, Zhao, Hongyan, Bozin, Tatjana, Westendorf, Kathryn, Kopko, Irina, Huang, Rachel, Arns, Steve, Tan, Jason, Zeng, Haishan, Boey, Anthony, Liggins, Richard, Jaquith, James, Cameron, Dale R., Papp, Anthony, and Granville, David J.

Published
2018
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30. A Cross-Sectional Study of Sex, Race, and Ethnic Representation in Burn Registered Clinical Trials

Author

Sheikh-Oleslami, Sara, Tao, Brendan, Papp, Bettina, Luthra, Shreya, and Papp, Anthony

Abstract

Purpose: The demographic proportions of plastic surgery trials approximating real-world disease have not well been studied. Judicious trial representation is essential in evaluation of treatments across diverse patient populations. Herein, we investigate sex, racial, and ethnic disparities in patient enrollment across burn trials. Methods: Cross-sectional analysis of participants enrolled in high-quality, with reduced risk of bias, randomized controlled trials (RCT) on burns registered on clinicaltrials.gov under the query “burn.” Completed RCTs reporting at least two demographic groups, employing double masking or greater, and with results accessible through the registry or publications were included. Trial characteristics (sponsor country, site location, initiation year, study phase, masking) and demographic data (sex, race, ethnicity per US reporting guidelines) were collected. The Global Burden of Disease database provided sex-based burn disease burdens. The primary outcome was the population-to-prevalence ratio of enrolled female participants. Secondary outcomes included representation of racial and ethnic populations as related to study blinding, phase, and study/sponsor locations. Results: Of 546 records, 39 trials met the inclusion criteria (2919 participants). All trials reported sex demographics, with females comprising 37.02% of all participants (PPR = 0.71, 95% CI [0.59, 0.82], likely indicating underrepresentation against their empiric disease burden). Only 7 and 9 trials reported ethnicity and race, respectively, although not comprehensively. Among trials reporting race or ethnicity, Caucasians and Black persons comprised 57.52% and 21.80% of participants, respectively, while only 9.80% had Hispanic/Latino ethnicity. Severe underreporting of race and ethnicity precluded much of secondary significance testing across study variables. Conclusions: Females are likely underrepresented in high-quality, US-registered burn trials, unreflective of their real-world disease burden. Further, severe underreporting of race and ethnicity was noted. Future trials should enroll diverse demographics and equitable populations for promotion of study generalizability.

Published
2024
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48. Incisional negative pressure therapy reduces complications and costs in pressure ulcer reconstruction.

Author

Papp, Anthony A.

Subjects
PREVENTION of surgical complications, SURGICAL complication risk factors, PRESSURE ulcers, COST control, LENGTH of stay in hospitals, LONGITUDINAL method, MEDICAL care costs, PLASTIC surgery, WOUND healing, DISEASE relapse, NEGATIVE-pressure wound therapy
Abstract

Complications after pressure ulcer reconstruction are common. A complication rate of 21% to 58% and a 27% wound recurrence has been reported. The aim of this study was to decrease postoperative wound‐healing complications with incisional negative pressure wound therapy (iNPWT) postoperatively. This was a prospective non‐randomised trial with a historic control. Surgically treated pressure ulcer patients receiving iNPWT were included in the prospective part of the study (Treatment group) and compared with the historic patient cohort of all consecutive surgically treated pressure ulcer patients during a 2‐year period preceding the initiation of iNPWT (Control). There were 24 patients in the Control and 37 in the Treatment groups. The demographics between groups were similar. There was a 74% reduction in in‐hospital complications in the Treatment group (10.8% vs 41.7%, P = 0.0051), 27% reduction in the length of stay (24.8 vs 33.8 days, P = 0.0103), and a 78% reduction in the number of open wounds at 3 months (5.4 vs 25%, P = −0.0481). Recurrent wounds and history of previous surgery were risk factors for complications. Incisional negative pressure wound therapy shortens hospital stay, number of postoperative complications, and the number of recurrent open wounds at 3 months after reconstructive pressure ulcer surgery, resulting in significant cost savings. [ABSTRACT FROM AUTHOR]

Published
2019
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