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224 results on '"Papparella, S"'

3. Standardization initiative for canine mammary tumours: national guidelines, multi-institutional ring test and diagnostic algorithm

Author

Cocumelli, C., primary, Crescio, M.I., additional, Baldassarre, V., additional, Brunetti, B., additional, Burrai, G.P., additional, Grieco, V., additional, Iussich, S., additional, Maniscalco, L., additional, Mariotti, F., additional, Millanta, F., additional, Paciello, O., additional, Rasotto, R., additional, Romanucci, M., additional, Sfacteria, A., additional, Papparella, S., additional, and Zappulli, V., additional

Published
2023
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9. The correlation between cardiac and skeletal muscle pathology in animal models of idiopathic inflammatory myopathies

Author

Prisco F., Papparella S., Paciello O., Prisco, F., Papparella, S., and Paciello, O.

Subjects
Myocarditi, Animal model, Idiopathic inflammatory myopathy, Myositi, Neuromuscular disorders
Abstract

Idiopathic inflammatory myopathies (IIMs) represent a heterogeneous group of disorders in which skeletal muscle is inappropriately targeted by the immune system. IIMs are characterized by inflammation of muscle and varying degrees of muscle dysfunction. Extra-muscular manifestations may involve heart, skin, joints, lungs, and gastrointestinal tract. Cardiovascular involvement is a feared event because is one of the leading causes of mortality in IIM patients. As the myocardium shares many features with the skeletal muscle, it is supposed that it can be affected by the same inflammatory processes, which take place during the different forms of IIMs. However, the full extent of this link and the mechanisms behind it are still not fully understood. Animal models have greatly improved our understanding of IIM pathomechanisms and have proven to be a useful tool for discovering therapeutic drug targets. Here we report the evidence of heart muscle involvement in different animal models of spontaneous IIMs, assuming a common autoimmune mechanism and presenting them as study models for human pathology.

Published
2020

20. Anti-skeletal muscle antibodies in sera of dogs with leishmaniasis

Author

Prisco F, Piegari G, De Biase D, Oriente F, Ricci S, Cimmino I, Pagnini U, Gizzarelli M, Oliva G, Papparella S, Paciello O, SISVet, Prisco, F, Piegari, G, De Biase, D, Oriente, F, Ricci, S, Cimmino, I, Pagnini, U, Gizzarelli, M, Oliva, G, Papparella, S, and Paciello, O

Published
2017

28. Turbe della conduzione atrio-ventricolare, familiari, associate a miopatia

Author

PALLADINO A, VENTRIGLIA V. M, PASSAMANO L, PETRETTA V. R, PACIELLO O, PAPPARELLA S, NIGRO, Vincenzo, POLITANO, Luisa, A., Palladino, V. M., Ventriglia, L., Passamano, V. R., Petretta, Paciello, Orlando, Papparella, Serenella, Nigro, Vincenzo, Politano, Luisa, Palladino, A, Ventriglia, V. M., Passamano, L, Petretta, V. R., Paciello, O, and Papparella, S

Published
2008

29. Gonadotropins effect on rat testis : an experimental study

Author

PAPPARELLA, Alfonso, Noviello C, Nino F, Romano M, Papparella S, Paciello O, Sinisi A, PARMEGGIANI, Pio, Holger Till, Coran A , Hoellwarth M , Teitelbaun D , Meuli M . Pierro A , Puri P , Rintala R , Rivosecchi M , Tovar J , Ure B, Papparella, Alfonso, Noviello, C, Nino, F, Romano, M, Papparella, S, Paciello, O, Sinisi, A, and Parmeggiani, Pio

Published
2008

31. Age-Related Changes in Skeletal Muscle of Cattle

Author

Costagliola, A., primary, Wojcik, S., additional, Pagano, T. B., additional, De Biase, D., additional, Russo, V., additional, Iovane, V., additional, Grieco, E., additional, Papparella, S., additional, and Paciello, O., additional

Published
2016
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33. Dysferlinopathy presenting as facio-scapulo-humeral dystrophy

Author

POLITANO, Luisa, PALLADINO A., PACIELLO O., PASSAMANO L., SANNINO P., FREDA, Fulvio, PAPPARELLA S., COMI L. I., NIGRO G., Politano, Luisa, Palladino, A., Paciello, O., Passamano, L., Sannino, P., Freda, Fulvio, Papparella, S., Comi, L. I., and Nigro, G.

Published
2005

37. Gentamicin administration in Duchenne patients with premature stop codon. Preliminary results

Author

Politano, L., Nigro, G., Nigro, V., Pilus, G., Papparella, S., Paciello, O., Comi, L. I., Politano, Luisa, Nigro, Giovanni, Nigro, Vincenzo, G., Piluso, Papparella, Serenella, Paciello, Orlando, Comi, LUCIA INES, Nigro, Gerardo, Piluso, Giulio, Papparella, S, Paciello, O, and Comi, Li

Subjects
Male, Time Factors, Drug Administration Schedule, Anti-Bacterial Agents, Dystrophin, Muscular Dystrophy, Duchenne, Treatment Outcome, Codon, Nonsense, Child, Preschool, Humans, Gentamicins, Child, Muscle, Skeletal, Follow-Up Studies
Abstract

Aim of the study was to investigate whether the administration of gentamicin could restore dystrophin expression in striated muscles of patients with Duchenne muscular dystrophy caused by premature stop codon, as reported in mdx mice. Four Duchenne patients, still ambulant or in wheelchair stage for less than 4 months, selected among those with point mutations resulting in premature stop codons, received two 6-day cycles of gentamicin sulfate, at an interval of 7 weeks, according to the protocol approved by the Ethics Committee of the Second University of Naples. A muscle biopsy was performed after the second cycle of administration; the specimens were analysed by both immuno-histochemistry and Western blotting. Skeletal muscle changes were monitored by dynamic tests and Creatine Kinase values; at the beginning and end of treatment, cardiac and respiratory status was evaluated by electrocardiography, echocardiography, acoustic densitometry and vital capacity. Side-effects such as nephrotoxicity and ototoxicity were also monitored. Three out of four patients, who had the most permissive UGA as stop codon, showed positive results. In one patient, there was a dramatic re-expression of dystrophin by both immuno-histochemistry and Western blot; in two patients, dystrophin positive fibres were seen by the antibody to the rod domain with immuno-histochemistry; the fourth patient, with UAA as stop codon, showed no expression of dystrophin at all. These results suggest that gentamicin is able to recover dystrophin expression in a subset of Duchenne patients with nonsense mutations, raising the possibility of the first pharmacological treatment for muscular dystrophy.

Published
2003

39. Indicatori biologici di inquinamento ambientale

Author

PACIELLO, ORLANDO, RESTUCCI B, MAIOLINO P. E. PAPPARELLA S., MARTANO, MANUELA, Paciello, Orlando, Martano, Manuela, Restucci, B, and Maiolino, P. E. PAPPARELLA S.

Published
2002

42. Amyloid precursor protein, lipofuscin accumulation and expression of autophagy markers in aged bovine brain.

Author

D. De Biase, Costagliola, A., Pagano, T.B., Piegari, G., Wojcik, S., Dziewiatkowski, J., Grieco, E., Mattace Raso, G., Russo, V., Papparella, S., and Paciello, O.

Subjects
AMYLOID beta-protein precursor, AMYLOID, LIPOFUSCINS, PROTEIN precursors, AUTOPHAGY, NEURODEGENERATION
Abstract

Background: Autophagy is a highly regulated process involving the bulk degradation of cytoplasmic macromolecules and organelles in mammalian cells via the lysosomal system. Dysregulation of autophagy is implicated in the pathogenesis of many neurodegenerative diseases and integrity of the autophagosomal - lysosomal network appears to be critical in the progression of aging. Our aim was to survey the expression of autophagy markers and Amyloid precursor protein (APP) in aged bovine brains. For our study, we collected samples from the brain of old (aged 11-20 years) and young (aged 1-5 years) Podolic dairy cows. Formalin-fixed and paraffin embedded sections were stained with routine and special staining techniques. Primary antibodies for APP and autophagy markers such as Beclin-1 and LC3 were used to perform immunofluorescence and Western blot analysis. Results: Histologically, the most consistent morphological finding was the age-related accumulation of intraneuronal lipofuscin. Furthermore, in aged bovine brains, immunofluorescence detected a strongly positive immunoreaction to APP and LC3. Beclin-1 immunoreaction was weak or absent. In young controls, the immunoreaction for Beclin-1 and LC3 was mild while the immunoreaction for APP was absent. Western blot analysis confirmed an increased APP expression and LC3-II/LC3-I ratio and a decreased expression of Beclin-1 in aged cows. Conclusions: These data suggest that, in aged bovine, autophagy is significantly impaired if compared to young animals and they confirm that intraneuronal APP deposition increases with age. [ABSTRACT FROM AUTHOR]

Published
2017
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