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10 results on '"Pappas, P.A."'

1. Coagulase-negative staphylococcal prosthetic valve endocarditis - a contemporary update based on the International Collaboration on Endocarditis: prospective cohort study

Author

Chu, V.H., Miro, J.M., Hoen, B., Cabell, C.H., Pappas, P.A., Jones, P., Stryjewski, M.E., Anguera, I., Braun, S., Munoz, P., Commerford, P., Tornos, P., Francis, J., Oyonarte, M., Selton-Suty, C., Morris, A.J., Habib, G., Almirante, B., Sexton, D.J., Corey, G.R., and Fowler, V.G., Jr.

Subjects
Endocarditis -- Research, Endocarditis -- Physiological aspects, Endocarditis -- Causes of, Staphylococcus -- Research, Staphylococcus -- Physiological aspects, Heart valve replacement -- Complications and side effects, Health
Published
2009

4. Comparison of Staphylococcus lugdunensis and Staphylococcus epidermidis native valve endocarditis from the International Collaboration on Endocarditis – Prospective Cohort Study

Author

Chu, V.H., Woods, C.W., Miro, J.M., Hoen, B., Cabell, C.H., Pappas, P.A., E. Athan, E., Baršić, Bruno, Bouza, E., Braun, S., Korman, T., Murdoch, D.R., Tripodi, M.-F., Corey, G.R., Fowler, V.G. Jr., and and the ICE-PCS Study Group

Subjects
native valve endocarditis, Staphylococcus lugdunensis, Staphylococcus epidermidis
Abstract

Staphylococcus lugdunensis native valve endocarditis (NVE) is rare and associated with an aggressive clinical course. Our current understanding of this disease is based on case reports and reviews of the literature. The purpose of this investigation is to compare the clinical features of S. lugdunensis and S. epidermidis NVE. The International Collaboration on Endocarditis – Prospective Cohort Study (ICE-PCS) is a cohort of >3000 patients with IE from 61 centers in 28 countries. The ICE – microbiology repository comprises a subset of bacterial isolates from ICE-PCS contributed by 18 centers in 12 countries. From the ICE-microbiology repository, there were 23 S. epidermidis and 4 S. lugdunensis NVE isolates available for comparison. All S. lugdunensis isolates were susceptible to penicillin compared to 4 (17%) S. epidermidis isolates. Patients with S. lugdunensis NVE were younger than patients with S. epidermidis NVE (median age 52 vs 73 years, respectively). Three of the 4 cases of S. lugdunensis NVE cases were community-acquired, while 65% of S. epidermidis cases were acquired in the healthcare setting. Healthcare-associated risks for staphylococcal infection were absent for patients with S. lugdunensis NVE. In contrast, hemodialysis dependence (17%), cardiac devices (17%), and receipt of invasive procedures (39%) were prominent characteristics of patients with S. epidermidis NVE. Complications occurred in a larger proportion of patients with S. lugdunensis NVE [systemic embolization 2 (50%) ; heart failure 3 (75%)] than S. epidermidis NVE [systemic embolization 3 (13%) ; heart failure 11 (48%)]. All 4 (100%) patients with S. lugdunensis NVE underwent surgery compared to 14 (61%) S. epidermidis NVE patients. The rate of death was similar in S. lugdunensis and S. epidermidis NVE [1 (25%) vs 6 (26%)]. Given the small sample size, p-values were not significant for all analyses. S. lugdunensis NVE is associated with an aggressive clinical course and a high rate of surgery. Clinicians should be suspicious for S. lugdunensis in patients who present with coagulase-negative staphylococcal NVE from the community, without healthcare associated risks.

Published
2007

5. Thrombocytopenia After Liver Transplantation

Author

Chatzipetrou, M.A., Tsaroucha, A.K., Weppler, D., Pappas, P.A., Kenyon, N.S., Nery, J.R., Khan, M.F., Kato, T., Pinna, A.D., Obrien, C., Viciana, A., Ricordi, C., and Tzakis, A.G.

Subjects
Transplantation of organs, tissues, etc., Liver -- Transplantation, Thrombocytopenia -- Risk factors -- Complications and side effects, Health, Complications and side effects, Risk factors
Abstract

Liver Transplantation Chatzipetrou, M.A.; Tsaroucha, A.K.; Weppler, D.; Pappas, P.A.; Kenyon, N.S.; Nery, J.R.; Khan, M.F.; Kato, T.; Pinna, A.D.; Obrien, C.; Viciana, A.; Ricordi, C.; Tzakis, A.G. 'Thrombocytopenia After [...]

Published
1999

6. Enterococcal endocarditis: 107 cases from the international collaboration on endocarditis merged database

Author

McDonald, J.R., Olaison, L., Anderson, D.J., Hoen, B., Miro, J.M., Eykyn, S., Abrutyn, E., Fowler, V.G., Habib, G., Selton-Suty, C., Pappas, P.A., Cabell, C.H., Corey, G.R., Marco, F., Sexton, D.J., and Fowler, V G Jr

Subjects
*HEART disease related mortality, *HEART diseases, *HEART failure, *PATHOGENIC microorganisms, *STREPTOCOCCAL disease diagnosis, *COMPARATIVE studies, *DIFFERENTIAL diagnosis, *ECHOCARDIOGRAPHY, *ENTEROCOCCUS, *INFECTIVE endocarditis, *INTERNATIONAL relations, *LONGITUDINAL method, *RESEARCH methodology, *MEDICAL cooperation, *PROGNOSIS, *RESEARCH, *RESEARCH funding, *STREPTOCOCCAL diseases, *STREPTOCOCCUS, *SURVIVAL, *TRICUSPID valve, *GRAM-positive bacterial infections, *EVALUATION research, *PULMONARY valve, *DISEASE incidence, *SEVERITY of illness index, *DIAGNOSIS, CARDIAC surgery patients
Abstract

Purpose: To describe clinical features and outcomes of enterococcal left-sided native valve endocarditis and to compare it to endocarditis caused by other pathogens. Subjects and Methods: Patients in the International Collaboration on Endocarditis-Merged Database were included if they had left-sided native valve endocarditis. Demographic characteristics, clinical features, and outcomes were analyzed. Multivariable analysis evaluated enterococcus as a predictor of mortality. Results: Of 1285 patients with left-sided native valve endocarditis, 107 had enterococcal endocarditis. Enterococcal endocarditis was most frequently seen in elderly men, frequently involved the aortic valve, tended to produce heart failure rather than embolic events, and had relatively low short-term mortality. Compared to patients with non-enterococcal endocarditis, patients with enterococcal endocarditis had similar rates of nosocomial acquisition, heart failure, embolization, surgery, and mortality. Compared to patients with streptococcal endocarditis, patients with enterococcal endocarditis were more likely to be nosocomially acquired (9 of 59 [15%] vs 2 of 400 [1%]; P <.0001) and have heart failure (49 of 107 [46%] vs 234 of 666 [35%]; P = 0.03). Compared to patients with S. aureus endocarditis, patients with enterococcal endocarditis were less likely to embolize (28 of 107 [26%] vs 155 of 314 [49%]; P <.0001) and less likely to die (12 of 107 [11%] vs 83 of 313 [27%]; P = 0.001). Multivariable analysis of all patients with left-sided native valve endocarditis showed that enterococcal endocarditis was associated with lower mortality (odds ratio [OR] 0.49; 95% confidence interval [CI] 0.24 to 0.97). Conclusions: Enterococcal native valve endocarditis has a distinctive clinical picture with a good prognosis. [ABSTRACT FROM AUTHOR]

Published
2005
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7. Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study

Author

Murdoch , David R, Corey , G Ralph, Hoen , Bruno, Miró , José M, Fowler , Vance G, Bayer , Arnold S, Karchmer , Adolf W, Olaison , Lars, Pappas , Paul A, Moreillon , Philippe, Chambers , Stephen T, Chu , Vivian H, Falcó , Vicenç, Holland , David J, Jones , Philip, Klein , John L, Raymond , Nigel J, Read , Kerry M, Tripodi , Marie Francoise, Utili , Riccardo, Wang , Andrew, Woods , Christopher W, Cabell , Christopher H, Renseigné , Non, International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS) Investigators, Gordon, D., Devi, U., Spelman, D., van der Meer, J.T., Kauffman, C., Bradley, S., Armstrong, W., Giannitsioti, E., Giamarellou, H., Lerakis, S., del Rio, A., Moreno, A., Mestres, C.A., Ninot, C.A., Pare, C., de la Maria, C.G., Armero, Y., de Lazzari, E., Marco, F., Gatell, J.M., Almela, M., Azqueta, M., Sitges, M., Claramonte, X., Jiménez-Expósito, M.J., de Benito, N., Ramirez, J., Perez, N., Miro, J.M., Almirante, B., Fernandez-Hidalgo, N., de Vera, P.R., Tornos, P., Falco, V., Sidani, N., Kanj-Sharara, S., Kanafani, Z., Raglio, A., Goglio, A., Gnecchi, F., Suter, F., Valsecchi, G., Rizzi, M., Ravasio, V., Hoen, B., Chirouze, C., Leroy, J., Plesiat, P., Bernard, Y., Casey, A., Lambert, P., Watkin, R., Elliott, T., Patel, M., Dismukes, W., Pan, A., Caros, G., Mathiron, A.B., Tribouilloy, C., Goissen, T., Delahaye, A., Delahaye, F., Vandenesch, F., Vizzotti, C., Nacinovich, F.M., Marin, M., Trivi, M., Lombardero, M., Cortes, C., Casabé, J.H., Altclas, J., Kogan, S., Clara, L., Sanchez, M., Commerford, A., Hansa, C., Deetlefs, E., Ntsekhe, M., Commerford, P., Wray, D., Steed, L.L., Church, P., Cantey, R., Morris, A., Holland, D.J., Murdoch, D.R., Chambers, S.T., Read, K.M., Raymond, N.J., Lang, S., Kotsanas, D., Korman, T.M., Peterson, G., Purcell, J., Southern, P.M., Shah, M., Bedimo, R., Reddy, A., Levine, D., Dhar, G., Hanlon-Feeney, A., Hannan, M., Kelly, S., Wang, A., Cabell, C.H., Woods, C.W., Sexton, D.J., Benjamin, D.J., McDonald, J.R., Federspiel, J., Engemann, J.J., Reller, B., Drew, L., Caram, L.B., Stryjewski, M., Morpeth, S., Lalani, T., Fowler, V.G., Chu, V.H., Mazaheri, B., Neuerburg, C., Naber, C., Athan, E., Henry, M., Harris, O., Alestig, E., Olaison, L., Wikstrom, L., Snygg-Martin, U., Francis, J., Venugopal, K., Nair, L., Thomas, V., Chaiworramukkun, J., Pachirat, O., Chetchotisakd, P., Suwanich, T., Kamarulzaman, A., Tamin, S.S., Premru, M.M., Logar, M., Lejko-Zupanc, T., Orezzi, C., Klein, J.L., Bouz, E., Rodríguez-Créixems, M., Marín, M., Fernández, M., Muñoz, P., Fernández, R., Ramallo, V., Raoult, D., Thuny, F., Habib, G., Casalta, J.P., Fournier, P.E., Chipigina, N., Kirill, O., Vinogradova, T., Kulichenko, V.P., Butkevich, O.M., Lion, C., Selton-Suty, C., Coyard, H., Doco-Lecompte, T., Iarussi, D., Durante-Mangoni, E., Ragone, E., Dialetto, G., Tripodi, M.F., Utili, R., Casillo, R., Kumar, A.S., Sharma, G., Dickerman, S.A., Street, A., Eisen, D.P., McBryde, E.S., Grigg, L., Abrutyn, E., Michelet, C., Tattevin, P., Donnio, P.Y., Fortes, C.Q., Edathodu, J., Al-Hegelan, M., Font, B., Anguera, I., Guma, J.R., Cereceda, M., Oyonarte, M.J., Mella, R.M., Garcia, P., Jones, S.B., Ramos, A.I., Paiva, M.G., Tranchesi, R.A., Woon, L.L., Lum, L.N., Tan, R.S., Rees, D., Kornecny, P., Lawrence, R., Dever, R., Post, J., Jones, P., Ryan, S., Harkness, J., Feneley, M., Rubinstein, E., Strahilewitz, J., Ionac, A., Mornos, C., Dragulescu, S., Forno, D., Cecchi, E., De Rosa, F., Imazio, M., Trinchero, R., Wiesbauer, F., Gattringer, R., Deans, G., Andrasevic, A.T., Barsic, B., Klinar, I., Vincelj, J., Bukovski, S., Krajinovic, V., Stafford, J., Baloch, K., Pappas, P.A., Redick, T., Harding, T., Karchmer, A.W., Bayer, A.S., Corey, R., Moreillon, P., Durack, D.T., Eykyn, S., Service des maladies infectieuses et tropicales, Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Hôpital Saint-Jacques, Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Hôpital Saint-Jacques, Murdoch, D., Corey, G., Miro', J., Fowler, V. J., Bayer, A., Karchmer, A., Pappas, P., Chambers, S., Chu, V., Falco', V., Holland, D., Klein, J., Raymond, N., Read, K., Tripodi, M. F., Utili, Riccardo, Woods, C., Cabell, C., AII - Amsterdam institute for Infection and Immunity, Infectious diseases, Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), and Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)

Subjects
Male, MESH: Endocarditis, MESH : Aged, MESH : Prospective Studies, 030204 cardiovascular system & hematology, endocarditi, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Mitral valve, MESH: Staphylococcus aureus, MESH : Female, Prospective Studies, Prospective cohort study, Abscess, MESH: Aged, Adult, Aged, Endocarditis/microbiology, Endocarditis/mortality, Endocarditis/therapy, Female, Humans, Middle Aged, Staphylococcal Infections/microbiology, Staphylococcus aureus/isolation & purification, endocarditis, hospital mortality, 0303 health sciences, MESH: Middle Aged, Endocarditis, MESH : Staphylococcus aureus, Staphylococcal Infections, MESH : Adult, MESH : Endocarditis, 3. Good health, [ SDV.MHEP.MI ] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, medicine.anatomical_structure, Infective endocarditis, epidemiology, Staphylococcus aureus, medicine.medical_specialty, complications, MESH : Male, MESH: Staphylococcal Infections, Staphylococcal infections, Article, 03 medical and health sciences, Endocarditis, clinical presentattion, S. aureus, Internal medicine, Internal Medicine, medicine, MESH : Middle Aged, staphylococci, MESH: Humans, 030306 microbiology, business.industry, clinical presentattion, MESH : Humans, MESH: Adult, Odds ratio, S. aureus, medicine.disease, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, MESH: Male, MESH: Prospective Studies, Surgery, Etiology, MESH : Staphylococcal Infections, business, MESH: Female
Abstract

International audience; BACKGROUND: We sought to provide a contemporary picture of the presentation, etiology, and outcome of infective endocarditis (IE) in a large patient cohort from multiple locations worldwide. METHODS: Prospective cohort study of 2781 adults with definite IE who were admitted to 58 hospitals in 25 countries from June 1, 2000, through September 1, 2005. RESULTS: The median age of the cohort was 57.9 (interquartile range, 43.2-71.8) years, and 72.1% had native valve IE. Most patients (77.0%) presented early in the disease (

Published
2009

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