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2. Lyme endocarditis

Author

Hidri, N., Barraud, O., de Martino, S., Garnier, F., Paraf, F., Martin, C., Sekkal, S., Laskar, M., Jaulhac, B., and Ploy, M.-C.

Published
2012
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12. Cancérologie digestive : pratiques chirurgicales

Author

J.-M. Regimbeau, Paraf F, Slim K, Christophe Mariette, Bertrand Millat, Thierry Perniceni, Dominique Elias, Chollet P, R. Kianmanesh, Jean-François Fléjou, Comy M, Antoine Brouquet, Sastre B, Vons C, Fourquier P, Garcier Jm, Brice Gayet, Guillaume Piessen, Michel Scotté, Laurence Chiche, Delpero, Partensky C, Jean-Yves Scoazec, Schmitt G, Meyer C, Kohneh-Shahri N, Jacques Belghiti, Blay Jy, Bernard Nordlinger, Pierre Déchelotte, Trillaud H, Denis Chatelain, Champault G, Alain Sauvanet, Mehdi Karoui, Marc Pocard, Olivier Glehen, F. Peschaud, Nicolet J, David Fuks, Mickael Lesurtel, Lasser P, Gouillat C, Simon Msika, Christophe Laurent, S. Berdah, J.-P. Triboulet, Chipponi J, Rouanet P, Patrice Valleur, Denet C, De Baère T, and François Mauvais

Subjects
Lymphatic metastasis, medicine.medical_specialty, business.industry, Internal medicine, General surgery, Medicine, Surgery, business, Gastroenterology
Published
2009
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13. Naltrexone et tramadol

Author

Gaulier, J.-M., primary, Carton, L., additional, Coeffeteau, C., additional, Moreau, F., additional, and Paraf, F., additional

Published
2017
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15. Cyclooxygenase-2 is expressed frequently and early in Barrett's oesophagus and associated adenocarcinoma

Author

Martin A, Vidaud D, Anne Couvelard, Paraf F, Jean-François Fléjou, Lagorce C, and Dominique Wendum

Subjects
medicine.medical_specialty, Pathology, Histology, Esophageal disease, General Medicine, Biology, medicine.disease, digestive system, Gastroenterology, digestive system diseases, Pathology and Forensic Medicine, surgical procedures, operative, medicine.anatomical_structure, Tumor progression, Dysplasia, Internal medicine, medicine, Immunohistochemistry, Adenocarcinoma, Neoplastic transformation, Esophagus, neoplasms
Abstract

Aims: To establish the prevalence of cyclooxygenase-2 (COX-2) expression in a large series of resected Barrett's adenocarcinoma and associated preneoplastic lesions and to correlate this expression with clinicopathological data and prognosis. Methods: COX-2 expression was assessed by immunohistochemistry in resected surgical specimens of 66 Barrett's adenocarcinomas and 32 cases of Barrett's mucosa (with dysplasia in 17 cases). Results: Epithelial expression of COX-2 protein was increased in Barrett's mucosa compared with normal oesophagus. Epithelial expression of COX-2 was found in 91% of Barrett's specialized mucosa negative for dysplasia, 94% of Barrett's mucosa with dysplasia, and 97% of Barrett's adenocarcinoma. COX-2 expression was significantly higher in the well-differentiated adenocarcinomas when compared with the poorly differentiated tumours. There was no significant correlation between COX-2 expression and the other pathological features of the tumours. Survival analysis showed no significant prognostic value for COX-2. Conclusion: Our results confirm up-regulation of COX-2 in Barrett's oesophagus—metaplastic and dysplastic—and in Barrett's adenocarcinoma. Increased COX-2 expression did not differ during the progression from Barrett's oesophagus negative for dysplasia to Barrett's adenocarcinoma and is related to adenocarcinoma whose histology is well differentiated. This suggests that enhanced expression of COX-2 may occur early during Barrett's-associated neoplastic transformation.

Published
2003
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17. Searching for a link between the L-BMAA neurotoxin and amyotrophic lateral sclerosis: a study protocol of the French BMAALS programme

Author

Delzor, A., primary, Couratier, P., additional, Boumediene, F., additional, Nicol, M., additional, Druet-Cabanac, M., additional, Paraf, F., additional, Mejean, A., additional, Ploux, O., additional, Leleu, J.-P., additional, Brient, L., additional, Lengronne, M., additional, Pichon, V., additional, Combes, A., additional, El Abdellaoui, S., additional, Bonneterre, V., additional, Lagrange, E., additional, Besson, G., additional, Bicout, D. J., additional, Boutonnat, J., additional, Camu, W., additional, Pageot, N., additional, Juntas-Morales, R., additional, Rigau, V., additional, Masseret, E., additional, Abadie, E., additional, Preux, P.-M., additional, and Marin, B., additional

Published
2014
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19. KRAS gene amplification in colorectal cancer and impact on response to EGFR-targeted therapy

Author

Valtorta, E., Misale, S., Sartore-Bianchi, A., Nagtegaal, I.D., Paraf, F., Lauricella, C., Dimartino, V., Hobor, S., Jacobs, B., Ercolani, C., Lamba, S., Scala, E., Veronese, S., Laurent-Puig, P., Siena, S. Di, Tejpar, S., Mottolese, M., Punt, C.J.A., Gambacorta, M., Bardelli, A., Nicolantonio, F. Di, Valtorta, E., Misale, S., Sartore-Bianchi, A., Nagtegaal, I.D., Paraf, F., Lauricella, C., Dimartino, V., Hobor, S., Jacobs, B., Ercolani, C., Lamba, S., Scala, E., Veronese, S., Laurent-Puig, P., Siena, S. Di, Tejpar, S., Mottolese, M., Punt, C.J.A., Gambacorta, M., Bardelli, A., and Nicolantonio, F. Di

Abstract

Contains fulltext : 127308pub.pdf (publisher's version ) (Closed access), KRAS mutations are the most common oncogenic event in colorectal cancer (CRC) progression and their occurrence is associated with lack of response to anti epidermal growth factor receptor (EGFR) targeted therapies. Using preclinical models and patients' samples we recently reported that the emergence of KRAS mutations but also KRAS amplification is associated with acquired resistance to the EGFR inhibitors cetuximab or panitumumab. We reasoned that KRAS amplification may also be responsible for primary resistance to these agents. Furthermore, while the prevalence of KRAS mutations has been well established in CRC, little is known about the frequency of KRAS amplification in large CRC series. We performed a screening of 1,039 CRC samples to assess the prevalence of KRAS amplification in this tumor type and further evaluated the role of this genetic alteration on the sensitivity to anti EGFR therapies. We detected KRAS amplification in 7/1,039 (0.67%) and 1/102 evaluable CRC specimens and cell lines, respectively. KRAS amplification was mutually exclusive with KRAS mutations. Tumors or cell lines harboring this genetic lesion are not responsive to anti-EGFR inhibitors. Although KRAS amplification is an infrequent event in CRC, it might be responsible for precluding response to anti-EGFR treatment in a small proportion of patients.

Published
2013

20. [Epidural non-Hodgkin's lymphoma presenting as a spinal cord compression]

Author

Petit B, Roche I, Paraf F, Jaccard A, Mp, Boncoeur, Jj, Moreau, Bordessoule D, and Francois Labrousse

Subjects
Adult, Male, Lymphoma, B-Cell, Radiotherapy, Antineoplastic Agents, Middle Aged, Combined Modality Therapy, Immunohistochemistry, Survival Rate, Humans, Female, Epidural Neoplasms, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Follicular, Spinal Cord Compression, Aged, Neoplasm Staging
Abstract

epidural localization is a rare presenting sign of non Hodgkin's lymphoma. In this study, we describe the clinical, histological and immunohistochemical data in 13 cases (9 men and 4 women) of non-Hodgkin's lymphoma with epidural involvement.the median age was 63 years (range 36-76 years). Clinically, most patients complained of back pain (median duration, 3.4 months) followed by acute neurological deterioration. In 10 out of 13 tumors, a thoracic localization was observed and a decompressive laminectomy was performed in all cases. Histology and immunohistochemistry showed all tumors to be B-cell lymphomas which were classified as: lymphocytic lymphoma (3 cases), prolymphocytic lymphoma (1 case), follicular lymphoma (2 cases), diffuse large cell lymphoma (6 cases) and AIDS associated Burkitt lymphoma (1 case). Post-operative staging revealed bone and/or paravertebral involvement in 11 cases and disseminated disease in 5 cases. Median survival following complementary therapy, radiotherapy and chemotherapy in most cases, was 20 months.histological features of epidural lymphomas are similar to other extranodal lymphomas and their prognosis is better than other epidural neoplasms, especially when the tumor is localized.

Published
2001

21. [External iliac artery endofibrosis of the cyclist]

Author

Paraf F, Petit B, Roux J, Bertin F, Laskar M, and Francois Labrousse

Subjects
Adult, Male, Humans, Arterial Occlusive Diseases, Fibrosis, Iliac Artery, Bicycling
Abstract

Arterial endofibrosis is a rare disease usually affecting the external iliac artery in highly trained athletes. We report a case of bilateral external iliac endofibrosis in a 44-year-old cyclist. Microscopic examination of the resection specimen showed an isolated thickening of the arterial intima, and confirmed the diagnosis of this entity of unknown etiology.

Published
2000

22. [A misleading spinal metastasis]

Author

Petit B, Paraf F, Colombeau P, and Francois Labrousse

Subjects
Diagnosis, Differential, Male, Spinal Neoplasms, Laminectomy, Humans, Prostatic Neoplasms, Adenocarcinoma, Immunohistochemistry, Aged, Carcinoembryonic Antigen
Published
2000

29. Pituitary adenylate cyclase activating peptide and its receptors are expressed in human neuroblastomas.

Author

Vertongen, Pascale, Devalck, Christine, Sariban, Eric, De Laet, Marc-Henri, Martelli, H, Paraf, F, Hélardot, P, Robberecht, Patrick, Vertongen, Pascale, Devalck, Christine, Sariban, Eric, De Laet, Marc-Henri, Martelli, H, Paraf, F, Hélardot, P, and Robberecht, Patrick

Abstract

Vasoactive intestinal peptide (VIP) has been considered as an autocrine growth factor in neuroblastomas. Pituitary adenylate cyclase activating polypeptides (PACAPs) are newly recognized members of the VIP family of neurohormones. As compared to VIP, PACAP has been reported to be biologically more potent and more efficient in tissues expressing selective PACAP receptors rather than common VIP/PACAP receptors. PACAPs and VIP interact with the same affinity and stimulate adenylate cyclase activity with the same efficacy and potency on the VIP receptors, but PACAPs act also on a more selective PACAP receptor that also recognizes VIP but with a 100- to 1,000-fold lower affinity. Thus, depending on the type of receptors expressed at a cell surface, PACAP may be more potent and efficient than VIP. The capacity of 22 surgical specimens of neuroblastomas and of 5 established cell lines to synthesize PACAP and VIP and to synthesize and express PACAP receptors and VIP receptors was studied. Using the reverse transcriptase-polymerase chain (RT-PCR) method with specific primers, we detected the mRNAs coding for PACAP and VIP in 19 and 3 out of 22 samples, respectively. PACAP mRNA was expressed in 3 of the 5 cell lines studied and VIP mRNA in 4. Using the same techniques, PACAP and VIP receptors mRNA were detected in 21, and 13 of the 22 tumor samples and in 5 and 1 of the cell lines studied, respectively. The expression of the PACAP receptor was demonstrated by direct binding studies and/or by the relative potency of PACAPs and VIP to stimulate adenylate cyclase activity in 16 of the 22 tumors and in all the cell lines. In addition, there was no correlation between tumor stage and the expression of mRNA coding for the peptides and the receptors. The present results demonstrated that PACAP could also be a candidate as an autocrine regulator of neuroblastoma which a higher activity than VIP., Journal Article, Research Support, Non-U.S. Gov't, SCOPUS: ar.j, FLWIN, info:eu-repo/semantics/published

Published
1996

34. Local staging of prostate cancer by endorectal MRI using fast spin-echo sequences: prospective correlation with pathological findings after radical prostatectomy

Author

Cornud, F., primary, Belin, X., additional, Flam, T., additional, Chretien, Y., additional, Deslignieres, S., additional, Paraf, F., additional, Casanova, J.M., additional, Thiounn, N., additional, Helenon, O., additional, Debre, B., additional, Dufour, B., additional, and Moreau, J.F., additional

Published
1996
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40. Reply

Author

Poynard, T., primary, Aubert, A., additional, Bedossa, P., additional, Abella, A., additional, Naveau, S., additional, Paraf, F., additional, and Chaput, J.C., additional

Published
1991
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41. Molecular study of an IgG1κ cryoglobulin yielding organized microtubular deposits and glomerulonephritis in the course of chronic lymphocytic leukaemia.

Author

GALEA, H. R., BRIDOUX, F., ALDIGIER, J.-C., PARAF, F., BORDESSOULE, D., TOUCHARD, G., and COGNÉ, M.

Subjects
CRYOGLOBULINS, GLOMERULONEPHRITIS, CHRONIC lymphocytic leukemia, IMMUNOGLOBULINS
Abstract

SUMMARY Glomerulonephritis with organized microtubular monoclonal immunoglobulin deposits (GOMMID) and glomerulonephritis related to type I cryoglobulin are well-known but rare complications of B cell derived chronic lymphocytic leukaemia. In these disorders, monoclonal Ig have never been studied at the molecular level. We conducted a pathological and molecular analysis in a patient with chronic lymphocytic leukaemia, glomerulonephritis and a single circulating monoclonal Ig. Unusual IgG1κ kidney deposits were observed. The heavy and light chain variable region sequences of that cryoprecipitating monoclonal Ig were characterized. Light microscopy revealed glomerulonephritis typical of cryoglobulinaemia, with neutrophil and macrophage infiltration, endocapillary hyperplasia and few protein thrombi. Electron microscopic study clearly evidenced numerous subepithelial mixed granular and organized deposits with a unique microtubular organization, reminiscent of the GOMMID. The Ig molecule sequence revealed alterations of charge and hydrophobicity potentially promoting a crystal-like aggregation and the aggregation of microtubules.This description suggests that common mechanisms are involved in various forms of precipitation and/or deposition of complete Ig molecules, with a variable extent of organization and with a possible overlap between pathological patterns of either glomerulonephritis with microtubular deposits or type I cryoglobulinic glomerulonephritis. [ABSTRACT FROM AUTHOR]

Published
2002
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42. 220: A Web-Based Pilot Study of Inter-Pathologist Reproducibility Using the ISHLT 2004 Classification System for Biopsy Diagnosis of Acute Cardiac Allograft Rejection: The European Experience on Behalf of the Transplant Working Group of the Association for European Cardiovascular Pathology

Author

Angelini, A., Andersen, C., Bartoloni, G., Black, F., Bishop, P., Doran, H., Fedrigo, M., Fries, J., Goddard, M., Goebel, H., Neil, D., Leone, O., Marzullo, A., Ortmann, M., Paraf, F., Rotman, S., Turhan, N., Frigo, A.C., Grigoletto, F., Gasparetto, A., Mencarelli, R., Thiene, G., and Burke, M.

Published
2010
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43. Intraoperative localization of neuroblastoma in children with 123I- or 125I-radiolabeled metaiodobenzylguanidine

Author

Martelli, H., Ricard, M., Larroquet, M., Wioland, M., Paraf, F., Fabre, M., Josset, P., Helardot, P.G., Gauthier, F., Terrier-Lacombe, M.J., Michon, J., Hartmann, O., Tabone, M.D., Patte, C., Lumbroso, J., and Gruner, M.

Abstract

Background: This study describes a novel method of intraoperative localization of neuroblastoma with a gamma-detecting probe, to detect in situ tumor binding of radiolabeled ^1^2^3I- or ^1^2^5I-metaiodobenzylguanidine (MIBG) and improve the quality of tumor resection. Methods: Fifty-eight children underwent 66 surgical procedures with intraoperative detection of radiolabeled MIBG. All patients with positive MIBG scintiscans at diagnosis were included in the study. A tumor/background ratio exceeding 2:1 at the time of operation was considered positive, indicating a significant uptake of MIBG, compatible with the presence of malignant cells. The surgeons were requested to evaluate the contribution of the method to the surgical procedure. Sensitivity and specificity of the method with either ^1^2^3I-labeled MIBG or ^1^2^5I-labeled MIBG, on the basis of correlations between probe findings and pathologic analysis of 288 resected specimens, were determined. Results: Intraoperative detection was helpful in 65% of surgical procedures, allowing a better definition of tumor limits and extension to locoregional nodes or detection of small and nonpalpable tumors in sites with difficult surgical access, especially during operation for relapse. The detection was not contributory in 35% of the procedures (well-localized tumors, thoracic neuroblastoma for technical reasons, highly differentiated tumors as ganglioneuroma, and tumors with mainly necrosis or fibrosis). The sensitivity of ^1^2^3I and ^1^2^5I was the same (91% and 92%), but the specificity of ^1^2^5I (85%) was significantly higher than that of ^1^2^3I (55%) (p < 0.005). Conclusions: First, this study demonstrates the feasibility of intraoperative detection, with radiolabeled MIBG, of neuroblastoma in children. We advocate the use of ^1^2^5I rather than ^1^2^3I. Second, the method is useful to improve the quality of macroscopic resection in widespread neuroblastoma with nodal involvement, in sites with difficult access, and in operations for relapse. (Surgery 1998;123:51-7.)

Published
1998
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45. « Complètement dément?... »

Author

Liozon, E., Soria, P., Paraf, F., Riche, A., Bernard, C., Kim Heang Ly, Loustaud, V., Vidal, E., and Chassagne, P.

46. [Pancreatic neuroendocrine tumors and von Hippel-Lindau disease]

Author

Musso C, Paraf F, Petit B, Archambeaud-Mouveroux F, Valleix D, and Francois Labrousse

Subjects
Adult, Diagnosis, Differential, Pancreatic Neoplasms, Neuroendocrine Tumors, von Hippel-Lindau Disease, Adrenal Gland Neoplasms, Humans, Female, Neoplasms, Second Primary, Pheochromocytoma
Abstract

Pancreatic neuroendocrine tumors are rare in von Hippel-Lindau disease, most often asymptomatic, nonfunctioning, non secreting, and benign. We report a case of low grade malignant pancreatic, secreting and asymptomatic neuroendocrine tumors, occurring in a 27 year old woman in the setting von Hippel-Lindau disease with recurrent pheochromocytoma, retinal and medullary hemangioblastomas, paraganglioma of the carotid body and ovarian cystadenoma. Neuroendocrine pancreatic tumors of von Hippel-Lindau disease are often constituted by clear cells, in the contrary of other neuroendocrine tumors of the pancreas. Occurrence of a pancreatic neuroendocrine tumor, especially in association with pheochromocytoma, may be misdiagnosed with a type 2 multiple endocrine neoplasia syndrom instead of von Hippel-Lindau disease.

48. Renal lesions and pheochromocytoma in von Hippel-Lindau disease

Author

Stéphane RICHARD, Chauveau, D., Chrétien, Y., Beigelman, C., Denys, A., Fendler, J. P., Fromont, G., Paraf, F., Hélénon, O., and Nizard, S.

Subjects
Adult, Male, Polycystic Kidney Diseases, von Hippel-Lindau Disease, Adolescent, Adrenal Gland Neoplasms, Pheochromocytoma, Adenocarcinoma, Middle Aged, Kidney Neoplasms, Pedigree, Diagnosis, Differential, Humans, Female, Kidney Diseases, Carcinoma, Renal Cell, Aged

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