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627 results on '"Parameswaran, Narayanan"'

5. Approach to fever in children

Author

Jayashree, Muralidharan, Parameswaran, Narayanan, Nallasamy, Karthi, Chidambaram, Aakash Chandran, Rajasegar, Raajashri, Dhodapkar, Rahul, Chhabra, Mala, Gupta, Nivedita, Kaur, Harmanmeet, Velayudhan, Anoop, Deol, Saumya, Lodha, Rakesh, Vasanthapuram, Ravi, Verghese, Valsan Philip, and Rose, Winsley

Published
2024
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23. Probiotics in Gut-Bone Signaling

Author

Schepper, Jonathan D., Irwin, Regina, Kang, Jun, Dagenais, Kevin, Lemon, Tristan, Shinouskis, Ally, Parameswaran, Narayanan, McCabe, Laura R., COHEN, IRUN R., Series editor, LAJTHA, ABEL, Series editor, LAMBRIS, JOHN D., Series editor, PAOLETTI, RODOLFO, Series editor, REZAEI, NIMA, Series editor, McCabe, Laura R., editor, and Parameswaran, Narayanan, editor

Published
2017
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24. Epithelial Barrier Function in Gut-Bone Signaling

Author

Rios-Arce, Naiomy Deliz, Collins, Fraser L., Schepper, Jonathan D., Steury, Michael D., Raehtz, Sandi, Mallin, Heather, Schoenherr, Danny T., Parameswaran, Narayanan, McCabe, Laura R., COHEN, IRUN R., Series editor, LAJTHA, ABEL, Series editor, LAMBRIS, JOHN D., Series editor, PAOLETTI, RODOLFO, Series editor, REZAEI, NIMA, Series editor, McCabe, Laura R., editor, and Parameswaran, Narayanan, editor

Published
2017
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25. Immunology of Gut-Bone Signaling

Author

Collins, Fraser L., Schepper, Jonathan D., Rios-Arce, Naiomy Deliz, Steury, Michael D., Kang, Ho Jun, Mallin, Heather, Schoenherr, Daniel, Camfield, Glen, Chishti, Saima, McCabe, Laura R., Parameswaran, Narayanan, COHEN, IRUN R., Series editor, LAJTHA, ABEL, Series editor, LAMBRIS, JOHN D., Series editor, PAOLETTI, RODOLFO, Series editor, REZAEI, NIMA, Series editor, McCabe, Laura R., editor, and Parameswaran, Narayanan, editor

Published
2017
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26. GRK2 suppresses lymphomagenesis by inhibiting the MALT1 proto-oncoprotein

Author

Cheng, Jing, Klei, Linda R., Hubel, Nathaniel E., Zhang, Ming, Schairer, Rebekka, Maurer, Lisa M., Klei, Hanna B., Kang, Heejae, Concel, Vincent J., Delekta, Phillip C., Dang, Eric V., Mintz, Michelle A., Baens, Mathijs, Cyster, Jason G., Parameswaran, Narayanan, Thome, Margot, Lucas, Peter C., and McAllister-Lucas, Linda M.

Subjects
Proteases, Protein binding, Non-Hodgkin's lymphomas, Immune response, Antigens, B cells, G proteins, Membrane proteins, Health care industry
Abstract

Antigen receptor-dependent (AgR-dependent) stimulation of the NF-[kappa]B transcription factor in lymphocytes is a required event during adaptive immune response, but dysregulated activation of this signaling pathway can lead to lymphoma. AgR stimulation promotes assembly of the CARMA1-BCL10-MALT1 complex, wherein MALT1 acts as (a) a scaffold to recruit components of the canonical NF-[kappa]B machinery and (b) a protease to cleave and inactivate specific substrates, including negative regulators of NF-[kappa]B. In multiple lymphoma subtypes, malignant B cells hijack AgR signaling pathways to promote their own growth and survival, and inhibiting MALT1 reduces the viability and growth of these tumors. As such, MALT1 has emerged as a potential pharmaceutical target. Here, we identified G protein-coupled receptor kinase 2 (GRK2) as a new MALT1-interacting protein. We demonstrated that GRK2 binds the death domain of MALT1 and inhibits MALT1 scaffolding and proteolytic activities. We found that lower GRK2 levels in activated B cell-type diffuse large B cell lymphoma (ABC-DLBCL) are associated with reduced survival, and that GRK2 knockdown enhances ABC-DLBCL tumor growth in vitro and in vivo. Together, our findings suggest that GRK2 can function as a tumor suppressor by inhibiting MALT1 and provide a roadmap for developing new strategies to inhibit MALT1-dependent lymphomagenesis., Introduction Diffuse large B cell lymphoma (DLBCL) is the most frequent subtype of non-Hodgkin lymphoma (NHL), accounting for 30%-40% of newly diagnosed cases (1). With more than 20,000 deaths from [...]

Published
2020
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29. A rare cause of acute febrile encephalopathy in a four year old boy-A case report with review of literature

Author

Sugumar, Kiruthiga, Srinivasan, Vaishnavi, Chidambaram, Aakash, Gunasekaran, Dhandapany, Chandrasekaran, Venkatesh, Parameswaran, Narayanan, and Srinivas, Bheemanathi

Subjects
Encephalopathy -- Case studies -- Causes of, Fever in children -- Case studies -- Causes of, Central nervous system diseases -- Case studies -- Complications and side effects, Pediatric research, Health
Abstract

Byline: Kiruthiga. Sugumar, Vaishnavi. Srinivasan, Aakash. Chidambaram, Dhandapany. Gunasekaran, Venkatesh. Chandrasekaran, Narayanan. Parameswaran, Bheemanathi. Srinivas A 4-year-old developmentally normal boy was brought with complaints of fever and vomiting of one [...]

Published
2022

38. Introduction to Ramps

Author

Parameswaran, Narayanan, Spielman, William S., Spielman, William S., editor, and Parameswaran, Narayanan, editor

Published
2012
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49. SERUM LEVELS OF COPPER AND IRON IN DENGUE FEVER

Author

Rajendiran SOUNDRAVALLY, Jacob SHERIN, Balakrishna Pillai AGIESHKUMAR, Mariya Samadanam DAISY, Cherupanakkal CLEETUS, Parameswaran NARAYANAN, Tamilarasu KADHIRAVAN, Sistla SUJATHA, and Kottyen Thazhath HARICHANDRAKUMAR

Subjects
Copper, Iron, Trace elements, Dengue severity, Dengue fever, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

SUMMARY The role of trace elements in dengue virulence is not yet known. The present study assessed the serum levels of two micronutrients, copper and iron, in cases of dengue fever. The study involved 96 patients of whom 48 had either severe or non-severe forms of dengue (with and without warning signs), and the remaining 48 were patients with other febrile illnesses (OFI), used as controls. Serum levels of copper and iron were evaluated at admission and by the time of defervescence using commercially available kits. At admission, no difference in the level of serum copper was observed between cases and controls. In the group of dengue cases, the copper level was found to be significantly decreased in severe and non-severe cases with warning signs, compared to non-severe cases without warning signs. In contrast, by the time of defervescence the copper level was found to be increased in all dengue cases compared to OFI controls, but no difference was observed among dengue cases. Unlike OFI controls, dengue cases showed an increasing pattern of copper levels from admission until defervescence. On the other hand, no such significant differences were observed in the serum level of iron in the clinical groups, except for a decreased iron level found in severe cases, compared to non-severe dengue without warning signs. The results show that copper is associated with dengue severity and this finding emphasizes the need to investigate the involvement of trace elements in disease severity so as to improve the prognosis of dengue.

Published
2015
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