Search

Your search keyword '"Parini A"' showing total 8,151 results
Start Over Author "Parini A"
8,151 results on '"Parini A"'

2. Ezrin, radixin, and moesin are dispensable for macrophage migration and cellular cortex mechanics

Author

Verdys, Perrine, Rey Barroso, Javier, Girel, Adeline, Vermeil, Joseph, Bergert, Martin, Sanchez, Thibaut, Métais, Arnaud, Mangeat, Thomas, Bellard, Elisabeth, Bigot, Claire, Astarie-Dequeker, Catherine, Labrousse, Arnaud, Girard, Jean-Philippe, Maridonneau-Parini, Isabelle, Vérollet, Christel, Lagarrigue, Frédéric, Diz-Muñoz, Alba, Heuvingh, Julien, Piel, Matthieu, du Roure, Olivia, Le Cabec, Véronique, Carréno, Sébastien, and Poincloux, Renaud

Published
2024
Full Text
View/download PDF

6. Uniqueness of least energy solutions to the fractional Lane-Emden equation in the ball

Author

DelaTorre, Azahara and Parini, Enea

Subjects
Mathematics - Analysis of PDEs
Abstract

We prove uniqueness of least-energy solutions to the fractional Lane-Emden equation, under homogeneous Dirichlet exterior conditions, when the underlying domain is a ball $B \subset \mathbb{R}^N$. The equation is characterized by a superlinear, subcritical power-like nonlinearity. The proof makes use of Morse theory and is inspired by some results obtained by C. S. Lin in the '90s. A new Hopf's Lemma-type result shown in this paper is an essential element in the proof of nondegeneracy of least-energy solutions., Comment: We corrected some minor issues of the previous version. The statement of the main theorem has been modified

Published
2023

8. Effect of red yeast rice combined with antioxidants on lipid pattern, hs-CRP level, and endothelial function in moderately hypercholesterolemic subjects

Author

Cicero AF, Morbini M, Parini A, Urso R, Rosticci M, Grandi E, and Borghi C

Subjects
Monacolins, LDL-cholesterol, metalloproteinases, high-sensitivity C-reactive protein, nutraceutical, clinical trial, Therapeutics. Pharmacology, RM1-950
Abstract

Arrigo F G Cicero, Martino Morbini, Angelo Parini, Riccardo Urso, Martina Rosticci, Elisa Grandi, Claudio Borghi Medical and Surgical Sciences Department, University of Bologna, Bologna, Italy Abstract: Our aim was to test, through a crossover, double-blind, placebo-controlled randomized clinical trial, if a short-term treatment with 10 mg monacolins combined with antioxidants could improve lipid pattern, high-sensitivity C-reactive protein (hs-CRP), and endothelial function in a small cohort of moderately hypercholesterolemic subjects. Thus, 25 healthy, moderately hypercholesterolemic subjects were consecutively enrolled and, after 4 weeks of stabilization diet, were randomized to the sequence placebo followed by a washout, monacolins or monacolins followed by a washout, placebo, with each period being 4 weeks long. At each study step, a complete lipid pattern, safety parameters, hs-CRP, and endothelial function have been measured. When compared to the placebo phase, during monacolin treatment, patients experienced a more favorable percentage change in total cholesterol (TC) (TC after monacolin treatment, -18.35%; TC after placebo treatment, -5.39%), low-density lipoprotein cholesterol (LDL-C) (LDL after monacolin treatment, -22.36%; LDL after placebo treatment, -1.38%), non-high-density lipoprotein cholesterol (HDL-C) (non-HDL after monacolin treatment, -22.83%; non-HDL after placebo treatment: -7.15%), hs-CRP (hs-CRP after monacolin treatment: -2.33%; hs-CRP after placebo treatment, 2.11%), and endothelial function (pulse volume displacement after monacolin treatment, 18.59%; pulse volume displacement after placebo treatment, -6.69%). No significant difference was observed with regard to triglycerides, HDL-cholesterol, and safety parameters. On the basis of our data, we could demonstrate that a 10 mg monacolin nutraceutical treatment appears to safely reduce cholesterolemia, hs-CRP, and markers of vascular remodeling in moderately hypercholesterolemic subjects. These results need to be confirmed in larger patient samples and in studies with longer duration. Keywords: monacolins, LDL-cholesterol, metalloproteinases, high-sensitivity C-reactive protein, nutraceutical, clinical trial

Published
2016

9. Enhanced perioperative care in emergency general surgery: the WSES position paper.

Author

Ceresoli, Marco, Braga, Marco, Zanini, Nicola, Abu-Zidan, Fikri, Parini, Dario, Langer, Thomas, Sartelli, Massimo, Damaskos, Dimitrios, Biffl, Walter, Amico, Francesco, Ansaloni, Luca, Balogh, Zsolt, Bonavina, Luigi, Civil, Ian, Cicuttin, Enrico, Chirica, Mircea, Cui, Yunfeng, De Simone, Belinda, Di Carlo, Isidoro, Fette, Andreas, Foti, Giuseppe, Fogliata, Michele, Fraga, Gustavo, Fugazzola, Paola, Galante, Joseph, Beka, Solomon, Hecker, Andreas, Jeekel, Johannes, Kirkpatrick, Andrew, Koike, Kaoru, Leppäniemi, Ari, Marzi, Ingo, Moore, Ernest, Picetti, Edoardo, Pikoulis, Emmanouil, Pisano, Michele, Podda, Mauro, Sakakushev, Boris, Shelat, Vishal, Tan, Edward, Tebala, Giovanni, Velmahos, George, Weber, Dieter, Agnoletti, Vanni, Kluger, Yoram, Baiocchi, Gianluca, Catena, Fausto, and Coccolini, Federico

Subjects
Humans, Perioperative Care, Elective Surgical Procedures
Abstract

Enhanced perioperative care protocols become the standard of care in elective surgery with a significant improvement in patients outcome. The key element of the enhanced perioperative care protocol is the multimodal and interdisciplinary approach targeted to the patient, focused on a holistic approach to reduce surgical stress and improve perioperative recovery. Enhanced perioperative care in emergency general surgery is still a debated topic with little evidence available. The present position paper illustrates the existing evidence about perioperative care in emergency surgery patients with a focus on each perioperative intervention in the preoperative, intraoperative and postoperative phase. For each item was proposed and approved a statement by the WSES collaborative group.

Published
2023

10. Strategies to prevent blood loss and reduce transfusion in emergency general surgery, WSES-AAST consensus paper

Author

Coccolini, Federico, Shander, Aryeh, Ceresoli, Marco, Moore, Ernest, Tian, Brian, Parini, Dario, Sartelli, Massimo, Sakakushev, Boris, Doklestich, Krstina, Abu-Zidan, Fikri, Horer, Tal, Shelat, Vishal, Hardcastle, Timothy, Bignami, Elena, Kirkpatrick, Andrew, Weber, Dieter, Kryvoruchko, Igor, Leppaniemi, Ari, Tan, Edward, Kessel, Boris, Isik, Arda, Cremonini, Camilla, Forfori, Francesco, Ghiadoni, Lorenzo, Chiarugi, Massimo, Ball, Chad, Ottolino, Pablo, Hecker, Andreas, Mariani, Diego, Melai, Ettore, Malbrain, Manu, Agostini, Vanessa, Podda, Mauro, Picetti, Edoardo, Kluger, Yoram, Rizoli, Sandro, Litvin, Andrey, Maier, Ron, Beka, Solomon Gurmu, De Simone, Belinda, Bala, Miklosh, Perez, Aleix Martinez, Ordonez, Carlos, Bodnaruk, Zenon, Cui, Yunfeng, Calatayud, Augusto Perez, de Angelis, Nicola, Amico, Francesco, Pikoulis, Emmanouil, Damaskos, Dimitris, Coimbra, Raul, Chirica, Mircea, Biffl, Walter L., and Catena, Fausto

Published
2024
Full Text
View/download PDF

11. Management of intra-abdominal infections: recommendations by the Italian council for the optimization of antimicrobial use

Author

Sartelli, Massimo, Tascini, Carlo, Coccolini, Federico, Dellai, Fabiana, Ansaloni, Luca, Antonelli, Massimo, Bartoletti, Michele, Bassetti, Matteo, Boncagni, Federico, Carlini, Massimo, Cattelan, Anna Maria, Cavaliere, Arturo, Ceresoli, Marco, Cipriano, Alessandro, Cortegiani, Andrea, Cortese, Francesco, Cristini, Francesco, Cucinotta, Eugenio, Dalfino, Lidia, De Pascale, Gennaro, De Rosa, Francesco Giuseppe, Falcone, Marco, Forfori, Francesco, Fugazzola, Paola, Gatti, Milo, Gentile, Ivan, Ghiadoni, Lorenzo, Giannella, Maddalena, Giarratano, Antonino, Giordano, Alessio, Girardis, Massimo, Mastroianni, Claudio, Monti, Gianpaola, Montori, Giulia, Palmieri, Miriam, Pani, Marcello, Paolillo, Ciro, Parini, Dario, Parruti, Giustino, Pasero, Daniela, Pea, Federico, Peghin, Maddalena, Petrosillo, Nicola, Podda, Mauro, Rizzo, Caterina, Rossolini, Gian Maria, Russo, Alessandro, Scoccia, Loredana, Sganga, Gabriele, Signorini, Liana, Stefani, Stefania, Tumbarello, Mario, Tumietto, Fabio, Valentino, Massimo, Venditti, Mario, Viaggi, Bruno, Vivaldi, Francesca, Zaghi, Claudia, Labricciosa, Francesco M., Abu-Zidan, Fikri, Catena, Fausto, and Viale, Pierluigi

Published
2024
Full Text
View/download PDF

13. Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago

Author

Perrone, Gennaro, Giuffrida, Mario, Abu-Zidan, Fikri, Kruger, Vitor F., Livrini, Marco, Petracca, Gabriele Luciano, Rossi, Giorgio, Tarasconi, Antonio, Tian, Brian W. C. A., Bonati, Elena, Mentz, Ricardo, Mazzini, Federico N., Campana, Juan P., Gasser, Elisabeth, Kafka-Ritsch, Reinhold, Felsenreich, Daniel M., Dawoud, Christopher, Riss, Stefan, Gomes, Carlos Augusto, Gomes, Felipe Couto, Gonzaga, Ricardo Alessandro Teixeira, Canton, Cassio Alfred Brattig, Pereira, Bruno Monteiro, Fraga, Gustavo P., Zem, Leticia Gonçalves, Cordeiro-Fonseca, Vinicius, de Mesquita Tauil, Renato, Atanasov, Boyko, Belev, Nikolay, Kovachev, Nikola, Meléndez, L. Juan José, Dimova, Ana, Dimov, Stefan, Zelić, Zdravko, Augustin, Goran, Bogdanić, Branko, Morić, Trpimir, Chouillard, Elie, Bajul, Melinda, De Simone, Belinda, Panis, Yves, Esposito, Francesco, Notarnicola, Margherita, Lauka, Lelde, Fabbri, Anna, Hentati, Hassen, Fnaiech, Iskander, Aurélien, Venara, Bougard, Marie, Roulet, Maxime, Demetrashvili, Zaza, Pipia, Irakli, Merabishvili, Giorgi, Bouliaris, Konstantinos, Koukoulis, Georgios, Doudakmanis, Christos, Xenaki, Sofia, Chrysos, Emmanuel, Kokkinakis, Stamatios, Vassiliu, Panteleimon, Michalopoulos, Nikolaos, Margaris, Ioannis, Kechagias, Aristotelis, Avgerinos, Konstantinos, Katunin, Jevgeni, Lostoridis, Eftychios, Nagorni, Eleni-Aikaterini, Pujante, Antonio, Mulita, Francesk, Maroulis, Ioannis, Vailas, Michail, Marinis, Athanasios, Siannis, Ioannis, Bourbouteli, Eirini, Manatakis, Dimitrios K., Tasis, Nikolaos, Acheimastos, Vasileios, Maria, Sotiropoulou, Stylianos, Kapiris, Kuzeridis, Harilaos, Korkolis, Dimitrios, Fradelos, Evangelos, Kavalieratos, George, Petropoulou, Thalia, Polydorou, Andreas, Papacostantinou, Ioannis, Triantafyllou, Tania, Kimpizi, Despina, Theodorou, Dimitrios, Toutouzas, Konstantinos, Chamzin, Alexandros, Frountzas, Maximos, Schizas, Dimitrios, Karavokyros, Ioannis, Syllaios, Athanasios, Charalabopoulos, Alexandros, Boura, Maria, Baili, Efstratia, Ioannidis, Orestis, Loutzidou, Lydia, Anestiadou, Elissavet, Tsouknidas, Ioannis, Petrakis, Georgios, Polenta, Eleni, Bains, Lovenish, Gupta, Rahul, Singh, Sudhir K., Khanduri, Archana, Bala, Miklosh, Kedar, Asaf, Pisano, Marcello, Podda, Mauro, Pisanu, Adolfo, Martines, Gennaro, Trigiante, Giuseppe, Lantone, Giuliano, Agrusa, Antonino, Di Buono, Giuseppe, Buscemi, Salvatore, Veroux, Massimiliano, Gioco, Rossella, Veroux, Gastone, Oragano, Luigi, Zonta, Sandro, Lovisetto, Federico, Feo, Carlo V., Pesce, Antonio, Fabbri, Nicolò, Lantone, Giulio, Marino, Fabio, Perrone, Fabrizio, Vincenti, Leonardo, Papagni, Vincenzo, Picciariello, Arcangelo, Rossi, Stefano, Picardi, Biagio, Del Monte, Simone Rossi, Visconti, Diego, Osella, Giulia, Petruzzelli, Luca, Pignata, Giusto, Andreuccetti, Jacopo, D’Alessio, Rossella, Buonfantino, Massimo, Guaitoli, Eleonora, Spinelli, Stefano, Sampietro, Gianluca Matteo, Corbellini, Carlo, Lorusso, Leonardo, Frontali, Alice, Pezzoli, Isabella, Bonomi, Alessandro, Chierici, Andrea, Cotsoglou, Christian, Manca, Giuseppe, Delvecchio, Antonella, Musa, Nicola, Casati, Massimiliano, Letizia, Laface, Abate, Emmanuele, Ercolani, Giorgio, D’Acapito, Fabrizio, Solaini, Leonardo, Guercioni, Gianluca, Cicconi, Simone, Sasia, Diego, Borghi, Felice, Giraudo, Giorgio, Sena, Giuseppe, Castaldo, Pasquale, Cardamone, Eugenia, Portale, Giuseppe, Zuin, Matteo, Spolverato, Ylenia, Esposito, Marialusia, Isernia, Roberta Maria, Di Salvo, Maria, Manunza, Romina, Esposito, Giuseppe, Agus, Marcello, Asti, Emanuele Luigi Giuseppe, Bernardi, Daniele Tiziano, Tonucci, Tommaso Panici, Luppi, Davide, Casadei, Massimiliano, Bonilauri, Stefano, Pezzolla, Angela, Panebianco, Annunziata, Laforgia, Rita, De Luca, Maurizio, Zese, Monica, Parini, Dario, Jovine, Elio, De Sario, Giuseppina, Lombardi, Raffaele, Aprea, Giovanni, Palomba, Giuseppe, Capuano, Marianna, Argenio, Giulio, Orio, Gianluca, Armellino, Mariano Fortunato, Troian, Marina, Guerra, Martina, Nagliati, Carlo, Biloslavo, Alan, Germani, Paola, Aizza, Giada, Monsellato, Igor, Chahrour, Ali Chaouki, Anania, Gabriele, Bombardini, Cristina, Bagolini, Francesco, Sganga, Gabriele, Fransvea, Pietro, Bianchi, Valentina, Boati, Paolo, Ferrara, Francesco, Palmieri, Francesco, Cianci, Pasquale, Gattulli, Domenico, Restini, Enrico, Cillara, Nicola, Cannavera, Alessandro, Nita, Gabriela Elisa, Sarnari, Jlenia, Roscio, Francesco, Clerici, Federico, Scandroglio, Ildo, Berti, Stefano, Cadeo, Alessandro, Filippelli, Alice, Conti, Luigi, Grassi, Carmine, Cattaneo, Gaetano Maria, Pighin, Marina, Papis, Davide, Gambino, Giovanni, Bertino, Vanessa, Schifano, Domenico, Prando, Daniela, Fogato, Luisella, Cavallo, Fabio, Ansaloni, Luca, Picheo, Roberto, Pontarolo, Nicholas, Depalma, Norma, Spampinato, Marcello, D’Ugo, Stefano, Lepre, Luca, Capponi, Michela Giulii, Campa, Rossella Domenica, Sarro, Giuliano, Dinuzzi, Vincenza Paola, Olmi, Stefano, Uccelli, Matteo, Ferrari, Davide, Inama, Marco, Moretto, Gianluigi, Fontana, Michele, Favi, Francesco, Picariello, Erika, Rampini, Alessia, Barberis, Andrea, Azzinnaro, Antonio, Oliva, Alba, Totaro, Luigi, Benzoni, Ilaria, Ranieri, Valerio, Capolupo, Gabriella Teresa, Carannante, Filippo, Caricato, Marco, Ronconi, Maurizio, Casiraghi, Silvia, Casole, Giovanni, Pantalone, Desire, Alemanno, Giovanni, Scheiterle, Maximilian, Ceresoli, Marco, Cereda, Marco, Fumagalli, Chiara, Zanzi, Federico, Bolzon, Stefano, Guerra, Enrico, Lecchi, Francesca, Cellerino, Paola, Ardito, Antonella, Scaramuzzo, Rosa, Balla, Andrea, Lepiane, Pasquale, Tartaglia, Nicola, Ambrosi, Antonio, Pavone, Giovanna, Palini, Gian Marco, Veneroni, Simone, Garulli, Gianluca, Ricci, Claudio, Torre, Beatrice, Russo, Iris Shari, Rottoli, Matteo, Tanzanu, Marta, Belvedere, Angela, Milone, Marco, Manigrasso, Michele, De Palma, Giovanni Domenico, Piccoli, Micaela, Pattacini, Gianmaria Casoni, Magnone, Stefano, Bertoli, Paolo, Pisano, Michele, Massucco, Paolo, Palisi, Marco, Luzzi, Andrea-Pierre, Fleres, Francesco, Clarizia, Guglielmo, Spolini, Alessandro, Kobe, Yoshiro, Toma, Takayuki, Shimamura, Fumihiko, Parker, Robert, Ranketi, Sinkeet, Mitei, Mercy, Svagzdys, Saulius, Pauzas, Henrikas, Zilinskas, Justas, Poskus, Tomas, Kryzauskas, Marius, Jakubauskas, Matas, Zakaria, Andee Dzulkarnaen, Zakaria, Zaidi, Wong, Michael Pak-Kai, Jusoh, Asri Che, Zakaria, Muhammad Nazreen, Cruz, Daniel Rios, Elizalde, Aurea Barbara Rodriguez, Reynaud, Alejandro Bañon, Hernandez, Edgard Efren Lozada, Monroy, Jose maria Victor Palomo, Hinojosa-Ugarte, Diego, Quiodettis, Martha, Du Bois, María Esther, Latorraca, José, Major, Piotr, Pędziwiatr, Michał, Pisarska-Adamczyk, Magdalena, Walędziak, Maciej, Kwiatkowski, Andrzej, Czyżykowski, Łukasz, da Costa, Silvia Dantas, Pereira, Bela, Ferreira, Ana Rita Oliveira, Almeida, Filipe, Rocha, Ricardo, Carneiro, Carla, Perez, Diego Pita, Carvas, João, Rocha, Catarina, Ferreira, Cátia, Marques, Rita, Fernandes, Urânia, Leao, Pedro, Goulart, André, Pereira, Rita Gonçalves, Patrocínio, Sara Daniela Direito, de Mendonça, Nuno Gonçalo Gonçalves, Manso, Maria Isabel Cerqueira, Morais, Henrique Manuel Cardoso, Cardoso, Paulo Sebastião, Calu, Valentin, Miron, Adrian, Toma, Elena Adelina, Gachabayov, Mahir, Abdullaev, Abakar, Litvin, Andrey, Nechay, Taras, Tyagunov, Alexander, Yuldashev, Anvar, Bradley, Alison, Wilson, Michael, Panyko, Arpád, Látečková, Zuzana, Lacko, Vladimír, Lesko, Dusan, Soltes, Marek, Radonak, Jozef, Turrado-Rodriguez, Victor, Termes-Serra, Roser, Morales-Sevillano, Xavier, Lapolla, Pierfrancesco, Mingoli, Andrea, Brachini, Gioia, Degiuli, Maurizio, Sofia, Silvia, Reddavid, Rossella, de Manzoni Garberini, Andrea, Buffone, Angelica, del Pozo, Eduardo Perea, Aparicio-Sánchez, Daniel, Dos Barbeito, Sandra, Estaire-Gómez, Mercedes, Vitón-Herrero, Rebeca, de los Ángeles Gil Olarte-Marquez, Mª, Gil-Martínez, José, Alconchel, Felipe, Nicolás-López, Tatiana, Rahy-Martin, Aida Cristina, Pelloni, María, Bañolas-Suarez, Raquel, Mendoza-Moreno, Fernando, Nisa, Francisca García-Moreno, Díez-Alonso, Manuel, Rodas, María Elisa Valle, Agundez, María Carmona, Andrés, María Inmaculada Pérez, Moreira, Claudia Cristina Lopes, Perez, Aintzane Lizarazu, Ponce, Iñigo Augusto, González-Castillo, Ana María, Membrilla-Fernández, Estela, Salvans, Silvia, Serradilla-Martín, Mario, Pardo, Pablo Sancho, Rivera-Alonso, Daniel, Dziakova, Jana, Huguet, Jose Mugüerza, Valle, Naila Pagès, Ruiz, Enrique Colás, Valcárcel, Cristina Rey, Moreno, Cristina Ruiz, Salazar, Yeniffer Tatiana Moreno, García, Juan Jesús Rubio, Micó, Silvia Sevila, López, Joaquín Ruiz, Farré, Silvia Pérez, Gomez, Maite Santamaria, Petit, Nuria Mestres, Titos-García, Alberto, Aranda-Narváez, Jose Manuel, Romacho-López, Laura, Sánchez-Guillén, Luis, Aranaz-Ostariz, Veronica, Bosch-Ramírez, Marina, Martínez-Pérez, Aleix, Martínez-López, Elías, Sebastián-Tomás, Juan Carlos, Jimenez-Riera, Granada, Jimenez-Vega, Javier, Cuellar, Jose Aurelio Navas, Campos-Serra, Andrea, Muñoz-Campaña, Anna, Gràcia-Roman, Raquel, Alegre, Javier Martínez, Pinto, Francisca Lima, O’Sullivan, Sara Nuñez, Antona, Francisco Blanco, Jiménez, Beatriz Muñoz, López-Sánchez, Jaime, Carmona, Zahira Gómez, Fernández, Rocio Torres, Sierra, Isabel Blesa, de León, Laura Román García, Moreno, Verónica Polaino, Iglesias, Eva, Cumplido, Paola Lora, Bravo, Altea Arango, Simó, Ignacio Rey, Domínguez, Carlota López, Caamaño, Aloia Guerreiro, Lozano, Rafael Calleja, Martínez, Manuel Durán, Torres, Álvaro Naranjo, de Quiros, Javier Tomas Morales Bernaldo, Pellino, Gianluca, Cloquell, Miriam Moratal, Moller, Elsa García, Jalal-Eldin, Sami, Abdoun, Ahmed K., Hamid, Hytham K. S., Lohsiriwat, Varut, Mongkhonsupphawan, Aitsariya, Baraket, Oussama, Ayed, Karim, Abbassi, Imed, Ali, Ali Ben, Ammar, Houssem, Kchaou, Ali, Tlili, Ahmed, Zribi, Imen, Colak, Elif, Polat, Suleyman, Koylu, Zehra Alan, Guner, Ali, Usta, Mehmet Arif, Reis, Murat Emre, Mantoglu, Baris, Gonullu, Emre, Akin, Emrah, Altintoprak, Fatih, Bayhan, Zulfu, Firat, Necattin, Isik, Arda, Memis, Ufuk, Bayrak, Mehmet, Altıntaş, Yasemin, Kara, Yasin, Bozkurt, Mehmet Abdussamet, Kocataş, Ali, Das, Koray, Seker, Ahmet, Ozer, Nazmi, Atici, Semra Demirli, Tuncer, Korhan, Kaya, Tayfun, Ozkan, Zeynep, Ilhan, Onur, Agackiran, Ibrahim, Uzunoglu, Mustafa Yener, Demirbas, Eren, Altinel, Yuksel, Meric, Serhat, Hacım, Nadir Adnan, Uymaz, Derya Salim, Omarov, Nail, Balık, Emre, Tebala, Giovanni D., Khalil, Hany, Rana, Mridul, Khan, Mansoor, Florence, Charlotte, Swaminathan, Christie, Leo, Cosimo Alex, Liasis, Lampros, Watfah, Josef, Trostchansky, Ivan, Delgado, Edward, Pontillo, Marcelo, Latifi, Rifat, Coimbra, Raul, Edwards, Sara, Lopez, Ana, Velmahos, George, Dorken, Ander, Gebran, Anthony, Palmer, Amanda, Oury, Jeffrey, Bardes, James M., Seng, Sirivan Suon, Coffua, Lauren S., Ratnasekera, Asanthi, Egodage, Tanya, Echeverria-Rosario, Karla, Armento, Isabella, Napolitano, Lena M., Sangji, Naveen F., Hemmila, Mark, Quick, Jacob A., Austin, Tyler R., Hyman, Theodore S., Curtiss, William, McClure, Amanda, Cairl, Nicholas, Biffl, Walter L., Truong, Hung P., Schaffer, Kathryn, Reames, Summer, Banchini, Filippo, Capelli, Patrizio, Coccolini, Federico, Sartelli, Massimo, Bravi, Francesca, Vallicelli, Carlo, Agnoletti, Vanni, Baiocchi, Gian Luca, and Catena, Fausto

Published
2024
Full Text
View/download PDF

14. Acute cholecystitis management in high-risk, critically ill, and unfit-for-surgery patients: the Italian Society of Emergency Surgery and Trauma (SICUT) guidelines

Author

Coccolini, Federico, Cucinotta, Eugenio, Mingoli, Andrea, Zago, Mauro, Altieri, Gaia, Biloslavo, Alan, Caronna, Roberto, Cengeli, Ismail, Cicuttin, Enrico, Cirocchi, Roberto, Cobuccio, Luigi, Costa, Gianluca, Cozza, Valerio, Cremonini, Camilla, Del Vecchio, Giovanni, Dinatale, Giuseppe, Fico, Valeria, Galatioto, Christian, Kuriara, Hayato, Lacavalla, Domenico, La Greca, Antonio, Larghi, Alberto, Mariani, Diego, Mirco, Paolo, Occhionorelli, Savino, Parini, Dario, Polistina, Francesco, Rimbas, Mihai, Sapienza, Paolo, Tartaglia, Dario, Tropeano, Giuseppe, Venezia, Piero, Venezia, Dario Francesco, Zaghi, Claudia, and Chiarugi, Massimo

Published
2024
Full Text
View/download PDF

15. The paradigm change from reactive medical services to 3PM in ischemic stroke: a holistic approach utilising tear fluid multi-omics, mitochondria as a vital biosensor and AI-based multi-professional data interpretation

Author

Golubnitschaja, Olga, Polivka, Jr., Jiri, Potuznik, Pavel, Pesta, Martin, Stetkarova, Ivana, Mazurakova, Alena, Lackova, Lenka, Kubatka, Peter, Kropp, Martina, Thumann, Gabriele, Erb, Carl, Fröhlich, Holger, Wang, Wei, Baban, Babak, Kapalla, Marko, Shapira, Niva, Richter, Kneginja, Karabatsiakis, Alexander, Smokovski, Ivica, Schmeel, Leonard Christopher, Gkika, Eleni, Paul, Friedemann, Parini, Paolo, and Polivka, Jiri

Published
2024
Full Text
View/download PDF

16. Strategies to prevent blood loss and reduce transfusion in emergency general surgery, WSES-AAST consensus paper

Author

Federico Coccolini, Aryeh Shander, Marco Ceresoli, Ernest Moore, Brian Tian, Dario Parini, Massimo Sartelli, Boris Sakakushev, Krstina Doklestich, Fikri Abu-Zidan, Tal Horer, Vishal Shelat, Timothy Hardcastle, Elena Bignami, Andrew Kirkpatrick, Dieter Weber, Igor Kryvoruchko, Ari Leppaniemi, Edward Tan, Boris Kessel, Arda Isik, Camilla Cremonini, Francesco Forfori, Lorenzo Ghiadoni, Massimo Chiarugi, Chad Ball, Pablo Ottolino, Andreas Hecker, Diego Mariani, Ettore Melai, Manu Malbrain, Vanessa Agostini, Mauro Podda, Edoardo Picetti, Yoram Kluger, Sandro Rizoli, Andrey Litvin, Ron Maier, Solomon Gurmu Beka, Belinda De Simone, Miklosh Bala, Aleix Martinez Perez, Carlos Ordonez, Zenon Bodnaruk, Yunfeng Cui, Augusto Perez Calatayud, Nicola de Angelis, Francesco Amico, Emmanouil Pikoulis, Dimitris Damaskos, Raul Coimbra, Mircea Chirica, Walter L. Biffl, and Fausto Catena

Subjects
Blood management, Mortality, Morbidity, Policy, Management, Jehovah’s witnesses, Surgery, RD1-811, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Emergency general surgeons often provide care to severely ill patients requiring surgical interventions and intensive support. One of the primary drivers of morbidity and mortality is perioperative bleeding. In general, when addressing life threatening haemorrhage, blood transfusion can become an essential part of overall resuscitation. However, under all circumstances, indications for blood transfusion must be accurately evaluated. When patients decline blood transfusions, regardless of the reason, surgeons should aim to provide optimal care and respect and accommodate each patient’s values and target the best outcome possible given the patient’s desires and his/her clinical condition. The aim of this position paper was to perform a review of the existing literature and to provide comprehensive recommendations on organizational, surgical, anaesthetic, and haemostatic strategies that can be used to provide optimal peri-operative blood management, reduce, or avoid blood transfusions and ultimately improve patient outcomes.

Published
2024
Full Text
View/download PDF

17. Management of intra-abdominal infections: recommendations by the Italian council for the optimization of antimicrobial use

Author

Massimo Sartelli, Carlo Tascini, Federico Coccolini, Fabiana Dellai, Luca Ansaloni, Massimo Antonelli, Michele Bartoletti, Matteo Bassetti, Federico Boncagni, Massimo Carlini, Anna Maria Cattelan, Arturo Cavaliere, Marco Ceresoli, Alessandro Cipriano, Andrea Cortegiani, Francesco Cortese, Francesco Cristini, Eugenio Cucinotta, Lidia Dalfino, Gennaro De Pascale, Francesco Giuseppe De Rosa, Marco Falcone, Francesco Forfori, Paola Fugazzola, Milo Gatti, Ivan Gentile, Lorenzo Ghiadoni, Maddalena Giannella, Antonino Giarratano, Alessio Giordano, Massimo Girardis, Claudio Mastroianni, Gianpaola Monti, Giulia Montori, Miriam Palmieri, Marcello Pani, Ciro Paolillo, Dario Parini, Giustino Parruti, Daniela Pasero, Federico Pea, Maddalena Peghin, Nicola Petrosillo, Mauro Podda, Caterina Rizzo, Gian Maria Rossolini, Alessandro Russo, Loredana Scoccia, Gabriele Sganga, Liana Signorini, Stefania Stefani, Mario Tumbarello, Fabio Tumietto, Massimo Valentino, Mario Venditti, Bruno Viaggi, Francesca Vivaldi, Claudia Zaghi, Francesco M. Labricciosa, Fikri Abu-Zidan, Fausto Catena, and Pierluigi Viale

Subjects
Antimicrobial resistance, Antimicrobial therapy, Intra-abdominal infections, Source control, Surgery, RD1-811, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Intra-abdominal infections (IAIs) are common surgical emergencies and are an important cause of morbidity and mortality in hospital settings, particularly if poorly managed. The cornerstones of effective IAIs management include early diagnosis, adequate source control, appropriate antimicrobial therapy, and early physiologic stabilization using intravenous fluids and vasopressor agents in critically ill patients. Adequate empiric antimicrobial therapy in patients with IAIs is of paramount importance because inappropriate antimicrobial therapy is associated with poor outcomes. Optimizing antimicrobial prescriptions improves treatment effectiveness, increases patients’ safety, and minimizes the risk of opportunistic infections (such as Clostridioides difficile) and antimicrobial resistance selection. The growing emergence of multi-drug resistant organisms has caused an impending crisis with alarming implications, especially regarding Gram-negative bacteria. The Multidisciplinary and Intersociety Italian Council for the Optimization of Antimicrobial Use promoted a consensus conference on the antimicrobial management of IAIs, including emergency medicine specialists, radiologists, surgeons, intensivists, infectious disease specialists, clinical pharmacologists, hospital pharmacists, microbiologists and public health specialists. Relevant clinical questions were constructed by the Organizational Committee in order to investigate the topic. The expert panel produced recommendation statements based on the best scientific evidence from PubMed and EMBASE Library and experts’ opinions. The statements were planned and graded according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) hierarchy of evidence. On November 10, 2023, the experts met in Mestre (Italy) to debate the statements. After the approval of the statements, the expert panel met via email and virtual meetings to prepare and revise the definitive document. This document represents the executive summary of the consensus conference and comprises three sections. The first section focuses on the general principles of diagnosis and treatment of IAIs. The second section provides twenty-three evidence-based recommendations for the antimicrobial therapy of IAIs. The third section presents eight clinical diagnostic-therapeutic pathways for the most common IAIs. The document has been endorsed by the Italian Society of Surgery.

Published
2024
Full Text
View/download PDF

18. Youtube

Author

Parini, Alejandro, primary, Galende, Edgardo, additional, and Vera, Verónica, additional

Published
2024
Full Text
View/download PDF

25. Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago

Author

Gennaro Perrone, Mario Giuffrida, Fikri Abu-Zidan, Vitor F. Kruger, Marco Livrini, Gabriele Luciano Petracca, Giorgio Rossi, Antonio Tarasconi, Brian W. C. A. Tian, Elena Bonati, Ricardo Mentz, Federico N. Mazzini, Juan P. Campana, Elisabeth Gasser, Reinhold Kafka-Ritsch, Daniel M. Felsenreich, Christopher Dawoud, Stefan Riss, Carlos Augusto Gomes, Felipe Couto Gomes, Ricardo Alessandro Teixeira Gonzaga, Cassio Alfred Brattig Canton, Bruno Monteiro Pereira, Gustavo P. Fraga, Leticia Gonçalves Zem, Vinicius Cordeiro-Fonseca, Renato de Mesquita Tauil, Boyko Atanasov, Nikolay Belev, Nikola Kovachev, L. Juan José Meléndez, Ana Dimova, Stefan Dimov, Zdravko Zelić, Goran Augustin, Branko Bogdanić, Trpimir Morić, Elie Chouillard, Melinda Bajul, Belinda De Simone, Yves Panis, Francesco Esposito, Margherita Notarnicola, Lelde Lauka, Anna Fabbri, Hassen Hentati, Iskander Fnaiech, Venara Aurélien, Marie Bougard, Maxime Roulet, Zaza Demetrashvili, Irakli Pipia, Giorgi Merabishvili, Konstantinos Bouliaris, Georgios Koukoulis, Christos Doudakmanis, Sofia Xenaki, Emmanuel Chrysos, Stamatios Kokkinakis, Panteleimon Vassiliu, Nikolaos Michalopoulos, Ioannis Margaris, Aristotelis Kechagias, Konstantinos Avgerinos, Jevgeni Katunin, Eftychios Lostoridis, Eleni-Aikaterini Nagorni, Antonio Pujante, Francesk Mulita, Ioannis Maroulis, Michail Vailas, Athanasios Marinis, Ioannis Siannis, Eirini Bourbouteli, Dimitrios K. Manatakis, Nikolaos Tasis, Vasileios Acheimastos, Sotiropoulou Maria, Kapiris Stylianos, Harilaos Kuzeridis, Dimitrios Korkolis, Evangelos Fradelos, George Kavalieratos, Thalia Petropoulou, Andreas Polydorou, Ioannis Papacostantinou, Tania Triantafyllou, Despina Kimpizi, Dimitrios Theodorou, Konstantinos Toutouzas, Alexandros Chamzin, Maximos Frountzas, Dimitrios Schizas, Ioannis Karavokyros, Athanasios Syllaios, Alexandros Charalabopoulos, Maria Boura, Efstratia Baili, Orestis Ioannidis, Lydia Loutzidou, Elissavet Anestiadou, Ioannis Tsouknidas, Georgios Petrakis, Eleni Polenta, Lovenish Bains, Rahul Gupta, Sudhir K. Singh, Archana Khanduri, Miklosh Bala, Asaf Kedar, Marcello Pisano, Mauro Podda, Adolfo Pisanu, Gennaro Martines, Giuseppe Trigiante, Giuliano Lantone, Antonino Agrusa, Giuseppe Di Buono, Salvatore Buscemi, Massimiliano Veroux, Rossella Gioco, Gastone Veroux, Luigi Oragano, Sandro Zonta, Federico Lovisetto, Carlo V. Feo, Antonio Pesce, Nicolò Fabbri, Giulio Lantone, Fabio Marino, Fabrizio Perrone, Leonardo Vincenti, Vincenzo Papagni, Arcangelo Picciariello, Stefano Rossi, Biagio Picardi, Simone Rossi Del Monte, Diego Visconti, Giulia Osella, Luca Petruzzelli, Giusto Pignata, Jacopo Andreuccetti, Rossella D’Alessio, Massimo Buonfantino, Eleonora Guaitoli, Stefano Spinelli, Gianluca Matteo Sampietro, Carlo Corbellini, Leonardo Lorusso, Alice Frontali, Isabella Pezzoli, Alessandro Bonomi, Andrea Chierici, Christian Cotsoglou, Giuseppe Manca, Antonella Delvecchio, Nicola Musa, Massimiliano Casati, Laface Letizia, Emmanuele Abate, Giorgio Ercolani, Fabrizio D’Acapito, Leonardo Solaini, Gianluca Guercioni, Simone Cicconi, Diego Sasia, Felice Borghi, Giorgio Giraudo, Giuseppe Sena, Pasquale Castaldo, Eugenia Cardamone, Giuseppe Portale, Matteo Zuin, Ylenia Spolverato, Marialusia Esposito, Roberta Maria Isernia, Maria Di Salvo, Romina Manunza, Giuseppe Esposito, Marcello Agus, Emanuele Luigi Giuseppe Asti, Daniele Tiziano Bernardi, Tommaso Panici Tonucci, Davide Luppi, Massimiliano Casadei, Stefano Bonilauri, Angela Pezzolla, Annunziata Panebianco, Rita Laforgia, Maurizio De Luca, Monica Zese, Dario Parini, Elio Jovine, Giuseppina De Sario, Raffaele Lombardi, Giovanni Aprea, Giuseppe Palomba, Marianna Capuano, Giulio Argenio, Gianluca Orio, Mariano Fortunato Armellino, Marina Troian, Martina Guerra, Carlo Nagliati, Alan Biloslavo, Paola Germani, Giada Aizza, Igor Monsellato, Ali Chaouki Chahrour, Gabriele Anania, Cristina Bombardini, Francesco Bagolini, Gabriele Sganga, Pietro Fransvea, Valentina Bianchi, Paolo Boati, Francesco Ferrara, Francesco Palmieri, Pasquale Cianci, Domenico Gattulli, Enrico Restini, Nicola Cillara, Alessandro Cannavera, Gabriela Elisa Nita, Jlenia Sarnari, Francesco Roscio, Federico Clerici, Ildo Scandroglio, Stefano Berti, Alessandro Cadeo, Alice Filippelli, Luigi Conti, Carmine Grassi, Gaetano Maria Cattaneo, Marina Pighin, Davide Papis, Giovanni Gambino, Vanessa Bertino, Domenico Schifano, Daniela Prando, Luisella Fogato, Fabio Cavallo, Luca Ansaloni, Roberto Picheo, Nicholas Pontarolo, Norma Depalma, Marcello Spampinato, Stefano D’Ugo, Luca Lepre, Michela Giulii Capponi, Rossella Domenica Campa, Giuliano Sarro, Vincenza Paola Dinuzzi, Stefano Olmi, Matteo Uccelli, Davide Ferrari, Marco Inama, Gianluigi Moretto, Michele Fontana, Francesco Favi, Erika Picariello, Alessia Rampini, Andrea Barberis, Antonio Azzinnaro, Alba Oliva, Luigi Totaro, Ilaria Benzoni, Valerio Ranieri, Gabriella Teresa Capolupo, Filippo Carannante, Marco Caricato, Maurizio Ronconi, Silvia Casiraghi, Giovanni Casole, Desire Pantalone, Giovanni Alemanno, Maximilian Scheiterle, Marco Ceresoli, Marco Cereda, Chiara Fumagalli, Federico Zanzi, Stefano Bolzon, Enrico Guerra, Francesca Lecchi, Paola Cellerino, Antonella Ardito, Rosa Scaramuzzo, Andrea Balla, Pasquale Lepiane, Nicola Tartaglia, Antonio Ambrosi, Giovanna Pavone, Gian Marco Palini, Simone Veneroni, Gianluca Garulli, Claudio Ricci, Beatrice Torre, Iris Shari Russo, Matteo Rottoli, Marta Tanzanu, Angela Belvedere, Marco Milone, Michele Manigrasso, Giovanni Domenico De Palma, Micaela Piccoli, Gianmaria Casoni Pattacini, Stefano Magnone, Paolo Bertoli, Michele Pisano, Paolo Massucco, Marco Palisi, Andrea-Pierre Luzzi, Francesco Fleres, Guglielmo Clarizia, Alessandro Spolini, Yoshiro Kobe, Takayuki Toma, Fumihiko Shimamura, Robert Parker, Sinkeet Ranketi, Mercy Mitei, Saulius Svagzdys, Henrikas Pauzas, Justas Zilinskas, Tomas Poskus, Marius Kryzauskas, Matas Jakubauskas, Andee Dzulkarnaen Zakaria, Zaidi Zakaria, Michael Pak-Kai Wong, Asri Che Jusoh, Muhammad Nazreen Zakaria, Daniel Rios Cruz, Aurea Barbara Rodriguez Elizalde, Alejandro Bañon Reynaud, Edgard Efren Lozada Hernandez, Jose maria Victor Palomo Monroy, Diego Hinojosa-Ugarte, Martha Quiodettis, María Esther Du Bois, José Latorraca, Piotr Major, Michał Pędziwiatr, Magdalena Pisarska-Adamczyk, Maciej Walędziak, Andrzej Kwiatkowski, Łukasz Czyżykowski, Silvia Dantas da Costa, Bela Pereira, Ana Rita Oliveira Ferreira, Filipe Almeida, Ricardo Rocha, Carla Carneiro, Diego Pita Perez, João Carvas, Catarina Rocha, Cátia Ferreira, Rita Marques, Urânia Fernandes, Pedro Leao, André Goulart, Rita Gonçalves Pereira, Sara Daniela Direito Patrocínio, Nuno Gonçalo Gonçalves de Mendonça, Maria Isabel Cerqueira Manso, Henrique Manuel Cardoso Morais, Paulo Sebastião Cardoso, Valentin Calu, Adrian Miron, Elena Adelina Toma, Mahir Gachabayov, Abakar Abdullaev, Andrey Litvin, Taras Nechay, Alexander Tyagunov, Anvar Yuldashev, Alison Bradley, Michael Wilson, Arpád Panyko, Zuzana Látečková, Vladimír Lacko, Dusan Lesko, Marek Soltes, Jozef Radonak, Victor Turrado-Rodriguez, Roser Termes-Serra, Xavier Morales-Sevillano, Pierfrancesco Lapolla, Andrea Mingoli, Gioia Brachini, Maurizio Degiuli, Silvia Sofia, Rossella Reddavid, Andrea de Manzoni Garberini, Angelica Buffone, Eduardo Perea del Pozo, Daniel Aparicio-Sánchez, Sandra Dos Barbeito, Mercedes Estaire-Gómez, Rebeca Vitón-Herrero, Mª de los Ángeles Gil Olarte-Marquez, José Gil-Martínez, Felipe Alconchel, Tatiana Nicolás-López, Aida Cristina Rahy-Martin, María Pelloni, Raquel Bañolas-Suarez, Fernando Mendoza-Moreno, Francisca García-Moreno Nisa, Manuel Díez-Alonso, María Elisa Valle Rodas, María Carmona Agundez, María Inmaculada Pérez Andrés, Claudia Cristina Lopes Moreira, Aintzane Lizarazu Perez, Iñigo Augusto Ponce, Ana María González-Castillo, Estela Membrilla-Fernández, Silvia Salvans, Mario Serradilla-Martín, Pablo Sancho Pardo, Daniel Rivera-Alonso, Jana Dziakova, Jose Mugüerza Huguet, Naila Pagès Valle, Enrique Colás Ruiz, Cristina Rey Valcárcel, Cristina Ruiz Moreno, Yeniffer Tatiana Moreno Salazar, Juan Jesús Rubio García, Silvia Sevila Micó, Joaquín Ruiz López, Silvia Pérez Farré, Maite Santamaria Gomez, Nuria Mestres Petit, Alberto Titos-García, Jose Manuel Aranda-Narváez, Laura Romacho-López, Luis Sánchez-Guillén, Veronica Aranaz-Ostariz, Marina Bosch-Ramírez, Aleix Martínez-Pérez, Elías Martínez-López, Juan Carlos Sebastián-Tomás, Granada Jimenez-Riera, Javier Jimenez-Vega, Jose Aurelio Navas Cuellar, Andrea Campos-Serra, Anna Muñoz-Campaña, Raquel Gràcia-Roman, Javier Martínez Alegre, Francisca Lima Pinto, Sara Nuñez O’Sullivan, Francisco Blanco Antona, Beatriz Muñoz Jiménez, Jaime López-Sánchez, Zahira Gómez Carmona, Rocio Torres Fernández, Isabel Blesa Sierra, Laura Román García de León, Verónica Polaino Moreno, Eva Iglesias, Paola Lora Cumplido, Altea Arango Bravo, Ignacio Rey Simó, Carlota López Domínguez, Aloia Guerreiro Caamaño, Rafael Calleja Lozano, Manuel Durán Martínez, Álvaro Naranjo Torres, Javier Tomas Morales Bernaldo de Quiros, Gianluca Pellino, Miriam Moratal Cloquell, Elsa García Moller, Sami Jalal-Eldin, Ahmed K. Abdoun, Hytham K. S. Hamid, Varut Lohsiriwat, Aitsariya Mongkhonsupphawan, Oussama Baraket, Karim Ayed, Imed Abbassi, Ali Ben Ali, Houssem Ammar, Ali Kchaou, Ahmed Tlili, Imen Zribi, Elif Colak, Suleyman Polat, Zehra Alan Koylu, Ali Guner, Mehmet Arif Usta, Murat Emre Reis, Baris Mantoglu, Emre Gonullu, Emrah Akin, Fatih Altintoprak, Zulfu Bayhan, Necattin Firat, Arda Isik, Ufuk Memis, Mehmet Bayrak, Yasemin Altıntaş, Yasin Kara, Mehmet Abdussamet Bozkurt, Ali Kocataş, Koray Das, Ahmet Seker, Nazmi Ozer, Semra Demirli Atici, Korhan Tuncer, Tayfun Kaya, Zeynep Ozkan, Onur Ilhan, Ibrahim Agackiran, Mustafa Yener Uzunoglu, Eren Demirbas, Yuksel Altinel, Serhat Meric, Nadir Adnan Hacım, Derya Salim Uymaz, Nail Omarov, Emre Balık, Giovanni D. Tebala, Hany Khalil, Mridul Rana, Mansoor Khan, Charlotte Florence, Christie Swaminathan, Cosimo Alex Leo, Lampros Liasis, Josef Watfah, Ivan Trostchansky, Edward Delgado, Marcelo Pontillo, Rifat Latifi, Raul Coimbra, Sara Edwards, Ana Lopez, George Velmahos, Ander Dorken, Anthony Gebran, Amanda Palmer, Jeffrey Oury, James M. Bardes, Sirivan Suon Seng, Lauren S. Coffua, Asanthi Ratnasekera, Tanya Egodage, Karla Echeverria-Rosario, Isabella Armento, Lena M. Napolitano, Naveen F. Sangji, Mark Hemmila, Jacob A. Quick, Tyler R. Austin, Theodore S. Hyman, William Curtiss, Amanda McClure, Nicholas Cairl, Walter L. Biffl, Hung P. Truong, Kathryn Schaffer, Summer Reames, Filippo Banchini, Patrizio Capelli, Federico Coccolini, Massimo Sartelli, Francesca Bravi, Carlo Vallicelli, Vanni Agnoletti, Gian Luca Baiocchi, and Fausto Catena

Subjects
Hartmann’s procedure, Ostomy, Emergency surgery, Resection, Primary anastomosis, Left side, Surgery, RD1-811, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Background Literature suggests colonic resection and primary anastomosis (RPA) instead of Hartmann’s procedure (HP) for the treatment of left-sided colonic emergencies. We aim to evaluate the surgical options globally used to treat patients with acute left-sided colonic emergencies and the factors that leading to the choice of treatment, comparing HP and RPA. Methods This is a prospective, international, multicenter, observational study registered on ClinicalTrials.gov. A total 1215 patients with left-sided colonic emergencies who required surgery were included from 204 centers during the period of March 1, 2020, to May 31, 2020. with a 1-year follow-up. Results 564 patients (43.1%) were females. The mean age was 65.9 ± 15.6 years. HP was performed in 697 (57.3%) patients and RPA in 384 (31.6%) cases. Complicated acute diverticulitis was the most common cause of left-sided colonic emergencies (40.2%), followed by colorectal malignancy (36.6%). Severe complications (Clavien-Dindo ≥ 3b) were higher in the HP group (P

Published
2024
Full Text
View/download PDF

26. Single Cell Atlas: a single-cell multi-omics human cell encyclopedia

Author

Lu Pan, Paolo Parini, Roman Tremmel, Joseph Loscalzo, Volker M. Lauschke, Bradley A. Maron, Paola Paci, Ingemar Ernberg, Nguan Soon Tan, Zehuan Liao, Weiyao Yin, Sundararaman Rengarajan, Xuexin Li, and The SCA Consortium

Subjects
Single-cell omics, Multi-omics, Single Cell Atlas, Human database, Single-cell RNA-sequencing, Spatial transcriptomics, Biology (General), QH301-705.5, Genetics, QH426-470
Abstract

Abstract Single-cell sequencing datasets are key in biology and medicine for unraveling insights into heterogeneous cell populations with unprecedented resolution. Here, we construct a single-cell multi-omics map of human tissues through in-depth characterizations of datasets from five single-cell omics, spatial transcriptomics, and two bulk omics across 125 healthy adult and fetal tissues. We construct its complement web-based platform, the Single Cell Atlas (SCA, www.singlecellatlas.org ), to enable vast interactive data exploration of deep multi-omics signatures across human fetal and adult tissues. The atlas resources and database queries aspire to serve as a one-stop, comprehensive, and time-effective resource for various omics studies.

Published
2024
Full Text
View/download PDF

27. Ryanodine receptor dysfunction causes senescence and fibrosis in Duchenne dilated cardiomyopathy

Author

Monia Souidi, Jessica Resta, Haikel Dridi, Yvonne Sleiman, Steve Reiken, Karina Formoso, Sarah Colombani, Pascal Amédro, Pierre Meyer, Azzouz Charrabi, Marie Vincenti, Yang Liu, Rajesh Kumar Soni, Frank Lezoualc'h, D.V.M. Stéphane Blot, François Rivier, Olivier Cazorla, Angelo Parini, Andrew R. Marks, Jeanne Mialet‐Perez, Alain Lacampagne, and Albano C. Meli

Subjects
Calcium, DMD, hiPSC‐derived cardiomyocytes, Ryanodine receptor, Senescence, Diseases of the musculoskeletal system, RC925-935, Human anatomy, QM1-695
Abstract

Abstract Background Duchenne muscular dystrophy (DMD) is an X‐linked disorder characterized by progressive muscle weakness due to the absence of functional dystrophin. DMD patients also develop dilated cardiomyopathy (DCM). We have previously shown that DMD (mdx) mice and a canine DMD model (GRMD) exhibit abnormal intracellular calcium (Ca2+) cycling related to early‐stage pathological remodelling of the ryanodine receptor intracellular calcium release channel (RyR2) on the sarcoplasmic reticulum (SR) contributing to age‐dependent DCM. Methods Here, we used hiPSC‐CMs from DMD patients selected by Speckle‐tracking echocardiography and canine DMD cardiac biopsies to assess key early‐stage Duchenne DCM features. Results Dystrophin deficiency was associated with RyR2 remodelling and SR Ca2+ leak (RyR2 Po of 0.03 ± 0.01 for HC vs. 0.16 ± 0.01 for DMD, P

Published
2024
Full Text
View/download PDF

28. Optimization of the anisotropic Cheeger constant with respect to the anisotropy

Author

Parini, Enea and Saracco, Giorgio

Subjects
Mathematics - Optimization and Control, Mathematics - Metric Geometry
Abstract

Given an open, bounded set $\Omega$ in $\mathbb{R}^N$, we consider the minimization of the anisotropic Cheeger constant $h_K(\Omega)$ with respect to the anisotropy $K$, under a volume constraint on the associated unit ball. In the planar case, under the assumption that $K$ is a convex, centrally symmetric body, we prove the existence of a minimizer. Moreover, if $\Omega$ is a ball, we show that the optimal anisotropy $K$ is not a ball and that, among all regular polygons, the square provides the minimal value.

Published
2022
Full Text
View/download PDF

29. Unified Scattering Parameters formalism in terms of Coupled-Mode Theory for investigating hybrid single-mode/two-mode photonic interconnects

Author

Boucher Yann G., Parini Alberto, and Féron Patrice

Subjects
Physics, QC1-999
Abstract

In terms of Linear Algebra, a directional coupler between a single-mode waveguide and a two-mode waveguide can be thought of as formally equivalent to a set of three mutually coupled single-mode waveguides. Its responses, easily derived in the frame of ternary Coupled-Mode Theory, are used to establish analytically the scattering parameters of a hybrid ring-based modal multiplexer.

Published
2017
Full Text
View/download PDF

30. List of contributors

Author

Behera, Manaswini, primary, Bhadra, Sudipa, additional, Bhaduri, Soumyadeep, additional, Bhowmick, G.D., additional, Cardozo, Jussara Câmara, additional, Cavalcanti, Lívia N., additional, Chakraborty, Annesha, additional, Chhatbar, Monali, additional, Das, Bhaskar, additional, Das, Pranjal P., additional, Das, Sovik, additional, Das, Indrasis, additional, Deore, Dipak, additional, dos Santos, Elisama V., additional, Ghangrekar, M.M., additional, Ghosh, Rahul, additional, Ghosh, Dipankar, additional, Gole, Ankita, additional, Gondim, Amanda D., additional, Guha, Shreyasmita, additional, Ihjas, K., additional, Jadhav, Dipak Ashok, additional, Jayaraj, K.K., additional, Kailasa, Suresh Kumar, additional, Kaushik, Anubha, additional, Loor-Urgilés, Luis D., additional, Maddirala, Shivani, additional, Mal, Supriyo, additional, Malkapuram, Surya Teja, additional, Martínez-Huitle, Carlos A., additional, Mungray, Alka, additional, Mungray, Arvind Kumar, additional, Neethu, B., additional, Oliveira, Herbet L., additional, Pendse, Vedant Vijay, additional, Prasad, Shiv, additional, Pulipati, Tejovardhan, additional, Purkait, Mihir K., additional, Rao, Ankit, additional, Rathore, Dheeraj, additional, Roy, Dona, additional, Sai Teja, A., additional, Samanta, Ayan, additional, Santos, José Eudes L., additional, Sevda, Surajbhan, additional, Sharma, Mukesh, additional, Singh, Anoop, additional, Sinha, Juhi, additional, Sonawane, Shirish Hari, additional, Surti, Parini, additional, Thakur, Somil, additional, Venkatramanan, Veluswamy, additional, and Zekker, Ivar, additional

Published
2024
Full Text
View/download PDF

32. Postoperative pain management in non-traumatic emergency general surgery: WSES-GAIS-SIAARTI-AAST guidelines.

Author

Coccolini, Federico, Corradi, Francesco, Sartelli, Massimo, Coimbra, Raul, Kryvoruchko, Igor, Leppaniemi, Ari, Doklestic, Krstina, Bignami, Elena, Biancofiore, Giandomenico, Bala, Miklosh, Marco, Ceresoli, Damaskos, Dimitris, Biffl, Walt, Fugazzola, Paola, Santonastaso, Domenico, Agnoletti, Vanni, Sbarbaro, Catia, Nacoti, Mirco, Hardcastle, Timothy, Mariani, Diego, De Simone, Belinda, Tolonen, Matti, Ball, Chad, Podda, Mauro, Di Carlo, Isidoro, Di Saverio, Salomone, Navsaria, Pradeep, Bonavina, Luigi, Abu-Zidan, Fikri, Soreide, Kjetil, Fraga, Gustavo, Carvalho, Vanessa, Batista, Sergio, Hecker, Andreas, Cucchetti, Alessandro, Ercolani, Giorgio, Tartaglia, Dario, Wani, Imtiaz, Kurihara, Hayato, Tan, Edward, Litvin, Andrey, Melotti, Rita, Sganga, Gabriele, Zoro, Tamara, Isirdi, Alessandro, DeAngelis, Nicola, Weber, Dieter, Hodonou, Adrien, tenBroek, Richard, Parini, Dario, Khan, Jim, Sbrana, Giovanni, Coniglio, Carlo, Giarratano, Antonino, Gratarola, Angelo, Zaghi, Claudia, Romeo, Oreste, Kelly, Michael, Forfori, Francesco, Chiarugi, Massimo, Moore, Ernest, Catena, Fausto, Malbrain, Manu, and Galante, Joseph

Subjects
Acute, Emergency, Morbidity, Pain, Surgery, Treatment, Abdomen, Analgesics, Anesthesia, Humans, Pain, Postoperative, Perioperative Care, United States
Abstract

BACKGROUND: Non-traumatic emergency general surgery involves a heterogeneous population that may present with several underlying diseases. Timeous emergency surgical treatment should be supplemented with high-quality perioperative care, ideally performed by multidisciplinary teams trained to identify and handle complex postoperative courses. Uncontrolled or poorly controlled acute postoperative pain may result in significant complications. While pain management after elective surgery has been standardized in perioperative pathways, the traditional perioperative treatment of patients undergoing emergency surgery is often a haphazard practice. The present recommended pain management guidelines are for pain management after non-traumatic emergency surgical intervention. It is meant to provide clinicians a list of indications to prescribe the optimal analgesics even in the absence of a multidisciplinary pain team. MATERIAL AND METHODS: An international expert panel discussed the different issues in subsequent rounds. Four international recognized scientific societies: World Society of Emergency Surgery (WSES), Global Alliance for Infection in Surgery (GAIS), Italian Society of Anesthesia, Analgesia Intensive Care (SIAARTI), and American Association for the Surgery of Trauma (AAST), endorsed the project and approved the final manuscript. CONCLUSION: Dealing with acute postoperative pain in the emergency abdominal surgery setting is complex, requires special attention, and should be multidisciplinary. Several tools are available, and their combination is mandatory whenever is possible. Analgesic approach to the various situations and conditions should be patient based and tailored according to procedure, pathology, age, response, and available expertise. A better understanding of the patho-mechanisms of postoperative pain for short- and long-term outcomes is necessary to improve prophylactic and treatment strategies.

Published
2022

34. Submucosal Necrotic Nodule of the Colon: An Enigmatic Entity Potentially Related to Anisakis Infection

Author

Gonzalez, Raul S., Pastrian, Laura G., Pyatibrat, Sergey, Arias, Hernan Dario Quiceno, Gil, Yolanda Rodriguez, Booth, Adam L., Navarro, Itziar de la Pena, Garmendia-Irizar, Maddi, Lapointe, Jennifer R., Mobarki, Mousa, Nova-Camacho, Luiz Miguel, Parini, Gina, Romio, Estefania, Alayza, Alejandra Rosell, Pritt, Bobbi S., and Ruz-Caracuel, Ignacio

Subjects
Diseases -- Relapse, Health
Abstract

* Context.--Discrete submucosal necrotic nodules may rarely manifest as colon polyps. Objective.--To characterize the clinical and pathologic features of this lesion, which has been under-studied in the literature. Design.--We conducted an international search to compile a series. For each potential case, photomicrographs were centrally reviewed to confirm the diagnosis. We gathered clinical and pathologic information on each confirmed case. Results.--The final cohort included 25 patients, with 23 having 1 lesion and 2 having several (31 lesions total). Mean patient age was 62 years; 13 patients (52%) were male. Symptoms were nonspecific, although 4 patients (16%) had blood in stool; 14 patients were asymptomatic. Patient history and medications appeared noncontributory. Most cases were located in the right colon (n = 18; 58%). Mean lesion size was 0.4 cm (range, 0.1-1.7 cm). Histology typically showed a centrally necrotic nodule with peripheral fibrosis, chronic inflammation, and sometimes palisading granulomatous inflammation. Percent necrosis ranged from 5% to 95% (average, 70%), and percent fibrosis ranged from 3% to 70% (average, 25%). In 3 cases, degenerated parasitic structures consistent with Anisakis could be seen on hematoxylin-eosin and trichrome special stain. No patient experienced disease recurrence. Conclusions.--Submucosal necrotic nodules can present as colon polyps. Most cases are unifocal, and patients do well on follow-up. At least some examples appear to be caused by Anisakis, implicating patient diet. Patients are often asymptomatic, and many cases show no histologic evidence of the causative agent. doi: 10.5858/arpa.2022-0267-OA, Colon polyps are a relatively common finding on colonoscopy and are usually biopsied or excised for pathologic evaluation. (1) Most of these polyps represent epithelial proliferations involving the mucosal surface [...]

Published
2023
Full Text
View/download PDF

36. Bowel preparation before elective right colectomy: Multitreatment machine-learning analysis on 2,617 patients

Author

Ciano, Paolo, Benedetti, Michele, Montemurro, Leonardo Antonio, Clementi, Marco, Bertocchi, Elisa, Masini, Gaia, Altamura, Amedeo, Rubichi, Francesco, Migliore, Marco, Parlanti, Daniele, Vago, Gabriele, Sciuto, Antonio, Pace, Ugo, Bucci, Andrea Fares, Simone, Michele, Cassini, Diletta, Pandolfini, Lorenzo, Falsetto, Alessandro, Ficari, Ferdinando, Giudici, Francesco, Cianchi, Fabio, Patriti, Alberto, Ricci, Marcella Lodovica, Siquini, Walter, Cardinali, Alessandro, D'Ugo, Stefano, Spampinato, Marcello, Scabini, Stefano, Aprile, Alessandra, Soriero, Domenico, Caricato, Marco, Capolupo, Gabriella Teresa, Pignata, Giusto, Andreuccetti, Jacopo, Canfora, Ilaria, Liverani, Andrea, Lamacchia, Giuseppe, Franceschilli, Claudia, Campagnacci, Roberto, Maurizi, Angela, Marini, Pierluigi, Attinà, Grazia Maria, Elmore, Ugo, Puccetti, Francesco, Corcione, Francesco, Bracale, Umberto, Peltrini, Roberto, Santoro, Roberto, Amodio, Pietro, Carlini, Massimo, Spoletini, Domenico, Marcellinaro, Rosa, Giuliani, Antonio, Del Vecchio, Giovanni, Sorrentino, Mario, Stefanoni, Massimo, Ferrari, Giovanni, Lombardi, Pietro Maria, Di Leo, Alberto, Crepaz, Lorenzo, Verzelli, Augusto, Budassi, Andrea, Sica, Giuseppe, Bagaglini, Giulia, Rausei, Stefano, Tenconi, Silvia, Cavaliere, Davide, Solaini, Leonardo, Ercolani, Giorgio, Baiocchi, Gian Luca, Molfino, Sarah, Milone, Marco, De Palma, Giovanni Domenico, Ciaccio, Giovanni, Locurto, Paolo, Tebala, Giovanni Domenico, Di Cintio, Antonio, Boni, Luigi, Cassinott, Elisa, Mancini, Stefano, Sagnotta, Andrea, Guerrieri, Mario, Ortenzi, Monica, Persiani, Roberto, Biondi, Alberto, Lucchi, Andrea, Vitali, Giulia, Parini, Dario, De Luca, Maurizio, Spinelli, Antonino, Carrano, Francesco, Genna, Michele, Fior, Francesca, Bottino, Vincenzo, Ferronetti, Antonio, Coratti, Andrea, Giuliani, Giuseppe, Benigni, Roberto, Scala, Dario, Puppio, Battistino, Vagliasindi, Alessio, Muratore, Andrea, Marsanic, Patrizia, Pipitone Federico, Nicoletta Sveva, Pavanello, Maurizio, Di Marco, Carlo, Rivolta, Umberto, Bertoglio, Camillo Leonardo, Piccoli, Micaela, Pecchini, Francesca, Talarico, Carlo, Greco, Vincenzo, Carrara, Alessandro, Motter, Michele, Tirone, Giuseppe, Totis, Mauro, Tamini, Nicolò, Roviello, Franco, Piagnerelli, Riccardo, Anastasi, Alessandro, Canonico, Giuseppe, Guercioni, Gianluca, Cicconi, Simone, Ettorre, Giuseppe Maria, Colasanti, Marco, Montuori, Mauro, Pinotti, Enrico, Mariani, Pierpaolo, Carminati, Roberta, de Manzini, Nicolò, Osenda, Edoardo, Donini, Annibale, Graziosi, Luigina, Armellino, Mariano Fortunato, De Martino, Ciro, Taglietti, Lucio, Birindelli, Arianna, Anania, Gabriele, Chiozza, Matteo, Di Cosmo, Mariantonietta, Zigiotto, Daniele, Feo, Carlo Vittorio, Pindozzi, Fioralba, Millo, Paolo, Grivon, Manuela, Pedrazzani, Corrado, Conti, Cristian, Guerriero, Silvio, Organetti, Lorenzo, Costanzi, Andrea, Monteleone, Michela, Vettoretto, Nereo, Botteri, Emanuele, Marchesi, Federico, Dalmonte, Giorgio, Basti, Massimo, Frazzini, Diletta, Longo, Graziano, Santoni, Simone, Cicetti, Moreno, La Gioia, Gabriele, Brisinda, Giuseppe, Berti, Stefano, Catarci, Marco, Guadagni, Stefano, Masedu, Francesco, Ruffo, Giacomo, Viola, Massimo Giuseppe, and Scatizzi, Marco

Published
2024
Full Text
View/download PDF

40. The pan - COVID - AGICT study. The impact of COVID-19 pandemic on surgically treated pancreatic cancer patients. A multicentric Italian study

Author

Giuliani, Giuseppe, Guerra, Francesco, Santelli, Francesco, Esposito, Alessandro, De Pastena, Matteo, Cova, Chiara, Bianchi, Beatrice, Nobile, Sara, Maruccio, Martina, Faustini, Federico, Turri, Giulia, Pedrazzani, Corrado, Kauffmann, Emanuele Federico, Boggi, Ugo, Solaini, Leonardo, Ercolani, Giorgio, Mastrangelo, Laura, Jovine, Elio, Di Franco, Gregorio, Morelli, Luca, Mazzola, Michele, Ferrari, Giovanni, Langella, Serena, Ferrero, Alessandro, La Mendola, Roberta, Hilal, Mohamnad Abu, Depalma, Norma, D'Ugo, Stefano, Spampinato, Marcello Giuseppe, Frisini, Marco, Brolese, Alberto, Palaia, Raffaele, Belli, Andrea, Cillara, Nicola, Deserra, Antonello, Cannavera, Alessandro, Sagnotta, Andrea, Mancini, Stefano, Pinotti, Enrico, Montuori, Mauro, Pecora, Irene, Messinese, Simona, Salvischiani, Lucia, Esposito, Sofia, Ferraro, Luca, Rega, Daniela, Delrio, Paolo, La Raja, Carlotta, Spinelli, Antonino, Massaron, Simonetta, De Nardi, Paola, Deidda, Simona, Restivo, Angelo, Marano, Alessandra, Borghi, Felice, Piccoli, Micaela, Cozzani, Federico, Del Rio, Paolo, Marcellinaro, Rosa, Carlini, Massimo, De Rosa, Raffaele, Scabini, Stefano, Maiello, Fabio, Polastri, Roberto, Zese, Monica, Parini, Dario, Casaril, Andrea, Moretto, Gianluigi, De Leo, Antonio, Catarci, Marco, Trapani, Renza, Zonta, Sandro, Marsanic, Patrizia, Muratore, Andrea, Coppola, Alessandro, Caputo, Damiano, Andreuccetti, Jacopo, Pignata, Giusto, Mariani, Lorenzo, Ceccarelli, Graziano, Giuseppe, Rocco, Bolzon, Stefano, Grasso, Mariateresa, Testa, Silvio, Germani, Paola, de Manzini, Nicolò, Coletta, Diego, De Franco, Lorenzo, Benigni, Roberto, Tribuzi, Angela, Marra, Ubaldo, Di Marino, Michele, Zorcolo, Luigi, Lisi, Giorgio, Allisiardi, Fabrizio, Grieco, Michele, Righetti, Carolina, Grassia, Michele, Lucchi, Andrea, Bagaglini, Giulia, Sica, Giuseppe S., Manara, Michele, Turati, Luca, Macone, Lorenzo, Carminati, Roberta, Mariani, Pierpaolo, Rizzo, Gianluca, Coco, Claudio, Pennella, Francesca Pennetti, Rondelli, Fabio, Romano, Lucia, Giuliani, Antonio, Albino, Vittorio, Leongito, Maddalena, David, Giulia, Misitano, Pasquale, Pasulo, Silvia, Baiocchi, Gian Luca, Baldari, Ludovica, Cassinotti, Elisa, Boni, Luigi, Capolupo, Gabriella Teresa, Caricato, Marco, Bombardini, Cristina, Anania, Gabriele, Dibra, Rigers, Martines, Gennaro, Oliva, Renato, Carati, Maria Vittoria, Grazi, Gian Luca, Marchegiani, Francesco, Spolverato, Gaya, Celotto, Francesco, Pucciarelli, Salvatore, La Torre, Filippo, Iannone, Immacolata, Krizzuk, Dimitri, Sammartino, Francesco, Catalano, Giorgia, Strignano, Paolo, Romagnoli, Renato, Piccione, Domenico, Nardo, Bruno, Reddavid, Rossella, Degiuli, Maurizio, Gerosa, Martino, Maggioni, Dario, Zuolo, Michele, Rigamonti, Marco, Ghazouani, Omar, Galleano, Raffaele, Percivale, Andrea, Tirloni, Luca, Moraldi, Luca, Fabbri, Nicolò, Feo, Carlo Vittorio, Colombo, Samuele, Merlini, Ilenia, Di Saverio, Salomone, Barbato, Giuseppe, Coratti, Francesco, Formisano, Giampaolo, Bianchi, Paolo Pietro, Bengala, Carmelo, Coratti, Andrea, Dorma, Maria Pia Federica, Abu Hilal, Mohamnad, and Di Benedetto, Fabrizio

Published
2024
Full Text
View/download PDF

42. Safety outcomes and patients’ preferences for home-based intravenous enzyme replacement therapy (ERT) in pompe disease and mucopolysaccharidosis type I (MPS I) disorder: COVID-19 and beyond

Author

Toscano, Antonio, Musumeci, Olimpia, Sacchini, Michele, Ravaglia, Sabrina, Siciliano, Gabriele, Fiumara, Agata, Verrecchia, Elena, Maione, Melania, Gentile, Jennifer, Fischetto, Rita, Crescimanno, Grazia, Taurisano, Roberta, Sechi, Annalisa, Gasperini, Serena, Cianci, Vittoria, Maggi, Lorenzo, Parini, Rossella, Lupica, Antonino, and Scarpa, Maurizio

Published
2023
Full Text
View/download PDF

46. The nonvesicular sterol transporter Aster-C plays a minor role in whole body cholesterol balance

Author

Rakhee Banerjee, Rachel C. Hohe, Shijie Cao, Bryan M. Jung, Anthony J. Horak, Iyappan Ramachandiran, William J. Massey, Venkateshwari Varadharajan, Natalie I. Zajczenko, Amy C. Burrows, Sumita Dutta, Maryam Goudarzi, Kala Mahen, Abigail Carter, Robert N. Helsley, Scott M. Gordon, Richard E. Morton, Christopher Strauch, Belinda Willard, Camelia Baleanu Gogonea, Valentin Gogonea, Matteo Pedrelli, Paolo Parini, and J. Mark Brown

Subjects
cholesterol, lipoprotein, metabolism, steroid hormone, oxysterol, Physiology, QP1-981
Abstract

Introduction:The Aster-C protein (encoded by the Gramd1c gene) is an endoplasmic reticulum (ER) resident protein that has been reported to transport cholesterol from the plasma membrane to the ER. Although there is a clear role for the closely-related Aster-B protein in cholesterol transport and downstream esterification in the adrenal gland, the specific role for Aster-C in cholesterol homeostasis is not well understood. Here, we have examined whole body cholesterol balance in mice globally lacking Aster-C under low or high dietary cholesterol conditions.Method:Age-matched Gramd1c+/+ and Gramd1c−/− mice were fed either low (0.02%, wt/wt) or high (0.2%, wt/wt) dietarycholesterol and levels of sterol-derived metabolites were assessed in the feces, liver, and plasma.Results:Compared to wild type controls (Gramd1c+/+) mice, mice lackingGramd1c (Gramd1c−/−) have no significant alterations in fecal, liver, or plasma cholesterol. Given the potential role for Aster C in modulating cholesterol metabolism in diverse tissues, we quantified levels of cholesterol metabolites such as bile acids, oxysterols, and steroid hormones. Compared to Gramd1c+/+ controls, Gramd1c−/− mice had modestly reduced levels of select bile acid species and elevated cortisol levels, only under low dietary cholesterol conditions. However, the vast majority of bile acids, oxysterols, and steroid hormones were unaltered in Gramd1c−/− mice. Bulk RNA sequencing in the liver showed that Gramd1c−/− mice did not exhibit alterations in sterol-sensitive genes, but instead showed altered expression of genes in major urinary protein and cytochrome P450 (CYP) families only under low dietary cholesterol conditions.Discussion:Collectively, these data indicate nominal effects of Aster-C on whole body cholesterol transport and metabolism under divergent dietary cholesterol conditions. These results strongly suggest that Aster-C alone is not sufficient to control whole body cholesterol balance, but can modestly impact circulating cortisol and bile acid levels when dietary cholesterol is limited.

Published
2024
Full Text
View/download PDF

48. Reconfigurable Intelligent Surface Assisted Device-to-Device Communications

Author

Ji, Zelin, Qin, Zhijin, and Parini, Clive G.

Subjects
Electrical Engineering and Systems Science - Signal Processing, Electrical Engineering and Systems Science - Systems and Control
Abstract

Reconfigurable intelligent surface (RIS) technology is a promising method to enhance wireless communications services and to realize the smart radio environment. In this paper, we investigate the application of RIS in D2D communications, and maximize the sum of the transmission rate of the D2D underlaying networks in a new perspective. Instead of solving similarly formulated resource allocation problems for D2D communications, this paper treats the wireless environment as a variable by adjusting the position and phase shift of the RIS. To solve this non-convex problem, we propose a novel double deep Q-network (DDQN) based structure which is able to achieve the near-optimal performance with lower complexity and enhanced robustness. Simulation results illustrate that the proposed DDQN based structure can achieve a higher uplink rate compared to the benchmarks, meanwhile meeting the quality of service (QoS) requirements at the base station (BS) and D2D receivers., Comment: This work have been submitted to IEEE Transactions on Communications

Published
2021

50. Certified Food Safety Management Systems Assessed through the Lenses of Food Safety Culture and Locus of Control: A Pilot Study

Author

Giada Forte, Simona Tornielli, Daniela Parini, and Vera Lavelli

Subjects
food safety culture, locus of control, certified company, management system, Chemical technology, TP1-1185
Abstract

The approach to ensure food safety (FS) has evolved, including the concept of FS culture, which has been shaped by both the legislation and the scientific literature. In this study, two companies that produce foods associated with potential risks of cross-contamination (gluten-free foods and frozen pastry, respectively) and are certified according to international voluntary FS standards, such as the British Retail Council Global Standard (BRC) and the International Featured Standards Food Version (IFS), were investigated to assess: (a) if the assessment of FS culture’s pillars can uncover unexpected critical areas; (b) if the scores of the FS culture’s pillars are related to personal traits, namely, age, seniority in the company and locus of control orientation, i.e., the beliefs that an event is the result of external factors (luck, destiny or superior beings), or the result of internal factors (human behavior). Questionnaires for the survey and the scoring system applied were selected from the literature. Results showed that all food handlers had an optimistic bias, which paradoxically could be the consequence of the rigorous application of hygienic procedures. The younger food handlers had significantly (p < 0.05) lower commitment than the older ones. Moreover, the segment of food handlers having an external locus orientation demonstrated weaker normative beliefs than those having an internal locus of control orientation. Results showed that the FS culture survey, which is related to the shared FS culture, could disclose unknown weakness in third-party certified companies, even if the well implemented principles of voluntary FS standards are aligned with the FS-culture pillars. Moreover, the segmentation of food handlers according to their age and the locus of control assessment could provide additional information on the individual orientation toward FS behavior. Hence these tools could assist the leaders in the management of the dynamic nature of human capital.

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results