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3. Indefinite and bidirectional near-infrared nanocrystal photoswitching

Author

Lee, Changhwan, Xu, Emma Z, Kwock, Kevin WC, Teitelboim, Ayelet, Liu, Yawei, Park, Hye Sun, Ursprung, Benedikt, Ziffer, Mark E, Karube, Yuzuka, Fardian-Melamed, Natalie, Pedroso, Cassio CS, Kim, Jongwoo, Pritzl, Stefanie D, Nam, Sang Hwan, Lohmueller, Theobald, Owen, Jonathan S, Ercius, Peter, Suh, Yung Doug, Cohen, Bruce E, Chan, Emory M, and Schuck, P James

Subjects
Engineering, Nanotechnology, General Science & Technology
Abstract

Materials whose luminescence can be switched by optical stimulation drive technologies ranging from superresolution imaging1-4, nanophotonics5, and optical data storage6,7, to targeted pharmacology, optogenetics, and chemical reactivity8. These photoswitchable probes, including organic fluorophores and proteins, can be prone to photodegradation and often operate in the ultraviolet or visible spectral regions. Colloidal inorganic nanoparticles6,9 can offer improved stability, but the ability to switch emission bidirectionally, particularly with near-infrared (NIR) light, has not, to our knowledge, been reported in such systems. Here, we present two-way, NIR photoswitching of avalanching nanoparticles (ANPs), showing full optical control of upconverted emission using phototriggers in the NIR-I and NIR-II spectral regions useful for subsurface imaging. Employing single-step photodarkening10-13 and photobrightening12,14-16, we demonstrate indefinite photoswitching of individual nanoparticles (more than 1,000 cycles over 7 h) in ambient or aqueous conditions without measurable photodegradation. Critical steps of the photoswitching mechanism are elucidated by modelling and by measuring the photon avalanche properties of single ANPs in both bright and dark states. Unlimited, reversible photoswitching of ANPs enables indefinitely rewritable two-dimensional and three-dimensional multilevel optical patterning of ANPs, as well as optical nanoscopy with sub-Å localization superresolution that allows us to distinguish individual ANPs within tightly packed clusters.

Published
2023

4. Indefinite and Bidirectional Near Infrared Nanocrystal Photoswitching

Author

Lee, Changhwan, Xu, Emma Z., Kwock, Kevin W. C., Teitelboim, Ayelet, Liu, Yawei, Fardian-Melamed, Natalie, Pedroso, Cassio C. S., Park, Hye Sun, Kim, Jongwoo, Pritzl, Stefanie D., Nam, Sang Hwan, Lohmueller, Theobald, Ercius, Peter, Suh, Yung Doug, Cohen, Bruce E, Chan, Emory M, and Schuck, P. James

Subjects
Physics - Optics
Abstract

Materials whose luminescence can be switched by optical stimulation drive technologies ranging from superresolution imaging1-4, nanophotonics5, and optical data storage6-8, to targeted pharmacology, optogenetics, and chemical reactivity9. These photoswitchable probes, including organic fluorophores and proteins, are prone to photodegradation, and often require phototoxic doses of ultraviolet (UV) or visible light. Colloidal inorganic nanoparticles have significant stability advantages over existing photoswitchable materials, but the ability to switch emission bidirectionally, particularly with NIR light, has not been reported with nanoparticles. Here, we present 2-way, near-infrared (NIR) photoswitching of avalanching nanoparticles (ANPs), showing full optical control of upconverted emission using phototriggers in the NIR-I and NIR-II spectral regions useful for subsurface imaging. Employing single-step photodarkening10-13 and photobrightening12,14-18, we demonstrate indefinite photoswitching of individual nanoparticles (>1000 cycles over 7 h) in ambient or aqueous conditions without measurable photodegradation. Critical steps of the photoswitching mechanism are elucidated by modeling and by measuring the photon avalanche properties of single ANPs in both bright and dark states. Unlimited, reversible photoswitching of ANPs enables indefinitely rewritable 2D and 3D multi-level optical patterning of ANPs, as well as optical nanoscopy with sub-{\AA} localization superresolution that allows us to distinguish individual ANPs within tightly packed clusters., Comment: 15 pages, 5 figures

Published
2022
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13. Evaluation of unmodified human cell‐derived extracellular vesicle mitochondrial deoxyribonucleic acid‐based biodistribution in rodents.

Author

Cho, Young‐Woo, Cho, Mi Young, Yoon, Jaehyeon, Hong, Da Eun, Lee, Ju‐young, Park, Hye Sun, Lee, Hyunseung, Hong, Kwan Soo, Won‐Kyu, Lee, Saehae, Choi, Song, Suk‐Gil, and Noh, Young‐Woock

Subjects
EXTRACELLULAR vesicles, MITOCHONDRIAL DNA, MITOCHONDRIA, DNA, RODENTS, POLYMERASE chain reaction, DNA primers
Abstract

Recently, extracellular vesicles (EVs) have been developed as therapeutic targets for various diseases. Biodistribution is crucial for EVs intended for therapeutic purposes because it can determine the degree of on‐ and off‐target effects. This study aimed to explore techniques to evaluate the biodistribution of unmodified EVs. We devised a novel quantitative polymerase chain reaction (qPCR)‐based assay to detect unmodified EVs by targeting mitochondrial deoxyribonucleic acid (mtDNA), a constituent of EVs. We focused on specific mtDNA regions that exhibited homologous variations distinct from their rodent mtDNA counterparts to establish this analytical approach. Herein, we successfully designed primers and probes targeting human and rodent mtDNA sequences and developed a highly specific and sensitive qPCR method. Furthermore, the quantification range of EVs isolated from various cells differed based on the manufacturer and cell source. IRDye 800CW‐labelled Expi293F EV mimetics were administered to the animals via the tail vein to compare the imaging test and mtDNA‐qPCR results. The results obtained from imaging tests and mtDNA‐qPCR to investigate EV biodistribution patterns revealed differences. The results revealed that our newly developed method effectively determined the biodistribution of unmodified EVs with high sensitivity and reproducibility. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Exploring the Value of Shared Experience in Augmented Reality Games

Author

Park, Hye Sun, Seo, Byung-Kuk, Lee, Gun A., Billinghurst, Mark, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Kotenko, Igor, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Stephanidis, Constantine, editor, and Antona, Margherita, editor

Published
2020
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18. Improving User Experience in Augmented Reality Mirrors with 3D Displays

Author

Lee, Gun A., Park, Hye Sun, Kim, Seungwon, Billinghurst, Mark, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Bebis, George, editor, Yin, Zhaozheng, editor, Kim, Edward, editor, Bender, Jan, editor, Subr, Kartic, editor, Kwon, Bum Chul, editor, Zhao, Jian, editor, Kalkofen, Denis, editor, and Baciu, George, editor

Published
2020
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21. Longitudinal Analysis of SARS-CoV-2-Specific Cellular and Humoral Immune Responses and Breakthrough Infection following BNT162b2/BNT162b2/BNT162b2 and ChAdOx1/ChAdOx1/BNT162b2 Vaccination: A Prospective Cohort in Naive Healthcare Workers

Author

Ko, Geon Young, primary, Lee, Jihyun, additional, Bae, Hyunjoo, additional, Ryu, Ji Hyeong, additional, Park, Hye-Sun, additional, Kang, Hyunhye, additional, Jung, Jin, additional, Choi, Ae-Ran, additional, Lee, Raeseok, additional, Lee, Dong-Gun, additional, and Oh, Eun-Jee, additional

Published
2023
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30. Dynamic-Interaction UI/UX Design for the AREIS

Author

Park, Hye Sun, Kim, Ho Won, Park, Chang Joon, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, and Kurosu, Masaaki, editor

Published
2016
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35. A modifiable universal cotinine-chimeric antigen system of NK cells with multiple targets

Author

Kang, Hee Young, primary, Lee, Soo Yun, additional, Kim, Hyun Min, additional, Lee, Su Ui, additional, Lee, Hyunseung, additional, Cho, Mi Young, additional, Oh, Se-Chan, additional, Kim, Seok-Min, additional, Park, Hye Sun, additional, Han, Eun Hee, additional, Kim, Seong-Eun, additional, Kim, Hyori, additional, Yoon, Suk Ran, additional, Doh, Junsang, additional, Chung, Junho, additional, Hong, Kwan Soo, additional, Choi, Inpyo, additional, and Kim, Tae-Don, additional

Published
2023
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36. AR-Based Vehicular Safety Information System for Forward Collision Warning

Author

Park, Hye Sun, Kim, Kyong-Ho, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Kobsa, Alfred, editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Weikum, Gerhard, editor, Shumaker, Randall, editor, and Lackey, Stephanie, editor

Published
2014
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43. Human Pose Tracking Using Motion-Based Search

Author

Jung, Do Joon, Park, Hye Sun, Kim, Hang Joon, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Muneesawang, Paisarn, editor, Wu, Feng, editor, Kumazawa, Itsuo, editor, Roeksabutr, Athikom, editor, Liao, Mark, editor, and Tang, Xiaoou, editor

Published
2009
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44. Vision-Based Game Interface Using Human Gesture

Author

Park, Hye Sun, Jung, Do Joon, Kim, Hang Joon, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Chang, Long-Wen, editor, and Lie, Wen-Nung, editor

Published
2006
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46. HMM-Based Gesture Recognition for Robot Control

Author

Park, Hye Sun, Kim, Eun Yi, Jang, Sang Su, Park, Se Hyun, Park, Min Ho, Kim, Hang Joon, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Marques, Jorge S., editor, Pérez de la Blanca, Nicolás, editor, and Pina, Pedro, editor

Published
2005
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47. Recognition of Human Action for Game System

Author

Park, Hye Sun, Kim, Eun Yi, Jang, Sang Su, Kim, Hang Joon, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Carbonell, Jaime G., editor, Siekmann, Jörg, editor, and Kim, Tag Gon, editor

Published
2005
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