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389 results on '"Park, Joon Seok"'

1. Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl‐tRNA synthetase 1

Author

Yoon, Ina, Kim, Sulhee, Cho, Minjae, You, Kyung Ah, Son, Jonghyeon, Lee, Caroline, Suh, Ji Hun, Bae, Da‐Jeong, Kim, Jong Min, Oh, Sinae, Park, Songhwa, Kim, Sanga, Cho, Seong Hyeok, Park, Seonha, Bang, Kyuhyeon, Seo, Minjeong, Kim, Jong Hyun, Lee, Bongyong, Park, Joon Seok, Hwang, Kwang Yeon, and Kim, Sunghoon

Subjects
Biochemistry and Cell Biology, Biological Sciences, Genetics, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, collagen, drug development, fibrosis, prolyl-tRNA synthetase 1, Humans, Fibrosis, Amino Acyl-tRNA Synthetases, Proline, Protein Biosynthesis, Medical and Health Sciences, Biochemistry and cell biology
Abstract

Prolyl-tRNA synthetase 1 (PARS1) has attracted much interest in controlling pathologic accumulation of collagen containing high amounts of proline in fibrotic diseases. However, there are concerns about its catalytic inhibition for potential adverse effects on global protein synthesis. We developed a novel compound, DWN12088, whose safety was validated by clinical phase 1 studies, and therapeutic efficacy was shown in idiopathic pulmonary fibrosis model. Structural and kinetic analyses revealed that DWN12088 binds to catalytic site of each protomer of PARS1 dimer in an asymmetric mode with different affinity, resulting in decreased responsiveness at higher doses, thereby expanding safety window. The mutations disrupting PARS1 homodimerization restored the sensitivity to DWN12088, validating negative communication between PARS1 promoters for the DWN12088 binding. Thus, this work suggests that DWN12088, an asymmetric catalytic inhibitor of PARS1 as a novel therapeutic agent against fibrosis with enhanced safety.

Published
2023

6. Metabolic modulation of mitochondrial mass during CD4+ T cell activation

Author

Kurmi, Kiran, Liang, Dan, van de Ven, Robert, Georgiev, Peter, Gassaway, Brandon Mark, Han, SeongJun, Notarangelo, Giulia, Harris, Isaac S., Yao, Cong-Hui, Park, Joon Seok, Hu, Song-Hua, Peng, Jingyu, Drijvers, Jefte M., Boswell, Sarah, Sokolov, Artem, Dougan, Stephanie K., Sorger, Peter K., Gygi, Steven P., Sharpe, Arlene H., and Haigis, Marcia C.

Published
2023
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7. Effect of the sodium‐glucose cotransporter‐2 inhibitor, DWP16001, as an add‐on therapy to insulin for diabetic dogs: A pilot study

Author

An, Ju‐Hyun, primary, Choi, Han‐Sol, additional, Choi, Ji‐Soo, additional, Lim, Hyun‐Woo, additional, Huh, Wan, additional, Oh, Ye‐In, additional, Park, Joon Seok, additional, Han, Jumi, additional, Lim, Soo, additional, Lim, Chae‐Young, additional, Kim, Tae‐Hee, additional, Moon, Jae‐Bong, additional, and Youn, Hwa‐Young, additional

Published
2024
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11. Compositional tailoring of indium-free GZO layers via plasma-enhanced atomic layer deposition for highly stable IGZO/GZO TFT.

Author

Oh, Hye-Jin, Kim, Yoon-Seo, Jeong, Hyun-Jun, Lee, Sunhee, Park, Joon Seok, and Park, Jin-Seong

Subjects
ATOMIC layer deposition, INDIUM gallium zinc oxide, INDIUM, THIN film transistors, ZINC oxide, INDUCTIVE effect, THERMAL stresses
Abstract

Oxide semiconductor-based thin-film transistors (TFTs) are promising candidates for display backplanes and memory device applications. To achieve high device performance and sustain the electrical properties under prolonged operation, it is important to overcome the mobility–stability trade-off in oxide TFTs. Here, we propose a bilayer-structured semiconductor stack formed by plasma-enhanced atomic layer deposition (PEALD), where an indium-free gallium zinc oxide (GZO) film is grown on top of indium gallium zinc oxide (IGZO), to be implemented in top gate devices. Applying a GZO layer (with optimum Ga to Zn ratio) between the IGZO and the gate insulator (GI) resulted in two major effects: interface engineering and band alignment modulation. While maintaining a sufficiently large field effect mobility (31.9 cm2 V−1 s−1), considerable improvements in device reliability were observed concerning positive-bias thermal stress (PBTS) and negative-bias illumination stress (NBIS) compared to TFTs incorporating IGZO single layers. This suggests that proper composition control through PEALD in the bilayer oxide semiconductor TFT may help achieve an appropriate balance between mobility and reliability. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Supplementary Figure 6 from Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade

Author

Rowe, Jared H., primary, Elia, Ilaria, primary, Shahid, Osmaan, primary, Gaudiano, Emily F., primary, Sifnugel, Natalia E., primary, Johnson, Sheila, primary, Reynolds, Amy G., primary, Fung, Megan E., primary, Joshi, Shakchhi, primary, LaFleur, Martin W., primary, Park, Joon Seok, primary, Pauken, Kristen E., primary, Rabinowitz, Joshua D., primary, Freeman, Gordon J., primary, Haigis, Marcia C., primary, and Sharpe, Arlene H., primary

Published
2023
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17. Supplementary Figure 9 from Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade

Author

Rowe, Jared H., primary, Elia, Ilaria, primary, Shahid, Osmaan, primary, Gaudiano, Emily F., primary, Sifnugel, Natalia E., primary, Johnson, Sheila, primary, Reynolds, Amy G., primary, Fung, Megan E., primary, Joshi, Shakchhi, primary, LaFleur, Martin W., primary, Park, Joon Seok, primary, Pauken, Kristen E., primary, Rabinowitz, Joshua D., primary, Freeman, Gordon J., primary, Haigis, Marcia C., primary, and Sharpe, Arlene H., primary

Published
2023
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18. Supplementary Figure 13 from Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade

Author

Rowe, Jared H., primary, Elia, Ilaria, primary, Shahid, Osmaan, primary, Gaudiano, Emily F., primary, Sifnugel, Natalia E., primary, Johnson, Sheila, primary, Reynolds, Amy G., primary, Fung, Megan E., primary, Joshi, Shakchhi, primary, LaFleur, Martin W., primary, Park, Joon Seok, primary, Pauken, Kristen E., primary, Rabinowitz, Joshua D., primary, Freeman, Gordon J., primary, Haigis, Marcia C., primary, and Sharpe, Arlene H., primary

Published
2023
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19. Supplementary Figure 5 from Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade

Author

Rowe, Jared H., primary, Elia, Ilaria, primary, Shahid, Osmaan, primary, Gaudiano, Emily F., primary, Sifnugel, Natalia E., primary, Johnson, Sheila, primary, Reynolds, Amy G., primary, Fung, Megan E., primary, Joshi, Shakchhi, primary, LaFleur, Martin W., primary, Park, Joon Seok, primary, Pauken, Kristen E., primary, Rabinowitz, Joshua D., primary, Freeman, Gordon J., primary, Haigis, Marcia C., primary, and Sharpe, Arlene H., primary

Published
2023
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20. Supplementary Figure 3 from Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade

Author

Rowe, Jared H., primary, Elia, Ilaria, primary, Shahid, Osmaan, primary, Gaudiano, Emily F., primary, Sifnugel, Natalia E., primary, Johnson, Sheila, primary, Reynolds, Amy G., primary, Fung, Megan E., primary, Joshi, Shakchhi, primary, LaFleur, Martin W., primary, Park, Joon Seok, primary, Pauken, Kristen E., primary, Rabinowitz, Joshua D., primary, Freeman, Gordon J., primary, Haigis, Marcia C., primary, and Sharpe, Arlene H., primary

Published
2023
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21. Supplementary Figure 7 from Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade

Author

Rowe, Jared H., primary, Elia, Ilaria, primary, Shahid, Osmaan, primary, Gaudiano, Emily F., primary, Sifnugel, Natalia E., primary, Johnson, Sheila, primary, Reynolds, Amy G., primary, Fung, Megan E., primary, Joshi, Shakchhi, primary, LaFleur, Martin W., primary, Park, Joon Seok, primary, Pauken, Kristen E., primary, Rabinowitz, Joshua D., primary, Freeman, Gordon J., primary, Haigis, Marcia C., primary, and Sharpe, Arlene H., primary

Published
2023
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22. Supplementary Figure 2 from Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade

Author

Rowe, Jared H., primary, Elia, Ilaria, primary, Shahid, Osmaan, primary, Gaudiano, Emily F., primary, Sifnugel, Natalia E., primary, Johnson, Sheila, primary, Reynolds, Amy G., primary, Fung, Megan E., primary, Joshi, Shakchhi, primary, LaFleur, Martin W., primary, Park, Joon Seok, primary, Pauken, Kristen E., primary, Rabinowitz, Joshua D., primary, Freeman, Gordon J., primary, Haigis, Marcia C., primary, and Sharpe, Arlene H., primary

Published
2023
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23. Supplementary Figure 4 from Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade

Author

Rowe, Jared H., primary, Elia, Ilaria, primary, Shahid, Osmaan, primary, Gaudiano, Emily F., primary, Sifnugel, Natalia E., primary, Johnson, Sheila, primary, Reynolds, Amy G., primary, Fung, Megan E., primary, Joshi, Shakchhi, primary, LaFleur, Martin W., primary, Park, Joon Seok, primary, Pauken, Kristen E., primary, Rabinowitz, Joshua D., primary, Freeman, Gordon J., primary, Haigis, Marcia C., primary, and Sharpe, Arlene H., primary

Published
2023
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24. Data from Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade

Author

Rowe, Jared H., primary, Elia, Ilaria, primary, Shahid, Osmaan, primary, Gaudiano, Emily F., primary, Sifnugel, Natalia E., primary, Johnson, Sheila, primary, Reynolds, Amy G., primary, Fung, Megan E., primary, Joshi, Shakchhi, primary, LaFleur, Martin W., primary, Park, Joon Seok, primary, Pauken, Kristen E., primary, Rabinowitz, Joshua D., primary, Freeman, Gordon J., primary, Haigis, Marcia C., primary, and Sharpe, Arlene H., primary

Published
2023
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25. Supplementary Figure 8 from Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade

Author

Rowe, Jared H., primary, Elia, Ilaria, primary, Shahid, Osmaan, primary, Gaudiano, Emily F., primary, Sifnugel, Natalia E., primary, Johnson, Sheila, primary, Reynolds, Amy G., primary, Fung, Megan E., primary, Joshi, Shakchhi, primary, LaFleur, Martin W., primary, Park, Joon Seok, primary, Pauken, Kristen E., primary, Rabinowitz, Joshua D., primary, Freeman, Gordon J., primary, Haigis, Marcia C., primary, and Sharpe, Arlene H., primary

Published
2023
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28. Formate supplementation enhances anti-tumor CD8+ T cell fitness and efficacy of PD-1 blockade

Author

Rowe, Jared H., primary, Elia, Ilaria, additional, Shahid, Osmaan, additional, Gaudiano, Emily F., additional, Sifnugel, Natalia E., additional, Johnson, Sheila, additional, Reynolds, Amy G., additional, Fung, Megan E., additional, Joshi, Shakchhi, additional, LaFleur, Martin W., additional, Park, Joon Seok, additional, Pauken, Kristen E., additional, Rabinowitz, Joshua D., additional, Freeman, Gordon J., additional, Haigis, Marcia C., additional, and Sharpe, Arlene H., additional

Published
2023
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34. Physiologically Based Pharmacokinetic Modelling to Predict Pharmacokinetics of Enavogliflozin, a Sodium-Dependent Glucose Transporter 2 Inhibitor, in Humans

Author

Kim, Min-Soo, primary, Song, Yoo-Kyung, additional, Choi, Ji-Soo, additional, Ji, Hye Young, additional, Yang, Eunsuk, additional, Park, Joon Seok, additional, Kim, Hyung Sik, additional, Kim, Min-Joo, additional, Cho, In-Kyung, additional, Chung, Suk-Jae, additional, Chae, Yoon-Jee, additional, and Lee, Kyeong-Ryoon, additional

Published
2023
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40. Tailored Self-Assembled Monolayer using Chemical Coupling for Indium–Gallium–Zinc Oxide Thin-Film Transistors: Multifunctional Copper Diffusion Barrier

Author

Lee, Seungmin, primary, Lee, Sanghyeon, additional, Lee, Minkyu, additional, Rho, Sung Min, additional, Kim, Hyung Tae, additional, Won, Chihyeong, additional, Yoon, Kukro, additional, Kwon, Chaebeen, additional, Kim, Juyoung, additional, Park, Geun Chul, additional, Lim, Jun Hyung, additional, Park, Joon Seok, additional, Kwon, Woobin, additional, Park, Young-Bae, additional, Chun, Dong won, additional, Kim, Hyun Jae, additional, and Lee, Taeyoon, additional

Published
2022
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