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4. Identification of Leishmania donovani PEX5-PTS1 Interaction Inhibitors through Fluorescence Polarization-Based High-Throughput Screening.

Author

Phan, Trong-Nhat, Park, Kyu-Ho Paul, Shum, David, and No, Joo Hwan

Subjects
*HIGH throughput screening (Drug development), *SMALL molecules, *MOLECULAR docking, *FLUORESCENCE, *LEISHMANIA, *TRYPANOSOMA brucei, *LEISHMANIA donovani
Abstract

Leishmaniasis, an infectious disease caused by pathogenic Leishmania parasites, affects millions of people in developing countries, and its re-emergence in developed countries, particularly in Europe, poses a growing public health concern. The limitations of current treatments and the absence of effective vaccines necessitate the development of novel therapeutics. In this study, we focused on identifying small molecule inhibitors which prevents the interaction between peroxin 5 (PEX5) and peroxisomal targeting signal 1 (PTS1), pivotal for kinetoplastid parasite survival. The Leishmania donovani PEX5, containing a C-terminal tetratricopeptide repeat (TPR) domain, was expressed and purified, followed by the quantification of kinetic parameters of PEX5-PTS1 interactions. A fluorescence polarization-based high-throughput screening assay was developed and small molecules inhibiting the LdPEX5-PTS1 interaction were discovered through the screening of a library of 51,406 compounds. Based on the confirmatory assay, nine compounds showed half maximal inhibitory concentration (IC50) values ranging from 3.89 to 24.50 µM. In silico docking using a homology model of LdPEX5 elucidated that the molecular interactions between LdPEX5 and the inhibitors share amino acids critical for PTS1 binding. Notably, compound P20 showed potent activity against the growth of L. donovani promastigotes, L. major promastigotes, and Trypanosoma brucei blood stream form, with IC50 values of 12.16, 19.21, and 3.06 μM, respectively. The findings underscore the potential of targeting LdPEX5-PTS1 interactions with small molecule inhibitors as a promising strategy for the discovery of new anti-parasitic compounds. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Identification and characterization of new structural scaffolds modulating the activity of Mycobacterium tuberculosis dihydroneopterin aldolase (FolB) in vitro

Author

Falcão, Virginia Carla de Almeida, primary, Czeczot, Alexia de Matos, additional, Alam, Mohammad Maqusood, additional, Park, Kyu-Ho Paul, additional, Heo, Jinyeong, additional, Woo, Minjeong, additional, Camini, Ana Micaela, additional, Timmers, Luis Fernando Saraiva Macedo, additional, Shum, David, additional, Perelló, Marcia Alberton, additional, Basso, Luiz Augusto, additional, Machado, Pablo, additional, Bizarro, Cristiano Valim, additional, and Delorme, Vincent Pascal, additional

Published
2023
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6. Garbage in, garbage out: how reliable training data improved a virtual screening approach against SARS-CoV-2 MPro

Author

Ruatta, Santiago M., primary, Prada Gori, Denis N., additional, Fló Díaz, Martín, additional, Lorenzelli, Franca, additional, Perelmuter, Karen, additional, Alberca, Lucas N., additional, Bellera, Carolina L., additional, Medeiros, Andrea, additional, López, Gloria V., additional, Ingold, Mariana, additional, Porcal, Williams, additional, Dibello, Estefanía, additional, Ihnatenko, Irina, additional, Kunick, Conrad, additional, Incerti, Marcelo, additional, Luzardo, Martín, additional, Colobbio, Maximiliano, additional, Ramos, Juan Carlos, additional, Manta, Eduardo, additional, Minini, Lucía, additional, Lavaggi, María Laura, additional, Hernández, Paola, additional, Šarlauskas, Jonas, additional, Huerta García, César Sebastian, additional, Castillo, Rafael, additional, Hernández-Campos, Alicia, additional, Ribaudo, Giovanni, additional, Zagotto, Giuseppe, additional, Carlucci, Renzo, additional, Medrán, Noelia S., additional, Labadie, Guillermo R., additional, Martinez-Amezaga, Maitena, additional, Delpiccolo, Carina M. L., additional, Mata, Ernesto G., additional, Scarone, Laura, additional, Posada, Laura, additional, Serra, Gloria, additional, Calogeropoulou, Theodora, additional, Prousis, Kyriakos, additional, Detsi, Anastasia, additional, Cabrera, Mauricio, additional, Alvarez, Guzmán, additional, Aicardo, Adrián, additional, Araújo, Verena, additional, Chavarría, Cecilia, additional, Mašič, Lucija Peterlin, additional, Gantner, Melisa E., additional, Llanos, Manuel A., additional, Rodríguez, Santiago, additional, Gavernet, Luciana, additional, Park, Soonju, additional, Heo, Jinyeong, additional, Lee, Honggun, additional, Paul Park, Kyu-Ho, additional, Bollati-Fogolín, Mariela, additional, Pritsch, Otto, additional, Shum, David, additional, Talevi, Alan, additional, and Comini, Marcelo A., additional

Published
2023
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8. Drug repurposing screening validated by experimental assays identifies two clinical drugs targeting SARS-CoV-2 main protease

Author

Prada Gori, Denis N., primary, Ruatta, Santiago, additional, Fló, Martín, additional, Alberca, Lucas N., additional, Bellera, Carolina L., additional, Park, Soonju, additional, Heo, Jinyeong, additional, Lee, Honggun, additional, Park, Kyu-Ho Paul, additional, Pritsch, Otto, additional, Shum, David, additional, Comini, Marcelo A., additional, and Talevi, Alan, additional

Published
2023
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9. Garbage in, garbage out: how reliable training data improved a virtual screening approach against SARS-CoV-2 MPro

Author

Ruatta, Santiago M., Prada Gori, Denis N., Fló Díaz, Martín, Lorenzelli, Franca, Perelmuter, Karen, Alberca, Lucas N., Bellera, Carolina L., Medeiros, Andrea, López, Gloria V., Ingold, Mariana, Porcal, Williams, Dibello, Estefanía, Ihnatenko, Irina, Kunick, Conrad, Incerti, Marcelo, Luzardo, Martín, Colobbio, Maximiliano, Ramos, Juan Carlos, Manta, Eduardo, Minini, Lucía, Lavaggi, María Laura, Hernández, Paola, Šarlauskas, Jonas, Huerta García, César Sebastian, Castillo, Rafael, Hernández-Campos, Alicia, Ribaudo, Giovanni, Zagotto, Giuseppe, Carlucci, Renzo, Medrán, Noelia S., Labadie, Guillermo R., Martinez-Amezaga, Maitena, Delpiccolo, Carina M. L., Mata, Ernesto G., Scarone, Laura, Posada, Laura, Serra, Gloria, Calogeropoulou, Theodora, Prousis, Kyriakos, Detsi, Anastasia, Cabrera, Mauricio, Alvarez, Guzmán, Aicardo, Adrián, Araújo, Verena, Chavarría, Cecilia, Mašič, Lucija Peterlin, Gantner, Melisa E., Llanos, Manuel A., Rodríguez, Santiago, Gavernet, Luciana, Park, Soonju, Heo, Jinyeong, Lee, Honggun, Paul Park, Kyu-Ho, Bollati-Fogolín, Mariela, Pritsch, Otto, Shum, David, Talevi, Alan, and Comini, Marcelo A.

Published
2023

10. Design of Embedded Database Based on Hybrid Storage of PRAM and NAND Flash Memory

Author

Park, Youngwoo, Park, Sung Kyu, Park, Kyu Ho, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Xu, Jianliang, editor, Yu, Ge, editor, Zhou, Shuigeng, editor, and Unland, Rainer, editor

Published
2011
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11. Scalable Interactive Middleware Components for Ubiquitous Fashionable Computers

Author

Shim, Gyudong, Park, Kyu Ho, Akan, Ozgur, Series editor, Bellavista, Paolo, Series editor, Cao, Jiannong, Series editor, Dressler, Falko, Series editor, Ferrari, Domenico, Series editor, Gerla, Mario, Series editor, Kobayashi, Hisashi, Series editor, Palazzo, Sergio, Series editor, Sahni, Sartaj, Series editor, Shen, Xuemin (Sherman), Series editor, Stan, Mircea, Series editor, Xiaohua, Jia, Series editor, Zomaya, Albert, Series editor, Coulson, Geoffrey, Series editor, Bonnin, Jean-Marie, editor, Giannelli, Carlo, editor, and Magedanz, Thomas, editor

Published
2009
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13. U-Interactive: A Middleware for Ubiquitous Fashionable Computer to Interact with the Ubiquitous Environment by Gestures

Author

Shim, Gyudong, Moon, SangKwon, Song, Yong, Kim, Jaesub, Park, Kyu Ho, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Kuo, Tei-Wei, editor, Sha, Edwin, editor, Guo, Minyi, editor, Yang, Laurence T., editor, and Shao, Zili, editor

Published
2007
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14. Journal Remap-Based FTL for Journaling File System with Flash Memory

Author

Lim, Seung-Ho, Choi, Hyun Jin, Park, Kyu Ho, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Perrott, Ronald, editor, Chapman, Barbara M., editor, Subhlok, Jaspal, editor, de Mello, Rodrigo Fernandes, editor, and Yang, Laurence T., editor

Published
2007
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15. Write Back Routine for JFFS2 Efficient I/O

Author

Lim, Seung-Ho, Baek, Sung-Hoon, Hwang, Joo-Young, Park, Kyu-Ho, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Sha, Edwin, editor, Han, Sung-Kook, editor, Xu, Cheng-Zhong, editor, Kim, Moon-Hae, editor, Yang, Laurence T., editor, and Xiao, Bin, editor

Published
2006
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16. A Content Delivery Accelerator in Data-Intensive Servers

Author

Cho, Joon-Woo, Choi, Hyun-Jin, Lim, Seung-Ho, Park, Kyu-Ho, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Dough, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Jin, Hai, editor, Reed, Daniel, editor, and Jiang, Wenbin, editor

Published
2005
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17. A New Raid-Disk Placement Method for Interactive Media Server with an Accurate Bit Count Control

Author

Jeong, Yo-Won, Lim, Seung-Ho, Park, Kyu-Ho, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Dough, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Jin, Hai, editor, Reed, Daniel, editor, and Jiang, Wenbin, editor

Published
2005
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18. Autonomous Management of Clustered Server Systems Using JINI

Author

Lee, Chul, Lim, Seung Ho, Lim, Sang Soek, Park, Kyu Ho, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Dough, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Sahai, Akhil, editor, and Wu, Felix, editor

Published
2004
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19. Dengue virus NS1 protein conveys pro‐inflammatory signals by docking onto high‐density lipoproteins

Author

Benfrid, Souheyla, primary, Park, Kyu‐Ho, additional, Dellarole, Mariano, additional, Voss, James E, additional, Tamietti, Carole, additional, Pehau‐Arnaudet, Gérard, additional, Raynal, Bertrand, additional, Brûlé, Sébastien, additional, England, Patrick, additional, Zhang, Xiaokang, additional, Mikhailova, Anastassia, additional, Hasan, Milena, additional, Ungeheuer, Marie‐Noëlle, additional, Petres, Stéphane, additional, Biering, Scott B, additional, Harris, Eva, additional, Sakuntabhai, Anavaj, additional, Buchy, Philippe, additional, Duong, Veasna, additional, Dussart, Philippe, additional, Coulibaly, Fasséli, additional, Bontems, François, additional, Rey, Félix A, additional, and Flamand, Marie, additional

Published
2022
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25. The dengue virus NS1 protein conveys pro-inflammatory signals by docking onto human high-density lipoproteins

Author

Benfrid, Souheyla, primary, Park, Kyu-Ho, additional, Dellarole, Mariano, additional, Voss, James E., additional, Tamietti, Carole, additional, Pehau-Arnaudet, Gérard, additional, Raynal, Bertrand, additional, Brûlé, Sébastien, additional, England, Patrick, additional, Zhang, Xiaokang, additional, Mikhailova, Anastassia, additional, Ungeheuer, Marie-Noëlle, additional, Petres, Stéphane, additional, Biering, Scott B., additional, Harris, Eva, additional, Sakunthabaï, Anavaj, additional, Buchy, Philippe, additional, Duong, Veasna, additional, Dussart, Philippe, additional, Coulibaly, Fasséli, additional, Bontems, François, additional, Rey, Félix A., additional, and Flamand, Marie, additional

Published
2021
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29. A fast path planning by path graph optimization

Author

Hwang, Joo Young, Kim, Jun Song, Lim, Sang Seok, and Park, Kyu Ho

Abstract

In this paper, a fast path planning method by optimization of a path graph for both efficiency and accuracy is proposed. A conventional quadtree-based path planning approach is simple, robust, and efficient. However, it has two limitations. The first limitation is that many small cells are required to represent obstacles because the positions and shapes of the cells are not object-dependent and searching the shortest path in the path graph is slow. The second limitation is generation of nonoptimal paths due to large cells in a free space. The cost of traversing a cell is the same whether a path just clips a corner of the cell or actually passes through the entire width of the cell. The quadtree is very sensitive to obstacle placement and the error factor is proportional to the size of the cell. We propose a path graph optimization technique employing a compact mesh representation. A world space is triangulated into a base mesh and the base mesh is simplified to a compact mesh. The compact mesh representation is object-dependent; the positions of vertexes of the mesh are optimized according to the curvatures of the obstacles. The compact mesh represents the obstacles as accurately as the quadtree even though using much fewer vertexes than the quadtree. The compact mesh distributes vertexes in a free space in a balanced way by ensuring that the lengths of edges are below an edge length threshold. An optimized path graph is extracted from the compact mesh. An iterative vertex pushing method is proposed to include important obstacle boundary edges in the path graph. Dijkstra's shortest path searching algorithm is used to search the shortest path in the path graph. Experimental results show that the path planning using the optimized path graph is an order of magnitude faster than the quadtree approach while the length of the path generated by the proposed method is almost the same as that of the path generated by the quadtree. Index Terms--Mesh simplification, path planning.

Published
2003

36. A highly miniaturized active 90-degree power combiner MMIC employing CE and CC circuits

Author

Park, Young-Bae, Yun, Young, Kang, Suk-Youb, Kang, In-Ho, Jung, Ji-Won, Park, Kyu-Ho, and Anh, Kwang-Ho

Subjects
Microwave integrated circuits -- Research, Bipolar transistors -- Research, Signal processing -- Equipment and supplies, Signal processing -- Research, Business, Electronics and electrical industries, Engineering and manufacturing industries, Telecommunications industry
Abstract

A highly miniaturized monolithic microwave integrated circuit using common-emitter and common-collector circuits is fabricated for signal mixing. The active 90-degree power combiner's performance is superior to a passive combiner at S-band.

Published
2009

39. Event suppression by optimizing VHDL programs

Author

Park, Kwang II and Park, Kyu Ho

Subjects
Sequential circuits -- Research, Combinational circuits -- Analysis, Algorithms -- Research, Hardware description languages -- Research
Published
1998

42. A compact LTCC bandpass filter using resonators loaded with spiral-shaped open-circuited stubs

Author

Park, Kyu-Ho, Song, Hee-Seok, Lee, Young-Shin, and Jeong, Yong-Chae

Subjects
Electric filters, Bandpass -- Design and construction, Business, Electronics and electrical industries, Engineering and manufacturing industries, Telecommunications industry
Abstract

A novel compact multi-layer low temperature co-fired ceramic bandpass filter is presented. The composition, working, technical specifications and other relevant information pertaining to the new gadget are provided.

Published
2005

49. SUPA

Author

Kim, Dongjin, primary, Park, Kyu Ho, additional, and Youn, Chan-Hyun, additional

Published
2017
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