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32 results on '"Park, No-June"'

6. Artificial Octopus-Limb-Like Adhesive Patches for Cupping-Driven Transdermal Delivery with Nanoscale Control of Stratum Corneum

Author

Lee, Jihyun, primary, Hwang, Gui Won, additional, Lee, Bum Soo, additional, Park, No-June, additional, Kim, Su-Nam, additional, Lim, Dohyun, additional, Kim, Da Wan, additional, Lee, Yeon Soo, additional, Park, Hyoung-Ki, additional, Kim, Seulgi, additional, Kim, Jin Woong, additional, Yi, Gi-Ra, additional, Kim, Ki Hyun, additional, and Pang, Changhyun, additional

Published
2024
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31. Stellera chamaejasme and Its Main Compound Luteolin 7- O -Glucoside Alleviates Skin Lesions in Oxazolone- and 2,4-Dinitrochlorobenzene-Stimulated Murine Models of Atopic Dermatitis.

Author

Jo, Beom-Geun, Park, No-June, Jegal, Jonghwan, Choi, Sangho, Lee, Sang Woo, Yi, Li Wan, Kim, Su-Nam, and Yang, Min Hye

Subjects
*ANIMAL experimentation, *ATOPIC dermatitis, *BIOLOGICAL models, *ERYTHEMA, *GLYCOSIDES, *HETEROCYCLIC compounds, *IMMUNOGLOBULINS, *INTERLEUKINS, *ITCHING, *MICE, *PLANT extracts, *COMPULSIVE skin picking, *FLAVONES, *SYMPTOMS, *PREVENTION
Abstract

Stellera chamaejasme , also known as " Langdu ", has been traditionally used for the management of skin-related diseases such as psoriasis and skin ulcers. The aim of this study was to determine whether S. chamaejasme and its major component, luteolin 7- O -glucoside, have a preventive effect on the development of atopic dermatitis in oxazolone-treated BALB/c mice and 2,4-dinitrochlorobenzene-treated hairless mice. The epicutaneous applications of oxazolone and 2,4-dinitrochlorobenzene evoke an experimental murine atopic dermatitis-like reaction in BALB/c mouse ears and SKH-1 hairless mice. Atopic skin symptoms, including erythema (redness), pruritus (itching), exudation (weeping), excoriation (peeling), and lichenification (skin thickening), responded to treatment with S. chamaejasme aerial parts EtOH extract for 2 or 3 weeks. Histopathological examination revealed S. chamaejasme aerial parts EtOH extract significantly reduced inflammatory cell infiltration when applied to atopic dermatitis mice. In addition, luteolin 7- O -glucoside, the major active compound of the S. chamaejasme aerial parts EtOH extract, decreased serum IgE and IL-4 levels and transepidermal water loss and increased skin hydration, therefore exhibiting strong anti-atopic dermatitis activity in 2,4-dinitrochlorobenzene-induced atopic dermatitis mice. In this study, we confirmed antipruritic and antidermatitic effects of S. chamaejasme extract and its main component luteolin 7- O -glucoside in atopic dermatitis murine models. The study shows S. chamaejasme aerial parts EtOH extract and luteolin 7- O -glucoside are most likely to be potential drug candidates for atopic dermatitis treatment. [ABSTRACT FROM AUTHOR]

Published
2019
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32. Wikstroemia ganpi Extract Improved Atopic Dermatitis-Like Skin Lesions via Suppression of Interleukin-4 in 2,4-Dinitrochlorobenzene-Induced SKH-1 Hairless Mice.

Author

Jegal, Jonghwan, Park, No-June, Jo, Beom-Geun, Kim, Tae-Young, Bong, Sim-Kyu, Choi, Sangho, Paik, Jin-Hyub, Kim, Jung-Won, Kim, Su-Nam, Yang, Min Hye, and Epifano, Francesco

Subjects
*INTERLEUKIN-4, *ATOPIC dermatitis, *MICE, *CHINESE medicine, *KERATINIZATION
Abstract

Plants of the genus Wikstroemia are used in Chinese traditional medicine to treat inflammatory diseases, such as arthritis, bronchitis, and pneumonia. The present study was designed to determine whether Wikstroemia ganpi (Siebold and Zucc.) Maxim. offers a potential means of treating 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in mice. Symptoms such as redness, edema, and keratinization in AD mice induced by DNCB were alleviated by the co-application of an ethanolic extract of W. ganpi for 2 weeks. The severity of skin barrier function damage was evaluated by measuring TEWL (transepidermal water loss). TEWLs of DNCB sensitized mouse dorsal skin were reduced by the application of a W. ganpi ethanolic extract, and skin hydration was increased. In addition, the infiltration of inflammatory cells into the dermis was significantly reduced, as were blood levels of IgE and IL-4, which play an important role in the expression of AD. The results of this experiment suggest that W. ganpi is a potential therapeutic agent for AD. [ABSTRACT FROM AUTHOR]

Published
2021
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