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BackgroundIn hereditary breast and ovarian cancer (HBOC), family communication of genetic test results is essential for cascade genetic screening, that is, identifying and testing blood relatives of known mutation carriers to determine whether they also carry the pathogenic variant, and to propose preventive and clinical management options. However, up to 50% of blood relatives are unaware of relevant genetic information, suggesting that potential benefits of genetic testing are not communicated effectively within family networks. Technology can facilitate communication and genetic education within HBOC families. ObjectiveThe aims of this study are to develop the K-CASCADE (Korean–Cancer Predisposition Cascade Genetic Testing) cohort in Korea by expanding an infrastructure developed by the CASCADE (Cancer Predisposition Cascade Genetic Testing) Consortium in Switzerland; develop a digital health intervention to support the communication of cancer predisposition for Swiss and Korean HBOC families, based on linguistic and cultural adaptation of the Family Gene Toolkit; evaluate its efficacy on primary (family communication of genetic results and cascade testing) and secondary (psychological distress, genetic literacy, active coping, and decision making) outcomes; and explore its translatability using the reach, effectiveness, adoption, implementation, and maintenance framework. MethodsThe digital health intervention will be available in French, German, Italian, Korean, and English and can be accessed via the web, mobile phone, or tablet (ie, device-agnostic). K-CASCADE cohort of Korean HBOC mutation carriers and relatives will be based on the CASCADE infrastructure. Narrative data collected through individual interviews or mini focus groups from 20 to 24 HBOC family members per linguistic region and 6-10 health care providers involved in genetic services will identify the local cultures and context, and inform the content of the tailored messages. The efficacy of the digital health intervention against a comparison website will be assessed in a randomized trial with 104 HBOC mutation carriers (52 in each study arm). The translatability of the digital health intervention will be assessed using survey data collected from HBOC families and health care providers. ResultsFunding was received in October 2019. It is projected that data collection will be completed by January 2023 and results will be published in fall 2023. ConclusionsThis study addresses the continuum of translational research, from developing an international research infrastructure and adapting an existing digital health intervention to testing its efficacy in a randomized controlled trial and exploring its translatability using an established framework. Adapting existing interventions, rather than developing new ones, takes advantage of previous valid experiences without duplicating efforts. Culturally sensitive web-based interventions that enhance family communication and understanding of genetic cancer risk are timely. This collaboration creates a research infrastructure between Switzerland and Korea that can be scaled up to cover other hereditary cancer syndromes. Trial RegistrationClinicalTrials.gov NCT04214210; https://clinicaltrials.gov/ct2/show/NCT04214210 and CRiS KCT0005643; https://cris.nih.go.kr/cris/ International Registered Report Identifier (IRRID)PRR1-10.2196/26264

This study aims to identify the non-value-adding activities during vehicle stowage operations in automobile terminals and propose a connected automated vehicle (CAV) loading system, a self-driving-car-loading system. Furthermore, the productivity of the CAV loading system is compared with the current loading system. A simulation model of an actual loading system was developed using the software FlexSim. The simulation results showed that the walking time of workers, operation time of shuttle vans, and waiting time occupied a large part of the cycle time in the current operation system. The proposed CAV loading system has eliminated these inefficiencies, and increased productivity by 26.78%. This is the first study to (1) present a self-driving-car-loading system in a simulated automobile terminal of a real-world size, and (2) propose a CAV loading system. Results provide useful insights for the integration of self-driving technology into future automobile port operations. [ABSTRACT FROM AUTHOR]

Automatic guided vehicles (AGVs) have been successfully applied to cargo terminals to reduce operating costs and improve productivity. However, the focus was on container terminal operations. Ports with roll-on/roll-off (RORO) terminals still heavily depend on human resources for the loading/unloading processes. Work operations are affected by human errors and safety issues. In particular, terminals where vehicles cannot be stacked pressure workers to handle cargo more rapidly, which induces more errors. In this study, we propose automating RORO terminal operations by using AGVs. We assessed the impact of AGVs on the productivity, cost efficiency, and environment. A series of simulation models was developed on the basis of the current loading system at an actual port to test the impact of AGVs. Then, we developed a cost model to analyze the economic benefit of AGVs compared with the current loading system. The environmental benefits were also analyzed. Results revealed that a system using 29 AGVs matched the productivity of the current loading system, and using more AGVs increased the productivity. For a given productivity level, the total operating cost of the AGV system was three times less than that of the current system over a 15-year period. The AGV system also showed great potential for improving the environmental friendliness of terminal operations. This is the first study to propose automating RORO terminal operations to improve productivity and sustainability through AGV technology rather than human factors. AGVs are expected to become a good option in the future to address labor shortages and the “untact” era., Author(s): Sang Hyung Park [1]; Jeho Hwang [2]; Sohyun Yun [1]; Sihyun Kim (corresponding author) [2] 1. Introduction Seaports are one of the most important elements of a country's economy [...]