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1. Clinical impact of genetic alterations including germline DDX41 mutations in MDS/low-blast count AML patients treated with azacitidine-based regimens

Author

Sébert, Marie, Freiman, Lucie, Chaffaut, Cendrine, Guerci, Agnès, Peterlin, Pierre, Thépot, Sylvain, Beyne-Rauzy, Odile, Park, Sophie, Cluzeau, Thomas, Chermat, Fatiha, Fenaux, Pierre, Preudhomme, Claude, Clappier, Emmanuelle, Chevret, Sylvie, Adès, Lionel, Duployez, Nicolas, and Duchmann, Matthieu

Published
2024
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7. Reduced peripheral blood dendritic cell and monocyte subsets in MDS patients with systemic inflammatory or dysimmune diseases

Author

Jachiet, Vincent, Ricard, Laure, Hirsch, Pierre, Malard, Florent, Pascal, Laurent, Beyne-Rauzy, Odile, Peterlin, Pierre, Maria, Alexandre Thibault Jacques, Vey, Norbert, D’Aveni, Maud, Gourin, Marie-Pierre, Dimicoli-Salazar, Sophie, Banos, Anne, Wickenhauser, Stefan, Terriou, Louis, De Renzis, Benoit, Durot, Eric, Natarajan-Ame, Shanti, Vekhoff, Anne, Voillat, Laurent, Park, Sophie, Vinit, Julien, Dieval, Céline, Dellal, Azeddine, Grobost, Vincent, Willems, Lise, Rossignol, Julien, Solary, Eric, Kosmider, Olivier, Dulphy, Nicolas, Zhao, Lin Pierre, Adès, Lionel, Fenaux, Pierre, Fain, Olivier, Mohty, Mohamad, Gaugler, Béatrice, and Mekinian, Arsène

Published
2023
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9. Accelerated DNA replication fork speed due to loss of R-loops in myelodysplastic syndromes with SF3B1 mutation

Author

Rombaut, David, Lefèvre, Carine, Rached, Tony, Bondu, Sabrina, Letessier, Anne, Mangione, Raphael M., Farhat, Batoul, Lesieur-Pasquier, Auriane, Castillo-Guzman, Daisy, Boussaid, Ismael, Friedrich, Chloé, Tourville, Aurore, De Carvalho, Magali, Levavasseur, Françoise, Leduc, Marjorie, Le Gall, Morgane, Battault, Sarah, Temple, Marie, Houy, Alexandre, Bouscary, Didier, Willems, Lise, Park, Sophie, Raynaud, Sophie, Cluzeau, Thomas, Clappier, Emmanuelle, Fenaux, Pierre, Adès, Lionel, Margueron, Raphael, Wassef, Michel, Alsafadi, Samar, Chapuis, Nicolas, Kosmider, Olivier, Solary, Eric, Constantinou, Angelos, Stern, Marc-Henri, Droin, Nathalie, Palancade, Benoit, Miotto, Benoit, Chédin, Frédéric, and Fontenay, Michaela

Published
2024
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12. General practitioner workforce sustainability to maximise effective and equitable patient care: a realist review protocol

Author

Park, Sophie, primary, Owen-Boukra, Emily, additional, Burford, Bryan, additional, Cohen, Tanya, additional, Duddy, Claire, additional, Dunn, Harry, additional, Fadia, Vacha, additional, Goodman, Claire, additional, Henry, Cecily, additional, Lamb, Elizabeth I, additional, Ogden, Margaret, additional, Rapley, Tim, additional, Rees, Eliot, additional, Vance, Gillian, additional, and Wong, Geoff, additional

Published
2024
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13. CPX-351 in higher risk myelodysplastic syndrome and chronic myelomonocytic leukaemia: a multicentre, single-arm, phase 2 study

Author

Peterlin, Pierre, Le Bris, Yannick, Turlure, Pascal, Chevallier, Patrice, Ménard, Audrey, Gourin, Marie-Pierre, Dumas, Pierre-Yves, Thepot, Sylvain, Berceanu, Ana, Park, Sophie, Hospital, Marie-Anne, Cluzeau, Thomas, Bouzy, Simon, Torregrosa-Diaz, Jose-Miguel, Drevon, Louis, Sapena, Rosa, Chermat, Fatiha, Ades, Lionel, Dimicoli-Salazar, Sophie, Chevret, Sylvie, Béné, Marie-Christine, and Fenaux, Pierre

Published
2023
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14. Prospective validation of a biomarker-driven response prediction model to romiplostim in lower-risk myelodysplastic neoplasms – results of the EUROPE trial by EMSCO

Author

Kubasch, Anne Sophie, Giagounidis, Aristoteles, Metzgeroth, Georgia, Jonasova, Anna, Herbst, Regina, Diaz, Jose Miguel Torregrosa, De Renzis, Benoit, Götze, Katharina S., Huetter-Kroenke, Marie-Luise, Gourin, Marie-Pierre, Slama, Borhane, Dimicoli-Salazar, Sophie, Cony-Makhoul, Pascale, Laribi, Kamel, Park, Sophie, Jersemann, Katja, Schipp, Dorothea, Metzeler, Klaus H., Tiebel, Oliver, Sockel, Katja, Gloaguen, Silke, Mies, Anna, Chermat, Fatiha, Thiede, Christian, Sapena, Rosa, Schlenk, Richard F., Fenaux, Pierre, Platzbecker, Uwe, and Adès, Lionel

Published
2022
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16. Lost in Reviews: Looking for the Involvement of Stakeholders, Patients, Public and Other Non-Researcher Contributors in Realist Reviews

Author

Abrams, Ruth, Park, Sophie, Wong, Geoff, Rastogi, Juhi, Boylan, Anne-Marie, Tierney, Stephanie, Petrova, Mila, Dawson, Shoba, and Roberts, Nia

Abstract

The involvement of non-researcher contributors (eg, stakeholders, patients and the public, decision and policy makers, experts, lay contributors) has taken a variety of forms within evidence syntheses. Realist reviews are a form of evidence synthesis that involves non-researcher contributors yet this practice has received little attention. In particular, the role of patient and public involvement (PPI) has not been clearly documented. This review of reviews describes the ways in which contributor involvement, including PPI, is documented within healthcare realist reviews published over the last five years. A total of 448 papers published between 2014 and 2019 were screened, yielding 71 full-text papers included in this review. Statements about contributor involvement were synthesized across each review using framework analysis. Three themes are described in this article including nomenclature, nature of involvement, and reporting impact.

Published
2021
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18. A variant erythroferrone disrupts iron homeostasis in SF3B1-mutated myelodysplastic syndrome.

Author

Bondu, Sabrina, Alary, Anne-Sophie, Lefèvre, Carine, Houy, Alexandre, Jung, Grace, Lefebvre, Thibaud, Rombaut, David, Boussaid, Ismael, Bousta, Abderrahmane, Guillonneau, François, Perrier, Prunelle, Alsafadi, Samar, Wassef, Michel, Margueron, Raphaël, Rousseau, Alice, Droin, Nathalie, Cagnard, Nicolas, Kaltenbach, Sophie, Winter, Susann, Kubasch, Anne-Sophie, Bouscary, Didier, Santini, Valeria, Toma, Andrea, Hunault, Mathilde, Stamatoullas, Aspasia, Gyan, Emmanuel, Cluzeau, Thomas, Platzbecker, Uwe, Adès, Lionel, Puy, Hervé, Stern, Marc-Henri, Karim, Zoubida, Mayeux, Patrick, Nemeth, Elizabeta, Park, Sophie, Ganz, Tomas, Kautz, Léon, Kosmider, Olivier, and Fontenay, Michaëla

Subjects
Alternative Splicing, Amino Acid Sequence, Animals, Blood Transfusion, Cell Line, Cell Lineage, Cell Survival, Clone Cells, Erythroid Cells, Hepcidins, Homeostasis, Humans, Iron, Lenalidomide, Mice, Mutation, Myelodysplastic Syndromes, Peptide Hormones, Phosphoproteins, Protein Biosynthesis, RNA Splice Sites, RNA Splicing Factors, RNA, Messenger, Up-Regulation
Abstract

Myelodysplastic syndromes (MDS) with ring sideroblasts are hematopoietic stem cell disorders with erythroid dysplasia and mutations in the SF3B1 splicing factor gene. Patients with MDS with SF3B1 mutations often accumulate excessive tissue iron, even in the absence of transfusions, but the mechanisms that are responsible for their parenchymal iron overload are unknown. Body iron content, tissue distribution, and the supply of iron for erythropoiesis are controlled by the hormone hepcidin, which is regulated by erythroblasts through secretion of the erythroid hormone erythroferrone (ERFE). Here, we identified an alternative ERFE transcript in patients with MDS with the SF3B1 mutation. Induction of this ERFE transcript in primary SF3B1-mutated bone marrow erythroblasts generated a variant protein that maintained the capacity to suppress hepcidin transcription. Plasma concentrations of ERFE were higher in patients with MDS with an SF3B1 gene mutation than in patients with SF3B1 wild-type MDS. Thus, hepcidin suppression by a variant ERFE is likely responsible for the increased iron loading in patients with SF3B1-mutated MDS, suggesting that ERFE could be targeted to prevent iron-mediated toxicity. The expression of the variant ERFE transcript that was restricted to SF3B1-mutated erythroblasts decreased in lenalidomide-responsive anemic patients, identifying variant ERFE as a specific biomarker of clonal erythropoiesis.

Published
2019

19. Congratulations, You're the Oldest Person in Town! Please Accept This Cane

Author

Russell, Jenna and Park, Sophie

Subjects
Displays (Marketing), General interest
Abstract

Byline: Jenna Russell and Sophie Park Congratulations, You're the Oldest Person in Town! Please Accept This Cane. We're exploring how America defines itself one place at a time. In towns [...]

Published
2024

20. To Town Elders, A Gift of a Cane Steeped in Lore

Author

Russell, Jenna and Park, Sophie

Subjects
Aged -- Appreciation, Theft -- Investigations, Staffs (Sticks, canes, etc.) -- Distribution, Company legal issue, Company distribution practices, General interest, News, opinion and commentary
Abstract

Congratulations, You're the Oldest Person in Town! Please Accept This Cane. We're exploring how America defines itself one place at a time. In towns across New England, antique canes or [...]

Published
2024

21. The Newest Union Members Are Undergrads

Author

Blinder, Alan and Park, Sophie

Subjects
Labor unions, Sexual abuse, College students, General interest, Boston University, Tufts University
Abstract

Byline: Alan Blinder and Sophie Park Sam Betsko figured out fast that being a resident assistant in a college dorm would demand more than helping locked-out students and pleading with [...]

Published
2023

22. Look Who's Unionizing On Campus: Undergrads

Author

Blinder, Alan and Park, Sophie

Subjects
College students -- Labor relations, Labor unions -- Organizing, Universities and colleges -- Labor relations -- United States, Labor movement -- Forecasts and trends, Market trend/market analysis, General interest, News, opinion and commentary
Abstract

Sam Betsko figured out fast that being a resident assistant in a college dorm would demand more than helping locked-out students and pleading with sophomores to, for the love of [...]

Published
2023

27. As Migrants Are Placed Around Massachusetts, Towns Are Welcoming but Worried

Author

Russell, Jenna and Park, Sophie

Subjects
Government regulation, General interest
Abstract

Byline: Jenna Russell and Sophie Park The mayor of Woburn, where hotels are housing 150 migrant families, said the state's 40-year-old right-to-shelter law 'was not meant to cover what we're [...]

Published
2023

28. In Massachusetts, Towns Are Welcoming to Migrants, but Overwhelmed

Author

Russell, Jenna and Park, Sophie

Subjects
Government regulation, General interest, News, opinion and commentary
Abstract

The mayor of Woburn, where hotels are housing 150 migrant families, said the state's 40-year-old right-to-shelter law ''was not meant to cover what we're seeing now.'' Barely two weeks had [...]

Published
2023

30. Integration of social determinants of health information within the primary care electronic health record: a systematic review of patient perspectives and experiences.

Author

Caicedo, Nicolle Marianne Arroyave, Parry, Emma, Arslan, Nazan, and Park, Sophie

Subjects
CLINICAL medicine, MEDICAL information storage & retrieval systems, SELF-evaluation, SOCIAL determinants of health, HUMAN services programs, FAMILY medicine, RESEARCH funding, ACADEMIC medical centers, HEALTH, PRIMARY health care, CINAHL database, INFORMATION resources, EXPERIENCE, SYSTEMATIC reviews, THEMATIC analysis, MEDLINE, ELECTRONIC health records, CONCEPTUAL structures, MEDICAL records, ACQUISITION of data, MEDICAL databases, LITERATURE reviews, PHYSICIAN-patient relations, RESOURCE-limited settings, MEDICAL screening, PATIENTS' attitudes
Abstract

Background: Social determinants of health (SDOH) are the non-medical factors that impact health. Although geographical measures of deprivation are used, individual measures of social risk could identify those most at risk and generate more personalised care and targeted referrals to community resources. We know SDOH are important to health care, but it is not yet known whether their collection via the electronic health record (EHR) is acceptable and useful from the patient perspective. Aim: To synthesise relevant literature to explore patient perspectives on integrating information about SDOH into primary care EHRs, and the opportunities and challenges of its implementation in a general practice setting. Design & setting: Systematic review of primary care-based qualitative and mixed-method studies using thematic framework analysis. Method: Key databases were searched for articles reporting patient perspectives of SDOH collection within the primary care EHR. Qualitative and mixed-methods studies written in English were included. A framework analysis was conducted to identify themes. Results: From 14 included studies, the following five main themes were identified: rationale for SDOH screening and the anticipated outcomes; impact of the provider-patient relationship on patient perceptions; data, which included privacy concerns; screening process and referral; and recommendations for future research. Conclusion: Integration of information on SDOH into the EHR appears acceptable to patients. This review has added to the discussion of whether and how to implement SDOH screening and referral programmes into UK primary care systems. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Becoming a member of a nursing community of practice: negotiating performance competence and identity.

Author

Chen, Mary XiaoRong, Newman, Mark, and Park, Sophie

Subjects
NURSING education, UNDERGRADUATES, NURSES' attitudes, WORK environment, ACQUISITION of data
Abstract

The challenge faced by newly graduated nurses from undergraduate study to practice is a persistent theme in nursing practice literatures. However, there is a lack of understanding about how this transition happens. This focused ethnographic study explored how newly graduated nurses (novices) interacted with experienced nurses and learnt in a hospital ward in Singapore. Using the 'Trajectory of identification framework' developed from Wenger's Community of Practice theory, data was collected through observation and focused group discussions. This research revealed the participating rules as the sociocultural characteristics of the nursing community, and how these characteristics are ongoingly negotiated among the nurses. The nurses' changing performative competence and identity in different situations are conceptualised as the 'Participation Space'. This study also showed how concepts of Community of Practice theory can be analytically applied and further developed in empirical study. Specifically, a conceptual 'Participation Matrix' is theorised which adds an additional tool to understand the nurses' dynamic participation and negotiation of membership in a Community of Practice. Novices' transition should be viewed as an ongoing dynamic workplace learning, through which negotiation of performative competence and identity among members take place. The soon to be novices and workplaces should be prepared with this understanding. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Extracellular vesicles from myelodysplastic mesenchymal stromal cells induce DNA damage and mutagenesis of hematopoietic stem cells through miRNA transfer

Author

Meunier, Mathieu, Guttin, Audrey, Ancelet, Sarah, Laurin, David, Zannoni, Johanna, Lefebvre, Christine, Tondeur, Sylvie, Persoons, Virginie, Pezet, Mylène, Pernet-Gallay, Karin, Chuffart, Florent, Rousseaux, Sophie, Testard, Quentin, Thevenon, Julien, Jouzier, Claire, Deleuze, Jean-François, Laulagnier, Karine, Sadoul, Rémy, Chatellard, Christine, Hainaut, Pierre, Polack, Benoît, Cahn, Jean-Yves, Issartel, Jean-Paul, and Park, Sophie

Published
2020
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36. In Provincetown, Mass., a Matchmaker Helps the Desperate Find Housing

Author

Russell, Jenna and Park, Sophie

Subjects
News, opinion and commentary, Facebook (Online social network)
Abstract

In Provincetown, Mass., a Matchmaker Helps the Desperate Find Housing We’re exploring how America defines itself one place at a time. In this coastal New England town, a booming summer [...]

Published
2023

37. In Provincetown, a Matchmaker Whose Prize Catch Is a Home

Author

Russell, Jenna and Park, Sophie

Subjects
Rental housing -- Forecasts and trends, Consultants -- Appreciation, Residential real estate -- Forecasts and trends, Market trend/market analysis, General interest, News, opinion and commentary
Abstract

In Provincetown, Mass., a Matchmaker Helps the Desperate Find Housing We're exploring how America defines itself one place at a time. In this coastal New England town, a booming summer [...]

Published
2023

40. Element Selection of Three-Dimensional Objects in Virtual Reality

Author

Fox, Dylan, Park, Sophie So Yeon, Borcar, Amol, Brewer, Anna, Yang, Joshua, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Weikum, Gerhard, Series Editor, Chen, Jessie Y.C., editor, and Fragomeni, Gino, editor

Published
2018
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41. Clinical impact of genetic alterations including germline DDX41mutations in MDS/low-blast count AML patients treated with azacitidine-based regimens

Author

Sébert, Marie, Freiman, Lucie, Chaffaut, Cendrine, Guerci, Agnès, Peterlin, Pierre, Thépot, Sylvain, Beyne-Rauzy, Odile, Park, Sophie, Cluzeau, Thomas, Chermat, Fatiha, Fenaux, Pierre, Preudhomme, Claude, Clappier, Emmanuelle, Chevret, Sylvie, Adès, Lionel, Duployez, Nicolas, and Duchmann, Matthieu

Published
2024
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48. Waste Mixes With Warm Water, Blighting the Shores of Cape Cod

Author

Flavelle, Christopher and Park, Sophie

Subjects
Cape Cod -- Environmental aspects, Water pollution -- Environmental aspects -- United States, Water bloom -- Environmental aspects, Climatic changes -- Environmental aspects, Sewer systems -- Environmental aspects, General interest, News, opinion and commentary
Abstract

Climate change is contributing to electric-green algae blooms. Massachusetts wants a cleanup of the antiquated septic systems feeding the mess, but it could cost billions. MASHPEE, Mass. -- Ashley K. [...]

Published
2023

50. Supplementary Figure Legend, Table 1 from Dual Inhibition of PI3K and mTORC1/2 Signaling by NVP-BEZ235 as a New Therapeutic Strategy for Acute Myeloid Leukemia

Author

Chapuis, Nicolas, primary, Tamburini, Jerome, primary, Green, Alexa S., primary, Vignon, Christine, primary, Bardet, Valerie, primary, Neyret, Aymeric, primary, Pannetier, Melanie, primary, Willems, Lise, primary, Park, Sophie, primary, Macone, Alexandre, primary, Maira, Sauveur-Michel, primary, Ifrah, Norbert, primary, Dreyfus, François, primary, Herault, Olivier, primary, Lacombe, Catherine, primary, Mayeux, Patrick, primary, and Bouscary, Didier, primary

Published
2023
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