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Purpose: This study aims to estimate (a) the relationship between disability acceptance and depressive symptoms, and (b) how the quality and quantity of social support might moderate the link between disability acceptance and depressive symptoms. Materials and methods: The data for this study included information from 5165 individuals with disability who participated in 3 waves of the Disability and Life Dynamic Panel spanning years 2018 to 2020. This study employed fixed effects models to estimate the association between disability acceptance and depressive symptoms. Interaction models were used to assess the moderating effects of both the quantity and quality of social support. Results: A lower acceptance of disability was positively associated with depressive symptoms. Moreover, both the quantity and quality of social support were associated with a decrease in depressive symptoms. Only the quality of social support played a significant role in moderating the relationship between disability acceptance and depressive symptoms. Conclusion: A lower acceptance of disability increases depressive symptoms in individuals with disabilities. This study underscores the need for interventions to focus on enhancing the quality of social support to mitigate the link between disability acceptance and depressive symptoms. IMPLICATIONS FOR REHABILITATION: A lower acceptance of disability is positively associated with depressive symptoms among persons with disability. The association between lower disability acceptance and depressive symptoms attenuates as emotional support from family and friends increases. The number of family and friends does not significantly change the relationship between lower disability acceptance and depressive symptoms. The findings highlight the importance of interventions enhancing quality of social support in order to mitigate the association between disability acceptance and psychological health. [ABSTRACT FROM AUTHOR]

Cellulosic biomass hydrolysates are rich in glucose and xylose, but most microorganisms, including Komagataella phaffii, are unable to utilize xylose effectively. To address this limitation, we engineered a K. phaffii strain optimized for xylose metabolism through the xylose oxidoreductase pathway and promoter optimization. A promoter library with varying strengths was used to fine-tune the expression levels of the XYL1, XYL2, and XYL3 genes, resulting in a strain with a strong promoter for XYL2 and weaker promoters for XYL1 and XYL3. This engineered strain exhibited superior growth, achieving 14 g cells/L and a maximal growth rate of 0.4 g cells/L-h in kenaf hydrolysate, outperforming a native strain by 17%. This study is the first to report the introduction of the xylose oxidoreductase pathway into K. phaffii, demonstrating its potential as an industrial platform for producing yeast protein and other products from cellulosic biomass. [ABSTRACT FROM AUTHOR]

Exchange interactions at the interfaces are the root to produce conventional exchange bias in ferromagnet/antiferromagnet (FM/AFM) heterostructures, which are extensively utilized in spintronics. This work proposes an unconventional approach for the growth of the CoMn2O4 interface in Mn2O3@Co3O4 core–shell, which led to an unprecedented exchange bias. Specimens were prepared with a modified two‐step co‐precipitation method followed by the controlled heating episodes, to initiate the Co2+/3+/Mn2+/3+/4+ cation exchange, which facilitates CoMn2O4 interface in the sample (SA‐1). For comparison, Mn2O3@Co3O4 composite was synthesized with inhibited cation exchange (SA‐2 specimen). X‐ray diffraction and high‐resolution transmission electron microscope results confirmed the presence of each phase with core–shell type morphology. SA‐1 sample experiences AFM–FiM (ferrimagnetic) exchange coupling, revealed by the strongly bifurcated zero field‐cooled and field‐cooled magnetization curves below the Néel temperature (TN‐86 K), resulting in large exchange bias field (HEB) strength of 2712 Oe. Training effect data fitted with thermal relaxation and frozen‐rotatable spin relaxation model suggests the dominant character of uncompensated rotating spins in AFM–FiM–AFM interfaces as opposed to the relaxing frozen spins found in conventional AFM–FM interfaces. [ABSTRACT FROM AUTHOR]

Magnetic susceptibility enhancement (kE) is useful for reconstructing terrestrial paleohydroclimate variabilities. However, kE and its driving process(es) in the Korean Peninsula remain uninvestigated. Therefore, this study investigated two kEs of similar magnitudes, dated MIS 1 (Holocene) and late MIS 3 (~ 29–36 ka), from a paleosol sequence in the upland of paleo-fluvial terrace in the central Korean Peninsula. We observed increased ferri- and antiferro-magnetic mineral components,including ultrafine particles, and stronger chlorite weathering for the two kEs, suggesting pedogenic component predominance. The Fe-bearing (phyllo)silicate weathering mechanism proposed for the Chinese Loess Plateau sequences can explain the pedogenesis-induced kEs for the studied site. Superparamagnetic-domain (SPD) to pseudo-single-domain sized particles of pedogenic magnetite are likely major contributors to kEs. Moreover, we recognized the younger kE interval as more SPD contribution but less in total ferrimagnetic contribution, and more antiferromagnetic contribution than the older ones. The magnetic differences between the periods can result from vegetation cover impact and surrounding hydroclimate conditions, consistent with the recent suggestion for part of the southeast Chinese sites with relatively more rainfall. Consequently, our study provides a baseline for improving the relationship between mineral magnetic signals and local/regional hydroclimatic and environmental variabilities. [ABSTRACT FROM AUTHOR]

Innovative for the scientific community and attracting attention in the extensive biomedical field are novel compact organic chemosensing systems built upon unique core molecular frameworks. These systems may demonstrate customized responses and may be adaptable to analytes, showing promise for potential in vivo applications. Our recent investigation focuses on a precursor of Mycophenolic acid, resulting in the development of LBM (LOD = 13 nM) – a specialized probe selective for H2O2. This paper details the synthesis, characterization, and thorough biological assessments of LBM. Notably, we conducted experiments involving living cells, daphnia, and zebrafish models, utilizing microscopy techniques to determine probe nontoxicity and discern distinct patterns of probe localization. Localization involved the distribution of the probe in the Zebrafish model within the gut, esophagus, and muscles of the antennae. [ABSTRACT FROM AUTHOR]

In several biological processes, H2S is known to function as an endogenous gaseous agent. It is very necessary to monitor H2S and relevant physiological processes in vivo. Herein, a new type of fluorophore with a reliable leaving group allows for excited‐state intramolecular transfer characteristics (ESIPT), inspired by mycophenolic acid. A morpholine ring was connected at the maleimide position of the probe to target the lysosome. Subsequently, the dinitrophenyl group known for a photoinduced electron transfer (PET) effect, was connected to allow for an effective "turn‐on" probe Lyso‐H2S. Lyso‐H2S demonstrated strong selectivity towards H2S, a large Stokes shift (111 nm), and an incredibly low detection limit (41.8 nM). The imaging of endogenous and exogenous H2S in living cells (A549 cell line) was successfully achieved because of the specificity and ultra‐low toxicity (100 % cell viability at 50 μM concentration of Lyso‐H2S.) Additionally, Lyso‐H2S was also employed to visualize the activity of H2S in the gallbladder and intestine in a living zebrafish model. This is the first report of a fluorescent probe to track H2S sensing in specific organ systems to our knowledge. [ABSTRACT FROM AUTHOR]