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2. How Large are Local Human Capital Spillovers?: Evidence from Korea

Author

PARK, WOO RAM

Subjects
Local Human Capital Spillovers, Plant Productivity, Instrumental Variable, College Education, South Korea, Social Sciences, Industries. Land use. Labor, HD28-9999, Economic theory. Demography, HB1-3840
Abstract

This paper examines the empirical magnitude of local human capital spillovers in Korea during the 1980s and mid-1990s. Local human capital spillovers exists if plants in regions with a higher level of human capital can produce more given their own amount of input (Moretti 2004c). In particular, this paper explores an educational reform in South Korea which exogenously induced a large amount of variation in regional human capital levels. Using annually collected plant level data, I explore the effect of changes in the regional human capital levels induced by this reform on plant productivity in Korea. My results suggest that this effect is limited. I find a positive correlation between a regional level of human capital and plant productivity. However, after further addressing endogeneity using an instrumental variable, the effect of the overall regional human capital level on productivity decreases and becomes statistically insignificant.

Published
2016
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13. Author Correction: Importance of dialysis specialists in early mortality in elderly hemodialysis patients: a multicenter retrospective cohort study

Author

Park, Yohan, Lee, Ji Won, Yoon, Se-Hee, Yun, Sung-Ro, Kim, Hyunsuk, Bae, Eunjin, Hyun, Young Youl, Chung, Sungjin, Kwon, Soon Hyo, Cho, Jang-Hee, Yoo, Kyung Don, Park, Woo Yeong, Sun, In O, Yu, Byung Chul, Ko, Gang-Jee, Yang, Jae Won, Song, Sang Heon, Shin, Sung Joon, Hong, Yu Ah, and Hwang, Won Min

Published
2024
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18. Quantitative Thrombogenesis Analysis in an In-vitro Microfluidic Chip Using Image Analysis and CFD

Author

Choi, Ji-Seob, Ham, Dong-Hwi, Kim, Jung-Hyun, Jeong, Pyeong-Ho, Marcial, Helem Betsua Flores, Choi, Jin-Ho, Park, Woo-Tae, Magjarević, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Vo, Van Toi, editor, Nguyen, Thi-Hiep, editor, Vong, Binh Long, editor, Le, Ngoc Bich, editor, and Nguyen, Thanh Qua, editor

Published
2024
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19. Development of a Smart Guidewire for Intravascular Sensing

Author

Dong, Chao-Wei, Joo, Dong-Hyun, Moon, Ki-Jeong, Yoon, Se-Yeon, Nguyen, Hua Quang Huy, Park, Woo-Tae, Magjarević, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Vo, Van Toi, editor, Nguyen, Thi-Hiep, editor, Vong, Binh Long, editor, Le, Ngoc Bich, editor, and Nguyen, Thanh Qua, editor

Published
2024
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21. Polysaccharides from Annona muricata leaves protect against cisplatin‑induced cytotoxicity in macrophages by alleviating mitochondrial dysfunction.

Author

Han, Jeong, Song, Ha-Yeon, Kim, Kunhwi, Park, Woo, Park, Sang-Hyun, Byun, Eui-Baek, and Byun, Eui-Hong

Subjects
Annona muricata, cisplatin, cytoprotection, macrophage, polysaccharides, toxic side effect, Annona, Cisplatin, Reactive Oxygen Species, Polysaccharides, Macrophages, Plant Leaves, Lung Neoplasms, Mitochondria
Abstract

Cisplatin is a prominent chemotherapeutic agent that can induce significant damage to normal cells. Therefore, it is important to develop agents that protect normal cells without influencing the chemotherapeutic effect of cisplatin. The present study was conducted to explore the protective effects of Annona muricata leaf polysaccharides (ALPS) against cisplatin‑induced toxicity in macrophages. Apoptosis was assessed in macrophages and lung cancer cells to investigate the cytoprotective effect of ALPS, their effect on the production of cisplatin‑induced reactive oxygen species (ROS) and the loss of the mitochondrial transmembrane potential (MTP). Cisplatin, when used alone or in combination with ALPS, showed significant toxicity against A549 and H460 lung cancer cells. However, cisplatin‑induced cytotoxicity was suppressed by cotreatment of RAW 264.7 macrophages with ALPS. ALPS significantly inhibited the upregulation of Bax, cytosolic cytochrome c and caspases‑3, ‑8 and ‑9. Moreover, ALPS resulted in the cleavage of PARP and downregulation of Bcl‑2 levels in a concentration‑dependent manner, which ultimately led to a reduction in the apoptotic and necrotic populations of cisplatin‑treated RAW 264.7 macrophages. The suppression of the apoptotic signaling pathways was mediated through the reduction of ROS and MTP loss in cisplatin‑treated RAW 264.7 macrophages. In addition, ALPS alleviated cell damage by suppressing the mitochondrial apoptotic pathways in cisplatin‑treated bone marrow‑derived macrophages. Together, these findings suggested that ALPS may alleviate the toxic side effects of chemotherapeutic agents and act as a potential candidate for use as an effective adjuvant therapy.

Published
2023

27. Biodegradable Polymer Versus Polymer-Free Ultrathin Sirolimus-Eluting Stents: Analysis of the Stent Arm Registry From the HOST-IDEA Randomized Trial

Author

Han, Jung-Kyu, Yang, Seokhun, Hwang, Doyeon, Park, Sang-Hyeon, Kang, Jeehoon, Yang, Han-Mo, Park, Kyung Woo, Kang, Hyun-Jae, Koo, Bon-Kwon, Cho, Jin-Man, Cho, Janghyun, Bang, Duk Won, Lee, Jae-Hwan, Lee, Han Cheol, Kim, Kyung-Jin, Chun, Woo Jung, Seo, Won-Woo, Park, Woo-Jung, Park, Sang Min, Kim, Jin Won, and Kim, Hyo-Soo

Published
2024
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46. Intrusion Detection System for Industrial Network

Author

Park, Woo Young, Kim, Sang Hyun, Vu, Duy-Son, Song, Chang Han, Jung, Hee Soo, Jo, Hyeon, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, and Arai, Kohei, editor

Published
2023
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