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14 results on '"Park Un Kyu"'

4. Anti-obesity Effects of Mulberry Leaf and Yacon Extract in Obese Rats

Author

Yong Lim, Park Un Kyu, Seock-Yeon Hwang, Ji Hye Oh, and Man Kyu Huh

Subjects
biology, Traditional medicine, business.industry, Leptin, Anti obesity, Yacón, Medicine, General Medicine, biology.organism_classification, business, medicine.disease, Obesity, Mulberry leaf
Published
2020

10. MP60-12 PROTECTIVE EFFECTS OF KOREAN RED GINSENG AGAINST SUB-ACUTE IMMOBILIZATION STRESS-INDUCED TESTICULAR DAMAGE IN EXPERIMENTAL RATS

Author

Choi, Kyung Hwa, primary, Lee, Sang-Ho, additional, Cha, Kyu-Min, additional, Hwang, Seock-Yeon, additional, Park, Un-Kyu, additional, Jeong, Min-Sik, additional, Kopalli, Spandana Rajendra, additional, Hong, Jae Yup, additional, Han, Chang Kyun, additional, In, Gyo, additional, Lee, Seung Ryeol, additional, Hong, Young Kwon, additional, Park, Dong Soo, additional, Jang, Seok Heun, additional, and Kim, Si-Kwan, additional

Published
2018
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12. Anti-Diabetic and Hepato-Renal Protective Effects of Ziyuglycoside II Methyl Ester in Type 2 Diabetic Mice

Author

Byoungsoo Kim, Park Un Kyu, Dong Ju Son, Seock Yeon Hwang, and Myung Hyun Kim

Subjects
Blood Glucose, Male, medicine.medical_specialty, medicine.medical_treatment, Sanguisorba officinalis, lcsh:TX341-641, Type 2 diabetes, Carbohydrate metabolism, Article, Sanguisorba, diabetic hepatopathy, Diabetic nephropathy, chemistry.chemical_compound, Mice, ziyuglycoside, diabetes, diabetic nephropathy, Mice, Inbred NOD, Internal medicine, Diabetes mellitus, medicine, Animals, Hypoglycemic Agents, Insulin, Nutrition and Dietetics, Molecular Structure, Metabolic disorder, Lipid metabolism, Saponins, medicine.disease, Lipids, Endocrinology, chemistry, Diabetes Mellitus, Type 2, Glycated hemoglobin, lcsh:Nutrition. Foods and food supply, Food Science
Abstract

Type 2 diabetes is a metabolic disorder caused by abnormal carbohydrate metabolism, and closely associated with abnormal lipid metabolism and hepato-renal dysfunction. This study investigated the anti-diabetic and hepato-renal protective properties of ziyuglycoside I (ZG01) derivative on type 2 diabetes. ZG01 was isolated from roots of Sanguisorba officinalis and chemically modified by deglycosylation and esterification to obtained ziyuglycoside II methyl ester (ZG02-ME). Here, we showed that ZG02-ME has stronger anti-diabetic activity than the original compound (ZG01) through decreasing blood glucose, glycated hemoglobin (HbA1c), and insulin levels in a mouse model of type 2 diabetes (db/db mice). We further found that ZG02-ME treatment effectively ameliorated serum insulin, leptin and C-peptide levels, which are key metabolic hormones, in db/db mice. In addition, we showed that elevated basal blood lipid levels were decreased by ZG02-ME treatment in db/db mice. Furthermore, treatment of ZG02-ME significantly decreased serum AST, ALT, BUN, creatinine, and liver lipid peroxidation in db/db mice. These results demonstrated that compared to ZG01, chemically modified ZG02-ME possess improved anti-diabetic properties, and has hepato-renal protective activities in type 2 diabetes.

Published
2015
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14. Anti-Diabetic and Hepato-Renal Protective Effects of Ziyuglycoside II Methyl Ester in Type 2 Diabetic Mice.

Author

Son DJ, Hwang SY, Kim MH, Park UK, and Kim BS

Subjects
Animals, Blood Glucose, Diabetes Mellitus, Type 2, Hypoglycemic Agents chemistry, Insulin blood, Insulin metabolism, Lipids blood, Male, Mice, Mice, Inbred NOD, Molecular Structure, Sanguisorba chemistry, Saponins chemistry, Hypoglycemic Agents pharmacology, Saponins pharmacology
Abstract

Type 2 diabetes is a metabolic disorder caused by abnormal carbohydrate metabolism, and closely associated with abnormal lipid metabolism and hepato-renal dysfunction. This study investigated the anti-diabetic and hepato-renal protective properties of ziyuglycoside I (ZG01) derivative on type 2 diabetes. ZG01 was isolated from roots of Sanguisorba officinalis and chemically modified by deglycosylation and esterification to obtained ziyuglycoside II methyl ester (ZG02-ME). Here, we showed that ZG02-ME has stronger anti-diabetic activity than the original compound (ZG01) through decreasing blood glucose, glycated hemoglobin (HbA1c), and insulin levels in a mouse model of type 2 diabetes (db/db mice). We further found that ZG02-ME treatment effectively ameliorated serum insulin, leptin and C-peptide levels, which are key metabolic hormones, in db/db mice. In addition, we showed that elevated basal blood lipid levels were decreased by ZG02-ME treatment in db/db mice. Furthermore, treatment of ZG02-ME significantly decreased serum AST, ALT, BUN, creatinine, and liver lipid peroxidation in db/db mice. These results demonstrated that compared to ZG01, chemically modified ZG02-ME possess improved anti-diabetic properties, and has hepato-renal protective activities in type 2 diabetes.

Published
2015
Full Text
View/download PDF

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