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5 results on '"Parnes ZN"'

1. [Suppression of cytomegalovirus infection in cell system by fullerene amino acid derivates].

Author

Fedorova NE, Adueva SM, Medzhidova AA, Romanova VS, Parnes ZN, Galegov GA, and Kushch AA

Subjects
Cell Culture Techniques, Cytomegalovirus chemistry, Cytomegalovirus pathogenicity, Cytomegalovirus Infections drug therapy, Cytomegalovirus Infections virology, Cytopathogenic Effect, Viral drug effects, Humans, Immediate-Early Proteins analysis, Immunohistochemistry, Viral Envelope Proteins analysis, Antiviral Agents pharmacology, Carbon pharmacology, Cytomegalovirus drug effects, Fullerenes
Abstract

Effects of two water-soluble derivatives of fullerene C60-o-aminocaproic acid (C60-ACA) and C60 sodium salt of omega-aminocaproic acid (C60-Na-ACA) on in vitro cytomegalovirus (CMV) infection were studied. C60-Na-ACA 4-5-fold inhibited the cytopathic effect of CMV in comparison with C60-ACA, the effective dose for C60-Na-ACA being 0.6 microgram/ml and that for C60-ACA 2.7 micrograms/ml. Immunocytochemical analysis of virus proteins in infected cells has shown that C60-Na-ACA inhibits the production of late structural CMV protein gB, but does not modify the expression of immediate early nonstructural protein IEp72. Studies of cell viability, growth characteristics, and DNA synthesis revealed that the cytotoxic effect of C60-Na-ACA on human diploid fibroblasts in negligible, the cytotoxicity index varying from 160 to 1500 micrograms/ml in different tests. Selectivity index for C60-Na-ACA is 267-2500, which differs negligibly from that of gancyclovir (100-1000), while the cytotoxicity of C60-Na-ACA is essentially lower.

Published
2002

2. [Structure formation of water insoluble fullerene amino acid derivatives in organic solvents].

Author

Belavtseva EM, Romanova VS, Kuleshova EF, Parnes ZN, and Vol'pin ME

Subjects
Microscopy, Electron, Solvents, 4-Aminobenzoic Acid chemistry, Carbon chemistry
Abstract

The time-dependent structure formation of the fullerene derivative of p-amino benzoic acid in organic solvents was studied by scanning electron microscopy. It was shown that, during storage of solutions, the structures are destroyed.

Published
2000

3. Immunogenic and allergenic properties of fulleren conjugates with aminoacids and proteins.

Author

Andreev SM, Babakhin AA, Petrukhina AO, Romanova VS, Parnes ZN, and Petrov RV

Subjects
Adjuvants, Immunologic, Amino Acids chemistry, Animals, Carbon chemistry, Immunization methods, Immunoglobulin G immunology, Mice, Passive Cutaneous Anaphylaxis immunology, Proteins chemistry, Allergens immunology, Antibody Formation immunology, Carbon immunology, Fullerenes
Published
2000

4. [Immunostimulating effect of water-soluble fullerene derivatives--perspective adjuvants for a new generation of vaccine].

Author

Masalova OV, Shepelev AV, Atanadze SN, Parnes ZN, Romanova VS, Vol'pina OM, Semiletov IuA, and Kushch AA

Subjects
Animals, Antibodies, Viral biosynthesis, Carbon chemistry, Hepatitis C prevention & control, Mice, Mice, Inbred BALB C, Solubility, Viral Nonstructural Proteins immunology, Water, Adjuvants, Immunologic pharmacology, Carbon pharmacology, Fullerenes, Viral Vaccines immunology
Published
1999

5. Membranotropic properties of the water soluble amino acid and peptide derivatives of fullerene C60.

Author

Kotelnikova RA, Kotelnikov AI, Bogdanov GN, Romanova VS, Kuleshova EF, Parnes ZN, and Vol'pin ME

Subjects
Alanine chemistry, Biological Transport, Cobalt chemistry, Cobalt metabolism, Erythrosine chemistry, Kinetics, Peptides chemistry, Permeability, Phosphatidylcholines chemistry, Pyrenes chemistry, Solubility, Spectrometry, Fluorescence methods, Titrimetry, Water, Carbon chemistry, Carbon pharmacology, Fullerenes, Lipid Bilayers chemistry, Liposomes chemistry
Abstract

The modifying effects of the products of the equimolar addition Of DL-alanine and DL-alanyl-DL-alanine to fullerene C60 on the structure and permeability of the lipid bilayer of phosphatidylcholine liposomes has been studied using the luminescence probe technique. It is shown that these water soluble amino acid and dipeptide derivatives of fullerene (C60-AD) are quenchers of pyrene fluorescence and erythrosine phosphorescence of in both a water solution and liposomes. To study the permeability of the lipid bilayer a procedure based on the triplet probe technique has been developed. It has been found that the C60-AD derivatives under study are able to localize inside the artificial membrane, to penetrate into the liposomes through the lipid bilayer and to perform activated transmembrane transport of bivalent metal ions.

Published
1996
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