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1. Polyfunctional CD4 T-cells correlating with neutralising antibody is a hallmark of COVISHIELDTM and COVAXIN® induced immunity in COVID-19 exposed Indians

Author

Rakshit, Srabanti, Babji, Sudhir, Parthiban, Chaitra, Madhavan, Ramya, Adiga, Vasista, J, Sharon Eveline, Chetan Kumar, Nirutha, Ahmed, Asma, Shivalingaiah, Sudarshan, Shashikumar, Nandini, V, Mamatha, Johnson, Avita Rose, Ramesh, Naveen, B, Ramkrishna Goud, Asokan, Mangaiarkarasi, Mayor, Satyajit, Kang, Gagandeep, D’souza, George, Dias, Mary, and Vyakarnam, Annapurna

Published
2023
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2. Immunogenicity of SARS-CoV-2 vaccines BBV152 (COVAXIN®) and ChAdOx1 nCoV-19 (COVISHIELD™) in seronegative and seropositive individuals in India: a multicentre, nonrandomised observational study

Author

Asokan, Mangaiarkarasi S., Joan, Roshni Florina, Babji, Sudhir, Dayma, Girish, Nadukkandy, Prajitha, Subrahmanyam, Vinutha, Pandey, Archana, Malagi, Girish, Arya, Pooja, Mahajan, Vibhuti, Bhavikatti, Jayateerth, Pawar, Ketakee, Thorat, Aishwarya, Shah, Priyanki, Goud, Ramakrishna B., Roy, Bishnudeo, Rajukutty, Shon, Immanuel, Sushil, Agarwal, Dhiraj, Saha, Sankhanil, Shivaraj, Akshatha, Panikulam, Patricia, Shome, Rajeshwari, Gulzar, Shah-E-Jahan, Sharma, Anusmrithi U., Naik, Ajinkya, Talashi, Shruti, Belekar, Madhuri, Yadav, Ritu, Khude, Poornima, V, Mamatha, Shivalingaiah, Sudarshan, Deshmukh, Urmila, Bhise, Chinmayee, Joshi, Manjiri, Inbaraj, Leeberk Raja, Chandrasingh, Sindhulina, Ghose, Aurnab, Jamora, Colin, Karumbati, Anandi S., Sundaramurthy, Varadharajan, Johnson, Avita, Ramesh, Naveen, Chetan, Nirutha, Parthiban, Chaitra, Ahmed, Asma, Rakshit, Srabanti, Adiga, Vasista, D'souza, George, Rale, Vinay, George, Carolin Elizabeth, John, Jacob, Kawade, Anand, Chaturvedi, Akanksha, Raghunathan, Anu, Dias, Mary, Bhosale, Anand, Raghu, Padinjat, Shashidhara, L.S., Vyakarnam, Annapurna, Bal, Vineeta, Kang, Gagandeep, and Mayor, Satyajit

Published
2024
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7. A Humanized Mouse Model for Plasmodium vivax to Test Interventions that Block Liver Stage to Blood Stage Transition and Blood Stage Infection

Author

Schäfer, Carola, Roobsoong, Wanlapa, Kangwanrangsan, Niwat, Bardelli, Martino, Rawlinson, Thomas A., Dambrauskas, Nicholas, Trakhimets, Olesya, Parthiban, Chaitra, Goswami, Debashree, Reynolds, Laura M., Kennedy, Spencer Y., Flannery, Erika L., Murphy, Sean C., Sather, D. Noah, Draper, Simon J., Sattabongkot, Jetsumon, Mikolajczak, Sebastian A., and Kappe, Stefan H.I.

Published
2020
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9. Differences in Immune Responses in Individuals of Indian and European Origin: Relevance for the COVID-19 Pandemic

Author

Geckin, Büsra, primary, Zoodsma, Martijn, additional, Kilic, Gizem, additional, Debisarun, Priya A., additional, Rakshit, Srabanti, additional, Adiga, Vasista, additional, Ahmed, Asma, additional, Parthiban, Chaitra, additional, Kumar, Nirutha Chetan, additional, D’Souza, George, additional, Baltissen, Marijke P., additional, Martens, Joost H. A., additional, Domínguez-Andrés, Jorge, additional, Li, Yang, additional, Vyakarnam, Annapurna, additional, and Netea, Mihai G., additional

Published
2023
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10. Polyfunctional CD4 T-cells correlating with neutralising antibody is a hallmark of COVISHIELDTM and COVAXIN® induced immunity in COVID-19 exposed Indians.

Author

Rakshit, Srabanti, Babji, Sudhir, Parthiban, Chaitra, Madhavan, Ramya, Adiga, Vasista, J, Sharon Eveline, Chetan Kumar, Nirutha, Ahmed, Asma, Shivalingaiah, Sudarshan, Shashikumar, Nandini, V, Mamatha, Johnson, Avita Rose, Ramesh, Naveen, B, Ramkrishna Goud, Asokan, Mangaiarkarasi, Mayor, Satyajit, Kang, Gagandeep, D'souza, George, Dias, Mary, and Vyakarnam, Annapurna

Subjects
T cells, MATERNALLY acquired immunity, SARS-CoV-2 Omicron variant, SARS-CoV-2 Delta variant, IMMUNITY, CD4 antigen, GENETIC vectors
Abstract

Detailed characterisation of immune responses induced by COVID-19 vaccines rolled out in India: COVISHIELDTM (CS) and COVAXIN® (CO) in a pre-exposed population is only recently being discovered. We addressed this issue in subjects who received their primary series of vaccination between November 2021 and January 2022. Both vaccines are capable of strongly boosting Wuhan Spike-specific neutralising antibody, polyfunctional Th1 cytokine producing CD4+ T-cells and single IFN-γ + CD8+ T-cells. Consistent with inherent differences in vaccine platform, the vector-based CS vaccine-induced immunity was of greater magnitude, breadth, targeting Delta and Omicron variants compared to the whole-virion inactivated vaccine CO, with CS vaccinees showing persistent CD8+ T-cells responses until 3 months post primary vaccination. This study provides detailed evidence on the magnitude and quality of CS and CO vaccine induced responses in subjects with pre-existing SARS-CoV-2 immunity in India, thereby mitigating vaccine hesitancy arguments in such a population, which remains a global health challenge. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Interim results from comparison of immune responses elicited by an inactivated and a vectored SARS-CoV-2 vaccine in seronegative and seropositive participants in India

Author

Asokan, Mangaiarkarasi, primary, Joan, Roshni Florina, additional, Babji, Sudhir, additional, Dayma, Girish, additional, Nitheesh, Prajitha, additional, Subrahmanyam, Vinutha, additional, Pandey, Archana, additional, Malagi, Girish, additional, Arya, Pooja, additional, Mahajan, Vibhuti, additional, Bhavikatti, Jayateerth, additional, Pawar, Ketakee, additional, Thorat, Aishwarya, additional, Shah, Priyanki, additional, Goud, Ramakrishna B, additional, Roy, Bishnudeo, additional, Rajukutty, Shon, additional, Immanuel, Sushil, additional, Agarwal, Dhiraj, additional, Saha, Sankhanil, additional, Shivaraj, Akshatha, additional, Panikulam, Patricia, additional, Shome, Rajeshwari, additional, Gulzar, Shah-E-Jahan, additional, Sharma, Anusmrithi U, additional, Naik, Ajinkya, additional, Talashi, Shruti, additional, Belekar, Madhuri, additional, Yadav, Ritu, additional, Khude, Poornima, additional, Mamatha, V, additional, Sudarshan, S, additional, Deshmukh, Urmila, additional, Bhise, Chinmayee, additional, Joshi, Manjiri, additional, Inbaraj, Leeberk Raja, additional, Chandrasingh, Sindhulina, additional, Ghose, Aurnab, additional, Jamora, Colin, additional, Karumbati, Anandi S, additional, Sundaramurthy, Varadharajan, additional, Johnson, Avita, additional, Ramesh, Naveen, additional, Chetan, Nirutha, additional, Parthiban, Chaitra, additional, Ahmed, Asma, additional, Rakshit, Srabanti, additional, Adiga, Vasista, additional, D’souza, George, additional, Rale, Vinay, additional, George, Carolin Elizabeth, additional, John, Jacob, additional, Kawade, Anand, additional, Chaturvedi, Akanksha, additional, Raghunathan, Anu, additional, Dias, Mary, additional, Bhosale, Anand, additional, Raghu, Padinjat, additional, Shashidhara, LS, additional, Vyakarnam, Annapurna, additional, Bal, Vineeta, additional, Kang, Gagandeep, additional, and Mayor, Satyajit, additional

Published
2023
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12. Evidence for the heterologous benefits of prior BCG vaccination on COVISHIELD™ vaccine-induced immune responses in SARS-CoV-2 seronegative young Indian adults

Author

Rakshit, Srabanti, primary, Adiga, Vasista, additional, Ahmed, Asma, additional, Parthiban, Chaitra, additional, Chetan Kumar, Nirutha, additional, Dwarkanath, Pratibha, additional, Shivalingaiah, Sudarshan, additional, Rao, Srishti, additional, D’Souza, George, additional, Dias, Mary, additional, Maguire, Thomas J. A., additional, Doores, Katie J., additional, Zoodsma, Martijn, additional, Geckin, Busranur, additional, Dasgupta, Prokar, additional, Babji, Sudhir, additional, van Meijgaarden, Krista E., additional, Joosten, Simone A., additional, Ottenhoff, Tom H. M., additional, Li, Yang, additional, Netea, Mihai G., additional, Stuart, Kenneth D., additional, De Rosa, Stephen C., additional, McElrath, M. Juliana, additional, and Vyakarnam, Annapurna, additional

Published
2022
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13. Differences in anti-viral immune responses in individuals of Indian and European origin: relevance for the COVID-19 pandemic

Author

Geckin, Büsranur, primary, Zoodsma, Martijn, additional, Kilic, Gizem, additional, Debisarun, Priya A., additional, Rakshit, Srabanti, additional, Adiga, Vasista, additional, Ahmed, Asma, additional, Parthiban, Chaitra, additional, Kumar, Nirutha Chetan, additional, D’Souza, George, additional, Baltissen, Marijke P, additional, Martens, Joost H A, additional, Andres, Jorge Dominguez, additional, Li, Yang, additional, Vyakarnam, Annapurna, additional, and Netea, Mihai G, additional

Published
2022
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14. Evidence for the heterologous benefits of prior BCG vaccination on COVISHIELD (TM) vaccine-induced immune responses in SARS-CoV-2 seronegative young Indian adults

Author

Rakshit, Srabanti, Adiga, Vasista, Ahmed, Asma, Parthiban, Chaitra, Chetan Kumar, Nirutha, Dwarkanath, Pratibha, Geckin, Busranur, Dasgupta, Prokar, Netea, M.G., Juliana McElrath, M., Vyakarnam, Annapurna, Rakshit, Srabanti, Adiga, Vasista, Ahmed, Asma, Parthiban, Chaitra, Chetan Kumar, Nirutha, Dwarkanath, Pratibha, Geckin, Busranur, Dasgupta, Prokar, Netea, M.G., Juliana McElrath, M., and Vyakarnam, Annapurna

Abstract

Contains fulltext : 283871.pdf (Publisher’s version ) (Open Access)

Published
2022

15. BCG revaccination qualitatively and quantitatively enhances SARS-CoV-2 spike-specific neutralizing antibody and T cell responses induced by the COVISHIELDTM vaccine in SARS-CoV-2 seronegative young Indian adults

Author

Rakshit, Srabanti, primary, Adiga, Vasista, additional, Ahmed, Asma, additional, Parthiban, Chaitra, additional, Kumar, Nirutha, additional, Shivalingaiah, Sudarshan, additional, Rao, Srishti, additional, D'Souza, George, additional, Dwarkanath, Pratibha, additional, Dias, Mary, additional, Maguire, Thomas, additional, Doores, Katie, additional, Dasgupta, Prokar, additional, Babji, Sudhir, additional, Ottenhoff, Tom, additional, Stuart, Kenneth, additional, De Rosa, Stephen, additional, McElrath, M. Juliana, additional, and Vyakarnam, Annapurna, additional

Published
2022
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16. A replication-competent late liver stage–attenuated human malaria parasite

Author

Goswami, Debashree, primary, Betz, William, additional, Locham, Navin K., additional, Parthiban, Chaitra, additional, Brager, Carolyn, additional, Schäfer, Carola, additional, Camargo, Nelly, additional, Nguyen, Thao, additional, Kennedy, Spencer Y., additional, Murphy, Sean C., additional, Vaughan, Ashley M., additional, and Kappe, Stefan H.I., additional

Published
2020
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19. BCG revaccination qualitatively and quantitatively enhances SARS-CoV-2 spike-specific neutralizing antibody and T cell responses induced by the COVISHIELD ™ vaccine in SARS-CoV-2 seronegative young Indian adults.

Author

Rakshit S, Adiga V, Ahmed A, Parthiban C, Kumar NC, Dwarkanath P, Shivalingaiah S, Rao S, D'Souza G, Dias M, Maguire TJA, Doores K, Dasgupta P, Babji S, Ottenhoff THM, Stuart KD, De Rosa S, McElrath MJ, and Vyakarnam A

Abstract

This study tested if prior BCG revaccination can further boost immune responses subsequently induced by a widely distributed and otherwise efficacious Oxford/AstraZeneca ChAdOx1nCoV-19 vaccine, referred to as COVISHIELD ™ , in India. We compared COVISHIELD ™ induced longitudinal immune responses in 21 BCG re-vaccinees (BCG-RV) and 13 BCG-non-revaccinees (BCG-NRV), all of whom were BCG vaccinated at birth and latent tuberculosis negative, after COVISHIELD ™ prime and boost with baseline samples that were collected pre-pandemic and pre-BCG revaccination. Compared to BCG-NRV, BCG-RV displayed significantly higher magnitude of spike-specific Ab and T cell responses, including a greater proportion of high responders; better quality polyfunctional CD4 and CD8 T cells that persisted and a more robust Ab and T cell response to the Delta mutant of SARS-CoV-2 highlighting greater breadth. Mechanistically, BCG adjuvant effects on COVISHIELD ™ induced adaptive responses was associated with more robust innate responses to pathogen-associated-molecular-patterns through TNF-α and IL-1β secretion. This study provides first in-depth analysis of immune responses induced by COVISHIELD ™ in India and highlights the potential of using a cheap and globally available vaccine, BCG, as an adjuvant to enhance heterologous adaptive immune responses induced by COVIDSHIELD ™ and other emerging vaccines., Competing Interests: Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Published
2022
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20. Dispersion Risk Associated With Surgical Debridement Devices.

Author

Granick M, Rubinsky L, Parthiban C, Shanmugam M, and Ramasubbu N

Subjects
Air Microbiology, Animals, Colony Count, Microbial, Cross Infection prevention & control, Debridement adverse effects, Equipment Design, Escherichia coli Infections prevention & control, Infection Control, Sonication, Staphylococcal Infections prevention & control, Therapeutic Irrigation, Water Microbiology, Cross Infection microbiology, Debridement instrumentation, Escherichia coli Infections microbiology, Red Meat microbiology, Staphylococcal Infections microbiology
Abstract

Introduction: Surgical instrumentation is now available to facilitate wound debridement. The 2 primary options involve different energy applications, but both have the potential to spray. The Versajet II (Smith & Nephew, London, UK) utilizes a high-powered water jet to disrupt tissue and remove debris by means of the Venturi effect. The SonicVac (Misonix, Farmingdale, NY) is a direct-contact, low-frequency ultrasound debriding device. It delivers a high-energy ultrasound to a wound surface via a fluid medium, causing bubble cavitation, a physical effect of rapid pressure waves causing bubbles to form and implode that releases mechanical energy., Objective: This study is designed to assess spray dispersion under ideal and challenging conditions., Materials and Methods: The 2 aforementioned instruments were tested in a laboratory situation. Bacteria (Escherichia coli [ATCC#54288] or Staphylococcus epidermidis [RP62A]) were seeded onto separate pieces of beef steak. Culture plates were set up in a predesignated position around the specimen; the specimen was then treated for 60 seconds at a power setting of 7 and 70% irrigation (ultrasound device) or 10 (waterjet device). After 60 seconds of debridement, about 4 mm to 5 mm of muscle tissue had been removed by the ultrasound device and 2 mm to 3 mm by the waterjet. In the bony specimen, the bone was more exposed after the treatment. The ultrasound device polished but did not remove the bone., Results: Both instruments performed well with minimal dispersion in the ideal setting. In beef steak with bone and grizzle, the waterjet created a lawn of bacterial spray in the plate in front of the surgeon. The ultrasound had a small number of contaminants in the same conditions., Conclusions: Both instruments can be used safely in the proper conditions, but the surgeon needs to be aware of the limitations and risks of spray dispersion.

Published
2017
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