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1. Associations between obesity, a composite risk score for probable long COVID, and sleep problems in SARS-CoV-2 vaccinated individuals

Author

Xue, Pei, Merikanto, Ilona, Delale, Eva A., Bjelajac, Adrijana, Yordanova, Juliana, Chan, Rachel N. Y., Korman, Maria, Mota-Rolim, Sérgio A., Landtblom, Anne-Marie, Matsui, Kentaro, Reis, Catia, Penzel, Thomas, Inoue, Yuichi, Nadorff, Michael R., Holzinger, Brigitte, Morin, Charles M., Espie, Colin A., Plazzi, Giuseppe, De Gennaro, Luigi, Chung, Frances, Bjorvatn, Bjørn, Wing, Yun Kwok, Dauvilliers, Yves, Partinen, Markku, and Benedict, Christian

Published
2024
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2. Estimation bias and agreement limits between two common self-report methods of habitual sleep duration in epidemiological surveys

Author

Korman, Maria, Zarina, Daria, Tkachev, Vadim, Merikanto, Ilona, Bjorvatn, Bjørn, Bjelajac, Adrijana Koscec, Penzel, Thomas, Landtblom, Anne-Marie, Benedict, Christian, Chan, Ngan Yin, Wing, Yun Kwok, Dauvilliers, Yves, Morin, Charles M., Matsui, Kentaro, Nadorff, Michael, Bolstad, Courtney J., Chung, Frances, Mota-Rolim, Sérgio, De Gennaro, Luigi, Plazzi, Giuseppe, Yordanova, Juliana, Holzinger, Brigitte, Partinen, Markku, and Reis, Cátia

Published
2024
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3. Israel−Palestine Conflict: Risk of Sleep Disorders and Post-Traumatic Stress Disorders

Author

Pandi‑Perumal, Seithikurippu R., Gulia, Kamalesh K., Mallick, Hruda Nanda, Shrivastava, Deepak, Mahalaksmi, Arehally Marappa, Chidambaram, Saravana Babu, Kumar, Ramasamy Rajesh, Saravanan, Konda Mani, Ramasubramanian, Chellamuthu, Sivasubramaniam, Sudhakar, Madoro, Derebe, Narasimhan, Meera, Agudelo, Hernán Andrés Marín, Corlateanu, Alexandru, Meira e Cruz, Miguel, Grønli, Janne, van de Put, Willem A. C. M., Hobfoll, Stevan E., van der Velden, Koos, Bjorvatn, Bjørn, Braakman, Mario H., Partinen, Markku, Maercker, Andreas, de Jong, Joop T. V. M., and Berk, Michael

Published
2023
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4. Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

Author

Ollila, Hanna M, Sharon, Eilon, Lin, Ling, Sinnott-Armstrong, Nasa, Ambati, Aditya, Yogeshwar, Selina M, Hillary, Ryan P, Jolanki, Otto, Faraco, Juliette, Einen, Mali, Luo, Guo, Zhang, Jing, Han, Fang, Yan, Han, Dong, Xiao Song, Li, Jing, Zhang, Jun, Hong, Seung-Chul, Kim, Tae Won, Dauvilliers, Yves, Barateau, Lucie, Lammers, Gert Jan, Fronczek, Rolf, Mayer, Geert, Santamaria, Joan, Arnulf, Isabelle, Knudsen-Heier, Stine, Bredahl, May Kristin Lyamouri, Thorsby, Per Medbøe, Plazzi, Giuseppe, Pizza, Fabio, Moresco, Monica, Crowe, Catherine, Van den Eeden, Stephen K, Lecendreux, Michel, Bourgin, Patrice, Kanbayashi, Takashi, Martínez-Orozco, Francisco J, Peraita-Adrados, Rosa, Benetó, Antonio, Montplaisir, Jacques, Desautels, Alex, Huang, Yu-Shu, Jennum, Poul, Nevsimalova, Sona, Kemlink, David, Iranzo, Alex, Overeem, Sebastiaan, Wierzbicka, Aleksandra, Geisler, Peter, Sonka, Karel, Honda, Makoto, Högl, Birgit, Stefani, Ambra, Coelho, Fernando Morgadinho, Mantovani, Vilma, Feketeova, Eva, Wadelius, Mia, Eriksson, Niclas, Smedje, Hans, Hallberg, Pär, Hesla, Per Egil, Rye, David, Pelin, Zerrin, Ferini-Strambi, Luigi, Bassetti, Claudio L, Mathis, Johannes, Khatami, Ramin, Aran, Adi, Nampoothiri, Sheela, Olsson, Tomas, Kockum, Ingrid, Partinen, Markku, Perola, Markus, Kornum, Birgitte R, Rueger, Sina, Winkelmann, Juliane, Miyagawa, Taku, Toyoda, Hiromi, Khor, Seik-Soon, Shimada, Mihoko, Tokunaga, Katsushi, Rivas, Manuel, Pritchard, Jonathan K, Risch, Neil, Kutalik, Zoltan, O’Hara, Ruth, Hallmayer, Joachim, Ye, Chun Jimmie, and Mignot, Emmanuel J

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Biological Sciences, Prevention, Vaccine Related, Influenza, Autoimmune Disease, Immunization, Pneumonia & Influenza, Emerging Infectious Diseases, Infectious Diseases, 2.1 Biological and endogenous factors, Aetiology, Infection, Inflammatory and immune system, Good Health and Well Being, Humans, Autoimmunity, Influenza, Human, Influenza A Virus, H1N1 Subtype, Autoimmune Diseases, Influenza Vaccines, Narcolepsy, FinnGen
Abstract

Narcolepsy type 1 (NT1) is caused by a loss of hypocretin/orexin transmission. Risk factors include pandemic 2009 H1N1 influenza A infection and immunization with Pandemrix®. Here, we dissect disease mechanisms and interactions with environmental triggers in a multi-ethnic sample of 6,073 cases and 84,856 controls. We fine-mapped GWAS signals within HLA (DQ0602, DQB1*03:01 and DPB1*04:02) and discovered seven novel associations (CD207, NAB1, IKZF4-ERBB3, CTSC, DENND1B, SIRPG, PRF1). Significant signals at TRA and DQB1*06:02 loci were found in 245 vaccination-related cases, who also shared polygenic risk. T cell receptor associations in NT1 modulated TRAJ*24, TRAJ*28 and TRBV*4-2 chain-usage. Partitioned heritability and immune cell enrichment analyses found genetic signals to be driven by dendritic and helper T cells. Lastly comorbidity analysis using data from FinnGen, suggests shared effects between NT1 and other autoimmune diseases. NT1 genetic variants shape autoimmunity and response to environmental triggers, including influenza A infection and immunization with Pandemrix®.

Published
2023

6. Associations between changes in habitual sleep duration and lower self-rated health among COVID-19 survivors: findings from a survey across 16 countries/regions

Author

Matsui, Kentaro, Chung, Frances, Bjelajac, Adrijana Koscec, Merikanto, Ilona, Korman, Maria, Mota-Rolim, Sérgio, Cunha, Ana Suely, Bjorvatn, Bjørn, Xue, Pei, Benedict, Christian, Morin, Charles M., Espie, Colin A., Landtblom, Anne-Marie, Penzel, Thomas, De Gennaro, Luigi, Holzinger, Brigitte, Hrubos-Strøm, Harald, Leger, Damien, Bolstad, Courtney J., Nadorff, Michael R., Plazzi, Giuseppe, Reis, Catia, Chan, Ngan Yin, Wing, Yun Kwok, Yordanova, Juliana, Dauvilliers, Yves, Partinen, Markku, and Inoue, Yuichi

Published
2023
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7. Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals

Author

Xue, Pei, Merikanto, Ilona, Chung, Frances, Morin, Charles M., Espie, Colin, Bjorvatn, Bjørn, Cedernaes, Jonathan, Landtblom, Anne-Marie, Penzel, Thomas, De Gennaro, Luigi, Holzinger, Brigitte, Matsui, Kentaro, Hrubos-Strøm, Harald, Korman, Maria, Leger, Damien, Mota-Rolim, Sérgio, Bolstad, Courtney J., Nadorff, Michael, Plazzi, Giuseppe, Reis, Catia, Chan, Rachel Ngan Yin, Wing, Yun Kwok, Yordanova, Juliana, Bjelajac, Adrijana Koscec, Inoue, Yuichi, Partinen, Markku, Dauvilliers, Yves, and Benedict, Christian

Published
2023
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8. The association of insomnia with long COVID: An international collaborative study (ICOSS-II)

Author

Chen, Si-Jing, Morin, Charles M., Ivers, Hans, Wing, Yun Kwok, Partinen, Markku, Merikanto, Ilona, Holzinger, Brigitte, Espie, Colin A., De Gennaro, Luigi, Dauvilliers, Yves, Chung, Frances, Yordanova, Juliana, Vidović, Domagoj, Reis, Catia, Plazzi, Giuseppe, Penzel, Thomas, Nadorff, Michael R., Matsui, Kentaro, Mota-Rolim, Sergio, Leger, Damien, Landtblom, Anne-Marie, Korman, Maria, Inoue, Yuichi, Hrubos-Strøm, Harald, Chan, Ngan Yin, Bjelajac, Adrijana Koscec, Benedict, Christian, and Bjorvatn, Bjørn

Published
2023
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9. Association between hypersomnolence and the COVID-19 pandemic: The International COVID-19 Sleep Study (ICOSS)

Author

Sarkanen, Tomi, Partinen, Markku, Bjorvatn, Bjørn, Merikanto, Ilona, Benedict, Christian, Nadorff, Michael R., Bolstad, Courtney J., Espie, Colin, Matsui, Kentaro, Chung, Frances, Morin, Charles M., Wing, Yun Kwok, Penzel, Thomas, Macêdo, Tainá, Mota-Rolim, Sérgio, Holzinger, Brigitte, Plazzi, Giuseppe, De Gennaro, Luigi, Landtblom, Anne-Marie, Inoue, Yuichi, Sieminski, Mariuz, Leger, Damien, and Dauvilliers, Yves

Published
2023
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11. Scientists Against War: A Plea to World Leaders for Better Governance

Author

Pandi-Perumal, Seithikurippu R., Kumar, Velayudhan Mohan, Pandian, Namasivayam Ganesh, de Jong, Joop T., Andiappan, Sudalaikannu, Corlateanu, Alexandru, Mahalaksmi, Arehally Marappa, Chidambaram, Saravana Babu, Kumar, Ramasamy Rajesh, Ramasubramanian, Chellamuthu, Sivasubramaniam, Sudhakar, Bjørkum, Alvhild Alette, Cutajar, JosAnn, Berk, Michael, Trakht, Ilya, Vrdoljak, Anton, Meira e Cruz, Miguel, Eyre, Harris A., Grønli, Janne, Cardinali, Dainiel P., Maercker, Andreas, van de Put, Willem A. C. M., Guzder, Jaswant, Bjorvatn, Bjørn, Tol, Wietse A., Acuña-Castroviejo, Darío, Meudec, Marie, Morin, Charles M., Partinen, Markku, Barbui, Corrado, Jordans, Mark J. D., Braakman, Mario H., Knaevelsrud, Christine, Pallesen, Ståle, Sijbrandij, Marit, Golombek, Diego Andrés, Espie, Colin A., Cuijpers, Pim, Agudelo, Hernán Andrés Marín, van der Velden, Koos, van der Kolk, Bessel A., Hobfoll, Stevan E., Devillé, Walter L. J. M., Gradisar, Michael, Riemann, Dieter, Axelsson, John, Benítez-King, Gloria, Macy, Robert D., Poberezhets, Vitalii, Hoole, Samuel Ratnajeevan Herbert, Murthy, Rangaswamy Srinivasa, Hegemann, Thomas, Heinz, Andreas, Salvage, Jane, McFarlane, Alexander C., Keukens, Rob, de Silva, Harendra, Oestereich, Cornelia, Wilhelm, Jochen, von Cranach, Michael, Hoffmann, Klaus, Klosinski, Matthias, Bhugra, Dinesh, and Seeman, Mary V.

Published
2022
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12. Heart Rate Variability and Interoception in Periodic Limb Movements in Sleep: Interference with Psychiatric Disorders?

Author

Małkiewicz, Marta A., Malinowski, Krzysztof S., Grzywińska, Małgorzata, Partinen, Eemil, Partinen, Markku, Pyrzowski, Jan, and Wszędybył-Winklewska, Magdalena

Subjects
HEART beat, AUTONOMIC nervous system, CARDIOVASCULAR system, INTEROCEPTION, HOMEOSTASIS
Abstract

Periodic limb movements in sleep (PLMS) are a prevalent disorder characterized by rhythmic, involuntary movements of the lower limbs, such as dorsiflexion of the ankle and extension of the big toe, occurring in periodic intervals during sleep. These movements are often linked to disrupted autonomic nervous system (ANS) activity and altered interoception. Interoception involves perceiving internal bodily states, like heartbeat, breathing, hunger, and temperature, and plays a crucial role in maintaining homeostasis and the mind–body connection. This review explores the complex relationships between PLMS, heart rate variability (HRV), ANS dysregulation, and their impact on psychiatric disorders. By synthesizing the existing literature, it provides insights into how ANS dysregulation and altered interoceptive processes, alongside PLMS, contribute to psychiatric conditions. The review highlights the potential for integrated diagnostic and therapeutic approaches and presents a cause-and-effect model illustrating the mutual influence of psychiatric disorders, ANS dysregulation, PLMS, and interoception. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Insomnia, anxiety, and depression during the COVID-19 pandemic: an international collaborative study

Author

Morin, Charles M., Bjorvatn, Bjørn, Chung, Frances, Holzinger, Brigitte, Partinen, Markku, Penzel, Thomas, Ivers, Hans, Wing, Yun Kwok, Chan, Ngan Yin, Merikanto, Ilona, Mota-Rolim, Sergio, Macêdo, Tainá, De Gennaro, Luigi, Léger, Damien, Dauvilliers, Yves, Plazzi, Giuseppe, Nadorff, Michael R., Bolstad, Courtney J., Sieminski, Mariusz, Benedict, Christian, Cedernaes, Jonathan, Inoue, Yuchi, Han, Fang, and Espie, Colin A.

Published
2021
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16. Habitual short sleepers with pre-existing medical conditions are at higher risk of Long COVID

Author

Berezin, Linor, Waseem, Rida, Merikanto, Ilona, Benedict, Christian, Holzinger, Brigitte, De Gennaro, Luigi, Wing, Yun Kwok, Bjorvatn, Bjørn, Korman, Maria, Morin, Charles M, Espie, Colin, Landtblom, Anne-Marie, Penzel, Thomas, Matsui, Kentaro, Hrubos-Strøm, Harald, Mota-Rolim, Sérgio, Nadorff, Michael R, Plazzi, Giuseppe, Reis, Catia, Chan, Rachel Ngan Yin, Cunha, Ana Suely, Yordanova, Juliana, Bjelajac, Adrijana Koscec, Inoue, Yuichi, Dauvilliers, Yves, Partinen, Markku, Chung, Frances, Berezin, Linor, Waseem, Rida, Merikanto, Ilona, Benedict, Christian, Holzinger, Brigitte, De Gennaro, Luigi, Wing, Yun Kwok, Bjorvatn, Bjørn, Korman, Maria, Morin, Charles M, Espie, Colin, Landtblom, Anne-Marie, Penzel, Thomas, Matsui, Kentaro, Hrubos-Strøm, Harald, Mota-Rolim, Sérgio, Nadorff, Michael R, Plazzi, Giuseppe, Reis, Catia, Chan, Rachel Ngan Yin, Cunha, Ana Suely, Yordanova, Juliana, Bjelajac, Adrijana Koscec, Inoue, Yuichi, Dauvilliers, Yves, Partinen, Markku, and Chung, Frances

Abstract

STUDY OBJECTIVES: Preliminary evidence suggests that the risk of Long COVID is higher among people with pre-existing medical conditions. Based on its proven adjuvant role in immunity, habitual sleep duration may alter the risk for developing Long COVID. The objective of this study was to determine whether the odds of Long COVID are higher amongst those with pre-existing medical conditions, and whether the strength of this association varies by habitual sleep duration. METHODS: Using data from 13,461 respondents from 16 countries who participated in the 2021 survey based International COVID Sleep Study II (ICOSS II), we studied the associations between habitual sleep duration, pre-existing medical conditions, and Long COVID. RESULTS: Of 2,508 individuals who had COVID-19, 61% reported at least one Long COVID symptom. Multivariable logistic regression analysis showed that the risk of having Long COVID was 1.8-fold higher for average-length sleepers (6-9h/night) with pre-existing medical conditions compared to those without pre-existing medical conditions [aOR 1.84 (1.18-2.90), P=0.008]. The risk of Long COVID was 3-fold higher for short sleepers with pre-existing medical conditions [aOR 2.95 (1.04-8.4), P=0.043] and not significantly higher for long sleepers with pre-existing conditions [aOR 2.11 (0.93-4.77), P=0.073] compared to average-length sleepers without pre-existing conditions. CONCLUSIONS: Habitual short nighttime sleep duration exacerbated the risk of Long COVID in individuals with pre-existing conditions. Restoring nighttime sleep to average duration represents a potentially modifiable behavioral factor to lower the odds of Long COVID for at-risk patients.

Published
2024
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17. Nightmare frequency is a risk factor for suicidal ideation during the COVID-19 pandemic.

Author

Bolstad, Courtney J, Holzinger, Brigitte, Scarpelli, Serena, De Gennaro, Luigi, Yordanova, Juliana, Koumanova, Silvia, Mota-Rolim, Sérgio, Benedict, Christian, Bjorvatn, Bjørn, Chan, Ngan Yin, Chung, Frances, Dauvilliers, Yves, Espie, Colin A, Inoue, Yuichi, Korman, Maria, Koscec Bjelajac, Adrijana, Landtblom, Anne-Marie, Matsui, Kentaro, Merikanto, Ilona, Morin, Charles M, Partinen, Markku, Penzel, Thomas, Plazzi, Giuseppe, Reis, Cátia, Ross, Biserka, Wing, Yun Kwok, Nadorff, Michael R, Bolstad, Courtney J, Holzinger, Brigitte, Scarpelli, Serena, De Gennaro, Luigi, Yordanova, Juliana, Koumanova, Silvia, Mota-Rolim, Sérgio, Benedict, Christian, Bjorvatn, Bjørn, Chan, Ngan Yin, Chung, Frances, Dauvilliers, Yves, Espie, Colin A, Inoue, Yuichi, Korman, Maria, Koscec Bjelajac, Adrijana, Landtblom, Anne-Marie, Matsui, Kentaro, Merikanto, Ilona, Morin, Charles M, Partinen, Markku, Penzel, Thomas, Plazzi, Giuseppe, Reis, Cátia, Ross, Biserka, Wing, Yun Kwok, and Nadorff, Michael R

Abstract

The association between nightmare frequency (NMF) and suicidal ideation (SI) is well known, yet the impact of the COVID-19 pandemic on this relation is inconsistent. This study aimed to investigate changes in NMF, SI, and their association during the COVID-19 pandemic. Data were collected in 16 countries using a harmonised questionnaire. The sample included 9328 individuals (4848 women; age M[SD] = 46.85 [17.75] years), and 17.60% reported previous COVID-19. Overall, SI was significantly 2% lower during the pandemic vs. before, and this was consistent across genders and ages. Most countries/regions demonstrated decreases in SI during this pandemic, with Austria (-9.57%), Sweden (-6.18%), and Bulgaria (-5.14%) exhibiting significant declines in SI, but Italy (1.45%) and Portugal (2.45%) demonstrated non-significant increases. Suicidal ideation was more common in participants with long-COVID (21.10%) vs. short-COVID (12.40%), though SI did not vary by COVID-19 history. Nightmare frequency increased by 4.50% during the pandemic and was significantly higher in those with previous COVID-19 (14.50% vs. 10.70%), during infection (23.00% vs. 8.10%), and in those with long-COVID (18.00% vs. 8.50%). The relation between NMF and SI was not significantly stronger during the pandemic than prior (rs = 0.18 vs. 0.14; z = 2.80). Frequent nightmares during the pandemic increased the likelihood of reporting SI (OR = 1.57, 95% CI 1.20-2.05), while frequent dream recall during the pandemic served a protective effect (OR = 0.74, 95% CI 0.59-0.94). These findings have important implications for identifying those at risk of suicide and may offer a potential pathway for suicide prevention.

Published
2024
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20. Nightmare frequency is a risk factor for suicidal ideation during the COVID‐19 pandemic

Author

Bolstad, Courtney J., primary, Holzinger, Brigitte, additional, Scarpelli, Serena, additional, De Gennaro, Luigi, additional, Yordanova, Juliana, additional, Koumanova, Silvia, additional, Mota‐Rolim, Sérgio, additional, Benedict, Christian, additional, Bjorvatn, Bjørn, additional, Chan, Ngan Yin, additional, Chung, Frances, additional, Dauvilliers, Yves, additional, Espie, Colin A., additional, Inoue, Yuichi, additional, Korman, Maria, additional, Koscec Bjelajac, Adrijana, additional, Landtblom, Anne‐Marie, additional, Matsui, Kentaro, additional, Merikanto, Ilona, additional, Morin, Charles M., additional, Partinen, Markku, additional, Penzel, Thomas, additional, Plazzi, Giuseppe, additional, Reis, Cátia, additional, Ross, Biserka, additional, Wing, Yun Kwok, additional, and Nadorff, Michael R., additional

Published
2024
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23. Harbingers of hope: Scientists and the pursuit of world peace

Author

Pandi-Perumal, Seithikurippu R., primary, van de Put, Willem A. C. M., additional, Maercker, Andreas, additional, Hobfoll, Stevan E., additional, Mohan Kumar, Velayudhan, additional, Barbui, Corrado, additional, Mahalaksmi, Arehally Marappa, additional, Chidambaram, Saravana Babu, additional, Lundmark, Per Olof, additional, Khai, Tual Sawn, additional, Atwoli, Lukoye, additional, Poberezhets, Vitalii, additional, Rajesh Kumar, Ramasamy, additional, Madoro, Derebe, additional, Andrés Marín Agudelo, Hernán, additional, Hoole, Samuel Ratnajeevan Herbert, additional, Teixeira-Santos, Luísa, additional, Pereira, Paulo, additional, Saravanan, Konda Mani, additional, Vrdoljak, Anton, additional, Meira e Cruz, Miguel, additional, Ramasubramanian, Chellamuthu, additional, Tay, Alvin Kuowei, additional, Grønli, Janne, additional, Sijbrandij, Marit, additional, Sivasubramaniam, Sudhakar, additional, Narasimhan, Meera, additional, Mbong, Eta Ngole, additional, Jansson-Fröjmark, Markus, additional, Bjorvatn, Bjørn, additional, de Jong, Joop T. V. M., additional, Braakman, Mario H., additional, Eisenbruch, Maurice, additional, Acuña-Castroviejo, Darío, additional, van der Velden, Koos, additional, Brown, Gregory M., additional, Partinen, Markku, additional, McFarlane, Alexander C., additional, and Berk, Michael, additional

Published
2023
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24. Pharmacological management of narcolepsy in children and adolescents

Author

Plazzi, Giuseppe, primary, Pizza, Fabio, additional, Lecendreux, Michel, additional, Gringras, Paul, additional, Barateau, Lucie, additional, Bruni, Oliviero, additional, Franco, Patricia, additional, Iranzo, Alex, additional, Jennum, Poul, additional, Khatami, Ramin, additional, Knudsen‐Heier, Stine, additional, Miano, Silvia, additional, Nobili, Lino, additional, Partinen, Markku, additional, Reading, Paul, additional, Sonka, Karel, additional, Szakacs, Attila, additional, Zenti, Massimo, additional, Kallweit, Ulf, additional, Lammers, Gert J., additional, Dauvilliers, Yves, additional, and Bassetti, Claudio L. A., additional

Published
2023
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27. Solriamfetol for the Treatment of Excessive Sleepiness in OSA: A Placebo-Controlled Randomized Withdrawal Study

Author

Partinen, Markku, Polo, Olli, Saaresranta, Tarja, Pépin, Jean-Louis, Paschen, Christine, Hedner, Jan, Leissner, Lena, Block, Bradley, Collop, Nancy, Doekel, Robert, Duntley, Stephen, Giangreco, Guillermo, Givelber, Rachel, Krystal, Andrew, Lal, Chitra, Lee, Mitchell, Lorch, Daniel G., Jr., Maynard, James, Norman, Daniel, Redline, Susan, Rosenberg, Russell, Rowe, Vernon, Sarmiento, Kathleen, Schreiber, Andrew, Schwab, Richard, Seiden, David, Shamsnia, Morteza, Strollo, Patrick J., Jr., Ware, J. Catesby, Chen, Dan, Carter, Lawrence P., Lu, Yuan, Lee, Lawrence, and Black, Jed

Published
2019
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28. Effect of series of periodic limb movements in sleep on blood pressure, heart rate and high frequency heart rate variability.

Author

Malkiewicz, Marta A., Grzywińska, Małgorzata, Malinowski, Krzysztof S., Partinen, Eemil, Partinen, Markku, Cubala, Wiesław J., Winklewski, Paweł J., and Siemiński, Mariusz

Subjects
HEART beat, BLOOD pressure, DIASTOLIC blood pressure, SYSTOLIC blood pressure, AUTONOMIC nervous system
Abstract

Introduction. The phenomenon known as periodic limb movements in sleep (PLMS) has been linked to a change in autonomic nervous system (ANS) activity and its effect on circulatory regulation. Autonomic dysfunction or dysregulation in patients with PLMS has been described in some domains; however, any relationship between heart rate variability (HRV) and PLMS has not been clearly established. HRV analysis is a recognised, non-invasive research method that describes the influence of the ANS on heart rate (HR). The aim of our study was to further investigate the dysregulation of autonomic HR control in patients with PLMS. Material and methods. We undertook a retrospective analysis of the polysomnographic (PSG), demographic and medical data of five patients with a total number of 1,348 PLMS. We analysed HR, HRV HF, systolic blood pressure (SBP), and diastolic blood pressure (DBP) for 10 heartbeats before the series of PLMS and 10 consecutive heartbeats as beat-to-beat measurements. The presented method of using successive, short, 10 RR interval segments refers to the time-frequency measurement, which is very clear and useful for presenting changes in the calculated parameters over time and thereby illustrating their dynamics. This method allowed us to assess dynamic changes in HRV HF during successive PLMS series. Statistical analysis was performed using IBM SPSS Statistics (v. 28.0.0.0). The Kruskal-Wallis test was performed to find statistically significant changes from baseline. Results. No statistically significant changes in HR, SBP, or DBP were found in our group, although an increase in the value of the HRV HF was noted, suggesting an increase in intracardiac parasympathetic activity during the subsequent series of PLMS. Conclusions. Our study indicates an increase in parasympathetic activity during the appearance of successive PLMS, which, with the simultaneous lack of changes in HR, may suggest an increase in sympathetic activity, and therefore the appearance of so-called 'autonomic co-activation' resulting in the possibility of life-threatening cardiac events. Clinical implications. Our findings add to the literature information regarding HRV in PLMS, and highlight the need for further studies to elucidate the effects of these conditions on the ANS, and on cardiovascular health. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Habitual short sleepers with pre-existing medical conditions are at higher risk of Long COVID

Author

Berezin, Linor, primary, Waseem, Rida, additional, Merikanto, Ilona, additional, Benedict, Christian, additional, Holzinger, Brigitte, additional, De Gennaro, Luigi, additional, Wing, Yun Kwok, additional, Bjorvatn, Bjørn, additional, Korman, Maria, additional, Morin, Charles M., additional, Espie, Colin, additional, Landtblom, Anne-Marie, additional, Penzel, Thomas, additional, Matsui, Kentaro, additional, Hrubos-Strøm, Harald, additional, Mota-Rolim, Sérgio, additional, Nadorff, Michael R., additional, Plazzi, Giuseppe, additional, Reis, Catia, additional, Chan, Rachel Ngan Yin, additional, Cunha, Ana Suely, additional, Yordanova, Juliana, additional, Bjelajac, Adrijana Koscec, additional, Inoue, Yuichi, additional, Dauvilliers, Yves, additional, Partinen, Markku, additional, and Chung, Frances, additional

Published
2023
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34. Pharmacological management of narcolepsy in children and adolescents.

Author

Plazzi, Giuseppe, Pizza, Fabio, Lecendreux, Michel, Gringras, Paul, Barateau, Lucie, Bruni, Oliviero, Franco, Patricia, Iranzo, Alex, Jennum, Poul, Khatami, Ramin, Knudsen‐Heier, Stine, Miano, Silvia, Nobili, Lino, Partinen, Markku, Reading, Paul, Sonka, Karel, Szakacs, Attila, Zenti, Massimo, Kallweit, Ulf, and Lammers, Gert J.

Subjects
CHILD patients, DROWSINESS, YOUNG adults, TEENAGERS, H2 receptor antagonists
Abstract

The article discusses the pharmacological management of narcolepsy in children and adolescents. It highlights the need for safe and effective treatments for young people with narcolepsy and mentions the European guidelines on the management of narcolepsy in adults and children. The article focuses on the efficacy and safety of pitolisant, a drug that has been approved by the European Medicine Agency for the treatment of narcolepsy in children and adolescents. It mentions a clinical trial that showed significant improvements in narcolepsy symptoms with pitolisant compared to a placebo. The article concludes by emphasizing the importance of early treatment for narcolepsy to prevent long-term consequences. [Extracted from the article]

Published
2024
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41. Sleep symptoms are essential features of long-COVID : Comparing healthy controls with COVID-19 cases of different severity in the international COVID sleep study (ICOSS-II)

Author

Merikanto, Ilona, Dauvilliers, Yves, Chung, Frances, Wing, Yun Kwok, De Gennaro, Luigi, Holzinger, Brigitte, Bjorvatn, Bjorn, Morin, Charles M., Penzel, Thomas, Benedict, Christian, Bjelajac, Adrijana Koscec, Chan, Ngan Yin, Espie, Colin A., Hrubos-Strom, Harald, Inoue, Yuichi, Korman, Maria, Landtblom, Anne-Marie, Leger, Damien, Matsui, Kentaro, Mota-Rolim, Sergio, Nadorff, Michael R., Plazzi, Giuseppe, Reis, Catia, Yordanova, Juliana, Partinen, Markku, Merikanto, Ilona, Dauvilliers, Yves, Chung, Frances, Wing, Yun Kwok, De Gennaro, Luigi, Holzinger, Brigitte, Bjorvatn, Bjorn, Morin, Charles M., Penzel, Thomas, Benedict, Christian, Bjelajac, Adrijana Koscec, Chan, Ngan Yin, Espie, Colin A., Hrubos-Strom, Harald, Inoue, Yuichi, Korman, Maria, Landtblom, Anne-Marie, Leger, Damien, Matsui, Kentaro, Mota-Rolim, Sergio, Nadorff, Michael R., Plazzi, Giuseppe, Reis, Catia, Yordanova, Juliana, and Partinen, Markku

Abstract

Many people report suffering from post-acute sequelae of COVID-19 or "long-COVID", but there are still open questions on what actually constitutes long-COVID and how prevalent it is. The current definition of post-acute sequelae of COVID-19 is based on voting using the Delphi-method by the WHO post-COVID-19 working group. It emphasizes long-lasting fatigue, shortness of breath and cognitive dysfunction as the core symptoms of post-acute sequelae of COVID-19. In this international survey study consisting of 13,628 subjects aged 18-99 years from 16 countries of Asia, Europe, North America and South America (May-Dec 2021), we show that post-acute sequelae of COVID-19 symptoms were more prevalent amongst the more severe COVID-19 cases, i.e. those requiring hospitalisation for COVID-19. We also found that long-lasting sleep symptoms are at the core of post-acute sequelae of COVID-19 and associate with the COVID-19 severity when COVID-19 cases are compared with COVID-negative cases. Specifically, fatigue (61.3%), insomnia symptoms (49.6%) and excessive daytime sleepiness (35.8%) were highly prevalent amongst respondents reporting long-lasting symptoms after hospitalisation for COVID-19. Understanding the importance of sleep-related symptoms in post-acute sequelae of COVID-19 has a clinical relevance when diagnosing and treating long-COVID.

Published
2023
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42. Shift workers are at increased risk of severe COVID-19 compared with day workers : Results from the international COVID sleep study (ICOSS) of 7141 workers.

Author

Bjorvatn, Bjørn, Merikanto, Ilona, Reis, Catia, Korman, Maria, Bjelajac, Adrijana Koscec, Holzinger, Brigitte, De Gennaro, Luigi, Wing, Yun Kwok, Morin, Charles M, Espie, Colin A, Benedict, Christian, Landtblom, Anne-Marie, Matsui, Kentaro, Hrubos-Strøm, Harald, Mota-Rolim, Sérgio, Nadorff, Michael R, Plazzi, Giuseppe, Chan, Rachel Ngan Yin, Partinen, Markku, Dauvilliers, Yves, Chung, Frances, Forthun, Ingeborg, Bjorvatn, Bjørn, Merikanto, Ilona, Reis, Catia, Korman, Maria, Bjelajac, Adrijana Koscec, Holzinger, Brigitte, De Gennaro, Luigi, Wing, Yun Kwok, Morin, Charles M, Espie, Colin A, Benedict, Christian, Landtblom, Anne-Marie, Matsui, Kentaro, Hrubos-Strøm, Harald, Mota-Rolim, Sérgio, Nadorff, Michael R, Plazzi, Giuseppe, Chan, Rachel Ngan Yin, Partinen, Markku, Dauvilliers, Yves, Chung, Frances, and Forthun, Ingeborg

Abstract

The present study had two main aims. First, to investigate whether shift/night workers had a higher prevalence and severity of COVID-19 compared with day workers. Second, to investigate whether people regularly working in face-to-face settings during the pandemic exhibited a higher prevalence and severity of COVID-19 compared with those having no need to be in close contact with others at work. Data consisted of 7141 workers from 15 countries and four continents who participated in the International COVID Sleep Study-II (ICOSS-II) between May and December 2021. The associations between work status and a positive COVID-19 test and several indications of disease severity were tested with chi-square tests and logistic regressions adjusted for relevant confounders. In addition, statistical analyses were conducted for the associations between face-to-face work and COVID-19 status. Results showed that shift/night work was not associated with an increased risk of COVID-19 compared to day work. Still, shift/night workers reported higher odds for moderate to life-threatening COVID-19 (adjusted odds ratio (aOR) = 2.71, 95%-confidence interval = 1.23-5.95) and need for hospital care (aOR = 5.66, 1.89-16.95). Face-to-face work was associated with an increased risk of COVID-19 (aOR = 1.55, 1.12-2.14) but not with higher disease severity. In conclusion, shift/night work was not associated with an increased risk of COVID-19, but when infected, shift/night workers reported more severe disease. Impaired sleep and circadian disruption commonly seen among shift/night workers may be mediating factors. Working face-to-face increased the risk of COVID-19, likely due to increased exposure to the virus. However, face-to-face work was not associated with increased disease severity.

Published
2023
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43. Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

Author

Ollila, Hanna M., Sharon, Eilon, Lin, Ling, Sinnott-Armstrong, Nasa, Ambati, Aditya, Yogeshwar, Selina M., Hillary, Ryan P., Jolanki, Otto, Faraco, Juliette, Einen, Mali, Luo, Guo, Zhang, Jing, Han, Fang, Yan, Han, Dong, Xiao Song, Li, Jing, Zhang, Jun, Hong, Seung-Chul, Kim, Tae Won, Dauvilliers, Yves, Barateau, Lucie, Lammers, Gert Jan, Fronczek, Rolf, Mayer, Geert, Santamaria, Joan, Arnulf, Isabelle, Knudsen-Heier, Stine, Bredahl, May Kristin Lyamouri, Thorsby, Per Medboe, Plazzi, Giuseppe, Pizza, Fabio, Moresco, Monica, Crowe, Catherine, Van den Eeden, Stephen K., Lecendreux, Michel, Bourgin, Patrice, Kanbayashi, Takashi, Martinez-Orozco, Francisco J., Peraita-Adrados, Rosa, Beneto, Antonio, Montplaisir, Jacques, Desautels, Alex, Huang, Yu-Shu, FinnGen, Poul Jennum, Jennum, Poul, Nevsimalova, Sona, Kemlink, David, Iranzo, Alex, Overeem, Sebastiaan, Wierzbicka, Aleksandra, Geisler, Peter, Sonka, Karel, Honda, Makoto, Högl, Birgit, Stefani, Ambra, Coelho, Fernando Morgadinho, Mantovani, Vilma, Feketeova, Eva, Wadelius, Mia, Eriksson, Niclas, Smedje, Hans, Hallberg, Pär, Hesla, Per Egil, Rye, David, Pelin, Zerrin, Ferini-Strambi, Luigi, Bassetti, Claudio L., Mathis, Johannes, Khatami, Ramin, Aran, Adi, Nampoothiri, Sheela, Olsson, Tomas, Kockum, Ingrid, Partinen, Markku, Perola, Markus, Kornum, Birgitte R., Rueger, Sina, Winkelmann, Juliane, Miyagawa, Taku, Toyoda, Hiromi, Khor, Seik-Soon, Shimada, Mihoko, Tokunaga, Katsushi, Rivas, Manuel, Pritchard, Jonathan K., Risch, Neil, Kutalik, Zoltan, O'Hara, Ruth, Hallmayer, Joachim, Ye, Chun Jimmie, Mignot, Emmanuel J., Ollila, Hanna M., Sharon, Eilon, Lin, Ling, Sinnott-Armstrong, Nasa, Ambati, Aditya, Yogeshwar, Selina M., Hillary, Ryan P., Jolanki, Otto, Faraco, Juliette, Einen, Mali, Luo, Guo, Zhang, Jing, Han, Fang, Yan, Han, Dong, Xiao Song, Li, Jing, Zhang, Jun, Hong, Seung-Chul, Kim, Tae Won, Dauvilliers, Yves, Barateau, Lucie, Lammers, Gert Jan, Fronczek, Rolf, Mayer, Geert, Santamaria, Joan, Arnulf, Isabelle, Knudsen-Heier, Stine, Bredahl, May Kristin Lyamouri, Thorsby, Per Medboe, Plazzi, Giuseppe, Pizza, Fabio, Moresco, Monica, Crowe, Catherine, Van den Eeden, Stephen K., Lecendreux, Michel, Bourgin, Patrice, Kanbayashi, Takashi, Martinez-Orozco, Francisco J., Peraita-Adrados, Rosa, Beneto, Antonio, Montplaisir, Jacques, Desautels, Alex, Huang, Yu-Shu, FinnGen, Poul Jennum, Jennum, Poul, Nevsimalova, Sona, Kemlink, David, Iranzo, Alex, Overeem, Sebastiaan, Wierzbicka, Aleksandra, Geisler, Peter, Sonka, Karel, Honda, Makoto, Högl, Birgit, Stefani, Ambra, Coelho, Fernando Morgadinho, Mantovani, Vilma, Feketeova, Eva, Wadelius, Mia, Eriksson, Niclas, Smedje, Hans, Hallberg, Pär, Hesla, Per Egil, Rye, David, Pelin, Zerrin, Ferini-Strambi, Luigi, Bassetti, Claudio L., Mathis, Johannes, Khatami, Ramin, Aran, Adi, Nampoothiri, Sheela, Olsson, Tomas, Kockum, Ingrid, Partinen, Markku, Perola, Markus, Kornum, Birgitte R., Rueger, Sina, Winkelmann, Juliane, Miyagawa, Taku, Toyoda, Hiromi, Khor, Seik-Soon, Shimada, Mihoko, Tokunaga, Katsushi, Rivas, Manuel, Pritchard, Jonathan K., Risch, Neil, Kutalik, Zoltan, O'Hara, Ruth, Hallmayer, Joachim, Ye, Chun Jimmie, and Mignot, Emmanuel J.

Abstract

Narcolepsy type 1 (NT1) is caused by a loss of hypocretin/orexin transmission. Risk factors include pandemic 2009 H1N1 influenza A infection and immunization with Pandemrix (R). Here, we dissect disease mechanisms and interactions with environmental triggers in a multi-ethnic sample of 6,073 cases and 84,856 controls. We fine-mapped GWAS signals within HLA (DQ0602, DQB1*03:01 and DPB1*04:02) and discovered seven novel associations (CD207, NAB1, IKZF4-ERBB3, CTSC, DENND1B, SIRPG, PRF1). Significant signals at TRA and DQB1*06:02 loci were found in 245 vaccination-related cases, who also shared polygenic risk. T cell receptor associations in NT1 modulated TRAJ*24, TRAJ*28 and TRBV*4-2 chain-usage. Partitioned heritability and immune cell enrichment analyses found genetic signals to be driven by dendritic and helper T cells. Lastly comorbidity analysis using data from FinnGen, suggests shared effects between NT1 and other autoimmune diseases. NT1 genetic variants shape autoimmunity and response to environmental triggers, including influenza A infection and immunization with Pandemrix (R).

Published
2023
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44. Large registry-based analysis of genetic predisposition to tuberculosis identifies genetic risk factors at HLA

Author

Massachusetts Institute of Technology. Department of Biological Engineering, Tervi, Anniina, Junna, Nella, Broberg, Martin, Jones, Samuel E, Partinen, Markku, Pirinen, Matti, Bryson, Bryan, Strausz, Satu, Kreivi, Hanna-Riikka, Heckman, Caroline A, Ollila, Hanna M, Massachusetts Institute of Technology. Department of Biological Engineering, Tervi, Anniina, Junna, Nella, Broberg, Martin, Jones, Samuel E, Partinen, Markku, Pirinen, Matti, Bryson, Bryan, Strausz, Satu, Kreivi, Hanna-Riikka, Heckman, Caroline A, and Ollila, Hanna M

Abstract

Abstract Tuberculosis is a significant public health concern resulting in the death of over 1 million individuals each year worldwide. While treatment options and vaccines exist, a substantial number of infections still remain untreated or are caused by treatment resistant strains. Therefore, it is important to identify mechanisms that contribute to risk and prognosis of tuberculosis as this may provide tools to understand disease mechanisms and provide novel treatment options for those with severe infection. Our goal was to identify genetic risk factors that contribute to the risk of tuberculosis and to understand biological mechanisms and causality behind the risk of tuberculosis. A total of 1895 individuals in the FinnGen study had International Classification of Diseases-based tuberculosis diagnosis. Genome-wide association study analysis identified genetic variants with statistically significant association with tuberculosis at the human leukocyte antigen (HLA) region (P < 5e−8). Fine mapping of the HLA association provided evidence for one protective haplotype tagged by HLA DQB1*05:01 (P = 1.82E−06, OR = 0.81 [CI 95% 0.74–0.88]), and predisposing alleles tagged by HLA DRB1*13:02 (P = 0.00011, OR = 1.35 [CI 95% 1.16–1.57]). Furthermore, genetic correlation analysis showed association with earlier reported risk factors including smoking (P < 0.05). Mendelian randomization supported smoking as a risk factor for tuberculosis (inverse-variance weighted P < 0.05, OR = 1.83 [CI 95% 1.15–2.93]) with no significant evidence of pleiotropy. Our findings indicate that specific HLA alleles associate with the risk of tuberculosis. In addition, lifestyle risk factors such as smoking contribute to the risk of developing tuberculosis.

Published
2023

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