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Introduction: Chronic Suppurative otitis media is one of the most commonly encountered diseases in the otolaryngeal practice, which is well known for its multiple etiology, persistence and recurrence. Reevaluation of aerobic bacterial and fungal study to know the microbiotia in this location and also for treatment purpose antibiotic susceptibility testing using current available antibiotics of predominant bacterial pathogens were depicted in this study. Materials and Methods: In this prospective study Patients with chronic suppurative otitis media (CSOM) presenting with more than 3 weeks of ear discharge and who did not receive any topical or systemic antibiotics in the past one week were included in this study. All swabs were processed for gram stain, KOH mount, culture, biochemical reactions and sensitivity testing according to CLSI guidelines. Results: Most common organism isolated from CSOM study population was Pseudomonas aeruginosa (42.1%), followed by Staphylococcus aureus (34.2%). Most common organism isolated from CSOM study population was Pseudomonas aeruginosa (42.1%), followed by Staphylococcus aureus (34.2%). Pseudomonas aeruginosa which were isolated showed 93.7% susceptibility to amikacin, 78.1% to levofloxacin, 81.2% to Ceftazidime-clavulanic acid, 81.2% to piperacillin+tazobactum, 75% to ceftazidime, and 87.5% sensitive to meropenem. Klebsiella pneumoniae showed 75% sensitivity to amikacin and levofloxacin, 100% sensitive to meropenem, ertapenem and tigecycline. Escherichia coli and Proteus mirabilis showed 100% sensitivity to amikacin, ciprofloxacin and meropenem. S.aureus showed 84.6% susceptibility to clindamycin, 76.9% to ciprofloxacin, 84.6% to amoxicillin+clavulanic acid, 96.1% to amikacin, and all were cefoxitin sensitive. Conclusion: Microbiological testing of specimen prior to start the antibiotic therapy in CSOM patients alleviate the emergence of drug resistant of pathogens and also helps clinicians to give accurate and prompt treatment. [ABSTRACT FROM AUTHOR]