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206 results on '"Pascale Vicat"'

1. Pharmacokinetics of novel Fc-engineered monoclonal and multispecific antibodies in cynomolgus monkeys and humanized FcRn transgenic mouse models

Author

Delphine Valente, Christine Mauriac, Thorsten Schmidt, Ingo Focken, Jochen Beninga, Brian Mackness, Huawei Qiu, Pascale Vicat, Abdullah Kandira, Katarina Radošević, Srini Rao, John Darbyshire, and Mostafa Kabiri

Subjects
Bispecific antibody, trispecific antibody, multispecific antibody, Fc-engineering, Tg32 mice, NHP, Therapeutics. Pharmacology, RM1-950, Immunologic diseases. Allergy, RC581-607
Abstract

Monoclonal antibodies (mAbs) are among the fastest growing and most effective therapies for myriad diseases. Multispecific antibodies are an emerging class of novel therapeutics that can target more than one tumor- or immune-associated modulators per molecule. The combination of different binding affinities and target classes, such as soluble or membrane-bound antigens, within multispecific antibodies confers unique pharmacokinetic (PK) properties. Numerous factors affect an antibody’s PK, with affinity to the neonatal Fc receptor (FcRn) a key determinant of half-life. Recent work has demonstrated the potential for humanized FcRn transgenic mice to predict the PK of mAbs in humans. However, such work has not been extended to multispecific antibodies. We engineered mAbs and multispecific antibodies with various Fc modifications to enhance antibody performance. PK analyses in humanized FcRn transgenic mouse (homozygous Tg32 and Tg276) and non-human primate (NHP) models showed that FcRn-binding mutations improved the plasma half-lives of the engineered mAbs and multispecific antibodies, while glycan engineering to eliminate effector function did not affect the PK compared with wild-type controls. Furthermore, results suggest that the homozygous Tg32 mouse model can replace NHP models to differentiate PK of variants during lead optimization, not only for wild-type mAbs but also for Fc-engineered mAbs and multispecific antibodies. This Tg32-mouse model would enable prediction of half-life and linear clearance of mAbs and multispecific antibodies in NHPs to guide the design of further pharmacology/safety studies in this species. The allometric exponent for clearance scaling from Tg32 mice to NHPs was estimated to be 0.91 for all antibodies.

Published
2020
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8. The GEYSERS Concept and Major Outcomes.

Author

Anna Tzanakaki, Sergi Figuerola, Joan Antoni García Espín, Dimitra Simeonidou, Nicola Ciulli, Philip Robinson, Juan Rodríguez Martinez, Giada Landi, Bartosz Belter, Pascale Vicat-Blanc, Matteo Biancani, Cees de Laat, Eduard Escalona, and Artur Binczewski

Published
2013
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9. Virtual infrastructure planning: The GEYSERS approach.

Author

Anna Tzanakaki, Markos P. Anastasopoulos, Konstantinos Georgakilas, J. A. Garciaespin, Jordi Ferrer Riera, Sergi Figuerola, Mattijs Ghijsen, Yuri Demchenko, Cees T. A. M. de Laat, Pascale Vicat-Blanc, Sebastien Soudan, Fabienne Anhalt, Shuping Peng 0001, Eduard Escalona, Reza Nejabati, and Dimitra Simeonidou

Published
2012

10. Bringing Optical Networks to the Cloud: An Architecture for a Sustainable future Internet.

Author

Pascale Vicat-Blanc, Sergi Figuerola, Xiaomin Chen, Giada Landi, Eduard Escalona, Chris Develder, Anna Tzanakaki, Yuri Demchenko, Joan Antoni García Espín, Jordi Ferrer Riera, Ester López, Sebastien Soudan, Jens Buysse, Admela Jukan, Nicola Ciulli, Marc Brogle, Luuk van Laarhoven, Bartosz Belter, Fabienne Anhalt, Reza Nejabati, Dimitra Simeonidou, Canh Ngo, Cees de Laat, Matteo Biancani, Michael Roth, Pasquale Donadio, Javier Jiménez, Monika Antoniak-Lewandowska, and Ashwin Gumaste

Published
2011
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11. GEYSERS: A novel architecture for virtualization and co-provisioning of dynamic optical networks and IT services.

Author

Eduard Escalona, Shuping Peng 0001, Reza Nejabati, Dimitra Simeonidou, Joan Antoni García Espín, Jordi Ferrer Riera, Sergi Figuerola, Giada Landi, Nicola Ciulli, Javier Jiménez, Bartosz Belter, Yuri Demchenko, Cees de Laat, Xiaomin Chen, Admela Yukan, Sebastien Soudan, Pascale Vicat-Blanc, Jens Buysse, Marc De Leenheer, Chris Develder, Anna Tzanakaki, Philip Robinson, Marc Brogle, and Thomas Michael Bohnert

Published
2011

20. Executing Distributed Applications on Virtualized Infrastructures Specified with the VXDL Language and Managed by the HIPerNET Framework

Author

Koslovski, Guilherme, Huu, Tram Truong, Montagnat, Johan, Primet, Pascale Vicat-Blanc, Akan, Ozgur, editor, Bellavista, Paolo, editor, Cao, Jiannong, editor, Dressler, Falko, editor, Ferrari, Domenico, editor, Gerla, Mario, editor, Kobayashi, Hisashi, editor, Palazzo, Sergio, editor, Sahni, Sartaj, editor, Shen, Xuemin, editor, Stan, Mircea, editor, Xiaohua, Jia, editor, Zomaya, Albert, editor, Coulson, Geoffrey, editor, Avresky, Dimiter R., editor, Diaz, Michel, editor, Bode, Arndt, editor, Ciciani, Bruno, editor, and Dekel, Eliezer, editor

Published
2010
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21. A Flow Scheduler Architecture

Author

Divakaran, Dinil Mon, Carofiglio, Giovanna, Altman, Eitan, Primet, Pascale Vicat-Blanc, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Crovella, Mark, editor, Feeney, Laura Marie, editor, Rubenstein, Dan, editor, and Raghavan, S. V., editor

Published
2010
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33. VXDL: Virtual Resources and Interconnection Networks Description Language

Author

Koslovski, Guilherme Piegas, Primet, Pascale Vicat-Blanc, Charão, Andrea Schwertner, Akan, Ozgur, Series editor, Bellavista, Paolo, Series editor, Cao, Jiannong, Series editor, Dressler, Falko, Series editor, Ferrari, Domenico, Series editor, Gerla, Mario, Series editor, Kobayashi, Hisashi, Series editor, Palazzo, Sergio, Series editor, Sahni, Sartaj, Series editor, Shen, Xuemin (Sherman), Series editor, Stan, Mircea, Series editor, Xiaohua, Jia, Series editor, Zomaya, Albert, Series editor, Coulson, Geoffrey, Series editor, Vicat-Blanc Primet, Pascale, editor, Kudoh, Tomohiro, editor, and Mambretti, Joe, editor

Published
2009
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34. Equilibrium in Size-Based Scheduling Systems

Author

Soudan, Sebastien, Divakaran, Dinil Mon, Altman, Eitan, Primet, Pascale Vicat-Blanc, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Al-Begain, Khalid, editor, Fiems, Dieter, editor, and Horváth, Gábor, editor

Published
2009
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47. Preclinical in vitro and in vivo pharmacokinetic properties of danicamtiv, a new targeted myosin activator for the treatment of dilated cardiomyopathy

Author

Mark P. Grillo, Svetlana Markova, Marc Evanchik, Marc Trellu, Patricia Moliner, Priscilla Brun, Anne Perreard-Dumaine, Pascale Vicat, Chun Yang, James P. Driscoll, and Tim J. Carlson

Subjects
medicine.medical_specialty, Health, Toxicology and Mutagenesis, Toxicology, Left ventricular enlargement, 030226 pharmacology & pharmacy, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, In vivo, Internal medicine, Myosin, medicine, cardiovascular diseases, Pharmacology, business.industry, Activator (genetics), Dilated cardiomyopathy, General Medicine, medicine.disease, In vitro, 030220 oncology & carcinogenesis, Heart failure, cardiovascular system, Cardiology, business
Abstract

Dilated cardiomyopathy (DCM) is a disease of the myocardium defined by left ventricular enlargement and systolic dysfunction leading to heart failure. Danicamtiv, a new targeted myosin activator de...

Published
2020

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