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2. The 2023 ACR/EULAR classification criteria for calcium pyrophosphate deposition disease.

Author

Iagnocco, AnnaMaria, Lioté, Frédéric, McCarthy, Geraldine, Ramonda, Roberta, Richette, Pascal, Sivera, Francisca, Andrés, Mariano, Cipolletta, Edoardo, Doherty, Michael, Pascual, Eliseo, Perez-Ruiz, Fernando, So, Alexander, Jansen, Tim, Kohler, Minna, Stamp, Lisa, Yinh, Janeth, Adinolfi, Antonella, Arad, Uri, Aung, Thanda, Benillouche, Eva, Bortoluzzi, Alessandra, Dau, Jonathan, Maningding, Ernest, Fang, Meika, Figus, Fabiana, Filippucci, Emilio, Haslett, Janine, Janssen, Matthijs, Kaldas, Marian, Kimoto, Maryann, Leamy, Kelly, Navarro, Geraldine, Sarzi-Puttini, Piercarlo, Scirè, Carlo, Silvagni, Ettore, Sirotti, Silvia, Stack, John, Truong, Linh, Abhishek, Abhishek, Tedeschi, Sara, Pascart, Tristan, Latourte, Augustin, Dalbeth, Nicola, Neogi, Tuhina, Fuller, Amy, Rosenthal, Ann, Becce, Fabio, Bardin, Thomas, Ea, Hang-Korng, Filippou, Georgios, Yokose, Chio, Hendry, Alison, Terkeltaub, Robert, Taylor, William, Choi, Hyon, FitzGerald, John, and Xie, Chen

Subjects
Autoimmune Diseases, Immune Complex Diseases, Immune System Diseases, Humans, United States, Chondrocalcinosis, Rheumatology, Calcium Pyrophosphate, Calcinosis, Syndrome
Abstract

OBJECTIVE: Calcium pyrophosphate deposition (CPPD) disease is prevalent and has diverse presentations, but there are no validated classification criteria for this symptomatic arthritis. The American College of Rheumatology (ACR) and EULAR have developed the first-ever validated classification criteria for symptomatic CPPD disease. METHODS: Supported by the ACR and EULAR, a multinational group of investigators followed established methodology to develop these disease classification criteria. The group generated lists of candidate items and refined their definitions, collected de-identified patient profiles, evaluated strengths of associations between candidate items and CPPD disease, developed a classification criteria framework, and used multi-criterion decision analysis to define criteria weights and a classification threshold score. The criteria were validated in an independent cohort. RESULTS: Among patients with joint pain, swelling, or tenderness (entry criterion) whose symptoms are not fully explained by an alternative disease (exclusion criterion), the presence of crowned dens syndrome or calcium pyrophosphate crystals in synovial fluid are sufficient to classify a patient as having CPPD disease. In the absence of these findings, a score>56 points using weighted criteria, comprising clinical features, associated metabolic disorders, and results of laboratory and imaging investigations, can be used to classify as CPPD disease. These criteria had a sensitivity of 92.2% and specificity of 87.9% in the derivation cohort (190 CPPD cases, 148 mimickers), whereas sensitivity was 99.2% and specificity was 92.5% in the validation cohort (251 CPPD cases, 162 mimickers). CONCLUSION: The 2023 ACR/EULAR CPPD disease classification criteria have excellent performance characteristics and will facilitate research in this field.

Published
2023

3. The 2023 ACR/EULAR Classification Criteria for Calcium Pyrophosphate Deposition Disease.

Author

Abhishek, Abhishek, Tedeschi, Sara, Pascart, Tristan, Latourte, Augustin, Dalbeth, Nicola, Neogi, Tuhina, Fuller, Amy, Rosenthal, Ann, Becce, Fabio, Bardin, Thomas, Ea, Hang, Filippou, Georgios, Iagnocco, AnnaMaria, Lioté, Frédéric, McCarthy, Geraldine, Ramonda, Roberta, Richette, Pascal, Sivera, Francisca, Andres, Mariano, Cipolletta, Edoardo, Doherty, Michael, Pascual, Eliseo, Perez-Ruiz, Fernando, So, Alexander, Jansen, Tim, Kohler, Minna, Stamp, Lisa, Yinh, Janeth, Adinolfi, Antonella, Arad, Uri, Aung, Thanda, Benillouche, Eva, Bortoluzzi, Alessandra, Dau, Jonathan, Maningding, Ernest, Fang, Meika, Figus, Fabiana, Filippucci, Emilio, Haslett, Janine, Janssen, Matthijs, Kimoto, Maryann, Leamy, Kelly, Navarro, Geraldine, Sarzi-Puttini, Piercarlo, Scirè, Carlo, Silvagni, Ettore, Sirotti, Silvia, Stack, John, Truong, Linh, Yokose, Chio, Hendry, Alison, Terkeltaub, Robert, Taylor, William, Choi, Hyon, FitzGerald, John, Kaldas, Marian, and Xie, Chen

Subjects
Humans, Calcinosis, Calcium Pyrophosphate, Chondrocalcinosis, Rheumatology, Syndrome, United States
Abstract

OBJECTIVE: Calcium pyrophosphate deposition (CPPD) disease is prevalent and has diverse presentations, but there are no validated classification criteria for this symptomatic arthritis. The American College of Rheumatology (ACR) and EULAR have developed the first-ever validated classification criteria for symptomatic CPPD disease. METHODS: Supported by the ACR and EULAR, a multinational group of investigators followed established methodology to develop these disease classification criteria. The group generated lists of candidate items and refined their definitions, collected de-identified patient profiles, evaluated strengths of associations between candidate items and CPPD disease, developed a classification criteria framework, and used multi-criterion decision analysis to define criteria weights and a classification threshold score. The criteria were validated in an independent cohort. RESULTS: Among patients with joint pain, swelling, or tenderness (entry criterion) whose symptoms are not fully explained by an alternative disease (exclusion criterion), the presence of crowned dens syndrome or calcium pyrophosphate crystals in synovial fluid are sufficient to classify a patient as having CPPD disease. In the absence of these findings, a score >56 points using weighted criteria, comprising clinical features, associated metabolic disorders, and results of laboratory and imaging investigations, can be used to classify as CPPD disease. These criteria had a sensitivity of 92.2% and specificity of 87.9% in the derivation cohort (190 CPPD cases, 148 mimickers), whereas sensitivity was 99.2% and specificity was 92.5% in the validation cohort (251 CPPD cases, 162 mimickers). CONCLUSION: The 2023 ACR/EULAR CPPD disease classification criteria have excellent performance characteristics and will facilitate research in this field.

Published
2023

5. Identifying Potential Classification Criteria for Calcium Pyrophosphate Deposition Disease: Item Generation and Item Reduction.

Author

Tedeschi, Sara, Pascart, Tristan, Latourte, Augustin, Godsave, Cattleya, Kundakci, Burak, Naden, Raymond, Taylor, William, Dalbeth, Nicola, Neogi, Tuhina, Perez-Ruiz, Fernando, Rosenthal, Ann, Becce, Fabio, Pascual, Eliseo, Andres, Mariano, Bardin, Thomas, Doherty, Michael, Ea, Hang-Korng, Filippou, Georgios, Guitierrez, Marwin, Iagnocco, Annamaria, Jansen, Tim, Kohler, Minna, Lioté, Frédéric, Matza, Mark, McCarthy, Geraldine, Ramonda, Roberta, Reginato, Anthony, Richette, Pascal, Singh, Jasvinder, Sivera, Francisca, So, Alexander, Stamp, Lisa, Yinh, Janeth, Yokose, Chio, Choi, Hyon, Abhishek, Abhishek, Terkeltaub, Robert, and FitzGerald, John

Subjects
Calcium Pyrophosphate, Chondrocalcinosis, Crystal Arthropathies, Humans, Knee Joint, Wrist Joint
Abstract

OBJECTIVE: Classification criteria for calcium pyrophosphate deposition (CPPD) disease will facilitate clinical research on this common crystalline arthritis. Our objective was to report on the first 2 phases of a 4-phase process for developing CPPD classification criteria. METHODS: CPPD classification criteria development is overseen by a 12-member steering committee. Item generation (phase I) included a scoping literature review of 5 literature databases and contributions from a 35-member combined expert committee and 2 patient research partners. Item reduction and refinement (phase II) involved a combined expert committee meeting, discussions among clinical, imaging, and laboratory advisory groups, and an item-rating exercise to assess the influence of individual items toward classification. The steering committee reviewed the modal rating score for each item (range -3 [strongly pushes away from CPPD] to +3 [strongly pushes toward CPPD]) to determine items to retain for future phases of criteria development. RESULTS: Item generation yielded 420 items (312 from the literature, 108 from experts/patients). The advisory groups eliminated items that they agreed were unlikely to distinguish between CPPD and other forms of arthritis, yielding 127 items for the item-rating exercise. Fifty-six items, most of which had a modal rating of +/- 2 or 3, were retained for future phases. As numerous imaging items were rated +3, the steering committee recommended focusing on imaging of the knee and wrist and 1 additional affected joint for calcification suggestive of CPP crystal deposition. CONCLUSION: A data- and expert-driven process is underway to develop CPPD classification criteria. Candidate items comprise clinical, imaging, and laboratory features.

Published
2022

7. The gout epidemic in French Polynesia: a modelling study of data from the Ma’i u’u epidemiological survey

Author

Pascart, Tristan, Wasik, Kaja A, Preda, Cristian, Chune, Valérie, Torterat, Jérémie, Prud’homme, Nicolas, Nassih, Maryline, Martin, Agathe, Le Masson, Julien, Rodière, Vahinetua, Frogier, Sylvain, Canova, Georges, Pescheux, Jean-Paul, Shan Sei Fan, Charles, Jauffret, Charlotte, Claeys, Patrick, von Baeyer, Sarah LeBaron, Castel, Stephane E, Emde, Anne-Katrin, Yerges-Armstrong, Laura, Fox, Keolu, Leask, Megan, Vitagliano, Jean-Jacques, Graf, Sahara, Norberciak, Laurène, Raynal, Jacques, Dalbeth, Nicola, Merriman, Tony, Bardin, Thomas, and Oehler, Erwan

Published
2024
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9. Evaluating the safety and short-term equivalence of colchicine versus prednisone in older patients with acute calcium pyrophosphate crystal arthritis (COLCHICORT): an open-label, multicentre, randomised trial

Author

Pascart, Tristan, Robinet, Pierre, Ottaviani, Sébastien, Leroy, Rémi, Segaud, Nicolas, Pacaud, Aurore, Grandjean, Agathe, Luraschi, Hélène, Rabin, Thibault, Deplanque, Xavier, Maciejasz, Pierre, Visade, Fabien, Mackowiak, Alexandre, Baclet, Nicolas, Maréchaux, Sylvestre, Lefebvre, Antoine, Budzik, Jean-François, Bardin, Thomas, Richette, Pascal, Norberciak, Laurène, Ducoulombier, Vincent, and Houvenagel, Eric

Published
2023
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10. Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of gout

Author

Bursill, David, Taylor, William J, Terkeltaub, Robert, Abhishek, Abhishek, So, Alexander K, Vargas-Santos, Ana Beatriz, Gaffo, Angelo Lino, Rosenthal, Ann, Tausche, Anne-Kathrin, Reginato, Anthony, Manger, Bernhard, Sciré, Carlo, Pineda, Carlos, van Durme, Caroline, Lin, Ching-Tsai, Yin, Congcong, Albert, Daniel Arthur, Biernat-Kaluza, Edyta, Roddy, Edward, Pascual, Eliseo, Becce, Fabio, Perez-Ruiz, Fernando, Sivera, Francisca, Lioté, Frédéric, Schett, Georg, Nuki, George, Filippou, Georgios, McCarthy, Geraldine, da Rocha Castelar Pinheiro, Geraldo, Ea, Hang-Korng, De Almeida Tupinambá, Helena, Yamanaka, Hisashi, Choi, Hyon K, Mackay, James, ODell, James R, Mellado, Janitzia Vázquez, Singh, Jasvinder A, Fitzgerald, John D, Jacobsson, Lennart TH, Joosten, Leo, Harrold, Leslie R, Stamp, Lisa, Andrés, Mariano, Gutierrez, Marwin, Kuwabara, Masanari, Dehlin, Mats, Janssen, Matthijs, Doherty, Michael, Hershfield, Michael S, Pillinger, Michael, Edwards, N Lawrence, Schlesinger, Naomi, Kumar, Nitin, Slot, Ole, Ottaviani, Sebastien, Richette, Pascal, MacMullan, Paul A, Chapman, Peter T, Lipsky, Peter E, Robinson, Philip, Khanna, Puja P, Gancheva, Rada N, Grainger, Rebecca, Johnson, Richard J, Kampe, Ritch Te, Keenan, Robert T, Tedeschi, Sara K, Kim, Seoyoung, Choi, Sung Jae, Fields, Theodore R, Bardin, Thomas, Uhlig, Till, Jansen, Tim, Merriman, Tony, Pascart, Tristan, Neogi, Tuhina, Klück, Viola, Louthrenoo, Worawit, and Dalbeth, Nicola

Subjects
Arthritis, Inflammatory and immune system, Consensus, Gout, Humans, Hyperuricemia, Terminology as Topic, gout, hyperuricemia, language, monosodium urate crystals, nomenclature, terminology, urate, Clinical Sciences, Immunology, Public Health and Health Services, Arthritis & Rheumatology
Abstract

ObjectiveThere is a lack of standardisation in the terminology used to describe gout. The aim of this project was to develop a consensus statement describing the recommended nomenclature for disease states of gout.MethodsA content analysis of gout-related articles from rheumatology and general internal medicine journals published over a 5-year period identified potential disease states and the labels commonly assigned to them. Based on these findings, experts in gout were invited to participate in a Delphi exercise and face-to-face consensus meeting to reach agreement on disease state labels and definitions.ResultsThe content analysis identified 13 unique disease states and a total of 63 unique labels. The Delphi exercise (n=76 respondents) and face-to-face meeting (n=35 attendees) established consensus agreement for eight disease state labels and definitions. The agreed labels were as follows: 'asymptomatic hyperuricaemia', 'asymptomatic monosodium urate crystal deposition', 'asymptomatic hyperuricaemia with monosodium urate crystal deposition', 'gout', 'tophaceous gout', 'erosive gout', 'first gout flare' and 'recurrent gout flares'. There was consensus agreement that the label 'gout' should be restricted to current or prior clinically evident disease caused by monosodium urate crystal deposition (gout flare, chronic gouty arthritis or subcutaneous tophus).ConclusionConsensus agreement has been established for the labels and definitions of eight gout disease states, including 'gout' itself. The Gout, Hyperuricaemia and Crystal-Associated Disease Network recommends the use of these labels when describing disease states of gout in research and clinical practice.

Published
2019

12. Features Associated With Different Inflammatory Phenotypes of Calcium Pyrophosphate Deposition Disease: Study Using Data From the International American College of Rheumatology/EULAR Calcium Pyrophosphate Deposition Classification Criteria Cohort.

Author

Pascart, Tristan, Latourte, Augustin, Tedeschi, Sara K., Dalbeth, Nicola, Neogi, Tuhina, Adinolfi, Antonella, Arad, Uri, Andres, Mariano, Becce, Fabio, Bardin, Thomas, Cipolletta, Edoardo, Ea, Hang‐Korng, Filippou, Georgios, Filippucci, Emilio, FitzGerald, John, Iagnocco, Annamaria, Jansen, Tim L., Janssen, Matthijs, Lioté, Frédéric, and So, Alexander

Subjects
*CHONDROCALCINOSIS, *LOGISTIC regression analysis, *METACARPOPHALANGEAL joint, *DISEASE duration, *ODDS ratio
Abstract

Objective Methods Results Conclusion The study objective was to examine the disease, demographic, and imaging features associated with different inflammatory phenotypes of calcium pyrophosphate deposition (CPPD) disease, ie, recurrent acute calcium pyrophosphate (CPP) crystal arthritis, chronic CPP crystal inflammatory arthritis, and crowned dens syndrome (CDS).Data from an international cohort (assembled from 25 sites in 7 countries for the development and validation of the 2023 CPPD classification criteria from the American College of Rheumatology/EULAR) that met the criteria were included. Three cross‐sectional studies were conducted to determine the phenotypic characteristics of recurrent acute CPP crystal arthritis, chronic CPP crystal inflammatory arthritis, and CDS. Multivariable logistic regression analysis was used to calculate adjusted odds ratio (aOR) and 95% confidence interval (CI) to examine the association between potential risk factors and the inflammatory phenotype.Among the 618 people included (56% female; mean age [standard deviation] 74.0 [11.9] years), 602 (97.4%) had experienced acute CPP crystal arthritis, 332 (53.7%) had recurrent acute arthritis, 158 (25.6%) had persistent inflammatory arthritis, and 45 (7.3%) had had CDS. Recurrent acute CPP crystal arthritis associated with longer disease duration (aOR 2.88 [95% CI 2.00–4.14]). Chronic CPP crystal inflammatory arthritis was associated with acute wrist arthritis (aOR 2.92 [95% CI 1.81–4.73]), metacarpophalangeal joint osteoarthritis (aOR 1.87 [95% CI 1.17–2.97]), and scapho‐trapezo‐trapezoid (STT) joint osteoarthritis (aOR 1.83 [95% CI 1.15–2.91]), and it was negatively associated with either metabolic or familial risk for CPPD (aOR 0.60 [95% CI 0.37–0.96]). CDS was associated with male sex (aOR 2.35 [95% CI 1.21–4.59]), STT joint osteoarthritis (aOR 2.71 [95% CI 1.22–6.05]), and more joints affected with chondrocalcinosis (aOR 1.46 [95% CI 1.15–1.85]).CPPD disease encompasses acute and chronic inflammatory phenotypes, each with specific clinical and imaging features that need to be considered in the diagnostic workup. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Intra‐Articular Mineralization on Computerized Tomography of the Knee and Risk of Cartilage Damage: The Multicenter Osteoarthritis Study

Author

Liew, Jean W., primary, Jarraya, Mohammed, additional, Guermazi, Ali, additional, Lynch, John, additional, Felson, David, additional, Nevitt, Michael, additional, Lewis, Cora E., additional, Torner, James, additional, Roemer, Frank W., additional, Crema, Michel D., additional, Wang, Na, additional, Becce, Fabio, additional, Rabasa, Gabriela, additional, Pascart, Tristan, additional, and Neogi, Tuhina, additional

Published
2024
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16. 2023 EULAR recommendations on imaging in diagnosis and management of crystal-induced arthropathies in clinical practice

Author

Mandl, Peter, primary, D’Agostino, Maria Antonietta, additional, Navarro-Compán, Victoria, additional, Geßl, Irina, additional, Sakellariou, Garifallia, additional, Abhishek, Abhishek, additional, Becce, Fabio, additional, Dalbeth, Nicola, additional, Ea, Hang-Korng, additional, Filippucci, Emilio, additional, Hammer, Hilde Berner, additional, Iagnocco, Annamaria, additional, de Thurah, Annette, additional, Naredo, Esperanza, additional, Ottaviani, Sebastien, additional, Pascart, Tristan, additional, Pérez-Ruiz, Fernando, additional, Pitsillidou, Irene A, additional, Proft, Fabian, additional, Rech, Juergen, additional, Schmidt, Wolfgang A, additional, Sconfienza, Luca Maria, additional, Terslev, Lene, additional, Wildner, Brigitte, additional, Zufferey, Pascal, additional, and Filippou, Georgios, additional

Published
2024
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17. COVID-19 outcomes in patients with inflammatory rheumatic and musculoskeletal diseases treated with rituximab: a cohort study

Author

Aeschlimann, Florence, Agard, Christian, Ait-Abdallah, Nassim, Albert, Jean-David, Alcais, Didier, Allain, Jean-Sébastien, Allanore, Yannick, Amador-Borreiro, Blanca, Amoura, Zahir, Andre, Emma, Arbault, Anaïs, Arlet, Jean-Benoît, Arnaud, Laurent, Arniaud, Denis, Arty-Hue, Herliette, Atlan, Lucie, Audemard-Verger, Alexandra, Audoin-Pajot, Christine, Audren, Victor, Bach-Bunner, Maxime, Bacquet-Deschryver, Hélène, Bader-Meunier, Brigitte, Balandraud, Nathalie, Balblanc, Jean-Charles, Bally, Stéphane, Banal, Frédéric, Barbery, Pierre, Barnetche, Thomas, Barrelet, Audre, Basch, André, Baumier, Vincent, Bayer, Guillaume, Bayle, Sophie, Beauvais, Catherine, Beinat, Rudie, Belin, Véronique, Belkhir, Rakiba, Benainous, Ruben, Belot, Alexandre, Benammar, Mohammed, Benhamou, Mathilde, Benhamou, Ygal, Benmansour, Ahmed, Bennet, Pascal, Bernoux-Manat, Brigitte, Berthet, Elise, Berthoux, Emilie, Bertolini, Ewa, Bigot, Adrien, Bisson-Vaivre, Aurélia, Blaison, Gilles, Bolla, Gilles, Bonidan, Olivier, Bonnet, Christine, Borie, Raphaël, Bossert, Marie, Boudou, Laurence, Bouhour, Françoise, Bouiller, Kévin, Bouldoires, Bastien, Boussoualim, Karima, Bouvard, Eric, Brondino, Regine, Buchlin, Pierre, Cabantous, Laurence, Cacoub, Patrice, Cadiou, Simon, Carteni, Maurizio, Carbasse, Aurélia, Castel, Brice, Cathebras, Pascal, Caumont, Hervé, Celant, Annalisa, Chaigne, Benjamin, Chaillous, Benoît, Champy, Romuald, Charcot, Agnès, Charles, Pierre, Charlot-Lambrecht, Isabelle, Charpin, Caroline, Chatelus, Emmanuel, Chaudier, Bernard, Chertok, Pascale, Chevalier, Xavier, Chevreau, Maxime, Chotard, Emilie, Chu Miow Lin, Delphine, Clavel, Gaëlle, Clavel-Osorio, Cyril, Cohen, Fleur, Cohen, Gregory, Colette-Cedoz, Marie-Eve, Collercandy, Nived, Colombey, Antoine, Comarmond, Chloé, Combe, Bernard, Comparon, Céline, Constant, Elodie, Coquerelle, Pascal, Corli, Justine, Corre, Clémence, Costedoat-Chalumeau, Nathalie, Couret, Marie, Courvoisier, Natacha, Coury-Lucas, Fabienne, Coutarel, Cécile, Coutier, Fabrice, Damade, Richard, Daver-Malaterre, Laurence, Dehimat, Sarahe, Delahousse, Michel, Barrois-Delattre, Emilie, Denarie, Delphine, Deprouw, Camille, Dernis, Emanuelle, Deroux, Alban, Desbarbieux, Renaud, Descamps, Elise, Deslandre, Chantal, Desmurs, Marie, Despaux, Jacques, Desplats, Marie, Detree, Frédérick, Devauchelle-Pensec, Valérie, Dhote, Robin, Dieude, Philippe, Dieudonne, Yannick, Diot, Elisabeth, Direz, Guillaume, Djeddi, Djamal-Dine, Douvier, Sarah, Drouet, Béatrice, Drumez, Elodie, Duc, Catherine, Ducornet, Angélique, Dufauret-Lombard, Carine, Duhamel, Alain, Dumaine, Cécile, Dumel, Anne-Elisabeth, Dumoulin-Richez, Chantal, Duquesne, Agnès, Durand, Géraldine, Durandin-Truffinet, Mariane, Duret, Pierre-Marie, Duval, Maïka, Ebbo, Mikaël, Ebstein, Esther, Economu-Dubosc, Andra, Emilie, Stéphanie, Euvrard, Romain, Evon, Philippe, Fabre, Sylvie, Fagedet, Dorothée, Farhat, Meryem, Fauconier, Marion, Fechtenbaum, Jacques, Felten, Renaud, Fernandes, Fanny, Ferreira-Maldent, Nicole, Feurer, Elodie, Fichet, Amandine, Flaisler, Françoise, Florens, Nans, Foltz, Violaine, Fontanges, Elisabeth, Foret, Jennifer, Fougerousse, Anne-Claire, Fouque-Aubert, Anne, Foutrier-Morello, Catherine, Francois-Pradier, Hélène, Frantzen, Léa, Fritz, Pierre, Froissart, Antoine, Fulpin, Jean, Fuzibet, Piera, Gaches, Francis, Gagneux-Lemoussu, Laurence, Penhoat-Gahier, Mélanie, Galland, Joris, Gandjbakhch, Frédérique, Garnier, Nicole, Garraud, Thomas, Garrot, Jean-François, Gastaldi, Romain, Gaud-Listrat, Véronique, Gauthier-Prieur, Maud, Georgescu, Dana, Gerard, Nathalie, Gervais, Elisabeth, Gibert, Christelle, Gibert, Eric, Gill, Ghislaine, Gillard, Jérôme, Gilson, Mélanie, Gimonnet, Pauline, Giraudet-Le Quintrec, Jeanine-Sophie, Giraud-Morelet, Aude, Glace, Baptiste, Glanowski, Camille, Godeau, Bertrand, Gombert, Bruno, Gonnet-Gracia, Camille, Goulenok, Tiphaine, Goupille, Philippe, Gourmelen, Olivier, Govindaraju-Audouard, Sophie, Grados, Franck, Grall-Lerosey, Martine, Grardel, Bruno, Grasland, Anne, Grateau, Gilles, Groza, Monica, Guillaud, Constance, Guillaume, Séverine, Guillibert, Caroline, Guillot, Xavier, Guilpain, Philippe, Gury, Aline, Guyot, Marie-Hélène, Hacquard-Bouder, Cécile, Havard, Marie-Noelle, Hellier, Jean-Pierre, Hennequin, Pascal, Henriot, Basile, Henry, Julien, Hentgen, Véronique, Hermet, Marion, Herasse, Muriel, Hernandez, Julie, Hie, Miguel, Hilliquin, Pascal, Hinschberger, Olivier, Hittinger-Roux, Ambre, Holubar, Jan, Hudry, Christophe, Huguenel, Serge, Jaccard, Clara, Jacquemier, Jean-Michel, Jamard, Bénédicte, Jan, Catherine, Jean, Sylvie, Jouvray, Mathieu, Juge, Pierre-Antoine, Juillard, Laurent, Jullien, Denis, Kabala, Anna, Kabchou, Abdelkrim, Karkowski, Ludovic, Karman, Françoise, Kemiche, Farid, Keraen, Jérémy, Kieffer, Pierre, Kone-Paut, Isabelle, Koreichi, Abdeldajallil, Kostine, Marie, La Batide Alanore, Sylvain, Lafforgue, Pierre, Lahalle, Sophie, Lambert, Marc, Lambrecht, Isabelle, Lanot, Sylvain, Lanteri, Aurélia, Larbre, Jean-Paul, Latourte, Augustin, Lavigne, Christian, Le Guen Guegan, Sophie, Le Guenno, Guillaume, Leguy, Diane, Lebrun, Agnès, Ledoult, Emmanuel, Legoupil, Nathalie, Legrand, Erick, Lejeune, Charlotte, Leloire, Olivier, Leroux, Christophe, Leroy, Rémi, Leroy-Gouix, Marie, Leturcq, Tifenn, Leurs, Amélie, Leveque-Michaud, Céline, Limbach, François-Xavier, Liote, Frédéric, Lohse, Anne, Lozac'h, Pierre, Lucas, Virginie, Madelon, Aurélie, Magy-Bertrand, Nadine, Mahevas, Matthieu, Maillard, Hélène, Maillet, Thibault, Malochet-Guinamand, Sandrine, Mangon, Quentin, Marchou-Lopez, Sylvie, Margarit, Nathalie, Marhadour, Thierry, Mariette, Xavier, Martin, Claire, Mathian, Alexis, Maurier, François, Maury, Frédéric, Mazet-Guillaume, Betty, Mazouyez, Arnaud, Mazyad, Hassan, Mehsen-Cetre, Nadia, Meinzer, Ulrich, Melki, Isabelle, Messer, Laurent, Miceli, Corinne, Michaud, Martin, Michel, Catherine, Michel, Matthias, Michon, Mathilde, Milesi-Lecat, Anne-Marie, Molto, Anna, Moly, Marie, Moranne, Olivier, Morel, Gautier, Morel, Hugo, Morel, Jacques, Morin, Franck, Moulinier, Laurence, Moulis, Guillaume, Moura, Bertrand, Nguyen, Minh, Nicolas-Vullierme, Sabine, Nielly, Hubert, Nocturne, Gaétane, Nottez, Aurore, Ollagnon, Henri-Olivier, Pacaud-Vitoux, Isabelle, Pagnier, Anne, Paris, Caroline, Parrot, Antoine, Pascart, Tristan, Pascaud-Mansour, Yasmina, Paulin, Lætitia, Pavy, Stephan, Perard, Laurent, Pers, Yves-Marie, Pha, Micheline, Pichon, Maud, Pierreisnard, Audrey, Pizana, Gabrielle, Poignant, Sylvaine, Poix, Elsa, Portier, Agnès, Poulet, Antoine, Plassard, Samira, Pugnet, Grégory, Puyraimond-Zemmour, Déborah, Quartier-Dit-Maire, Pierre, Quenet, Marion, Queyrel, Viviane, Raffray, Loïc, Remy, Philippe, Renard, Myriam, Rene, Jessica, Revuz, Sabine, Rey, Bénédicte, Richard-Colmant, Gaëlle, Riviere, Etienne, Riviere, Sébastien, Robin, Sophie, Rohmer, Julien, Roitg, Isabelle, Romier, Mélanie, Rolland, Michel, Roriz, Mélanie, Rosenberg, Carole, Rossi, Linda, Roth, Olivier, Rouidi, Sid-Ahmed, Roumier, Mathilde, Rousiere, Mickaël, Rousselin, Clémentine, Rouviere, Bénédicte, Roux, Christian, Roux, Fabienne, Roux, Marielle, Roux, Nicolas, Rouzaud, Diane, Rozenberg, Sylvie, Sacco, Isabelle, Sadji, Fatiha, Sailler, Laurent, Salliot, Carine, Salmon, Jean-Hugues, Saraux, Alain, Schmidt, Jean, Seguier, Julie, Sellam, Jérémie, Senbel, Eric, Sene, Thomas, Senet, Patricia, Seve, Pascal, Sicaud, Aurélie, Smets, Perrine, Sobanski, Vincent, Sordet, Christelle, Sornay-Rendu, Elisabeth, Souchaud-Debouverie, Odile, Sparsa, Lætitia, Spielmann, Lionel, Steib, Sarah, Stavris, Chloé, Straus, Catherine, Strotz, Victor, Szafors, Paulina, Taffignon-Clave, Séverine, Simoens, Justine, Theillac, Claire, Tenenbaum, Nora, Thomachot, Benoît, Tieulie, Nathalie, Tiriau, Soizic, Tison, Alice, Toussirot, Eric, Trefond, Ludovic, Trijau, Sophie, Trouillier, Sébastien, Trouvin, Anne-Priscille, Truchetet, Marie-Elise, Ulrich, Marc, Vaquier, Jacques, Veillard, Eric, Veillon, Laurent, Vial, Guillaume, Viallard, Jean-François, Victor, Judith, Vidon, Claire, Vidon, Mathias, Vigne, Camille, Virone, Alexandre, Warzocha, Ursula, Wendling, Daniel, Werle, Claude, Wibaux, Cécile, Willems, Alexandra, Wisniewski, Michel, Woessner, Juliette, Xerri-Campano, Bernadette, Avouac, Jérôme, Hachulla, Eric, Seror, Raphaèle, Georgin-Lavialle, Sophie, El Mahou, Soumaya, Pertuiset, Edouard, Pham, Thao, Marotte, Hubert, Servettaz, Amélie, Domont, Fanny, Chazerain, Pascal, Devaux, Mathilde, Claudepierre, Pascal, Langlois, Vincent, Mekinian, Arsène, Maria, Alexandre Thibault Jacques, Banneville, Béatrice, Fautrel, Bruno, Pouchot, Jacques, Thomas, Thierry, Flipo, René-Marc, and Richez, Christophe

Published
2021
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18. 14th European Crystal Network (ECN) Workshop—Abstract Proceedings

Author

Medicina, Medikuntza, Lioté, Frédéric, Pérez Ruiz, Fernando, Ea, Hang-Korng, Merriman, Tony, Pascart, Tristan, So, Alexander, Medicina, Medikuntza, Lioté, Frédéric, Pérez Ruiz, Fernando, Ea, Hang-Korng, Merriman, Tony, Pascart, Tristan, and So, Alexander

Abstract

The 14th annual international European Crystal Network was held in Paris on 2 and 3 March 2023. This in-person meeting was attended by 93 participants. Over 40 research abstract submissions were received from investigators, ranging from early career investigators to senior researchers, for plenary oral and poster presentations. Here, we present the accepted, lightly edited abstracts from the presenters consenting to have their work published. We thank and congratulate the presenters for their work and contributions to the meeting.

Published
2024

19. 2023 EULAR recommendations on imaging in diagnosis and management of crystal-induced arthropathies in clinical practice

Author

Mandl, Peter, D'Agostino, Maria Antonietta, Navarro-Compán, Victoria, Geßl, Irina, Sakellariou, Garifallia, Banerjee, Abhishek, Becce, Fabio, Dalbeth, Nicola, Ea, Hang-Korng, Filippucci, Emilio, Hammer, Hilde Berner, Iagnocco, Annamaria, de Thurah, Annette, Naredo, Esperanza, Ottaviani, Sebastien, Pascart, Tristan, Pérez-Ruiz, Fernando, Pitsillidou, Irene A, Proft, Fabian, Rech, Juergen, Schmidt, Wolfgang A, Sconfienza, Luca Maria, Terslev, Lene, Wildner, Brigitte, Zufferey, Pascal, Filippou, Georgios, D'Agostino, Maria Antonietta (ORCID:0000-0002-5347-0060), Abhishek, Abhishek, Mandl, Peter, D'Agostino, Maria Antonietta, Navarro-Compán, Victoria, Geßl, Irina, Sakellariou, Garifallia, Banerjee, Abhishek, Becce, Fabio, Dalbeth, Nicola, Ea, Hang-Korng, Filippucci, Emilio, Hammer, Hilde Berner, Iagnocco, Annamaria, de Thurah, Annette, Naredo, Esperanza, Ottaviani, Sebastien, Pascart, Tristan, Pérez-Ruiz, Fernando, Pitsillidou, Irene A, Proft, Fabian, Rech, Juergen, Schmidt, Wolfgang A, Sconfienza, Luca Maria, Terslev, Lene, Wildner, Brigitte, Zufferey, Pascal, Filippou, Georgios, D'Agostino, Maria Antonietta (ORCID:0000-0002-5347-0060), and Abhishek, Abhishek

Abstract

Objective: To formulate evidence-based recommendations and overarching principles on the use of imaging in the clinical management of crystal-induced arthropathies (CiAs). Methods: An international task force of 25 rheumatologists, radiologists, methodologists, healthcare professionals and patient research partners from 11 countries was formed according to the EULAR standard operating procedures. Fourteen key questions on the role of imaging in the most common forms of CiA were generated. The CiA assessed included gout, calcium pyrophosphate deposition disease and basic calcium phosphate deposition disease. Imaging modalities included conventional radiography, ultrasound, CT and MRI. Experts applied research evidence obtained from four systematic literature reviews using MEDLINE, EMBASE and CENTRAL. Task force members provided level of agreement (LoA) anonymously by using a Numerical Rating Scale from 0 to 10. Results: Five overarching principles and 10 recommendations were developed encompassing the role of imaging in various aspects of patient management: making a diagnosis of CiA, monitoring inflammation and damage, predicting outcome, response to treatment, guided interventions and patient education. Overall, the LoA for the recommendations was high (8.46-9.92). Conclusions: These are the first recommendations that encompass the major forms of CiA and guide the use of common imaging modalities in this disease group in clinical practice.

Published
2024

20. Usefulness of a Visual Analog Scale for Measuring Anxiety in Hospitalized Patients Experiencing Pain: A Multicenter Cross-Sectional Study

Author

Ducoulombier, Vincent, Chiquet, Roman, Graf, Sahara, Leroy, Bernard, Bouquet, Guillaume, Verdun, Stéphane, Martellier, Fabienne, Versavel, Adeline, Kone, Alexandre, Lacroix, Karine, Duthoit, Didier, Lenglet, Quentin, Devaux, Amelie, Jeanson, Robert, Lefebvre, Antoine, Coviaux, Benoit, Calais, Gauthier, Grimbert, Adeline, Ledein, Marie, Moukagni, Marie, Pascart, Tristan, and Houvenagel, Eric

Published
2020
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26. T1-weighted MRI images accurately represent the volume and surface of architectural mineral damage of osteonecrosis of the femoral head: Comparison with high-resolution computed tomography

Author

Pascart, Tristan, Paccou, Julien, Colard, Thomas, Norberciak, Laurène, Girard, Julien, Delattre, Jerôme, Marchandise, Pierre, Legrand, Julie, Penel, Guillaume, Coursier, Raphaël, Putman, Sophie, Cortet, Bernard, Kerckhofs, Greet, and Budzik, Jean-François

Published
2020
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30. Retention, safety and efficacy of off-label conventional treatments and biologics for chronic calcium pyrophosphate crystal inflammatory arthritis.

Author

Damart, Julien, Filippou, Georgios, Andrès, Mariano, Cipolletta, Edoardo, Sirotti, Silvia, Carboni, Davide, Filippucci, Emilio, Diez, Pilar, Abhishek, Abhishek, Latourte, Augustin, Ea, Hang-Korng, Ottaviani, Sébastien, Letarouilly, Jean-Guillaume, Desbarbieux, Renaud, Graf, Sahara, Norberciak, Laurène, Richette, Pascal, and Pascart, Tristan

Subjects
BIOTHERAPY, ARTHRITIS diagnosis, DRUG therapy for arthritis, DRUG efficacy, ADRENOCORTICAL hormones, INFLAMMATION, TOCILIZUMAB, RETROSPECTIVE studies, CHONDROCALCINOSIS, TREATMENT effectiveness, METHOTREXATE, DESCRIPTIVE statistics, COLCHICINE, HYDROXYCHLOROQUINE, PATIENT safety, OFF-label use (Drugs), LONGITUDINAL method, EVALUATION
Abstract

Objectives Very little is known on the efficacy and safety of drugs for the management of chronic calcium pyrophosphate (CPP) crystal inflammatory arthritis. The objectives of this work were to describe the drugs used in the management of chronic CPP crystal inflammatory arthritis in expert European centres, and to examine treatment retention. Methods This was a retrospective cohort study. Charts from patients with a diagnosis of persistent inflammatory and/or recurrent acute CPP crystal arthritis were reviewed in seven European centres. Baseline characteristics were collected, and visits at months 3, 6, 12 and 24 included an assessment of treatment response and safety. Results One hundred and ninety-four treatments were initiated in 129 patients. Colchicine (used first-line in n  = 73/86), methotrexate (used first-line in n  = 14/36), anakinra (n  = 27) and tocilizumab (n  = 25) were the most prescribed treatments, while long-term corticosteroids, hydroxychloroquine, canakinumab and sarilumab were used occasionally. The 24-month on-drug retention was higher for tocilizumab (40%) than anakinra (18.5%) (P  < 0.05), while the difference between colchicine (29.1%) and methotrexate (44.4%) was not statistically significant (P  = 0.10). Adverse events led to 14.1% of colchicine discontinuations (100% of diarrhoea), 4.3% for methotrexate, 31.8% for anakinra and 20% for tocilizumab; all other discontinuations were related to insufficient response or losses to follow-up. Efficacy outcomes did not differ significantly between treatments throughout follow-up. Conclusion Daily colchicine is the first-line therapy used in chronic CPP crystal inflammatory arthritis, which is considered efficient in a third to half of cases. Second-line treatments include methotrexate and tocilizumab, which have higher retention than anakinra. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Efficacité et tolérance du fébuxostat chez 73 patients goutteux avec une insuffisance rénale chronique stade 4/5 : étude rétrospective de 10 centres

Author

Juge, Pierre-Antoine, Truchetet, Marie-Elise, Pillebout, Evangeline, Ottaviani, Sébastien, Vigneau, Cécile, Loustau, Clotilde, Cornec, Divi, Pascart, Tristan, Snanoudj, Renaud, Bailly, Florian, Gall, Emilie Cornec-Le, Schaeverbeke, Thierry, Saraux, Alain, Dieudé, Philippe, Flipo, René-Marc, Richette, Pascal, Lioté, Frédéric, Bardin, Thomas, Chalès, Gérard, and Ea, Hang-Korng

Published
2018
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35. Retention, safety and efficacy of off-label conventional treatments and biologics for chronic calcium pyrophosphate crystal inflammatory arthritis

Author

Damart, Julien, primary, Filippou, Georgios, additional, Andrès, Mariano, additional, Cipolletta, Edoardo, additional, Sirotti, Silvia, additional, Carboni, Davide, additional, Filippucci, Emilio, additional, Diez, Pilar, additional, Abhishek, Abhishek, additional, Latourte, Augustin, additional, Ea, Hang-Korng, additional, Ottaviani, Sébastien, additional, Letarouilly, Jean-Guillaume, additional, Desbarbieux, Renaud, additional, Graf, Sahara, additional, Norberciak, Laurène, additional, Richette, Pascal, additional, and Pascart, Tristan, additional

Published
2023
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36. Efficacy and safety of febuxostat in 73 gouty patients with stage 4/5 chronic kidney disease: A retrospective study of 10 centers

Author

Juge, Pierre-Antoine, Truchetet, Marie-Elise, Pillebout, Evangeline, Ottaviani, Sébastien, Vigneau, Cécile, Loustau, Clotilde, Cornec, Divi, Pascart, Tristan, Snanoudj, Renaud, Bailly, Florian, Cornec-Le Gall, Emilie, Schaeverbeke, Thierry, Saraux, Alain, Dieudé, Philippe, Flipo, René-Marc, Richette, Pascal, Lioté, Frédéric, Bardin, Thomas, Chalès, Gérard, and Ea, Hang-Korng

Published
2017
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39. Reliability and Diagnostic Accuracy of Radiography for the Diagnosis of Calcium Pyrophosphate Deposition:Performance of the Novel Definitions Developed by an International Multidisciplinary Working Group

Author

Sirotti, Silvia, Becce, Fabio, Sconfienza, Luca M., Terslev, Lene, Naredo, Esperanza, Zufferey, Pascal, Pineda, Carlos, Gutierrez, Marwin, Adinolfi, Antonella, Serban, Teodora, MacCarter, Daryl, Mouterde, Gael, Zanetti, Anna, Scanu, Anna, Moeller, Ingrid, Novo-Rivas, Ulrike, Largo, Raquel, Sarzi-Puttini, Piercarlo, Abhishek, Abhishek, Choi, Hyon K., Dalbeth, Nicola, Pascart, Tristan, Tedeschi, Sara K., D'Agostino, Maria-Antonietta, Iagnocco, Annamaria, Keen, Helen I., Scire, Carlo A., Filippou, Georgios, Sirotti, Silvia, Becce, Fabio, Sconfienza, Luca M., Terslev, Lene, Naredo, Esperanza, Zufferey, Pascal, Pineda, Carlos, Gutierrez, Marwin, Adinolfi, Antonella, Serban, Teodora, MacCarter, Daryl, Mouterde, Gael, Zanetti, Anna, Scanu, Anna, Moeller, Ingrid, Novo-Rivas, Ulrike, Largo, Raquel, Sarzi-Puttini, Piercarlo, Abhishek, Abhishek, Choi, Hyon K., Dalbeth, Nicola, Pascart, Tristan, Tedeschi, Sara K., D'Agostino, Maria-Antonietta, Iagnocco, Annamaria, Keen, Helen I., Scire, Carlo A., and Filippou, Georgios

Abstract

Objective. To assess the reliability and diagnostic accuracy of new radiographic imaging definitions developed by an international multidisciplinary working group for identification of calcium pyrophosphate deposition (CPPD).Methods. Patients with knee osteoarthritis scheduled for knee replacement were enrolled. Two radiologists and 2 rheumatologists twice assessed radiographic images for presence or absence of CPPD in menisci, hyaline cartilage, tendons, joint capsule, or synovial membrane, using the new definitions. In case of disagreement, a consensus decision was made and considered for the assessment of diagnostic performance. Histologic examination of postsurgical specimens under compensated polarized light microscopy was the reference standard. Prevalence-adjusted bias-adjusted kappa values were used to assess reliability, and diagnostic performance statistics were calculated.Results. Sixty-seven patients were enrolled for the reliability study. The interobserver reliability was substantial in most of the assessed structures when considering all 4 readers (k range 0.59-0.90), substantial to almost perfect among radiologists (k range 0.70-0.91), and moderate to almost perfect among rheumatologists (k range 0.46-0.88). The intraobserver reliability was substantial to almost perfect for all the observers (k range 0.70-1). Fifty-one patients were included in the accuracy study. Radiography demonstrated an overall specificity of 92% for CPPD, but sensitivity remained low for all sites and for the overall diagnosis (54%).Conclusion. The new radiographic definitions of CPPD are highly specific against the gold standard of histologic diagnosis. When the described radiographic findings are present, these definitions allow for a definitive diagnosis of CPPD, rather than other calcium-containing crystal depositions; however, a negative radiographic finding does not exclude the diagnosis.

Published
2023

42. Reliability and Diagnostic Accuracy of Radiography for the Diagnosis of Calcium Pyrophosphate Deposition: Performance of the Novel Definitions Developed by an International Multidisciplinary Working Group

Author

Sirotti, Silvia, primary, Becce, Fabio, additional, Sconfienza, Luca M., additional, Terslev, Lene, additional, Naredo, Esperanza, additional, Zufferey, Pascal, additional, Pineda, Carlos, additional, Gutierrez, Marwin, additional, Adinolfi, Antonella, additional, Serban, Teodora, additional, MacCarter, Daryl, additional, Mouterde, Gael, additional, Zanetti, Anna, additional, Scanu, Anna, additional, Möller, Ingrid, additional, Novo‐Rivas, Ulrike, additional, Largo, Raquel, additional, Sarzi‐Puttini, Piercarlo, additional, Abhishek, Abhishek, additional, Choi, Hyon K., additional, Dalbeth, Nicola, additional, Pascart, Tristan, additional, Tedeschi, Sara K., additional, D'Agostino, Maria‐Antonietta, additional, Iagnocco, Annamaria, additional, Keen, Helen I., additional, Scirè, Carlo A., additional, and Filippou, Georgios, additional

Published
2023
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43. Characteristics of Patients Treated with JAK Inhibitors in Rheumatoid Arthritis before versus after VTE Risk Warnings

Author

Philippoteaux, Cécile, primary, Deprez, Valentine, additional, Nottez, Aurore, additional, Cailliau, Emeline, additional, Houvenagel, Eric, additional, Deprez, Xavier, additional, Philippe, Peggy, additional, Pascart, Tristan, additional, Flipo, René-Marc, additional, Goëb, Vincent, additional, and Letarouilly, Jean-Guillaume, additional

Published
2022
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46. Imaging Features of Calcium Pyrophosphate Deposition Disease: Consensus Definitions From an International Multidisciplinary Working Group

Author

Tedeschi, Sara K., primary, Becce, Fabio, additional, Pascart, Tristan, additional, Guermazi, Ali, additional, Budzik, Jean‐François, additional, Dalbeth, Nicola, additional, Filippou, Georgios, additional, Iagnocco, Annamaria, additional, Kohler, Minna J., additional, Laredo, Jean‐Denis, additional, Smith, Stacy E., additional, Simeone, F. Joseph, additional, Yinh, Janeth, additional, Choi, Hyon, additional, and Abhishek, Abhishek, additional

Published
2022
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48. sj-docx-1-car-10.1177_19476035231172152 – Supplemental material for Associations of Changes in Knee Hyaline Cartilage Composition Measured With Dual-Energy Computed Tomography in Gout, Aging and Osteoarthritis

Author

Legrand, Julie, Marzin, Claire, Neogi, Tuhina, Norberciak, Laurène, Budzik, Jean-François, and Pascart, Tristan

Subjects
FOS: Clinical medicine, FOS: Biological sciences, 110323 Surgery, 110604 Sports Medicine, FOS: Health sciences, 69999 Biological Sciences not elsewhere classified, 110314 Orthopaedics
Abstract

Supplemental material, sj-docx-1-car-10.1177_19476035231172152 for Associations of Changes in Knee Hyaline Cartilage Composition Measured With Dual-Energy Computed Tomography in Gout, Aging and Osteoarthritis by Julie Legrand, Claire Marzin, Tuhina Neogi, Laurène Norberciak, Jean-François Budzik and Tristan Pascart in CARTILAGE

Published
2023
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