20 results on '"Pasch S"'
Search Results
2. Comparative Accuracy Study Of LDV Profile-Sensor Acquisition Modes And Particle Diameters
- Author
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Pasch, S., primary, Leister, R., additional, Egner, M., additional, Büttner, L., additional, Czarske, J., additional, and Kriegseis, J., additional
- Published
- 2022
- Full Text
- View/download PDF
3. Guillain–Barré syndrome after SARS‐CoV‐2 infection
- Author
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Kilinc, D., primary, van de Pasch, S., additional, Doets, A. Y., additional, Jacobs, B. C., additional, van Vliet, J., additional, and Garssen, M. P. J., additional
- Published
- 2020
- Full Text
- View/download PDF
4. First Interferometric Trials with the Airborne Digital-Beamforming DBFSAR System
- Author
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Reigber, A., Nottensteiner, A., Limbach, M., Jäger, M., Kosc, A., Scheiber, R., Jens Fischer, Lorente, D., Müller, G., Künemund, M., Trappschuh, K., Pasch, S., Geßwein, D., Kirchner, D., Gabler, B., Keller, M., Horn, R., and Moreira, A.
- Subjects
XTI ,DBFSAR ,TanDEM-X DEM ,ATI ,interferometry ,airborne laser scanning (ALS) DEM ,SAR-Technologie - Abstract
The Microwaves and Radar Institute of the German Aerospace Center (DLR) is known for its consistent work on the field of airborne Synthetic Aperture Radar and its application. Currently, the Institute is developing a new advanced airborne SAR system, the DBFSAR, which is planned to supplement its operational F-SAR system in near future. The development of DBFSAR was triggered by the various evolving digital beamforming (DBF) techniques for future space-borne SAR systems and the need for an airborne experimental platform for preparation of such missions. Additionally, there is a demand for very high resolution SAR imagery, which cannot anymore be fully satisfied with the existing F-SAR system. This paper should give an overview over the current status and performance of the DBFSAR system, including interferometirc results from test flights performed in spring 2017.
- Published
- 2018
5. The relationship between vulvovaginal candidiasis and provoked vulvodynia: A systematic review
- Author
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Leusink, P.M., Pasch, S. van de, Teunissen, D., Laan, E.T.M., Lagro-Janssen, A.L.M., Leusink, P.M., Pasch, S. van de, Teunissen, D., Laan, E.T.M., and Lagro-Janssen, A.L.M.
- Abstract
Item does not contain fulltext, BACKGROUND: Provoked vulvodynia (PVD) is a chronic vulvar pain condition affecting up to 8.3% of the female population. Despite many years of research, no clear cause for PVD has been identified. Several risk factors have been studied, including vulvovaginal candidiasis (VVC). However, to date, the role of Candida infections in PVD has remained unclear. VVC and PVD have an overlap of symptoms that may contribute to diagnostic inaccuracy and mistreatment. AIM: To systematically review the literature on the relationship between VVC and PVD. METHODS: Cohort and case-control studies were included that compared women with PVD with healthy controls with respect to the presence of a history of Candida vulvovaginitis. PVD had to be diagnosed by Friedrich's criteria or the International Society for the Study of Vulvovaginal Disease criteria. The inclusion process as well as the quality appraisal of the studies, using the Newcastle-Ottawa Quality Assessment Scale, were performed independently by 2 authors. MAIN OUTCOME MEASURE: Outcomes of the population-based case-control studies were listed as odds ratio. Outcomes of the pathophysiological studies were based on local pro-inflammatory responses on Candida in vitro. RESULTS: We included a total of 14 studies, both population and clinic-based case-control, and pathophysiological research. 7 studies were of low methodological quality, and 7 studies were of medium methodological quality. The population-based case-control studies showed a significantly increased odds ratio for self-reported VVC in PVD cases compared with controls. The pathophysiological studies revealed a tendency for an increased local proinflammatory response on Candida in vitro in patients with PVD. Owing to the substantial heterogeneity of the studies, meta-analysis was not performed. CLINICAL IMPLICATIONS: Health care providers may consider a diagnosis of PVD in women with self-reported VVC, and to act on this properly. Reiteration of antifungal prescription
- Published
- 2018
6. DBFSAR: An airborne very high-resolution digital beamforming SAR system
- Author
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Reigber, A., primary, Nottensteiner, A., additional, Limbach, M., additional, Jager, M., additional, Kosc, A., additional, Scheiber, R., additional, Fischer, J., additional, Di Maria, A., additional, Muller, G., additional, Que, R., additional, Kunemund, M., additional, Trappschuh, K., additional, Pasch, S., additional, Geswein, D., additional, Hoflmayr, D., additional, Gabler, B., additional, Keller, M., additional, Horn, R., additional, and Moreira, A., additional
- Published
- 2017
- Full Text
- View/download PDF
7. Sweet Christmas: Do overweight and obese children associate special events more frequently with food than normal weight children?
- Author
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Martijn, C., Martijn, C., Pasch, S., Roefs, A., Martijn, C., Martijn, C., Pasch, S., and Roefs, A.
- Abstract
This study examined children's spontaneous associations of special events with food. Children in primary education (N=111, age between 10 - 13 years) at a school in Germany wrote down their first five associations with five special or festive events (Christmas, holidays, weekend, carnival and birthday). After completing the free-word association test, they were offered a choice between a candy and a toy. Finally, their body mass index (BMI) was measured. The first prediction was that overweight and obese children would associate special events more often with food than normal weight and leaner children. The second prediction was that choice for a candy would be predicted by a higher number of food-related associations. The first hypothesis was not supported: BMI was negatively related to number of food-related associations (the lower the BMI, the more food-related associations). The second hypothesis was also not supported: There was no relation between number of food-related associations and choice for a candy or toy. A possible explanation for the finding that leaner children reported more food-related associations is that for them specific sweets and snack food are more exclusively connected to special occasions than for overweight children. Speculatively, this may be the result in differences in food parenting styles between parents of heavier and leaner children. Parents of leaner children often have a more restrictive style, i.e., reserving specific foods for specific, relatively rare occasions whereas parents of overweight children adopt more liberal food rules.
- Published
- 2016
8. Sol-Gel Nanoporous Layers for (bio)sensing Applications
- Author
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Scolan, E., Steifer, R., Pugin, R., Talaei, S., Pasch, S., and Voirin, G.
9. Intraoperative cardiac arrest management.
- Author
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Ben-Jacob TK, Pasch S, Patel AD, and Mueller D
- Subjects
- Humans, Heart Arrest therapy, Intraoperative Care
- Published
- 2023
- Full Text
- View/download PDF
10. RGS3L allows for an M 2 muscarinic receptor-mediated RhoA-dependent inotropy in cardiomyocytes.
- Author
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Levay MK, Krobert KA, Vogt A, Ahmad A, Jungmann A, Neuber C, Pasch S, Hansen A, Müller OJ, Lutz S, and Wieland T
- Subjects
- Animals, Cholinergic Agents, Heart Ventricles, Rats, Receptors, Muscarinic, Heart Failure, Myocytes, Cardiac
- Abstract
The role and outcome of the muscarinic M
2 acetylcholine receptor (M2 R) signaling in healthy and diseased cardiomyocytes is still a matter of debate. Here, we report that the long isoform of the regulator of G protein signaling 3 (RGS3L) functions as a switch in the muscarinic signaling, most likely of the M2 R, in primary cardiomyocytes. High levels of RGS3L, as found in heart failure, redirect the Gi -mediated Rac1 activation into a Gi -mediated RhoA/ROCK activation. Functionally, this switch resulted in a reduced production of reactive oxygen species (- 50%) in cardiomyocytes and an inotropic response (+ 18%) in transduced engineered heart tissues. Importantly, we could show that an adeno-associated virus 9-mediated overexpression of RGS3L in rats in vivo, increased the contractility of ventricular strips by maximally about twofold. Mechanistically, we demonstrate that this switch is mediated by a complex formation of RGS3L with the GTPase-activating protein p190RhoGAP, which balances the activity of RhoA and Rac1 by altering its substrate preference in cardiomyocytes. Enhancement of this complex formation could open new possibilities in the regulation of the contractility of the diseased heart., (© 2022. The Author(s).)- Published
- 2022
- Full Text
- View/download PDF
11. The Relationship Between Vulvovaginal Candidiasis and Provoked Vulvodynia: A Systematic Review.
- Author
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Leusink P, van de Pasch S, Teunissen D, Laan ET, and Lagro-Janssen AL
- Subjects
- Adult, Candidiasis, Vulvovaginal complications, Case-Control Studies, Cohort Studies, Female, Humans, Pain Measurement, Self Report, Vulvodynia complications, Candidiasis, Vulvovaginal physiopathology, Vulvodynia physiopathology
- Abstract
Background: Provoked vulvodynia (PVD) is a chronic vulvar pain condition affecting up to 8.3% of the female population. Despite many years of research, no clear cause for PVD has been identified. Several risk factors have been studied, including vulvovaginal candidiasis (VVC). However, to date, the role of Candida infections in PVD has remained unclear. VVC and PVD have an overlap of symptoms that may contribute to diagnostic inaccuracy and mistreatment., Aim: To systematically review the literature on the relationship between VVC and PVD., Methods: Cohort and case-control studies were included that compared women with PVD with healthy controls with respect to the presence of a history of Candida vulvovaginitis. PVD had to be diagnosed by Friedrich's criteria or the International Society for the Study of Vulvovaginal Disease criteria. The inclusion process as well as the quality appraisal of the studies, using the Newcastle-Ottawa Quality Assessment Scale, were performed independently by 2 authors., Main Outcome Measure: Outcomes of the population-based case-control studies were listed as odds ratio. Outcomes of the pathophysiological studies were based on local pro-inflammatory responses on Candida in vitro., Results: We included a total of 14 studies, both population and clinic-based case-control, and pathophysiological research. 7 studies were of low methodological quality, and 7 studies were of medium methodological quality. The population-based case-control studies showed a significantly increased odds ratio for self-reported VVC in PVD cases compared with controls. The pathophysiological studies revealed a tendency for an increased local proinflammatory response on Candida in vitro in patients with PVD. Owing to the substantial heterogeneity of the studies, meta-analysis was not performed., Clinical Implications: Health care providers may consider a diagnosis of PVD in women with self-reported VVC, and to act on this properly. Reiteration of antifungal prescriptions by physicians without a decent diagnosis, will lead to mistreatment. Women should be informed by their health care provider that intercourse during (or shortly after) the treatment of VVC might worsen the vulnerability of the vulvar skin., Strength and Limitations: This is the first systematic review performed to describe the relation between VVC and PVD. An independently performed in- and exclusion process and quality appraisal, ensured optimal internal validity. However, there were important methodological limitations and the size of heterogeneity prevented establishing a meta-analysis., Conclusion: This systematic review is unable to draw conclusions regarding a relationship between actual VVC and PVD because studies were based on self-reported VVC. Until new evidence becomes available, we advocate that PVD should be considered as an unexplained chronic pain condition. In women with recurrent or persistent VVC-like complaints, physicians should consider a diagnosis of PVD. Leusink P, van de Pasch S, Teunissen D, et al. The Relationship Between Vulvovaginal Candidiasis and Provoked Vulvodynia: A Systematic Review. J Sex Med 2018;15:1310-1321., (Copyright © 2018 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
12. Diagnostic pathology of early systemic cancer: ERBB2 gene amplification in single disseminated cancer cells determines patient survival in operable esophageal cancer.
- Author
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Hoffmann M, Pasch S, Schamberger T, Maneck M, Möhlendick B, Schumacher S, Brockhoff G, Knoefel WT, Izbicki J, Polzer B, Stoecklein NH, and Klein CA
- Subjects
- Esophageal Neoplasms surgery, Female, Gene Amplification, Humans, Male, Middle Aged, Esophageal Neoplasms genetics, Esophageal Neoplasms pathology, Genes, erbB-2, Neoplastic Cells, Circulating pathology, Receptor, ErbB-2 genetics
- Abstract
Early metastatic dissemination and evolution of disseminated cancer cells (DCCs) outside the primary tumor is one reason for the failure of adjuvant therapies because it generates molecular genotypes and phenotypes different from primary tumors, which still underlie therapy decisions. Since ERBB2 amplification in esophageal DCCs but not in primary tumor cells predict outcome, we aimed to establish an assay with diagnostic reliability for single DCCs or circulating tumor cells. For this, we evaluated copy number alterations of more than 600 single DCCs from multiple cancer types to define reference regions suitable for quantification of target regions, such as ERBB2. We then compared ERBB2 quantitative PCR (qPCR) measurements with fluorescent in situ hybridization (FISH) data of various breast cancer cell lines and identified the aberration-calling threshold. The method was applied to two independent cohorts of esophageal cancer patients from Hamburg (n = 59) and Düsseldorf (n = 53). We found a high correlation between the single cell qPCR assay and the standard FISH assay (R = 0.98) and significant associations between amplification and survival for both patient cohorts (Hamburg (HH), p = 0.033; Düsseldorf (D), p = 0.052; pooled HH + D, p = 0.002) when applied to DCCs of esophageal cancer patients. Detection of a single ERBB2-amplified DCC was the most important risk factor for death from esophageal cancer (relative risk = 4.22; 95% CI = 1.91-9.32; p < 0.001). In our study, we detected ERBB2-amplified cells in 7% of patients. These patients could benefit from anti-ERBB2 targeting therapies., (© 2017 UICC.)
- Published
- 2018
- Full Text
- View/download PDF
13. Sweet Christmas: Do overweight and obese children associate special events more frequently with food than normal weight children?
- Author
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Martijn C, Pasch S, and Roefs A
- Subjects
- Adolescent, Body Mass Index, Child, Energy Intake, Female, Germany, Humans, Logistic Models, Male, Parenting, Choice Behavior, Feeding Behavior psychology, Holidays, Overweight psychology, Pediatric Obesity psychology, Thinness psychology
- Abstract
This study examined children's spontaneous associations of special events with food. Children in primary education (N = 111, age between 10 and 13 years) at a school in Germany wrote down their first five associations with five special or festive events (Christmas, holidays, weekend, carnival and birthday). After completing the free-word association test, they were offered a choice between a candy and a toy. Finally, their body mass index (BMI) was measured. The first prediction was that overweight and obese children would associate special events more often with food than normal weight and leaner children. The second prediction was that choice for a candy would be predicted by a higher number of food-related associations. The first hypothesis was not supported: BMI was negatively related to number of food-related associations (the lower the BMI, the more food-related associations). The second hypothesis was also not supported: There was no relation between number of food-related associations and choice for a candy or toy. A possible explanation for the finding that leaner children reported more food-related associations is that for them specific sweets and snack food are more exclusively connected to special occasions than for overweight children. Speculatively, this may be the result of differences in food parenting styles between parents of heavier and leaner children. Parents of leaner children often have a more restrictive style, i.e., reserving specific foods for specific, relatively rare occasions whereas parents of overweight children adopt more liberal food rules., (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
14. p63RhoGEF regulates auto- and paracrine signaling in cardiac fibroblasts.
- Author
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Ongherth A, Pasch S, Wuertz CM, Nowak K, Kittana N, Weis CA, Jatho A, Vettel C, Tiburcy M, Toischer K, Hasenfuss G, Zimmermann WH, Wieland T, and Lutz S
- Subjects
- Actin Cytoskeleton metabolism, Actin Cytoskeleton ultrastructure, Angiotensin II genetics, Angiotensin II metabolism, Animals, Animals, Newborn, Aorta surgery, Autocrine Communication genetics, Connective Tissue Growth Factor metabolism, Constriction, Female, Fibroblasts pathology, Fibroblasts ultrastructure, Gene Expression Regulation, Male, Mice, Mice, Inbred C57BL, Models, Cardiovascular, Myocardium pathology, Paracrine Communication genetics, Rats, Rats, Wistar, Rho Guanine Nucleotide Exchange Factors metabolism, Serum Response Factor metabolism, Signal Transduction, Ventricular Remodeling, rhoA GTP-Binding Protein metabolism, trans-Golgi Network metabolism, trans-Golgi Network ultrastructure, Connective Tissue Growth Factor genetics, Fibroblasts metabolism, Myocardium metabolism, Rho Guanine Nucleotide Exchange Factors genetics, Serum Response Factor genetics, rhoA GTP-Binding Protein genetics
- Abstract
Cardiac remodeling, a hallmark of heart disease, is associated with intense auto- and paracrine signaling leading to cardiac fibrosis. We hypothesized that the specific mediator of Gq/11-dependent RhoA activation p63RhoGEF, which is expressed in cardiac fibroblasts, plays a role in the underlying processes. We could show that p63RhoGEF is up-regulated in mouse hearts subjected to transverse aortic constriction (TAC). In an engineered heart muscle model (EHM), p63RhoGEF expression in cardiac fibroblasts increased resting and twitch tensions, and the dominant negative p63ΔN decreased both. In an engineered connective tissue model (ECT), p63RhoGEF increased tissue stiffness and its knockdown as well as p63ΔN reduced stiffness. In 2D cultures of neonatal rat cardiac fibroblasts, p63RhoGEF regulated the angiotensin II (Ang II)-dependent RhoA activation, the activation of the serum response factor, and the expression and secretion of the connective tissue growth factor (CTGF). All these processes were inhibited by the knockdown of p63RhoGEF or by p63ΔN likely based on their negative influence on the actin cytoskeleton. Moreover, we show that p63RhoGEF also regulates CTGF in engineered tissues and correlates with it in the TAC model. Finally, confocal studies revealed a closely related localization of p63RhoGEF and CTGF in the trans-Golgi network., (Copyright © 2015. Published by Elsevier Ltd.)
- Published
- 2015
- Full Text
- View/download PDF
15. Molecular profiling of single circulating tumor cells with diagnostic intention.
- Author
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Polzer B, Medoro G, Pasch S, Fontana F, Zorzino L, Pestka A, Andergassen U, Meier-Stiegen F, Czyz ZT, Alberter B, Treitschke S, Schamberger T, Sergio M, Bregola G, Doffini A, Gianni S, Calanca A, Signorini G, Bolognesi C, Hartmann A, Fasching PA, Sandri MT, Rack B, Fehm T, Giorgini G, Manaresi N, and Klein CA
- Subjects
- Female, Humans, Breast Neoplasms diagnosis, Genomics methods, Neoplastic Cells, Circulating pathology, Pathology, Molecular methods, Single-Cell Analysis methods
- Abstract
Several hundred clinical trials currently explore the role of circulating tumor cell (CTC) analysis for therapy decisions, but assays are lacking for comprehensive molecular characterization of CTCs with diagnostic precision. We therefore combined a workflow for enrichment and isolation of pure CTCs with a non-random whole genome amplification method for single cells and applied it to 510 single CTCs and 189 leukocytes of 66 CTC-positive breast cancer patients. We defined a genome integrity index (GII) to identify single cells suited for molecular characterization by different molecular assays, such as diagnostic profiling of point mutations, gene amplifications and whole genomes of single cells. The reliability of > 90% for successful molecular analysis of high-quality clinical samples selected by the GII enabled assessing the molecular heterogeneity of single CTCs of metastatic breast cancer patients. We readily identified genomic disparity of potentially high relevance between primary tumors and CTCs. Microheterogeneity analysis among individual CTCs uncovered pre-existing cells resistant to ERBB2-targeted therapies suggesting ongoing microevolution at late-stage disease whose exploration may provide essential information for personalized treatment decisions and shed light into mechanisms of acquired drug resistance., (© 2014 The Authors. Published under the terms of the CC BY 4.0 license.)
- Published
- 2014
- Full Text
- View/download PDF
16. Combined sleeve lobectomy and Ivor lLwis esophagectomy for synchronous primary carcinoma of the lung and Barrett esophagus.
- Author
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Kuhn K, Pasch S, Wojciechowski W, and Macchiarini P
- Subjects
- Adenocarcinoma complications, Barrett Esophagus complications, Carcinoma, Squamous Cell complications, Esophageal Neoplasms complications, Humans, Lung Neoplasms complications, Male, Middle Aged, Neoplasms, Multiple Primary complications, Adenocarcinoma surgery, Barrett Esophagus surgery, Carcinoma, Squamous Cell surgery, Esophageal Neoplasms surgery, Esophagectomy methods, Lung Neoplasms surgery, Neoplasms, Multiple Primary surgery, Pneumonectomy methods
- Published
- 2000
- Full Text
- View/download PDF
17. Increasing psychiatric inpatients' community adjustment through therapeutic passes.
- Author
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Donner LL, Kopytko EE, McFolling SD, Cronin-Stubbs D, Szczesny SG, Mayton K, and Pasch SK
- Subjects
- Adolescent, Adult, Aged, Humans, Middle Aged, Mood Disorders nursing, Hospitals, Psychiatric, Mood Disorders psychology, Patient Discharge, Social Adjustment
- Abstract
Using several self-generated instruments, the authors monitored patient care records and interviewed psychiatric patients, psychiatrists, and psychiatric nurses to identify the role of passes in discharge planning and community adjustment and to assess passes' utility in the inpatient treatment program. Findings indicate that while therapeutic passes are considered an integral component of discharge planning and community adjustment, the purposes and use of passes are ambiguous. The authors offer suggestions to maximize the benefits of passes in promoting patients' transition from the hospital to home settings.
- Published
- 1990
- Full Text
- View/download PDF
18. Discharge planning for psychiatric inpatients: evaluation of one technique.
- Author
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Cronin-Stubbs D, Donner LL, McFolling SD, Kopytko EE, Pasch SK, and Szczesny SG
- Subjects
- Adult, Clinical Nursing Research methods, Female, Humans, Interviews as Topic, Male, Middle Aged, Mental Disorders nursing, Patient Discharge
- Published
- 1988
- Full Text
- View/download PDF
19. Going home with COLD: is your patient ready?
- Author
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Pasch S and Jamieson T
- Subjects
- Chronic Disease, Female, Humans, Lung Diseases, Obstructive rehabilitation, Middle Aged, Patient Education as Topic, Lung Diseases, Obstructive nursing
- Published
- 1975
20. Are they ready? Preparing for patient passes.
- Author
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Szczesny SG, Mayton K, Cronin-Stubbs D, Donner LL, Kopytko EE, McFolling SD, and Pasch SK
- Subjects
- Adolescent, Adult, Aged, Female, Humans, Middle Aged, Nurse-Patient Relations, Nursing Assessment standards, Patient Care Planning standards, Personnel Management, Employee Performance Appraisal methods, Patient Discharge, Psychiatric Nursing standards
- Published
- 1989
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