1. Multi-modal immune dynamics of pre-COVID-19 Kawasaki Disease following intravenous immunoglobulin.
- Author
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Cotugno N, Olivieri G, Pascucci GR, Amodio D, Morrocchi E, Pighi C, Manno EC, Rotulo GA, D'Anna C, Chinali M, Tarissi de Jacobis I, Buonsenso D, Villani A, Rossi P, Marchesi A, and Palma P
- Subjects
- Humans, Male, Female, Child, Preschool, SARS-CoV-2 immunology, Infant, Child, T-Lymphocytes, Regulatory immunology, T-Lymphocyte Subsets immunology, Mucocutaneous Lymph Node Syndrome immunology, Mucocutaneous Lymph Node Syndrome blood, Immunoglobulins, Intravenous therapeutic use, COVID-19 immunology, COVID-19 complications
- Abstract
Despite progress, the molecular mechanisms underlying Kawasaki Disease (KD) and intravenous immunoglobulin's (IVIG) ability to mitigate the inflammatory process remain poorly understood. To characterize this condition, plasma proteomic profiles, flow cytometry, and gene expression of T cell subsets were investigated in longitudinal samples from KD patients and compared with two control groups. Systems-level analysis of samples in the acute phase revealed distinctive inflammatory features of KD, involving mainly Th-1 and Th-17 mediators and unveiled a potential disease severity signature. APBB1IP demonstrated an association with coronary artery involvement (CAI) and was significantly higher in CAI+ compared to CAI- patients. Integrative analysis revealed a transient reduction in CD4+ EM T cells and a comprehensive immune activation and exhaustion. Following treatment, Tregs at both frequency and gene expression levels revealed immune dynamics of recovery. Overall, our data provide insights into KD, which may offer valuable information on prognostic indicators and possible targets for novel treatments., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
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