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1. Association of Circulating Proinflammatory and Anti-inflammatory Protein Biomarkers in Extremely Preterm Born Children with Subsequent Brain Magnetic Resonance Imaging Volumes and Cognitive Function at Age 10 Years

Author

Ware, Janice, Coster, Taryn, Hanson, Brandi, Wilson, Rachel, McGhee, Kirsten, Lee, Patricia, Asgarian, Aimee, Sadhwani, Anjali, Perrin, Ellen, Neger, Emily, Mattern, Kathryn, Walkowiak, Jenifer, Barron, Susan, Shah, Bhavesh, Singh, Rachana, Smith, Anne, Klein, Deborah, McQuiston, Susan, Venuti, Lauren, Powers, Beth, Foley, Ann, Dessureau, Brian, Wood, Molly, Damon-Minow, Jill, Ehrenkranz, Richard, Benjamin, Jennifer, Romano, Elaine, Tsatsanis, Kathy, Chawarska, Katarzyna, Kim, Sophy, Dieterich, Susan, Bearrs, Karen, Peters, Nancy, Brown, Patricia, Ansusinha, Emily, Waldrep, Ellen, Friedman, Jackie, Hounshell, Gail, Allred, Debbie, Engelke, Stephen C., Darden-Saad, Nancy, Stainback, Gary, Warner, Diane, Wereszczak, Janice, Bernhardt, Janice, McKeeman, Joni, Meyer, Echo, Pastyrnak, Steve, Rathbun, Julie, Nota, Sarah, Crumb, Teri, Lenski, Madeleine, Weiland, Deborah, Lloyd, Megan, Hunter, Scott, Msall, Michael, Ramoskaite, Rugile, Wiggins, Suzanne, Washington, Krissy, Martin, Ryan, Prendergast, Barbara, Scott, Megan, Klarr, Judith, Kring, Beth, DeRidder, Jennifer, Vogt, Kelly, Yamamoto, Hidemi, Ryan, Stanthia, Junaid, Damilola, Dawood, Hassan, Beatty, Noah, Luu, Ngan, Tang, Vanessa, Sassi, Rosaria Rita, Pasicznyk, Jenna-Malia, Kuban, Karl C.K., Jara, Hernan, O'Shea, T. Michael, Heeren, Timothy, Joseph, Robert M., Fichorova, Raina N., Alshamrani, Khalid, Aakil, Adam, Beaulieu, Forrest, Horn, Mitchell, Douglass, Laurie M., Frazier, Jean A., Hirtz, Deborah, Rollins, Julie Vanier, Cochran, David, and Paneth, Nigel

Published
2019
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2. Among Children Born Extremely Preterm a Higher Level of Circulating Neurotrophins Is Associated with Lower Risk of Cognitive Impairment at School Age

Author

Ware, Janice, Coster, Taryn, Hanson, Brandi, Wilson, Rachel, McGhee, Kirsten, Lee, Patricia, Asgarian, Aimee, Sadhwani, Anjali, Perrin, Ellen, Neger, Emily, Mattern, Kathryn, Walkowiak, Jenifer, Barron, Susan, Shah, Bhavesh, Singh, Rachana, Smith, Anne, Klein, Deborah, McQuiston, Susan, Venuti, Lauren, Powers, Beth, Foley, Ann, Dessureau, Brian, Wood, Molly, Damon-Minow, Jill, Ehrenkranz, Richard, Benjamin, Jennifer, Romano, Elaine, Tsatsanis, Kathy, Chawarska, Katarzyna, Kim, Sophy, Dieterich, Susan, Bearrs, Karen, Peters, Nancy, Brown, Patricia, Ansusinha, Emily, Waldrep, Ellen, Friedman, Jackie, Hounshell, Gail, Allred, Debbie, Engelke, Stephen C., Darden-Saad, Nancy, Stainback, Gary, Warner, Diane, Wereszczak, Janice, Bernhardt, Janice, McKeeman, Joni, Meyer, Echo, Pastyrnak, Steve, Rathbun, Julie, Nota, Sarah, Crumb, Teri, Lenski, Madeleine, Weiland, Deborah, Lloyd, Megan, Hunter, Scott, Msall, Michael, Ramoskaite, Rugile, Wiggins, Suzanne, Washington, Krissy, Martin, Ryan, Prendergast, Barbara, Scott, Megan, Klarr, Judith, Kring, Beth, DeRidder, Jennifer, Vogt, Kelly, Yamamoto, Hidemi, Ryan, Stanthia, Junaid, Damilola, Dawood, Hassan, Beatty, Noah, Luu, Ngan, Tang, Vanessa, Sassi, Rosaria Rita, Pasicznyk, Jenna-Malia, Kuban, Karl C.K., Heeren, Timothy, O'Shea, T. Michael, Joseph, Robert M., Fichorova, Raina N., Douglass, Laurie, Jara, Hernan, Frazier, Jean A., Hirtz, Deborah, Taylor, H. Gerry, Rollins, Julie Vanier, and Paneth, Nigel

Published
2018
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3. Biological and technical variables affecting immuno-assay recovery of cytokines from human serum and simulated vaginal fluid: a multicenter study

Author

Fichorova, Raina N., Richardson-Harman, Nicola, Alfano, Massimo, Belec, Laurent, Carbonneil, Cedric, Chen, Silvia, Cosentino, Lisa, Curtis, Kelly, Dezzutti, Charlene S., Donoval, Betty, Doncel, Gustavo F., Donaghay, Melissa, Grivel, Jean-Charles, Guzman, Esmeralda, Hayes, Madeleine, Herold, Betsy, Hlllier, Sharon, Lackman-Smith, Carol, Landay, Alan, Margolis, Leonid, Mayer, Kenneth H., Pasicznyk, Jenna-Malia, Pallansch-Cokonis, Melanie, Poli, Guido, Reichelderfer, Patricia, Roberts, Paula, Rodriguez, Irma, Saldi, Hela, Sassi, Rosaria Rita, Shattock, Robin, and Cummins, James E., Jr.

Subjects
Cytokines -- Properties, Immunoassay -- Methods, Serum -- Properties, Vaginal smears -- Properties, Biological markers -- Research, Simulation methods -- Methods, Immune response -- Research, Vaginal mucosa -- Properties, Chemistry
Abstract

The increase of proinflammatory cytokines in vaginal secretions may serve as a surrogate marker of unwanted inflammatory reaction to microbicide products topically applied for the prevention of sexually transmitted diseases, including HIV-1. Interleukin (IL)-l[beta] and IL-6 have been proposed as indicators of inflammation and increased risk of HIV-1 transmission; however, the lack of information regarding detection platforms optimal for vaginal fluids and interlaboratory variation limit their use for microbicide evaluation and other clinical applications. This study examines fluid matrix variants relevant to vaginal sampling techniques and proposes a model for interlaboratory comparisons across current cytokine detection technologies. II-1[beta] and IL-6 standards were measured by 12 laboratories in four countries, using 14 immunoassays and four detection platforms based on absorbance, chemiluminescence, electrochemiluminescence, and fluorescence. International reference preparations of cytokines with defined biological activity were spiked into (1) a defined medium simulating the composition of human vaginal fluid at pH 4.5 and 7.2, (2) physiologic salt solutions (phosphate-buffered saline and saline) commonly used for vaginal lavage sampling in clinical studies of cytokines, and (3) human blood serum. Assays were assessed for reproducibility, linearity, accuracy, and significantly detectable fold difference in cytokine level. Factors with significant impact on cytokine recovery were determined by Kruskal-Wallis analysis of variance with Dunn's multiple comparison test and multiple regression models. All assays showed acceptable intra-assay reproducibility; however, most were associated with significant interlaboratory variation. The smallest reliably detectable cytokine differences (P < 0.05) derived from pooled interlaboratory data varied from 1.5- to 26-fold depending on assay, cytokine, and matrix type. IL-6 but not IL-1[beta] determinations were lower in both saline and phosphate-buffered saline as compared to vaginal fluid matrix, with no significant effect of pH. The (electro)chemiluminescence-based assays were most discriminative and consistently detected < 2-fold differences within each matrix type. The Luminex-based assays were less discriminative with lower reproducibility between laboratories. These results suggest the need for uniform vaginal sampling techniques and a better understanding of immunoassay platform differences and cross-validation before the biological significance of cytokine variations can be validated in clinical trials. This investigation provides the first standardized analytic approach for assessing differences in mucosal cytokine levels and may improve strategies for monitoring immune responses at the vaginal mucosal interface.

Published
2008

4. Association of Circulating Proinflammatory and Anti-inflammatory Protein Biomarkers in Extremely Preterm Born Children with Subsequent Brain Magnetic Resonance Imaging Volumes and Cognitive Function at Age 10 Years

Author

Kuban, Karl C.K., primary, Jara, Hernan, additional, O'Shea, T. Michael, additional, Heeren, Timothy, additional, Joseph, Robert M., additional, Fichorova, Raina N., additional, Alshamrani, Khalid, additional, Aakil, Adam, additional, Beaulieu, Forrest, additional, Horn, Mitchell, additional, Douglass, Laurie M., additional, Frazier, Jean A., additional, Hirtz, Deborah, additional, Rollins, Julie Vanier, additional, Cochran, David, additional, Paneth, Nigel, additional, Ware, Janice, additional, Coster, Taryn, additional, Hanson, Brandi, additional, Wilson, Rachel, additional, McGhee, Kirsten, additional, Lee, Patricia, additional, Asgarian, Aimee, additional, Sadhwani, Anjali, additional, Perrin, Ellen, additional, Neger, Emily, additional, Mattern, Kathryn, additional, Walkowiak, Jenifer, additional, Barron, Susan, additional, Shah, Bhavesh, additional, Singh, Rachana, additional, Smith, Anne, additional, Klein, Deborah, additional, McQuiston, Susan, additional, Venuti, Lauren, additional, Powers, Beth, additional, Foley, Ann, additional, Dessureau, Brian, additional, Wood, Molly, additional, Damon-Minow, Jill, additional, Ehrenkranz, Richard, additional, Benjamin, Jennifer, additional, Romano, Elaine, additional, Tsatsanis, Kathy, additional, Chawarska, Katarzyna, additional, Kim, Sophy, additional, Dieterich, Susan, additional, Bearrs, Karen, additional, Peters, Nancy, additional, Brown, Patricia, additional, Ansusinha, Emily, additional, Waldrep, Ellen, additional, Friedman, Jackie, additional, Hounshell, Gail, additional, Allred, Debbie, additional, Engelke, Stephen C., additional, Darden-Saad, Nancy, additional, Stainback, Gary, additional, Warner, Diane, additional, Wereszczak, Janice, additional, Bernhardt, Janice, additional, McKeeman, Joni, additional, Meyer, Echo, additional, Pastyrnak, Steve, additional, Rathbun, Julie, additional, Nota, Sarah, additional, Crumb, Teri, additional, Lenski, Madeleine, additional, Weiland, Deborah, additional, Lloyd, Megan, additional, Hunter, Scott, additional, Msall, Michael, additional, Ramoskaite, Rugile, additional, Wiggins, Suzanne, additional, Washington, Krissy, additional, Martin, Ryan, additional, Prendergast, Barbara, additional, Scott, Megan, additional, Klarr, Judith, additional, Kring, Beth, additional, DeRidder, Jennifer, additional, Vogt, Kelly, additional, Yamamoto, Hidemi, additional, Ryan, Stanthia, additional, Junaid, Damilola, additional, Dawood, Hassan, additional, Beatty, Noah, additional, Luu, Ngan, additional, Tang, Vanessa, additional, Sassi, Rosaria Rita, additional, and Pasicznyk, Jenna-Malia, additional

Published
2019
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5. Among Children Born Extremely Preterm a Higher Level of Circulating Neurotrophins Is Associated with Lower Risk of Cognitive Impairment at School Age

Author

Kuban, Karl C.K., primary, Heeren, Timothy, additional, O'Shea, T. Michael, additional, Joseph, Robert M., additional, Fichorova, Raina N., additional, Douglass, Laurie, additional, Jara, Hernan, additional, Frazier, Jean A., additional, Hirtz, Deborah, additional, Taylor, H. Gerry, additional, Rollins, Julie Vanier, additional, Paneth, Nigel, additional, Ware, Janice, additional, Coster, Taryn, additional, Hanson, Brandi, additional, Wilson, Rachel, additional, McGhee, Kirsten, additional, Lee, Patricia, additional, Asgarian, Aimee, additional, Sadhwani, Anjali, additional, Perrin, Ellen, additional, Neger, Emily, additional, Mattern, Kathryn, additional, Walkowiak, Jenifer, additional, Barron, Susan, additional, Shah, Bhavesh, additional, Singh, Rachana, additional, Smith, Anne, additional, Klein, Deborah, additional, McQuiston, Susan, additional, Venuti, Lauren, additional, Powers, Beth, additional, Foley, Ann, additional, Dessureau, Brian, additional, Wood, Molly, additional, Damon-Minow, Jill, additional, Ehrenkranz, Richard, additional, Benjamin, Jennifer, additional, Romano, Elaine, additional, Tsatsanis, Kathy, additional, Chawarska, Katarzyna, additional, Kim, Sophy, additional, Dieterich, Susan, additional, Bearrs, Karen, additional, Peters, Nancy, additional, Brown, Patricia, additional, Ansusinha, Emily, additional, Waldrep, Ellen, additional, Friedman, Jackie, additional, Hounshell, Gail, additional, Allred, Debbie, additional, Engelke, Stephen C., additional, Darden-Saad, Nancy, additional, Stainback, Gary, additional, Warner, Diane, additional, Wereszczak, Janice, additional, Bernhardt, Janice, additional, McKeeman, Joni, additional, Meyer, Echo, additional, Pastyrnak, Steve, additional, Rathbun, Julie, additional, Nota, Sarah, additional, Crumb, Teri, additional, Lenski, Madeleine, additional, Weiland, Deborah, additional, Lloyd, Megan, additional, Hunter, Scott, additional, Msall, Michael, additional, Ramoskaite, Rugile, additional, Wiggins, Suzanne, additional, Washington, Krissy, additional, Martin, Ryan, additional, Prendergast, Barbara, additional, Scott, Megan, additional, Klarr, Judith, additional, Kring, Beth, additional, DeRidder, Jennifer, additional, Vogt, Kelly, additional, Yamamoto, Hidemi, additional, Ryan, Stanthia, additional, Junaid, Damilola, additional, Dawood, Hassan, additional, Beatty, Noah, additional, Luu, Ngan, additional, Tang, Vanessa, additional, Sassi, Rosaria Rita, additional, and Pasicznyk, Jenna-Malia, additional

Published
2018
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6. Biological and Technical Variables Affecting Immunoassay Recovery of Cytokines from Human Serum and Simulated Vaginal Fluid: A Multicenter Study

Author

Fichorova, Raina N., primary, Richardson-Harman, Nicola, additional, Alfano, Massimo, additional, Belec, Laurent, additional, Carbonneil, Cedric, additional, Chen, Silvia, additional, Cosentino, Lisa, additional, Curtis, Kelly, additional, Dezzutti, Charlene S., additional, Donoval, Betty, additional, Doncel, Gustavo F., additional, Donaghay, Melissa, additional, Grivel, Jean-Charles, additional, Guzman, Esmeralda, additional, Hayes, Madeleine, additional, Herold, Betsy, additional, Hillier, Sharon, additional, Lackman-Smith, Carol, additional, Landay, Alan, additional, Margolis, Leonid, additional, Mayer, Kenneth H., additional, Pasicznyk, Jenna-Malia, additional, Pallansch-Cokonis, Melanie, additional, Poli, Guido, additional, Reichelderfer, Patricia, additional, Roberts, Paula, additional, Rodriguez, Irma, additional, Saidi, Hela, additional, Sassi, Rosaria Rita, additional, Shattock, Robin, additional, and Cummins, Jr., James E., additional

Published
2008
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9. Biological and technical variables affecting immunoassay recovery of cytokines from human serum and simulated vaginal fluid: A multicenter study

Author

Melanie Pallansch-Cokonis, Raina N. Fichorova, Jean-Charles Grivel, Alan L. Landay, Kelly A. Curtis, Esmeralda Guzman, Nicola Richardson-Harman, Cédric Carbonneil, Robin Shattock, Laurent Bélec, Gustavo F. Doncel, Jenna Malia Pasicznyk, Paula Roberts, Guido Poli, Leonid Margolis, Héla Saïdi, Betsy C. Herold, Lisa A. Cosentino, Madeleine Hayes, Massimo Alfano, Sharon L. Hillier, James E. Cummins, Irma Rodriguez, Melissa Donaghay, Rosaria Rita Sassi, Charlene S. Dezzutti, Patricia Reichelderfer, Betty A. Donoval, Silvia Chen, Carol Lackman-Smith, Kenneth H. Mayer, Fichorova Raina, N., Richardson Harman, Nicola, Alfano, Massimo, Belec, Laurent, Carbonneil, Cedric, Chen, Silvia, Cosentino, Lisa, Curtis, Kelly, Dezzutti Charlene, S., Donoval, Betty, Doncel Gustave, F., Donaghay, Melissa, Grivel Jean, Charle, Guzman, Esmeralda, Hayes, Madeleine, Herold, Betsy, Hillier, Sharon, Lackman Smith, Carol, Landay, Alan, Margolis, Leonid, Mayer Kenneth, H., Pasicznyk Jenna, Malia, Pallansch Cokonis, Melanie, Poli, Guido, Reicholderfer, Patricia, Roberts, Paula, Rodriguez, Irma, Saidi, Hela, Sassi Rosaria, Rita, Shattock, Robin, and Cummins James, E. J. r.

Subjects
medicine.medical_treatment, Interleukin-1beta, Fluorescence spectrometry, Analytical chemistry, Article, Analytical Chemistry, Proinflammatory cytokine, 03 medical and health sciences, 0302 clinical medicine, Microbicide, medicine, Humans, Saline, 030304 developmental biology, Immunoassay, 0303 health sciences, Reproducibility, medicine.diagnostic_test, Chemistry, Interleukin-6, Interleukin, Reproducibility of Results, Reference Standards, 3. Good health, Body Fluids, Cytokine, Immunology, Vagina, Female, 030217 neurology & neurosurgery
Abstract

The increase of proinflammatory cytokines in vaginal secretions may serve as a surrogate marker of unwanted inflammatory reaction to microbicide products topically applied for the prevention of sexually transmitted diseases, including HIV-1. Interleukin (IL)-1 beta and 11,6 have been proposed as indicators of inflammation and increased risk of HIV-1 transmission; however, the lack of information regarding detection platforms optimal for vaginal fluids and interlaboratory variation limit their use for microbicide evaluation and other clinical applications. This study examines fluid matrix variants relevant to vaginal sampling techniques and proposes a model for interlaboratory comparisons across current cytokine detection technologies. IL-1 beta and IL-6 standards were measured by 12 laboratories in four countries, using 14 immunoassays and four detection platforms based on absorbance, chemiluminescence, electrochemiluminescence, and fluorescence. International reference preparations of cytokines with defined biological activity were spiked into (1) a defined medium simulating the composition of human vaginal fluid at pH 4.5 and 7.2, (2) physiologic salt solutions (phosphate-buffered saline and saline) commonly used for vaginal lavage sampling in clinical studies of cytokines, and (3) human blood serum. Assays were assessed for reproducibility, linearity, accuracy, and significantly detectable fold difference in cytokine level. Factors with significant impact on cytokine recovery were determined by Kruskal-Wallis analysis of variance with Dunn's multiple comparison test and multiple regression models. All assays showed acceptable intra-assay reproducibility; however, most were associated with significant interlaboratory variation. The smallest reliably detectable cytokine differences (P < 0.05) derived from pooled interlaboratory data varied from 1.5- to 26-fold depending on assay, cytokine, and matrix type. IL-6 but not IL-1 beta determinations were lower in both saline and phosphate-buffered saline as compared to vaginal fluid matrix, with no significant effect of pH. The (electro)chemiluminescence-based assays were most discriminative and consistently detected < 2-fold differences within each matrix type. The Luminex-based assays were less discriminative with lower reproducibility between laboratories. These results suggest the need for uniform vaginal sampling techniques and a better understanding of immunoassay platform differences and cross-validation before the biological significance of cytokine variations can be validated in clinical trials. This investigation provides the first standardized analytic approach for assessing differences in mucosal cytokine levels and may improve strategies for monitoring immune responses at the vaginal mucosal interface.

Published
2008

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