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982 results on '"Pasqualetti, Patrizio"'

9. Asthma remission one, none and one-hundred thousand: the relevance of the patient's view.

Author

Bonini, Matteo, Barbaglia, Simona, Camiciottoli, Gianna, Del Giacco, Stefano, Di Marco, Fabiano, Matucci, Andrea, Micheletto, Claudio, Papi, Alberto, Pasqualetti, Patrizio, Pelaia, Girolamo, Ricciardolo, Fabio Luigi Massimo, Rogliani, Paola, Senna, Gianenrico, Triggiani, Massimo, Vancheri, Carlo, and Canonica, Giorgio Walter

Subjects
PATIENTS' attitudes, THERAPEUTIC alliance, PATIENT preferences, DISEASE management, INDIVIDUALIZED medicine
Abstract

Objective: Achieving remission in severe asthma holds paramount importance in elevating patient quality of life and reducing both individual and societal burdens associated with this chronic condition. This study centers on identifying pivotal patient-relevant endpoints through standardized, reproducible methods, while also developing a patient-centric definition of remission, essential for effective disease management. Methods: A discrete choice experiment (DCE) was conducted to assess patients' perceptions on the four primary criteria for defining severe asthma remission, as outlined by the SANI survey. Additionally, it investigated the correlation between these perceptions and improvements in the doctor-patient therapeutic alliance during treatment decision-making. Results: 249 patients (70% aged between 31–60, 59% women and 82% without other pathologies requiring corticosteroids) prioritize the use of oral corticosteroids (OCS, 48%) and the Asthma Control Test (ACT, 27%) in defining their condition, ranking these above lung function and exacerbations. This preference for OCS stems from its direct role in treatment, tangible tracking, immediate symptom relief, and being a concrete measure of disease severity compared to the less predictable and quantifiable exacerbations. Conclusions: This study explores severe asthma remission from patients' perspectives using clinician-evaluated parameters. The DCE revealed that most patients highly value OCS and the ACT, prefer moderate improvement, and avoid cortisone cycles. No definitive preference was found for lung function status. Integrating patient-reported information with professional insights is crucial for effective management and future research. Personalized treatment plans focusing on patient preferences, adherence, and alternative therapies aim to achieve remission and enhance quality of life. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Delphi definition of the EADC‐ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance

Author

Boccardi, Marina, Bocchetta, Martina, Apostolova, Liana G, Barnes, Josephine, Bartzokis, George, Corbetta, Gabriele, DeCarli, Charles, deToledo‐Morrell, Leyla, Firbank, Michael, Ganzola, Rossana, Gerritsen, Lotte, Henneman, Wouter, Killiany, Ronald J, Malykhin, Nikolai, Pasqualetti, Patrizio, Pruessner, Jens C, Redolfi, Alberto, Robitaille, Nicolas, Soininen, Hilkka, Tolomeo, Daniele, Wang, Lei, Watson, Craig, Wolf, Henrike, Duvernoy, Henri, Duchesne, Simon, Jack, Clifford R, Frisoni, Giovanni B, and Segmentation, EADC‐ADNI Working Group on the Harmonized Protocol for Manual Hippocampal

Subjects
Neurosciences, Alzheimer Disease, Atrophy, Consensus, Delphi Technique, Hippocampus, Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Internationality, Magnetic Resonance Imaging, Neuroimaging, Volumetry, Manual segmentation, Harmonization, Anatomical landmarks, Delphi procedure, Alzheimer's disease, Medial temporal Jobe, Hippocampal atrophy, Magnetic.resonance, Standard operational procedures, Enrichment, MCI, Reliability, EADC-ADNI Working Group on the Harmonized Protocol for Manual Hippocampal Segmentation, Magnetic resonance, Medial temporal lobe, Clinical Sciences, Geriatrics
Abstract

BackgroundThis study aimed to have international experts converge on a harmonized definition of whole hippocampus boundaries and segmentation procedures, to define standard operating procedures for magnetic resonance (MR)-based manual hippocampal segmentation.MethodsThe panel received a questionnaire regarding whole hippocampus boundaries and segmentation procedures. Quantitative information was supplied to allow evidence-based answers. A recursive and anonymous Delphi procedure was used to achieve convergence. Significance of agreement among panelists was assessed by exact probability on Fisher's and binomial tests.ResultsAgreement was significant on the inclusion of alveus/fimbria (P = .021), whole hippocampal tail (P = .013), medial border of the body according to visible morphology (P = .0006), and on this combined set of features (P = .001). This definition captures 100% of hippocampal tissue, 100% of Alzheimer's disease-related atrophy, and demonstrated good reliability on preliminary intrarater (0.98) and inter-rater (0.94) estimates.DiscussionConsensus was achieved among international experts with respect to hippocampal segmentation using MR resulting in a harmonized segmentation protocol.

Published
2015

17. The EADC‐ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity

Author

Frisoni, Giovanni B, Jack, Clifford R, Bocchetta, Martina, Bauer, Corinna, Frederiksen, Kristian S, Liu, Yawu, Preboske, Gregory, Swihart, Tim, Blair, Melanie, Cavedo, Enrica, Grothe, Michel J, Lanfredi, Mariangela, Martinez, Oliver, Nishikawa, Masami, Portegies, Marileen, Stoub, Travis, Ward, Chadwich, Apostolova, Liana G, Ganzola, Rossana, Wolf, Dominik, Barkhof, Frederik, Bartzokis, George, DeCarli, Charles, Csernansky, John G, deToledo‐Morrell, Leyla, Geerlings, Mirjam I, Kaye, Jeffrey, Killiany, Ronald J, Lehéricy, Stephane, Matsuda, Hiroshi, O'Brien, John, Silbert, Lisa C, Scheltens, Philip, Soininen, Hilkka, Teipel, Stefan, Waldemar, Gunhild, Fellgiebel, Andreas, Barnes, Josephine, Firbank, Michael, Gerritsen, Lotte, Henneman, Wouter, Malykhin, Nikolai, Pruessner, Jens C, Wang, Lei, Watson, Craig, Wolf, Henrike, deLeon, Mony, Pantel, Johannes, Ferrari, Clarissa, Bosco, Paolo, Pasqualetti, Patrizio, Duchesne, Simon, Duvernoy, Henri, Boccardi, Marina, Initiative, EADC‐ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Volumetry and for the Alzheimer's Disease Neuroimaging, Albert, Marilyn S, Bennet, David, Camicioli, Richard, Collins, D Louis, Dubois, Bruno, Hampel, Harald, denHeijer, Tom, Hock, Christofer, Jagust, William, Launer, Leonore, Maller, Jerome J, Mueller, Susan, Sachdev, Perminder, Simmons, Andy, Thompson, Paul M, Visser, Peter‐Jelle, Wahlund, Lars‐Olof, Weiner, Michael W, and Winblad, Bengt

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Brain Disorders, Biomedical Imaging, Clinical Research, Aged, Alzheimer Disease, Atrophy, Female, Functional Laterality, Hippocampus, Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Internet, Magnetic Resonance Imaging, Male, Middle Aged, Neuroimaging, Organ Size, Reproducibility of Results, Hippocampal volumetry, Magnetic resonance, Alzheimer's disease, Biomarkers, Diagnostic criteria, Enrichment, Clinical trials, Validation, Harmonized protocol, Standard operating procedures, Manual segmentation, EADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Volumetry and for the Alzheimer's Disease Neuroimaging Initiative, Geriatrics, Clinical sciences, Biological psychology
Abstract

BackgroundAn international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance.MethodsFourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T and 3T following local protocols, qualified for segmentation based on the HarP through a standard web-platform and resegmented following the HarP. The five most accurate tracers followed the HarP to segment 15 ADNI cases acquired at three time points on both 1.5 T and 3T.ResultsThe agreement among tracers was relatively low with the local protocols (absolute left/right ICC 0.44/0.43) and much higher with the HarP (absolute left/right ICC 0.88/0.89). On the larger set of 15 cases, the HarP agreement within (left/right ICC range: 0.94/0.95 to 0.99/0.99) and among tracers (left/right ICC range: 0.89/0.90) was very high. The volume variance due to different tracers was 0.9% of the total, comparing favorably to variance due to scanner manufacturer (1.2), atrophy rates (3.5), hemispheric asymmetry (3.7), field strength (4.4), and significantly smaller than the variance due to atrophy (33.5%, P < .001), and physiological variability (49.2%, P < .001).ConclusionsThe HarP has high measurement stability compared with local segmentation protocols, and good reproducibility within and among human tracers. Hippocampi segmented with the HarP can be used as a reference for the qualification of human tracers and automated segmentation algorithms.

Published
2015

20. Effect of once-daily, modified-release hydrocortisone versus standard glucocorticoid therapy on metabolism and innate immunity in patients with adrenal insufficiency (DREAM): a single-blind, randomised controlled trial

Author

Isidori, Andrea M, Venneri, Mary Anna, Graziadio, Chiara, Simeoli, Chiara, Fiore, Daniela, Hasenmajer, Valeria, Sbardella, Emilia, Gianfrilli, Daniele, Pozza, Carlotta, Pasqualetti, Patrizio, Morrone, Stefania, Santoni, Angela, Naro, Fabio, Colao, Annamaria, Pivonello, Rosario, and Lenzi, Andrea

Published
2018
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21. Psychopathological features in Noonan syndrome

Author

Perrino, Francesca, Licchelli, Serena, Serra, Giulia, Piccini, Giorgia, Caciolo, Cristina, Pasqualetti, Patrizio, Cirillo, Flavia, Leoni, Chiara, Digilio, Maria Cristina, Zampino, Giuseppe, Tartaglia, Marco, Alfieri, Paolo, and Vicari, Stefano

Published
2018
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22. Imaging markers for Alzheimer disease

Author

Frisoni, Giovanni B, Bocchetta, Martina, Chételat, Gael, Rabinovici, Gil D, de Leon, Mony J, Kaye, Jeffrey, Reiman, Eric M, Scheltens, Philip, Barkhof, Frederik, Black, Sandra E, Brooks, David J, Carrillo, Maria C, Fox, Nick C, Herholz, Karl, Nordberg, Agneta, Jack, Clifford R, Jagust, William J, Johnson, Keith A, Rowe, Christopher C, Sperling, Reisa A, Thies, William, Wahlund, Lars-Olof, Weiner, Michael W, Pasqualetti, Patrizio, and DeCarli, Charles

Subjects
Acquired Cognitive Impairment, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Clinical Research, Dementia, Aging, Alzheimer's Disease, Biomedical Imaging, Brain Disorders, Neurodegenerative, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, 4.2 Evaluation of markers and technologies, Alzheimer Disease, Biomarkers, Fluorodeoxyglucose F18, Humans, Magnetic Resonance Imaging, Radiography, Tomography, Emission-Computed, Single-Photon, ISTAART's NeuroImaging Professional Interest Area, Clinical Sciences, Cognitive Sciences, Neurology & Neurosurgery
Abstract

Revised diagnostic criteria for Alzheimer disease (AD) acknowledge a key role of imaging biomarkers for early diagnosis. Diagnostic accuracy depends on which marker (i.e., amyloid imaging, ¹⁸F-fluorodeoxyglucose [FDG]-PET, SPECT, MRI) as well as how it is measured ("metric": visual, manual, semiautomated, or automated segmentation/computation). We evaluated diagnostic accuracy of marker vs metric in separating AD from healthy and prognostic accuracy to predict progression in mild cognitive impairment. The outcome measure was positive (negative) likelihood ratio, LR+ (LR-), defined as the ratio between the probability of positive (negative) test outcome in patients and the probability of positive (negative) test outcome in healthy controls. Diagnostic LR+ of markers was between 4.4 and 9.4 and LR- between 0.25 and 0.08, whereas prognostic LR+ and LR- were between 1.7 and 7.5, and 0.50 and 0.11, respectively. Within metrics, LRs varied up to 100-fold: LR+ from approximately 1 to 100; LR- from approximately 1.00 to 0.01. Markers accounted for 11% and 18% of diagnostic and prognostic variance of LR+ and 16% and 24% of LR-. Across all markers, metrics accounted for an equal or larger amount of variance than markers: 13% and 62% of diagnostic and prognostic variance of LR+, and 29% and 18% of LR-. Within markers, the largest proportion of diagnostic LR+ and LR- variability was within ¹⁸F-FDG-PET and MRI metrics, respectively. Diagnostic and prognostic accuracy of imaging AD biomarkers is at least as dependent on how the biomarker is measured as on the biomarker itself. Standard operating procedures are key to biomarker use in the clinical routine and drug trials.

Published
2013

25. Impairment in Social Functioning differentiates youth meeting Ultra-High Risk for psychosis criteria from other mental health help-seekers: A validation of the Italian version of the Global Functioning: Social and Global Functioning: Role scales

Author

Lo Cascio, Nella, Curto, Martina, Pasqualetti, Patrizio, Lindau, Juliana Fortes, Girardi, Nicoletta, Saba, Riccardo, Brandizzi, Martina, Monducci, Elena, Masillo, Alice, Colafrancesco, Giada, Solfanelli, Andrea, De Crescenzo, Franco, Kotzalidis, Georgios D., Dario, Claudia, Ferrara, Mauro, Vicari, Stefano, Girardi, Paolo, Auther, Andrea M., Cornblatt, Barbara A., Correll, Christoph U., and Fiori Nastro, Paolo

Published
2017
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28. Effects on Corticospinal Tract Homology of Faremus Personalized Neuromodulation Relieving Fatigue in Multiple Sclerosis: A Proof-of-Concept Study

Author

Bertoli, Massimo, primary, Tataranni, Angela, additional, Porziani, Susanna, additional, Pasqualetti, Patrizio, additional, Gianni, Eugenia, additional, Grifoni, Joy, additional, L’Abbate, Teresa, additional, Armonaite, Karolina, additional, Conti, Livio, additional, Cancelli, Andrea, additional, Cottone, Carlo, additional, Marinozzi, Franco, additional, Bini, Fabiano, additional, Cecconi, Federico, additional, and Tecchio, Franca, additional

Published
2023
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29. On the Homology of the Dominant and Non-Dominant Corticospinal Tracts: A Novel Neurophysiological Assessment

Author

Pagliara, Maria Rita, primary, Cecconi, Federico, additional, Pasqualetti, Patrizio, additional, Bertoli, Massimo, additional, Armonaite, Karolina, additional, Gianni, Eugenia, additional, Grifoni, Joy, additional, L’Abbate, Teresa, additional, Marinozzi, Franco, additional, Conti, Livio, additional, Paulon, Luca, additional, Uncini, Antonino, additional, Zappasodi, Filippo, additional, and Tecchio, Franca, additional

Published
2023
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30. Frequency-Dependent Reduction of Cyber-Sickness in Virtual Reality by Transcranial Oscillatory Stimulation of the Vestibular Cortex

Author

Benelli, Alberto, primary, Neri, Francesco, additional, Cinti, Alessandra, additional, Pasqualetti, Patrizio, additional, Romanella, Sara M., additional, Giannotta, Alessandro, additional, De Monte, David, additional, Mandalà, Marco, additional, Smeralda, Carmelo, additional, Prattichizzo, Domenico, additional, Santarnecchi, Emiliano, additional, and Rossi, Simone, additional

Published
2023
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32. Violent behavior of patients living in psychiatric residential facilities: A comparison of male patients with different violence histories

Author

Andreose, S., Basso, P., Beneduce, R., Bongiorno, F., Braida, V., Cortini, E., Dagani, J., De Dominicis, F., Di Giovanni, A., Ghilardi, A., Jaretti Sodano, A., Magni, L., Milazzo, D., Lo Presti, E., Paulon, L., Pioli, R., Ricci, C., Rillosi, L., Savio, G., Scaratti, L., Scioli, R., Veneroni, L., Zamburlini, S., Zorzella, L., Candini, Valentina, Buizza, Chiara, Ferrari, Clarissa, Boero, Maria Elena, Giobbio, Gian Marco, Goldschmidt, Nicoletta, Greppo, Stefania, Iozzino, Laura, Maggi, Paolo, Melegari, Anna, Pasqualetti, Patrizio, Rossi, Giuseppe, and de Girolamo, Giovanni

Published
2015
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33. The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity

Author

Albert, Marilyn S., Bennet, David, Camicioli, Richard, Collins, D. Louis, Dubois, Bruno, Hampel, Harald, denHeijer, Tom, Hock, Christofer, Jagust, William, Launer, Leonore, Maller, Jerome J., Mueller, Susan, Sachdev, Perminder, Simmons, Andy, Thompson, Paul M., Visser, Peter-Jelle, Wahlund, Lars-Olof, Weiner, Michael W., Winblad, Bengt, Frisoni, Giovanni B., Jack, Clifford R., Jr., Bocchetta, Martina, Bauer, Corinna, Frederiksen, Kristian S., Liu, Yawu, Preboske, Gregory, Swihart, Tim, Blair, Melanie, Cavedo, Enrica, Grothe, Michel J., Lanfredi, Mariangela, Martinez, Oliver, Nishikawa, Masami, Portegies, Marileen, Stoub, Travis, Ward, Chadwich, Apostolova, Liana G., Ganzola, Rossana, Wolf, Dominik, Barkhof, Frederik, Bartzokis, George, DeCarli, Charles, Csernansky, John G., deToledo-Morrell, Leyla, Geerlings, Mirjam I., Kaye, Jeffrey, Killiany, Ronald J., Lehéricy, Stephane, Matsuda, Hiroshi, O'Brien, John, Silbert, Lisa C., Scheltens, Philip, Soininen, Hilkka, Teipel, Stefan, Waldemar, Gunhild, Fellgiebel, Andreas, Barnes, Josephine, Firbank, Michael, Gerritsen, Lotte, Henneman, Wouter, Malykhin, Nikolai, Pruessner, Jens C., Wang, Lei, Watson, Craig, Wolf, Henrike, deLeon, Mony, Pantel, Johannes, Ferrari, Clarissa, Bosco, Paolo, Pasqualetti, Patrizio, Duchesne, Simon, Duvernoy, Henri, and Boccardi, Marina

Published
2015
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34. Harmonized benchmark labels of the hippocampus on magnetic resonance: The EADC-ADNI project

Author

Bartzokis, George, DeCarli, Charles, deToledo-Morrell, Leyla, Fellgiebel, Andreas, Firbank, Michael, Gerritsen, Lotte, Henneman, Wouter, Killiany, Ronald J., Malykhin, Nikolai, Pruessner, Jens C., Soininen, Hilkka, Wang, Lei, Watson, Craig, Wolf, Henrike, Bocchetta, Martina, Boccardi, Marina, Ganzola, Rossana, Apostolova, Liana G., Preboske, Gregory, Wolf, Dominik, Ferrari, Clarissa, Pasqualetti, Patrizio, Robitaille, Nicolas, Duchesne, Simon, Jack, Clifford R., Jr., and Frisoni, Giovanni B.

Published
2015
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40. Deaf Children Attending Different School Environments: Sign Language Abilities and Theory of Mind

Author

Tomasuolo, Elena, Valeri, Giovanni, Di Renzo, Alessio, Pasqualetti, Patrizio, and Volterra, Virginia

Abstract

The present study examined whether full access to sign language as a medium for instruction could influence performance in Theory of Mind (ToM) tasks. Three groups of Italian participants (age range: 6-14 years) participated in the study: Two groups of deaf signing children and one group of hearing-speaking children. The two groups of deaf children differed only in their school environment: One group attended a school with a teaching assistant (TA; Sign Language is offered only by the TA to a single deaf child), and the other group attended a bilingual program (Italian Sign Language and Italian). Linguistic abilities and understanding of false belief were assessed using similar materials and procedures in spoken Italian with hearing children and in Italian Sign Language with deaf children. Deaf children attending the bilingual school performed significantly better than deaf children attending school with the TA in tasks assessing lexical comprehension and ToM, whereas the performance of hearing children was in between that of the two deaf groups. As for lexical production, deaf children attending the bilingual school performed significantly better than the two other groups. No significant differences were found between early and late signers or between children with deaf and hearing parents.

Published
2013
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46. Correlations of Obstructive Sleep Apnea Syndrome and Daytime Sleepiness with the Risk of Car Accidents in Adult Working Population: A Systematic Review and Meta-Analysis with a Gender-Based Approach

Author

Luzzi, Valeria, primary, Mazur, Marta, additional, Guaragna, Mariana, additional, Di Carlo, Gabriele, additional, Cotticelli, Luisa, additional, Magliulo, Giuseppe, additional, Marasca, Beatrice, additional, Pirro, Valentina, additional, Di Giorgio, Gianni, additional, Ndokaj, Artnora, additional, Pasqualetti, Patrizio, additional, Simonelli, Ilaria, additional, Martini, Agnese, additional, Pietrafesa, Emma, additional, and Polimeni, Antonella, additional

Published
2022
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47. Diffusion-weighted lesions after carotid artery stenting are associated with cognitive impairment

Author

Maggio, Paola, Altamura, Claudia, Landi, Doriana, Migliore, Simone, Lupoi, Domenico, Moffa, Filomena, Quintiliani, Livia, Vollaro, Stefano, Palazzo, Paola, Altavilla, Riccardo, Pasqualetti, Patrizio, Errante, Yuri, Quattrocchi, Carlo Cosimo, Tibuzzi, Francesco, Passarelli, Francesco, Arpesani, Roberto, di Giambattista, Guido, Grasso, Francesco Rosario, Luppi, Giacomo, and Vernieri, Fabrizio

Published
2013
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