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1. On-demand pre-exposure prophylaxis with tenofovir disoproxil fumarate plus emtricitabine among men who have sex with men with less frequent sexual intercourse: a post-hoc analysis of the ANRS IPERGAY trial

Author

Aboulker, Jean-Pierre, Bajos, Nathalie, Baril, Jean-Guy, Besnier, Michel, Binesse, Johan, Carette, Diane, Cattin, Grégoire, Chéret, Antoine, Chidiac, Christian, Choucair, Elias, Delfraissy, Jean-François, Demoulin, Baptiste, Diallo, Alpha, Durant-Zaleski, Isabelle, Doré, Véronique, Etien, Nicolas, Euphrasie, Françoise, Fonsart, Julien, Foubert, Valérie, Gibowski, Séverine, Girard, Gabriel, Guillon, Brigitte, Le Mestre, Soizic, Lert, France, Leturque, Nicolas, Lorente, Nicolas, Mennecier, Anaïs, Morin, Michel, Netzer, Emmanuelle, Otis, Joanne, Pasquet, Armelle, Peytavin, Gilles, Pialoux, Gilles, Préau, Marie, Rabian, Cécile, Rozenbaum, Willy, Sagaon-Teyssier, Luis, Saïdi, Yacine, Saouzanet, Marine, Simon, Marie-Christine, Suzan-Monti, Marie, Thompson, David, Timsit, Julie, Trottier, Benoît, Wainberg, Mark, Antoni, Guillemette, Tremblay, Cécile, Delaugerre, Constance, Charreau, Isabelle, Cua, Eric, Rojas Castro, Daniela, Raffi, François, Chas, Julie, Huleux, Thomas, Spire, Bruno, Capitant, Catherine, Cotte, Laurent, Meyer, Laurence, and Molina, Jean-Michel

Published
2020
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5. Efficacy, safety, and effect on sexual behaviour of on-demand pre-exposure prophylaxis for HIV in men who have sex with men: an observational cohort study

Author

Meyer, L, Capitant, C, Charreau, I, Netzer, E, Leturque, N, Binesse, J, Foubert, V, Saouzanet, M, Euphrasie, F, Carette, D, Guillon, B, Saïdi, Y, Aboulker, J P, Spire, B, Suzan, M, Cattin, G, Demoulin, B, Sagaon-Teyssier, L, Lorente, N, Doré, V, Choucair, E, Le Mestre, S, Mennecier, A, Etien, N, Simon, M C, Diallo, A, Gibowski, S, Delfraissy, J F, Thompson, D, Sas, J, Pankovitch, J, Klein, M, Anis, A, Molina, Jean-Michel, Wainberg, Mark A, Trottier, Benoit, Tremblay, Cécile, Baril, Jean-Guy, Pialoux, Gilles, Cotte, Laurent, Chéret, Antoine, Pasquet, Armelle, Cua, Eric, Besnier, Michel, Rozenbaum, Willy, Chidiac, Christian, Delaugerre, Constance, Bajos, Nathalie, Timsit, Julie, Peytavin, Gilles, Fonsart, Julien, Durand-Zaleski, Isabelle, Meyer, Laurence, Aboulker, Jean-Pierre, Spire, Bruno, Suzan-Monti, Marie, Girard, Gabriel, Castro, Daniela Rojas, Préau, Marie, Morin, Michel, Thompson, David, Capitant, Catherine, Mennecier, Anaïs, Choucair, Elias, Doré, Véronique, Simon, Marie-Christine, Charreau, Isabelle, Otis, Joanne, Lert, France, Diallo, Alpha, Gibowski, Séverine, Rabian, Cecile, Chas, Julie, Tremblay, Cecile, Rojas-Castro, Daniela, Bernaud, Camille, Pintado, Claire, Sagaon-Teyssier, Luis, Mestre, Soizic Le, Ponscarme, Diane, and Doré, Veronique

Published
2017
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6. Changes in kidney function among men having sex with men starting on demand tenofovir disoproxil fumarate – emtricitabine for HIV pre‐exposure prophylaxis

Author

Liegeon, Geoffroy, Antoni, Guillemette, Pialoux, Gilles, Capitant, Catherine, Cotte, Laurent, Charreau, Isabelle, Tremblay, Cécile, Cua, Eric, Senneville, Eric, Raffi, François, Meyer, Laurence, Molina, Jean?Michel, Meyer, L, Capitant, C, Charreau, I, Netzer, E, Leturque, N, Binesse, J, Foubert, V, Saouzanet, M, Euphrasie, F, Carette, D, Guillon, B, Saïdi, Y, Aboulker, J P., Spire, B, Suzan, M, Cattin, G, Demoulin, B, Sagaon?Teyssier, L, Lorente, N, Doré, V, Choucair, E, Le Mestre, S, Mennecier, A, Etien, N, Simon, M C., Diallo, A, Gibowski, S, Delfraissy, J F., Thompson, D, Sas, J, Pankovitch, J, Klein, M, Anis, A, Wainberg, Mark A., Trottier, Benoit, Baril, Jean?Guy, Chéret, Antoine, Pasquet, Armelle, Hall, Nolwenn, Rozenbaum, Willy, Chidiac, Christian, Delaugerre, Constance, Bajos, Nathalie, Timsit, Julie, Peytavin, Gilles, Fonsart, Julien, Durand?Zaleski, Isabelle, Aboulker, Jean?Pierre, Spire, Bruno, Suzan?Monti, Marie, Girard, Gabriel, Castro, Daniela Rojas, Préau, Marie, Morin, Michel, Thompson, David, Mennecier, Anaïs, Choucair, Elias, Doré, Véronique, Simon, Marie?Christine, Otis, Joanne, Lert, France, Diallo, Alpha, Gibowski, Séverine, and Rabian, Cecile

Subjects
MSM (Men who have sex with men) -- Health aspects, Tenofovir -- Patient outcomes, Glomerular filtration rate -- Testing, Emtricitabine -- Patient outcomes, HIV infection -- Prevention, Health
Abstract

: Introduction: Daily pre‐exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) is associated with a small but statistically significant decrease in estimated glomerular filtration rate (eGFR). We assessed the renal safety of on‐demand PrEP with TDF/FTC in HIV‐1 uninfected men. Methods: We used data from the randomized double‐blind placebo‐controlled ANRS‐IPERGAY trial and its open‐label extension conducted between February 2012 and June 2016 among HIV‐uninfected MSM starting on‐demand PrEP. Using linear mixed model, we evaluated the mean eGFR decline from baseline over time and determined risks factors associated with eGFR decline during the study. Results: During the blind phase, with a median follow‐up of 9.4 months, the mean decline slope of eGFR from baseline was −0.88 and −1.53 mL/min/1.73 m[sup.2] per year in the placebo (n = 201) and the TDF/FTC group (n = 198) respectively, with a slope difference of 0.65 mL/min/1.73 m[sup.2] per year (p = 0.27). Including both phases, 389 participants started on‐demand TDF/FTC with a median follow‐up of 19.2 months and a mean decline of eGFR from baseline of −1.14 mL/min/1.73 m[sup.2] per year (p < 0.001). The slope of eGFR reduction was not significantly different in participants with baseline eGFR ≤ 90 mL/min/1.73 m[sup.2] (p = 0.44), age >40 years (p = 0.24) or hypertension (p = 0.21). There was a dose‐response relationship between recent tenofovir exposure and lower eGFR when considering the number of pills taken in the two months prior the visit (eGFR difference of −0.88 mL/min/1.73 m[sup.2] between >15 pills/month vs. ≤15 pills/month, p < 0.01) or plasma tenofovir concentrations at the visit (eGFR difference compared to ≤2 ng/mL: >2 to ≤10ng/mL: −0.98 mL/min/1.73 m[sup.2], >10 to ≤40ng/mL: −1.28 mL/min/1.73 m[sup.2], >40 ng/mL: −1.82 mL/min/1.73 m[sup.2], p < 0.001). Three participants discontinued TDF/FTC for eGFR < 60 mL/min/1.73 m[sup.2] during the OLE phase. No case of Fanconi syndrome was reported. Conclusions: The renal safety of on‐demand PrEP with TDF/FTC was good. The overall reduction and intermittent exposure to TDF/FTC may explain this good renal safety., Introduction Pre‐exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate (TDF) – emtricitabine (FTC) raises a lot of expectations to hamper HIV epidemic due to its high effectiveness to prevent HIV acquisition [...]

Published
2020
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9. Smoking‐associated morbidities on computed tomography lung cancer screens in HIV‐infected smokers

Author

Bommart, S, Cournil, A, Eymard‐Duvernay, S, Raffi, F, Bouassida, I, Le Moing, V, Reynes, J, Makinson, A, Yazdanpanah, Yazdan, Cheret, Antoine, Ajana, Faïza, Alcaraz, Isabelle, Baclet, Véronique, Melliez, Hugues, Valette, Michel, Viget, Nathalie, De La Tribonniere, Xavier, Huleux, Thomas, Séverine, Séverine Bonne, Biekre, Raphaël, Pasquet, Armelle, Allienne, Christophe, Behra, Jean Marie, Meybeck, Agnès, Aissi, Emmanuelle, Abgrall, Sophie, Bouchaud, Olivier, Barruet, Régine, Rouges, François, Kandel, Tania, Mechai, Fréderic, Brillet, Pierre‐Yves, Brauner, Michel, Dellamonica, Pierre, De Salvador, Francine, Cua, Eric, Leplatois, Anne, Naqvi, Alissa, Durant, Jacques, Ceppi, Carole, Sanderson, Frédéric, Rosenthal, Eric, Chassang, Madleen, Chevallier, Patrick, Dunais, Brigitte, Tattevin, Pierre, Lena, Hervé, Lentz, Pierre‐Axel, Michelet, Christian, Arvieux, Cédric, Revest, Mathieu, Soula, Faouzi, Chapplain, Jean‐Marc, Leroy, Hélène, Meunier, Catherine, Poizot‐Martin, Isabelle, Faucher, Olivia, Menard, Amélie, Bregigeon, Sylvie, de Lamarliere, Perrine Geneau, Champsaur, Pierre, Durieux, Olivier, Cloarec, Nicolas, Allavena, Clotilde, Feuillebois, Nicolas, Mounoury, Olivier, Bouchez, Sabelline, Billaud, Eric, Reliquet, Véronique, Bonnet, Bénédicte, Brunet, Cécile, Point, Patrick, Boutoille, David, Le Houssine, Pascale Morineau, Delemazure, Anne Sophie, Duvivier, Claudine, Catherinot, Emilie, Tehrani, Michka Shoai, Poiree, Sylvain, Zucman, David, Majerholc, Catherine, Couderc, Louis‐Jean, Mellot, François, Sherrer, Antoine, Ferry, Tristan, Koffi, Joseph, Boibieux, André, Miailhes, Patrick, Cotte, Laurent, Perpoint, Thomas, Lippman, Joanna, Norman, Claude Augustin, biron, Francois, Senechar, Agathe, Ader, Florence, Pialloux, Gilles, LʼYavanc, Thomas, Slama, Laurence, Chas, Julie, Le Nagat, Sophie, Khalil, Antoine, Carette, Marie France, Bonnet, Fabrice, Morlat, Philippe, Lacoste, Denis, Vandenhende, Marie, Receveur, Marie Catherine, Paccalin, Francois, Caldato, Sabrina, Bernard, Noëlle, Hessemfar, Mojgan, Pistone, Thierry, Malvy, Denis, Thibaut, Pierre, Pertusa, Marie Carmen, Cornelou, Olivier, Laurent, Francois, Mercie, Patrick, Faure, Isabelle, Dondia, Denis, Martell, Cedric, Duffau, Pierre, Mauboussin, Jean Marc, Barbuat, Claudine, Rouanet, Isabelle, Metge, Liliane, Jacquet, Jean‐Marc, Atoui, Nadine, Loriette, Mickael, Morquin, David, Fauchere, Vincent, Favier, Carine, Merle, Corinne, Baillat, Vincent, Silva, Antoine Da, Mansouri, Rachid, Kovacsik‐Vernhet, Hélène, Pujol, Jean‐Louis, Quantin, Xavier, and Hayot, Maurice

Published
2017
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11. Hypogonadism: a neglected comorbidity in young and middle-aged HIV-positive men on effective combination antiretroviral therapy

Author

Lachâtre, Marie, primary, Pasquet, Armelle, additional, Ajana, Faïza, additional, Soudan, Benoit, additional, Quertainmont, Yann, additional, Lion, Georges, additional, Durand, Emmanuel, additional, Bocket, Laurence, additional, Mole, Martine, additional, Cornavin, Pauline, additional, Catalan, Pilartxo, additional, Senneville, Éric, additional, Goujard, Cécile, additional, Boufassa, Faroudy, additional, and Cheret, Antoine, additional

Published
2022
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13. On-Demand Preexposure Prophylaxis in Men at High Risk for HIV-1 Infection

Author

Molina, Jean-Michel, Capitant, Catherine, Spire, Bruno, Pialoux, Gilles, Cotte, Laurent, Charreau, Isabelle, Tremblay, Cecile, Le Gall, Jean-Marie, Cua, Eric, Pasquet, Armelle, Raffi, François, Pintado, Claire, Chidiac, Christian, Chas, Julie, Charbonneau, Pierre, Delaugerre, Constance, Suzan-Monti, Marie, Loze, Benedicte, Fonsart, Julien, Peytavin, Gilles, Cheret, Antoine, Timsit, Julie, Girard, Gabriel, Lorente, Nicolas, Préau, Marie, Rooney, James F., Wainberg, Mark A., Thompson, David, Rozenbaum, Willy, Doré, Veronique, Marchand, Lucie, Simon, Marie-Christine, Etien, Nicolas, Aboulker, Jean-Pierre, Meyer, Laurence, and Delfraissy, Jean-François

Published
2015
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18. On-demand pre-exposure prophylaxis with tenofovir disoproxil fumarate plus emtricitabine among men who have sex with men with less frequent sexual intercourse: a post-hoc analysis of the ANRS IPERGAY trial

Author

Antoni, Guillemette, primary, Tremblay, Cécile, additional, Delaugerre, Constance, additional, Charreau, Isabelle, additional, Cua, Eric, additional, Rojas Castro, Daniela, additional, Raffi, François, additional, Chas, Julie, additional, Huleux, Thomas, additional, Spire, Bruno, additional, Capitant, Catherine, additional, Cotte, Laurent, additional, Meyer, Laurence, additional, Molina, Jean-Michel, additional, Aboulker, Jean-Pierre, additional, Bajos, Nathalie, additional, Baril, Jean-Guy, additional, Besnier, Michel, additional, Binesse, Johan, additional, Carette, Diane, additional, Cattin, Grégoire, additional, Chéret, Antoine, additional, Chidiac, Christian, additional, Choucair, Elias, additional, Delfraissy, Jean-François, additional, Demoulin, Baptiste, additional, Diallo, Alpha, additional, Durant-Zaleski, Isabelle, additional, Doré, Véronique, additional, Etien, Nicolas, additional, Euphrasie, Françoise, additional, Fonsart, Julien, additional, Foubert, Valérie, additional, Gibowski, Séverine, additional, Girard, Gabriel, additional, Guillon, Brigitte, additional, Le Mestre, Soizic, additional, Lert, France, additional, Leturque, Nicolas, additional, Lorente, Nicolas, additional, Mennecier, Anaïs, additional, Morin, Michel, additional, Netzer, Emmanuelle, additional, Otis, Joanne, additional, Pasquet, Armelle, additional, Peytavin, Gilles, additional, Pialoux, Gilles, additional, Préau, Marie, additional, Rabian, Cécile, additional, Rozenbaum, Willy, additional, Sagaon-Teyssier, Luis, additional, Saïdi, Yacine, additional, Saouzanet, Marine, additional, Simon, Marie-Christine, additional, Suzan-Monti, Marie, additional, Thompson, David, additional, Timsit, Julie, additional, Trottier, Benoît, additional, and Wainberg, Mark, additional

Published
2020
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22. Efficacy, safety, and effect on sexual behaviour of on-demand pre-exposure prophylaxis for HIV in men who have sex with men: an observational cohort study

Author

Molina, Jean-Michel, primary, Charreau, Isabelle, additional, Spire, Bruno, additional, Cotte, Laurent, additional, Chas, Julie, additional, Capitant, Catherine, additional, Tremblay, Cecile, additional, Rojas-Castro, Daniela, additional, Cua, Eric, additional, Pasquet, Armelle, additional, Bernaud, Camille, additional, Pintado, Claire, additional, Delaugerre, Constance, additional, Sagaon-Teyssier, Luis, additional, Mestre, Soizic Le, additional, Chidiac, Christian, additional, Pialoux, Gilles, additional, Ponscarme, Diane, additional, Fonsart, Julien, additional, Thompson, David, additional, Wainberg, Mark A, additional, Doré, Veronique, additional, Meyer, Laurence, additional, Meyer, L, additional, Capitant, C, additional, Charreau, I, additional, Netzer, E, additional, Leturque, N, additional, Binesse, J, additional, Foubert, V, additional, Saouzanet, M, additional, Euphrasie, F, additional, Carette, D, additional, Guillon, B, additional, Saïdi, Y, additional, Aboulker, J P, additional, Spire, B, additional, Suzan, M, additional, Cattin, G, additional, Demoulin, B, additional, Sagaon-Teyssier, L, additional, Lorente, N, additional, Doré, V, additional, Choucair, E, additional, Le Mestre, S, additional, Mennecier, A, additional, Etien, N, additional, Simon, M C, additional, Diallo, A, additional, Gibowski, S, additional, Delfraissy, J F, additional, Thompson, D, additional, Sas, J, additional, Pankovitch, J, additional, Klein, M, additional, Anis, A, additional, Molina, Jean-Michel, additional, Trottier, Benoit, additional, Tremblay, Cécile, additional, Baril, Jean-Guy, additional, Chéret, Antoine, additional, Besnier, Michel, additional, Rozenbaum, Willy, additional, Bajos, Nathalie, additional, Timsit, Julie, additional, Peytavin, Gilles, additional, Durand-Zaleski, Isabelle, additional, Aboulker, Jean-Pierre, additional, Suzan-Monti, Marie, additional, Girard, Gabriel, additional, Castro, Daniela Rojas, additional, Préau, Marie, additional, Morin, Michel, additional, Mennecier, Anaïs, additional, Choucair, Elias, additional, Doré, Véronique, additional, Simon, Marie-Christine, additional, Otis, Joanne, additional, Lert, France, additional, Diallo, Alpha, additional, Gibowski, Séverine, additional, and Rabian, Cecile, additional

Published
2017
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23. Assessment of HIV Screening Tests for Pre-Exposure Prophylaxis Programs

Author

Delaugerre, Constance, primary, Antoni, Guillemette, additional, Mahjoub, Nadia, additional, Pialoux, Gilles, additional, Cua, Eric, additional, Pasquet, Armelle, additional, Hall, Nolwenn, additional, Tremblay, Cécile, additional, Cotte, Laurent, additional, Capitant, Catherine, additional, Chaix, Marie-Laure, additional, Meyer, Laurence, additional, and Molina, Jean-Michel, additional

Published
2017
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24. Community-Based Care in the ANRS-IPERGAY Trial: The Challenges of Combination Prevention.

Author

Puppo, Costanza, Mabire, Xavier, Cotte, Laurent, Castro, Daniela Rojas, Spire, Bruno, Cua, Eric, Pialoux, Gilles, Monti, Marie Suzan, Pasquet, Armelle, Raffi, François, Molina, Jean-Michel, and Préau, Marie

Subjects
HIV prevention, HIV infection risk factors, COMMUNITY health workers, COMMUNITY health services, DEPENDENCY (Psychology), MEDICAL personnel, PREVENTIVE medicine, PHYSICIAN-patient relations, SELF-efficacy, SELF-management (Psychology), TRUST, QUALITATIVE research, PSYCHOSOCIAL factors, SOCIAL support, RANDOMIZED controlled trials, BLIND experiment, MEN who have sex with men, PATIENTS' attitudes
Abstract

ANRS-IPERGAY was a community-based randomized trial investigating the efficacy of sexual activity-based HIV pre-exposure prophylaxis (PrEP) in a population of males and transgender females who had sex with men and were at high risk of HIV infection. We qualitatively analyzed the support provided to participants by community-based health workers (CBHW) throughout the trial's double-blind and open-label extension phases. In particular, we showed that the relationship between participants and CBHW strongly influenced self-managed pill intake. The delicate construction of this relationship, balanced between trust and dependence, played an important role in PrEP adherence. CBHW had to deal with various issues surrounding participants' feelings of empowerment regarding their role in the trial, as well as related tensions between various logics and rationalities. They were essential to participants' continued involvement. [ABSTRACT FROM AUTHOR]

Published
2019
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25. HIV and hypogonadism

Author

Lachâtre, Marie, primary, Pasquet, Armelle, additional, Ajana, Faïza, additional, Soudan, Benoit, additional, Lion, Georges, additional, Bocket, Laurence, additional, Cornavin, Pauline, additional, Senneville, Eric, additional, Boufassa, Faroudy, additional, and Chéret, Antoine, additional

Published
2017
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27. Assessment of HIV Screening Tests for Use in Preexposure Prophylaxis Programs.

Author

Delaugerre, Constance, Antoni, Guillemette, Mahjoub, Nadia, Pialoux, Gilles, Cua, Eric, Pasquet, Armelle, Hall, Nolwenn, Tremblay, Cécile, Cotte, Laurent, Capitant, Catherine, Chaix, Marie-Laure, Meyer, Laurence, Molina, Jean-Michel, and IPERGAY Study Group

Subjects
DIAGNOSIS of HIV infections, IMMUNOASSAY, ANTIGEN-antibody reactions, VIRAL transmission, DRUG resistance, HIV prevention, COMPARATIVE studies, HIV, RESEARCH methodology, MEDICAL cooperation, MEDICAL screening, PREVENTIVE health services, RESEARCH, RNA, SERODIAGNOSIS, VIRAL antibodies, VIRAL antigens, EVALUATION research, RETROSPECTIVE studies
Abstract

Preexposure prophylaxis programs involve frequent human immunodeficiency virus (HIV) testing. We evaluated the sensitivity of 2 antigen/antibody immunoassays (Architect and Bioplex), 2 antibody-based rapid tests (Vikia-HIV-1/2 and Autotest-VIH), and 1 antigen/antibody rapid test (Alere HIV Combo) for the diagnosis of HIV infection. Among the 31 HIV-1-infected participants in the ANRS-IPERGAY trial, HIV-1 RNA was detected alone in only 2. The sensitivities of the Architect and Bioplex assays were 83% (95% confidence interval [CI], 76%-99%) and 82% (95% CI, 63%-94%), respectively. The sensitivities of the Vikia, Autotest, and Alere tests were 54% (95% CI, 34%-72%), 50% (95% CI, 31%-69%), and 78% (95% CI, 58%-91%), respectively. Antigen/antibody tests should be preferred to avoid missing cases of acute HIV infection and to decrease the related risks of viral transmission and emergence of drug resistance. [ABSTRACT FROM AUTHOR]

Published
2017
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28. Impact of Drug Stock-Outs on Death and Retention to Care among HIV-Infected Patients on Combination Antiretroviral Therapy in Abidjan, Côte d'Ivoire

Author

Pasquet, Armelle, primary, Messou, Eugène, additional, Gabillard, Delphine, additional, Minga, Albert, additional, Depoulosky, Ayeby, additional, Deuffic-Burban, Sylvie, additional, Losina, Elena, additional, Freedberg, Kenneth A., additional, Danel, Christine, additional, Anglaret, Xavier, additional, and Yazdanpanah, Yazdan, additional

Published
2010
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29. Evaluation of Drug Abuse by Hair Analysis and Self-Reported Use Among MSM Under PrEP: Results From a French Substudy of the ANRS-IPERGAY Trial.

Author

Chas J, Bauer R, Larabi IA, Peytavin G, Roux P, Cua E, Cotte L, Pasquet A, Capitant C, Meyer L, Raffi F, Spire B, Pialoux G, Molina JM, and Alvarez JC

Subjects
Adult, Anti-HIV Agents, Hair Analysis, Humans, Male, Prevalence, Self Report, Sexual Behavior, Sexual Partners, Sexually Transmitted Diseases prevention & control, Surveys and Questionnaires, Unsafe Sex, HIV Infections drug therapy, Homosexuality, Male psychology, Pre-Exposure Prophylaxis, Sexual and Gender Minorities psychology, Substance-Related Disorders epidemiology
Abstract

Background: We used the Agence nationale de Recherches sur le sida et les hépatites virales (ANRS)-IPERGAY trial to qualitatively and quantitatively measure drug use among men who have sex with men under preexposure prophylaxis using 2 different methods, to better understand and collectively respond to risky practices., Method: We included 69 volunteers of the ANRS-IPERGAY trial. We measured drug use by 2 methods: (1) drug detection by hair analysis and (2) reported drug use by self-reported drug consumption., Results: New psychoactive substances (NPS) and conventional drugs were detected in 53 of the 69 (77%) volunteers by hair analysis and in 39 of the 69 (57%) volunteers by questionnaires. On the 219 hair segments analyzed, the most commonly used drugs were cocaine in 47 of the 69 (68%), 3,4-methylenedioxymethamphetamine/ecstasy in 31 of the 69 (45%), and NPS in 27 of the 69 (39%). On the 1061 collected questionnaires, the most commonly used drugs were cocaine in 31 of the 69 (45%), 3,4-methylenedioxymethamphetamine/ecstasy in 29 of the 69 (42%), and NPS in 16 of the 69 (23%). Hair analysis detects more conventional drugs and/or NPS use (P < 0.05). Drug use identified by hair was significantly associated with a higher number of sexual partners in the past 2 months (P ≤ 0.001), more often casual partners (P ≤ 0.001), condomless anal sex (P ≤ 0.005), hardcore sexual practices (P ≤ 0.001), a higher number of sexually transmitted infections, and chemsex (P ≤ 0.05)., Conclusions: Self-report drug use by questionnaires remains the reference tool for harm reduction at the individual level because of its feasibility and low cost. However, hair analysis is more sensitive, objectively assessing consumption, and interesting to understand uses and to be able to collectively respond to risky practices with adapted messages., Competing Interests: J.-M.M. reports receiving financial support as an adviser for Gilead Sciences, Merck, Janssen, Bristol-Myers Squibb, and ViiV Healthcare, and research grants from Gilead Sciences and Merck. F.R. reports receiving financial support as an adviser for Gilead Sciences, Merck, Janssen, and ViiV Healthcare, and research grants from Gilead Sciences. B.S. reports receiving support as an adviser for Gilead Sciences, Merck, Janssen, and Bristol-Myers Squibb, and research grants from ANRS, Fondation Pierre Bergé, Gilead Sciences, and Merck. L.C. has received research grants from ViiV Healthcare and Merck, personal fees from Mylan, and nonfinancial support from BMS, Gilead Science, Janssen Cilag, MSD, and ViiV Healthcare. G.P. has received consulting fees from Bristol-Myers Squibb, Boehringer Ingelheim, Tibotec, Nephrotek, Gilead, Roche, MSD, Abbott, and ViiV Healthcare, and research grants from Bristol-Myers Squibb and Gilead Sciences. E.C. reports receiving financial support as an adviser for Janssen, Merck, ViiV, and Novartis, and nonfinancial support from Gilead Sciences. J.C. reports receiving financial support as an adviser for Gilead Sciences, Bristol-Myers Squibb, and AbbVie. L.M. reports receiving grants from ANRS, the Bill & Melinda Gates Foundation, and Gilead. G. Peytavin has received travel grants, consultancy fees, honoraria, or study grants from various pharmaceutical companies, including Gilead Sciences, Janssen, Merck, and ViiV Healthcare. The other authors have no conflicts of interest to disclose., (Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.)

Published
2021
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31. [HIV infection].

Author

Pasquet A and Yazdanpanah Y

Subjects
AIDS-Related Opportunistic Infections diagnosis, AIDS-Related Opportunistic Infections epidemiology, AIDS-Related Opportunistic Infections prevention & control, Counseling methods, Disease Progression, HIV Infections epidemiology, HIV Infections prevention & control, HIV-1 chemistry, HIV-1 genetics, HIV-2 chemistry, HIV-2 genetics, Humans, Information Dissemination, Mass Screening, Models, Biological, Virus Replication physiology, HIV Infections diagnosis, HIV Infections therapy, HIV-1 physiology, HIV-2 physiology
Published
2012

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