255 results on '"Passarelli, Francesca"'
Search Results
2. A theory on party discipline and vote switching by legislators
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González, Paula, Passarelli, Francesca, and Puy, M. Socorro
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- 2021
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3. Conserved roles of chromatin remodellers in cohesin loading onto chromatin
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Muñoz, Sofía, Passarelli, Francesca, and Uhlmann, Frank
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- 2020
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4. Blood and skin-derived Sezary cells: differences in proliferation-index, activation of PI3K/AKT/mTORC1 pathway and its prognostic relevance
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Cristofoletti, Cristina, Bresin, Antonella, Picozza, Mario, Picchio, Maria Cristina, Monzo, Francesca, Helmer Citterich, Mauro, Passarelli, Francesca, Frezzolini, Alessandra, Scala, Enrico, Monopoli, Alessandro, Cantonetti, Maria, Benucci, Roberto, D’Atri, Stefania, Caprini, Elisabetta, Russo, Giandomenico, and Narducci, Maria Grazia
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- 2019
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5. Phytochemical analysis and effects on ingestive behaviour of a Caralluma fimbriata extract
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Vitalone, Annabella, Di Sotto, Antonella, Mammola, Caterina Loredana, Heyn, Rosemarie, Miglietta, Selenia, Mariani, Paola, Sciubba, Fabio, Passarelli, Francesca, Nativio, Paola, and Mazzanti, Gabriela
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- 2017
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6. Early inflammatory biomarkers and melanoma survival
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Fortes, Cristina, primary, Mastroeni, Simona, additional, Zappalà, Albina Rita, additional, Passarelli, Francesca, additional, Ricci, Francesco, additional, Abeni, Damiano, additional, and Michelozzi, Paola, additional
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- 2023
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7. Can ultraviolet radiation act as a survival enhancer for cutaneous melanoma?
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Fortes, Cristina, Mastroeni, Simona, Bonamigo, Renan, Mannooranparampil, Thomas, Marino, Claudia, Michelozzi, Paola, Passarelli, Francesca, and Boniol, Mathieu
- Published
- 2016
8. Cyclin B3 implements timely vertebrate oocyte arrest for fertilization
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Bouftas, Nora, primary, Schneider, Lena, additional, Halder, Marc, additional, Demmig, Rebecca, additional, Baack, Martina, additional, Cladière, Damien, additional, Walter, Melanie, additional, Al Abdallah, Hiba, additional, Kleinhempel, Camilla, additional, Messaritaki, Ria, additional, Müller, Janina, additional, Passarelli, Francesca, additional, Wehrle, Patrick, additional, Heim, Andreas, additional, Wassmann, Katja, additional, and Mayer, Thomas U., additional
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- 2022
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9. Comprehensive analysis of PTEN status in Sézary syndrome
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Cristofoletti, Cristina, Picchio, Maria Cristina, Lazzeri, Cristina, Tocco, Valeria, Pagani, Elena, Bresin, Antonella, Mancini, Barbara, Passarelli, Francesca, Facchiano, Antonio, Scala, Enrico, Lombardo, Giuseppe Alfonso, Cantonetti, Maria, Caprini, Elisabetta, Russo, Giandomenico, and Narducci, Maria Grazia
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- 2013
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10. Anti-Purkinje cell antibody as a biological marker in attention deficit/hyperactivity disorder: A pilot study
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Passarelli, Francesca, Donfrancesco, Renato, Nativio, Paola, Pascale, Esterina, Trani, Michela Di, Patti, Anna Maria, Vulcano, Antonella, Gozzo, Paolo, and Villa, Maria Pia
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- 2013
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11. Cyclin B3 implements timely vertebrate oocyte arrest for fertilization
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Bouftas, Nora, Schneider, Lena, Halder, Marc, Demmig, Rebecca, Baack, Martina, Cladière, Damien, Walter, Melanie, Al Abdallah, Hiba, Kleinhempel, Camilla, Messaritaki, Ria, Müller, Janina, Passarelli, Francesca, Wehrle, Patrick, Heim, Andreas, Wassmann, Katja, Mayer, Thomas U., Bouftas, Nora, Schneider, Lena, Halder, Marc, Demmig, Rebecca, Baack, Martina, Cladière, Damien, Walter, Melanie, Al Abdallah, Hiba, Kleinhempel, Camilla, Messaritaki, Ria, Müller, Janina, Passarelli, Francesca, Wehrle, Patrick, Heim, Andreas, Wassmann, Katja, and Mayer, Thomas U.
- Abstract
To ensure successful offspring ploidy, vertebrate oocytes must halt the cell cycle in meiosis II until sperm entry. Emi2 is essential to keep oocytes arrested until fertilization. However, how this arrest is implemented exclusively in meiosis II and not prematurely in meiosis I has until now remained enigmatic. Using mouse and frog oocytes, we show here that cyclin B3, an understudied B-type cyclin, is essential to keep Emi2 levels low in meiosis I. Direct phosphorylation of Emi2 at an evolutionarily highly conserved site by Cdk1/cyclin B3 targets Emi2 for degradation. In contrast, Cdk1/cyclin B1 is inefficient in Emi2 phosphorylation, and this provides a molecular explanation for the requirement of different B-type cyclins for oocyte maturation. Cyclin B3 degradation at exit from meiosis I enables Emi2 accumulation and thus timely arrest in meiosis II. Our findings illuminate the evolutionarily conserved mechanisms that control oocyte arrest for fertilization at the correct cell-cycle stage, which is essential for embryo viability.
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- 2022
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12. Reduced Interleukin-17-Expressing Cells in Cutaneous Melanoma
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Tosi, Anna, primary, Nardinocchi, Lavinia, additional, Carbone, Maria Luigia, additional, Capriotti, Lorena, additional, Pagani, Elena, additional, Mastroeni, Simona, additional, Fortes, Cristina, additional, Scopelliti, Fernanda, additional, Cattani, Caterina, additional, Passarelli, Francesca, additional, Rosato, Antonio, additional, D’Atri, Stefania, additional, Failla, Cristina Maria, additional, and Cavani, Andrea, additional
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- 2021
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13. Gliptin-associated bullous pemphigoid shows peculiar features of anti-BP180 and -BP230 humoral response: Results of a multicenter study
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Salemme, Adele, Fania, Luca, Scarabello, Alessandra, Caproni, Marzia, Marzano, Angelo Valerio, Cozzani, Emanuele, Feliciani, Claudio, De Simone, Clara, Papini, Manuela, Satta, Rosanna Rita, Parodi, Aurora, Mariotti, Feliciana, Lechiancole, Stefania, Genovese, Giovanni, Passarelli, Francesca, Festa, Francesca, Bellei, Barbara, Provini, Alessia, Donatella Sordi, Null, Pallotta, Sabatino, Abeni, Damiano, Mazzanti, Cinzia, Didona, Biagio, and Di Zenzo, Giovanni
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bullous pemphigoid ,epitope ,Dipeptidyl-Peptidase IV Inhibitors ,BP180 ,autoantibody ,gliptin ,humoral response ,Dermatology ,Non-Fibrillar Collagens ,Autoantigens ,Diabetes Mellitus, Type 2 ,Immunoglobulin G ,Pemphigoid, Bullous ,Humans ,Autoantibodies - Abstract
Recently, several case-control studies demonstrated an association between gliptins and bullous pemphigoid (BP) occurrence. However, data on the clinical and immunologic features of gliptin-associated bullous pemphigoid (GABP) are controversial.This study aimed to clinically and immunologically characterize a large cohort of GABP patients to get an insight into the pathophysiology of this emerging drug-induced variant of BP.Seventy-four GABP patients were prospectively enrolled and characterized from 9 different Italian dermatology units between 2013 and 2020.Our findings demonstrated the following in the GABP patients: (1) a noninflammatory phenotype, which is characterized by low amounts of circulating and skin-infiltrating eosinophils, is frequently found; (2) immunoglobulin (Ig)G, IgE, and IgA humoral responses to BP180 and BP230 antigens are reduced in frequency and titers compared with those in patients with idiopathic BP; (3) IgG reactivity targets multiple BP180 epitopes other than noncollagenous region 16A.A limitation of the study is that the control group did not comprise only type 2 diabetes mellitus patients with BP.GABP patients show peculiar features of anti-BP180 and -BP230 humoral responses, laying the foundation for diagnostic improvements and getting novel insights into understanding the mechanism of BP onset.
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- 2021
14. Clinical subtypes in Parkinson’s disease: the impact of MAPT haplotypes
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Di Battista, Maria Elena, Pascale, Esterina, Purcaro, Carlo, Passarelli, Francesca, Passarelli, Emanuela, Guglielmi, Renzo, Vanacore, Nicola, and Meco, Giuseppe
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- 2014
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15. Alcohol Dependence and Serotonin Transporter Functional Polymorphisms 5-HTTLPR and rs25531 in an Italian Population
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Pascale, Esterina, Ferraguti, Giampiero, Codazzo, Claudia, Passarelli, Francesca, Mancinelli, Rosanna, Bonvicini, Cristian, Bruno, Sabina Maria, Lucarelli, Marco, and Ceccanti, Mauro
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- 2015
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16. β-Amyloid deposition in brain is enhanced in mouse models of arterial hypertension
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Gentile, Maria Teresa, Poulet, Roberta, Pardo, Alba Di, Cifelli, Giuseppe, Maffei, Angelo, Vecchione, Carmine, Passarelli, Francesca, Landolfi, Alessandro, Carullo, Pierluigi, and Lembo, Giuseppe
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- 2009
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17. Genetic polymorphism of Angiotensin-Converting Enzyme is not associated with the development of Parkinson's disease and of l-dopa-induced adverse effects
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Pascale, Esterina, Purcaro, Carlo, Passarelli, Emanuela, Guglielmi, Renzo, Vestri, Anna Rita, Passarelli, Francesca, and Meco, Giuseppe
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- 2009
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18. Pleomorphicskin eruptions in a COVID‐19 affected patient: Case report and review of the literature
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Scala, Enrico, primary, Fania, Luca, additional, Bernardini, Filippo, additional, Calarco, Rodolfo, additional, Chiloiro, Sabrina, additional, Di Campli, Cristiana, additional, Erculei, Sabrina, additional, Giani, Mauro, additional, Giordano, Marzia, additional, Panebianco, Annarita, additional, Passarelli, Francesca, additional, Trovè, Andrea, additional, Verkhovskaia, Sofia, additional, Russo, Giandomenico, additional, Sgadari, Antonio, additional, Didona, Biagio, additional, and Abeni, Damiano, additional
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- 2021
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19. Opposite roles of dopamine and orexin in quinpirole-induced excessive drinking: a rat model of psychotic polydipsia
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Milella, Michele S., Passarelli, Francesca, De Carolis, Lorenza, Schepisi, Chiara, Nativio, Paola, Scaccianoce, Sergio, and Nencini, Paolo
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- 2010
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20. Amelanotic melanoma mimicking cutaneous epitheliomas
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Napolitano, Monica, Didona, Biagio, Passarelli, Francesca, Annessi, Giorgio, and Bono, Riccardo
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- 2014
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21. Pseudoangiomatous stromal hyperplasia: an unsuspected cause of anisomasty
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Pompeo, Fabio Santanelli di, Sorotos, Michail, Passarelli, Francesca, Berrino, Valeria, Firmani, Guido, Winters, H., Paolini, Guido, Pompeo, Fabio Santanelli di, Sorotos, Michail, Passarelli, Francesca, Berrino, Valeria, Firmani, Guido, Winters, H., and Paolini, Guido
- Abstract
Contains fulltext : 226135.pdf (Publisher’s version ) (Open Access)
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- 2020
22. Expression of vascular endothelial growth factor-C in primary cutaneous melanoma predicts sentinel lymph node positivity
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Cianfarani, Francesca, Mastroeni, Simona, Odorisio, Teresa, Passarelli, Francesca, Cattani, Caterina, Mannooranparampil, Thomas J., Fortes, Cristina, and Failla, Cristina M.
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- 2012
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23. Skin signs as early manifestations of Hutchinson-Gilford progeria syndrome
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d’Erme, Angelo Massimiliano, Gola, Maria Francesca, Paradisi, Mauro, Passarelli, Francesca, Milanesi, Nicola, and Gola, Massimo
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- 2012
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24. Timely diagnosis of cutaneous squamous cell carcinoma: the GPʼs role
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Renzi, Cristina, Mastroeni, Simona, Mannooranparampil, Thomas J, Passarelli, Francesca, and Pasquini, Paolo
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- 2011
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25. PLEOMORPHIC SKIN ERUPTIONS IN A COVID-19 AFFECTED PATIENT: CASE REPORT AND REVIEW OF THE LITERATURE
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Scala, Enrico, primary, Fania, Luca, additional, Bernardini, Filippo, additional, Calarco, Rodolfo, additional, Chiloiro, Sabrina, additional, Campli, Cristiana Di, additional, Erculei, Sabrina, additional, Giani, Mauro, additional, Giordano, Marzia, additional, Panebianco, Annarita, additional, Passarelli, Francesca, additional, Trovè, Andrea, additional, Verkhovskaia, Sofia, additional, Russo, Giandomenico, additional, Sgadari, Antonio, additional, Didona, Biagio, additional, and Abeni, Damiano, additional
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- 2020
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26. Reduction of T Lymphoma Cells and Immunological Invigoration in a Patient Concurrently Affected by Melanoma and Sezary Syndrome Treated With Nivolumab
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Narducci, Maria Grazia, primary, Tosi, Anna, additional, Frezzolini, Alessandra, additional, Scala, Enrico, additional, Passarelli, Francesca, additional, Bonmassar, Laura, additional, Monopoli, Alessandro, additional, Accetturi, Maria Pina, additional, Cantonetti, Maria, additional, Antonini Cappellini, Gian Carlo, additional, De Galitiis, Federica, additional, Rosato, Antonio, additional, Picozza, Mario, additional, Russo, Giandomenico, additional, and D’Atri, Stefania, additional
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- 2020
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27. Multiple Skin Squamous Cell Carcinomas in Junctional Epidermolysis Bullosa Due to Altered Laminin-332 Function
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Fortugno, Paola, primary, Condorelli, Angelo Giuseppe, additional, Dellambra, Elena, additional, Guerra, Liliana, additional, Cianfarani, Francesca, additional, Tinaburri, Lavinia, additional, Proto, Vittoria, additional, De Luca, Naomi, additional, Passarelli, Francesca, additional, Ricci, Francesca, additional, Zambruno, Giovanna, additional, and Castiglia, Daniele, additional
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- 2020
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28. Pseudoangiomatous stromal hyperplasia: an unsuspected cause of anisomasty
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Santanelli di Pompeo, Fabio, primary, Sorotos, Michail, additional, Passarelli, Francesca, additional, Berrino, Valeria, additional, Firmani, Guido, additional, Winters, Harm, additional, and Paolini, Guido, additional
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- 2020
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29. Factors associated with large cutaneous squamous cell carcinomas
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Renzi, Cristina, Mastroeni, Simona, Passarelli, Francesca, Mannooranparampil, Thomas J., Caggiati, Alessio, Potenza, Clemente, and Pasquini, Paolo
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- 2010
30. Functional correlates of nicotine administration: similarity with drugs of abuse
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Pontieri, F. E., Passarelli, Francesca, Calò, Laura, and Caronti, Brunella
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- 1998
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31. An old disease makes a comeback
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Noto, Pasquale, Boumis, Evangelo, Passarelli, Francesca, and Licci, Stefano
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- 2008
32. The integrated care pathway for melanoma: the Istituto Dermopatico dell’Immacolata experience in Rome
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Ricci, Francesco, Caggiati, Alessio, Ziparo, Vincenzo, Elia, Maurizio, Russo, Giandomenico, D'Atri, Stefania, Failla, Cristina Maria, Panebianco, Annarita, Annessi, Giorgio, Passarelli, Francesca, Perez, Marie, Tartaglione, Tommaso, Di Lella, Giovanni, Pallotta, Sabatino, Mazzanti, Cinzia, Nudo, Maurizio, Fortes, Cristina, Abeni, Damiano, De Galitiis, Federica, and Marchetti, Paolo
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lcsh:R ,Continuity of care ,lcsh:Medicine ,Patient care ,Integrated Care Pathway ,Melanoma - Abstract
Introduction: The Integrated Care Pathway (ICP) represents a multidisciplinary outline of anticipated care, placed in an appropriate timeframe, to support patients with specific conditions or symptoms. The aim of this paper is to define the ICP for patients with melanoma referring to the “Istituto Dermopatico dell’Immacolata-IRCCS di Roma e Villa Paola” (“Center”). Methods and results: A multidisciplinary group (oncologists, dermatologists, surgeons, pathologists etc.) was defined as well as a facilitator to act as a link between all experts. The first step of ICP development was a review of current practice for patients with melanoma referring to the Center. This first step had the scope to define the multidisciplinary process map (a “picture” of the care plan) for patients with melanoma. The process map defined: i) the activities performed during delivery of care to the patients, ii) the responsibilities for these activities and iii) potential problem areas or opportunities for improvements. The process map formed the basis of the final ICP document. Conclusion: The adoption of melanoma ICP will allow the multidisciplinary group to ensure that clinical guidelines and available evidence are incorporated into everyday practice. (Oncology, HTA & Market Access)
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- 2019
33. The integrated care pathway for melanoma: the Istituto Dermopatico dell’Immacolata experience in Rome: Il percorso diagnostico terapeutico e assistenziale nella gestione del paziente con melanoma cutaneo: l’esperienza dell’IDI di Roma
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Ricci, Francesco, Caggiati, Alessio, Ziparo, Vincenzo, Elia, Maurizio, Russo, Giandomenico, D'Atri, Stefania, Failla, Cristina Maria, Panebianco, Annarita, Annessi, Giorgio, Passarelli, Francesca, Perez, Marie, Tartaglione, Tommaso, Di Lella, Giovanni, Pallotta, Sabatino, Mazzanti, Cinzia, Nudo, Maurizio, Fortes, Cristina, Abeni, Damiano, De Galitiis, Federica, Marchetti, Paolo, Ricci, Francesco, Caggiati, Alessio, Ziparo, Vincenzo, Elia, Maurizio, Russo, Giandomenico, D'Atri, Stefania, Failla, Cristina Maria, Panebianco, Annarita, Annessi, Giorgio, Passarelli, Francesca, Perez, Marie, Tartaglione, Tommaso, Di Lella, Giovanni, Pallotta, Sabatino, Mazzanti, Cinzia, Nudo, Maurizio, Fortes, Cristina, Abeni, Damiano, De Galitiis, Federica, and Marchetti, Paolo
- Abstract
Introduction: The Integrated Care Pathway (ICP) represents a multidisciplinary outline of anticipated care, placed in an appropriate timeframe, to support patients with specific conditions or symptoms. The aim of this paper is to define the ICP for patients with melanoma referring to the “Istituto Dermopatico dell’Immacolata-IRCCS di Roma e Villa Paola” (“Center”). Methods and results: A multidisciplinary group (oncologists, dermatologists, surgeons, pathologists etc.) was defined as well as a facilitator to act as a link between all experts. The first step of ICP development was a review of current practice for patients with melanoma referring to the Center. This first step had the scope to define the multidisciplinary process map (a “picture” of the care plan) for patients with melanoma. The process map defined: i) the activities performed during delivery of care to the patients, ii) the responsibilities for these activities and iii) potential problem areas or opportunities for improvements. The process map formed the basis of the final ICP document. Conclusion: The adoption of melanoma ICP will allow the multidisciplinary group to ensure that clinical guidelines and available evidence are incorporated into everyday practice. (Oncology, HTA & Market Access)
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- 2019
34. Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium
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Granata, Filippo, Potenza, Rossella Luisa, Fiori, Anna, Strom, Roberto, Caronti, Brunella, Molinari, Paola, Donsante, Sonia, Citro, Gennaro, Iacovelli, Luisa, De Blasi, Antonio, Ngomba, Richard T., Palladini, Guido, and Passarelli, Francesca
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- 2003
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35. Metabotropic glutamate receptor 5 (mGluR5)-mediated phosphoinositide hydrolysis and NMDA-potentiating effects are blunted in the striatum of aged rats: a possible additional mechanism in striatal senescence
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Domenici, Maria Rosaria, Pintor, Annita, Potenza, Rosa Luisa, Gaudi, Simona, Grò, Maria Cristina, Passarelli, Francesca, Reggio, Rosaria, Galluzzo, Mariangela, Massotti, Marino, and Popoli, Patrizia
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- 2003
36. Integrated care pathways and the hub-and-spoke model for the management of non-melanoma skin cancer: A proposal of the Italian Association of Hospital Dermatologists (ADOI).
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Fania, Luca, Massone, Cesare, Cusano, Francesco, Fantini, Fabrizio, Dellambra, Elena, Samela, Tonia, Passarelli, Francesca, Morese, Roberto, Tartaglione, Tommaso, Maggiore, Marino, Gentile, Piercarlo, Osti, Mattia Falchetto, Sampogna, Francesca, Pallotta, Sabatino, Abeni, Damiano, Marchetti, Paolo, and Naldi, Luigi
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SKIN cancer ,PRECANCEROUS conditions ,INTEGRATIVE medicine ,BASAL cell carcinoma ,ACTINIC keratosis ,MEDICAL quality control ,DERMATOLOGISTS - Abstract
The term non-melanoma skin cancer (NMSC) refers to skin cancer different from melanoma, and it is usually restricted to basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and their pre-cancerous lesions, e.g., actinic keratosis. These conditions represent the most frequent tumors in Caucasians and are characterized by an increasing incidence worldwide and a high socio-economic impact. The term Integrated Care Pathway (ICP) refers to "a complex intervention for the mutual decision making and organization of care processes for a well-defined group of patients during a well-defined period". The purpose of this paper is to present a proposal from the Italian Association of Hospital Dermatologists (ADOI) for an ICP organization of care of NMSC, considering the hub-and-spoke model in the different geographical areas. This proposal is based on the most recent literature and on documents from the Italian Association of Medical Oncology (AIOM), the European consensus-based interdisciplinary guidelines from the European Association of Dermato-Oncology (EADO), and the National Comprehensive Cancer Network (NCCN). We initially discuss the NMSC outpatient clinic, the role of the multidisciplinary working groups, and the hub-and-spoke model regarding this topic. Then, we define the ICP processes specific for BCC and SCC. The ICP for NMSC is an innovative strategy to guarantee the highest possible quality of health care while the hub-andspoke model is crucial for the organization of different health care structures. Considering the importance on this topic, it is essential to create a valid ICP together with an efficient organization within the different geographical areas. [ABSTRACT FROM AUTHOR]
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- 2021
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37. integrated care pathway for melanoma: the Istituto Dermopatico dell’Immacolata experience in Rome
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Ricci, Francesco, primary, Caggiati, Alessio, additional, Ziparo, Vincenzo, additional, Elia, Maurizio, additional, Russo, Giandomenico, additional, D'Atri, Stefania, additional, Failla, Cristina Maria, additional, Panebianco, Annarita, additional, Annessi, Giorgio, additional, Passarelli, Francesca, additional, Perez, Marie, additional, Tartaglione, Tommaso, additional, Di Lella, Giovanni, additional, Pallotta, Sabatino, additional, Mazzanti, Cinzia, additional, Nudo, Maurizio, additional, Fortes, Cristina, additional, Abeni, Damiano, additional, De Galitiis, Federica, additional, and Marchetti, Paolo, additional
- Published
- 2019
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38. Severe forms of hidradenitis suppurativa with complications in the anogenital area
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Fania, Luca, primary, Caggiati, Alessio, additional, Laporta, Rosaria, additional, Nicodemi, Ezio Maria, additional, Passarelli, Francesca, additional, Fusari, Roberta, additional, Mazzanti, Cinzia, additional, and Abeni, Damiano, additional
- Published
- 2019
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39. Blood and skin-derived Sezary cells: differences in proliferation-index, activation of PI3K/AKT/mTORC1 pathway and its prognostic relevance
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Cristofoletti, Cristina, primary, Bresin, Antonella, additional, Picozza, Mario, additional, Picchio, Maria Cristina, additional, Monzo, Francesca, additional, Helmer Citterich, Mauro, additional, Passarelli, Francesca, additional, Frezzolini, Alessandra, additional, Scala, Enrico, additional, Monopoli, Alessandro, additional, Cantonetti, Maria, additional, Benucci, Roberto, additional, D’Atri, Stefania, additional, Caprini, Elisabetta, additional, Russo, Giandomenico, additional, and Narducci, Maria Grazia, additional
- Published
- 2018
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40. Análisis económico del transfuguismo político
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Passarelli, Francesca, González, Paula, and Puy Segura, Socorro
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Transfugismo político ,Partidos políticos ,España ,Consecuencias económicas - Abstract
Programa de Doctorado en Economía, La presente Tesis Doctoral se enmarca en la literatura de la Economía Política y se compone de tres capítulos independientes ( además de un primer capítulo introductorio) en los que se lleva a cabo un estudio del fenómeno político, conocido como transfuguismo, desde una perspectiva de análisis económico. El Capítulo 1 ofrece una introducción al fenómeno del transfuguismo y una ubicación del mismo en el correspondiente marco teórico doctrinal. El Capítulo 2 ofrece un análisis teórico comparativo del transfuguismo en dos escenarios políticos diferentes. La motivación para la realización de este capítulo surge del análisis del poder otorgado a los partidos políticos durante la historia de la democracia en España. Hasta 1983 los políticos legislaban bajo una fuerte disciplina de partido. A partir de esta fecha, se produce un cambio en la jurisprudencia constitucional (Sentencias del TC, 1983), que reconoce la titularidad del escaño al candidato electo y los partidos pierden el poder de control sobre sus miembros. Por tanto, se analiza un primer escenario en el que existe una fuerte disciplina de partido y donde aquellos políticos que no apoyan la línea política del partido al que pertenecen se enfrentan a una sanción "disciplinaria" (por ejemplo, la expulsión de los mismos del partido o la dimisión en el parlamento). Se analiza posteriormente un segundo escenario en el que dicha disciplina es débil o inexistente, de forma que los que incurren en comportamientos tránsfugas no sufren consecuencias en la titularidad del escaño. La finalidad última del Capítulo es analizar cómo el comportamiento tránsfuga puede verse afectado por la disciplina de partido y conjuntamente investigar si estos eventuales comportamientos tránsfugas pueden afectar a la decisión de los propios partidos a la hora de anunciar la localización de sus plataformas políticas. Ello permitirá comparar los resultados de este capítulo con el resultado clásico de Downs (1957) que sugiere que los partidos fijarán políticas moderadas para atraer el mayor número de votos posibles y, por tanto, se situarán en el centro del espectro político. Para abordar estos objetivos se utiliza un modelo de competencia electoral bipartidista de tipo Downsiano, en el que coexisten motivaciones tanto ideológicas como psicológicas en el comportamiento de los políticos (basadas en la ambición y/o la reputación). En una primera etapa, los partidos políticos establecen su posición electoral en el espectro político. En la segunda etapa los candidatos deben decidir con qué partido concurren a las elecciones. Posteriormente, los candidatos electos deciden si apoyar la línea política del mismo o apoyar la del otro partido, convirtiéndose en el segundo caso en tránsfugas. Los resultados apuntan a que los comportamientos tránsfugas sólo emergen en el escenario con disciplina de partido débil, y además muestran que el partido con ventaja electoral es la alternativa que satisface a aquellos candidatos con fuertes motivaciones ambiciosas. Por otro lado, se encuentra que cuando los motivos oportunistas de los candidatos ambiciosos son elevados, los partidos tienen incentivos a constituir plataformas políticas diferenciadas. En otro caso, los partidos convergerán al centro político, satisfaciéndose el resultado estándar de convergencia de Downs, mencionado anteriormente. Por último, se muestra que el escenario donde existe una disciplina de partido débil es más favorable si se quiere alcanzar la convergencia entre las dos plataformas políticas. Bajo una fuerte disciplina de partido, sólo se logra la convergencia de las dos plataformas políticas si las oportunidades de ambición relativas de los candidatos son suficientemente bajas. En el Capítulo 3 se extiende el modelo de base diseñado en el segundo Capítulo de la Tesis Doctoral. En el Capítulo 2 los candidatos podían adoptar conductas tránsfugas concurriendo a las elecciones con un partido político y, posteriormente, apoyando la línea política del otro partido. En este tercer capítulo se incluye la posibilidad de que los candidatos electorales, una vez elegidos, decidan romper la disciplina de su partido para implementar una política nueva, que no se corresponda con ninguna de las dos propuestas por los partidos ya existentes. Este tipo de conductas tránsfugas se corresponde con el patrón más generalizado en la vida política española. Se trata de aquellos casos protagonizados por representantes políticos que rompen la disciplina de su propio partido no para unirse a las filas del partido político rival en las elecciones, sino para crear una formación política independiente y agruparse en el grupo Mixto. El objetivo del Capítulo 3 de esta Tesis Doctoral es, por tanto, analizar los incentivos de los candidatos electos a convertirse en independientes y representar a una nueva formación. Los resultados apuntan a que surgen diferencias significativas respecto a los incentivos de los candidatos encontrados en el Capítulo 2. Por un lado, mientras que en el modelo de base sólo surgían tránsfugas en las filas del partido que presentaba ventaja electoral, ahora pueden surgir conductas tránsfugas en ambos partidos. Esto está relacionado con el hecho de que en este nuevo escenario el transfuguismo resulta más atractivo para el político. Como ahora los candidatos electos tienen la libertad de moverse hacia aquella posición política que les es más afín a su ideología, el transfuguismo no surge sólo por motivaciones oportunistas, sino también por motivaciones puramente ideológicas. El hecho de que puedan "graduar" el nivel de transfuguismo (la distancia ideológica a la que se sitúen con respecto al partido con el que concurrieron a las elecciones) reduce el coste de reputación asociado al transfuguismo y favorece la existencia del mismo. Por otro lado, los resultados dan lugar a dos escenarios distintos. Si bien en ambos escenarios los candidatos que tienen incentivos para hacer transfuguismo son aquellos que se sitúan en los extremos del espectro ideológico, sólo en uno de ellos surgen incentivos a comportamientos tránsfugas para los candidatos del centro político. Finalmente, el Capítulo 4 presenta un ejercicio empírico para cuantificar el fenómeno del transfuguismo en España. En concreto, este capítulo estima la frecuencia del transfuguismo en el panorama local de los municipios españoles. La decisión de trabajar con datos municipales se debe al hecho de que en España la aparición de conductas tránsfugas es mucho más frecuente en el ámbito local. Partiendo de la información facilitada por el Ministerio del Interior sobre los resultados de las elecciones municipales en España de los años 2003, 2007 y 2011, se ha construido una rica base de datos que ha sido la fuente del análisis realizado en este capítulo. Dicha base de datos se ha completado además con información del Instituto Nacional de Estadística referente a las características sociodemográficas de los municipios españoles. No disponiendo de la información acerca de los movimientos de candidatos tránsfugas durante el transcurso de las legislaturas, el estudio se enfoca en los cambios de partido realizados por los candidatos entre una legislatura y otra. Se realiza un análisis descriptivo de los datos y una posterior regresión logística para tratar de entender la incidencia y los patrones de conducta de los fenómenos de movilidad entre partidos en España. El objetivo es estimar la probabilidad del transfuguismo en el contexto de los municipios de España, y analizar sus correlaciones con ciertas variables cuantitativas y cualitativas. Para ello, utilizamos un modelo de regresión logística, cuya implementación y desarrollo de su estimación ha sido realizado mediante el lenguaje de programación específico del paquete estadístico Stata. Se pretende dar respuesta a una variedad de cuestiones. Para ello se estudia si existe relación entre el sexo de los candidatos, su ideología, sus motivaciones oportunistas, así como los factores geográficos y socioeconómicos de los municipios españoles y la ocurrencia del fenómeno de transfuguismo. Los resultados del análisis demuestran que: i) los hombres son más proclives a cambiar partido que las mujeres; ii) aquellos candidatos que habían obtenido el escaño en su última candidatura política son menos dispuestos a cambiarse de partido, mientras que resultar electo en el año de elección en el que un candidato se ha cambiado de partido está relacionado positivamente con la ocurrencia de conductas tránsfugas; iii) los candidatos afiliados a partidos de centro o de extrema derecha presentan mayor inclinación a cambiarse de partido, mientras que los candidatos de izquierda resultan los menos probables en incurrir en movimientos entre partidos; iv) los candidatos que pertenecen a capitales de provincias son menos proclives a hacer transfuguismo, mientras que los que se presentan como representantes de municipios con alta renta per cápita son más probables en incurrir en conductas tránsfugas que los que pertenecen a municipios de renta media y de renta baja; v) las conductas tránsfugas emergen con mayor frecuencia en los municipios con población inferior a 1.000 habitantes y resulta que hay una relación negativa entre la ocurrencia del fenómeno del transfuguismo y el tamaño de la población de los municipios españoles. Este último resultado nos parece particularmente interesante pues consideramos que se debe a que las asuntos que normalmente están al centro del debate político de las pequeñas realidades, como son los pueblos, van más allá de lo que es la lucha de partidos, pues se sitúan en ámbitos en donde las decisiones que se adoptan rompen con la ideología de los partidos. Esto nos lleva a concluir que los políticos de municipios más pequeños tienen mayores incentivos en cambiarse de partido, porque reciben menores "castigos" por parte de sus electores respeto a las ciudades grandes: los ciudadanos de estos municipios tienen en cuenta otras características del político más bien que su lealtad a la afiliación política., Universidad Pablo de Olavide. Departamento de Economía, Métodos Cuantitativos e Historia Económica, Postprint
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41. Topical Plant Polyphenols Prevent Type I Interferon Signaling in the Skin and Suppress Contact Hypersensitivity
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Carbone, Maria, primary, Lulli, Daniela, additional, Passarelli, Francesca, additional, and Pastore, Saveria, additional
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- 2018
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42. Recurrent Sweet's syndrome in a patient with multiple myeloma
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Gurnari, Carmelo, primary, Franceschini, Luca, additional, Anemona, Lucia, additional, Passarelli, Francesca, additional, Vaccarini, Sara, additional, Pupo, Livio, additional, Provenzano, Ida, additional, Nasso, Daniela, additional, Rizzo, Manuela, additional, and Cantonetti, Maria, additional
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- 2018
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43. Abstract 761: The role of PI3 kinase pathway in the the skin of Sezary syndrome
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Cristofoletti, Cristina, primary, Bresin, Antonella, additional, Picozza, Mario, additional, Picchio, Maria Cristina, additional, Passarelli, Francesca, additional, Monzo, Francesca, additional, Citterich, Mauro Helmer, additional, Monopoli, Alessandro, additional, Benucci, Roberto, additional, Cantonetti, Maria, additional, Frezzolini, Alessandra, additional, Scala, Enrico, additional, Caprini, Elisabetta, additional, Russo, Giandomenico, additional, and Narducci, Maria Grazia, additional
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- 2018
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44. “Interdigital pilonidal sinus in a hairdresser” a case report
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Ricci, Francesco, primary, Passarelli, Francesca, additional, Fiorentini, Stefano, additional, and Di Lella, Giovanni, additional
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- 2018
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45. Opioid–dopamine interaction in planaria: a behavioral study
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Passarelli, Francesca, Merante, Angelo, Pontieri, Francesco E., Margotta, Vito, Venturini, Giorgio, and Palladini, Guido
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- 1999
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46. Effects of haloperidol on the expression of lymphocyte dopamine receptor mRNAS in the rat
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Caronti, Brunella, Passarelli, Francesca, Calderaro, Caterina, Palladini, Guido, and Pontieri, Francesco E.
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47. Melanoma and immunotherapy bridge 2015
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Nanda, Vashisht G. Y., Peng, Weiyi, Hwu, Patrick, Davies, Michael A., Ciliberto, Gennaro, Fattore, Luigi, Malpicci, Debora, Aurisicchio, Luigi, Ascierto, Paolo Antonio, Croce, Carlo M., Mancini, Rita, Spranger, Stefani, Gajewski, Thomas F., Wang, Yangyang, Ferrone, Soldano, Vanpouille-Box, Claire, Wennerberg, Erik, Pilones, Karsten A., Formenti, Silvia C., Demaria, Sandra, Tang, Haidong, Wang, Yang, Fu, Yang-Xin, Dummer, Reinhard, Puzanov, Igor, Tarhini, Ahmad, Chauvin, Joe-Marc, Pagliano, Ornella, Fourcade, Julien, Sun, Zhaojun, Wang, Hong, Sanders, Cindy, Kirkwood, John M., Chen, Tseng-hui Timothy, Maurer, Mark, Korman, Alan J., Zarour, Hassane M., Stroncek, David F., Huber, Veronica, Rivoltini, Licia, Thurin, Magdalena, Rau, Tilman, Lugli, Alessandro, Pagès, Franck, Camarero, Jorge, Sancho, Arantxa, Jommi, Claudio, de Coaña, Yago Pico, Wolodarski, Maria, Yoshimoto, Yuya, Gentilcore, Giusy, Poschke, Isabel, Masucci, Giuseppe V., Hansson, Johan, Kiessling, Rolf, Scognamiglio, Giosuè, Sabbatino, Francesco, Marino, Federica Zito, Anniciello, Anna Maria, Cantile, Monica, Cerrone, Margherita, Scala, Stefania, D’alterio, Crescenzo, Ianaro, Angela, Cirin, Giuseppe, Liguori, Giuseppina, Bott, Gerardo, Chapman, Paul B., Robert, Caroline, Larkin, James, Haanen, John B., Ribas, Antoni, Hogg, David, Hamid, Omid, Testori, Alessandro, Lorigan, Paul, Sosman, Jeffrey A., Flaherty, Keith T., Yue, Huibin, Coleman, Shelley, Caro, Ivor, Hauschild, Axel, McArthur, Grant A., Sznol, Mario, Callahan, Margaret K., Kluger, Harriet, Postow, Michael A., Gordan, RuthAnn, Segal, Neil H., Rizvi, Naiyer A., Lesokhin, Alexander, Atkins, Michael B., Burke, Matthew M., Ralabate, Amanda, Rivera, Angel, Kronenberg, Stephanie A., Agunwamba, Blessing, Ruisi, Mary, Horak, Christine, Jiang, Joel, Wolchok, Jedd, Ascierto, Paolo A., Liszkay, Gabriella, Maio, Michele, Mandalà, Mario, Demidov, Lev, Stoyakovskiy, Daniil, Thomas, Luc, de la Cruz-Merino, Luis, Atkinson, Victoria, Dutriaux, Caroline, Garbe, Claus, Wongchenko, Matthew, Chang, Ilsung, Koralek, Daniel O., Rooney, Isabelle, Yan, Yibing, Dréno, Brigitte, Sullivan, Ryan, Patel, Manish, Hodi, Stephen, Amaria, Rodabe, Boasberg, Peter, Wallin, Jeffrey, He, Xian, Cha, Edward, Richie, Nicole, Ballinger, Marcus, Smith, David C., Bauer, Todd M., Wasser, Jeffrey S., Luke, Jason J., Balmanoukian, Ani S., Kaufman, David R., Zhao, Yufan, Maleski, Janet, Leopold, Lance, Gangadhar, Tara C., Long, Georgina V., Michielin, Olivier, VanderWalde, Ari, Andtbacka, Robert H. I., Cebon, Jonathan, Fernandez, Eugenio, Malvehy, Josep, Olszanski, Anthony J., Gause, Christine, Chen, Lisa, Chou, Jeffrey, Stephen Hodi, F., Brady, Benjamin, Mortier, Laurent, Hassel, Jessica C., Rutkowski, Piotr, McNeil, Catriona, Kalinka-Warzocha, Ewa, Lebbé, Celeste, Ny, Lars, Chacon, Matias, Queirolo, Paola, Loquai, Carmen, Cheema, Parneet, Berrocal, Alfonso, Eizmendi, Karmele Mujika, Bar-Sela, Gil, Hardy, Helene, Weber, Jeffrey S., Grob, Jean-Jacques, Marquez-Rodas, Ivan, Schmidt, Henrik, Briscoe, Karen, Baurain, Jean-François, Wolchok, Jedd D., Pinto, Rosamaria, De Summa, Simona, Garrisi, Vito Michele, Strippoli, Sabino, Azzariti, Amalia, Guida, Gabriella, Guida, Michele, Tommasi, Stefania, Jacquelot, Nicolas, Enot, David, Flament, Caroline, Pitt, Jonathan M., Vimond, Nadège, Blattner, Carolin, Yamazaki, Takahiro, Roberti, Maria-Paula, Vetizou, Marie, Daillere, Romain, Poirier-Colame, Vichnou, la Semeraro, Michaë, Caignard, Anne, Slingluff, Craig L, Sallusto, Federica, Rusakiewicz, Sylvie, Weide, Benjamin, Marabelle, Aurélien, Kohrt, Holbrook, Dalle, Stéphane, Cavalcanti, Andréa, Kroemer, Guido, Di Giacomo, Anna Maria, Maio, Michaele, Wong, Phillip, Yuan, Jianda, Umansky, Viktor, Eggermont, Alexander, Zitvogel, Laurence, Anna, Passarelli, Marco, Tucci, Stefania, Stucci, Francesco, Mannavola, Mariaelena, Capone, Gabriele, Madonna, Antonio, Ascierto Paolo, Franco, Silvestris, Roberti, María Paula, Enot, David P., Semeraro, Michaela, Jégou, Sarah, Flores, Camila, Kwon, Byoung S., Anderson, Ana Carrizossa, Borg, Christophe, Aubin, François, Ayyoub, Maha, De Presbiteris, Anna Lisa, Cordaro, Fabiola Gilda, Camerlingo, Rosa, Fratangelo, Federica, Mozzillo, Nicola, Pirozzi, Giuseppe, Patriarca, Eduardo J., Caputo, Emilia, Motti, Maria Letizia, Falcon, Rosaria, Miceli, Roberta, Capone, Mariaelena, Madonna, Gabriele, Mallardo, Domenico, Carrier, Maria Vincenza, Panza, Elisabetta, De Cicco, Paola, Armogida, Chiara, Ercolano, Giuseppe, Botti, Gerardo, Cirino, Giuseppe, Sandru, Angela, Blank, Miri, Balatoni, Timea, Olasz, Judit, Farkas, Emil, Szollar, Andras, Savolt, Akos, Godeny, Maria, Csuka, Orsolya, Horvath, Szabolcs, Eles, Klara, Shoenfeld, Yehuda, Kasler, Miklos, Costantini, Susan, Capone, Francesca, Moradi, Farnaz, Berglund, Pontus, Leandersson, Karin, Linnskog, Rickard, Andersson, Tommy, Prasad, Chandra Prakash, Nigro, Cristiana Lo, Lattanzio, Laura, Wang, Hexiao, Proby, Charlotte, Syed, Nelofer, Occelli, Marcella, Cauchi, Carolina, Merlano, Marco, Harwood, Catherine, Thompson, Alastair, Crook, Tim, Bifulco, Katia, Ingangi, Vincenzo, Minopoli, Michele, Ragone, Concetta, Pessi, Antonello, Mannavola, Francesco, D’Oronzo, Stella, Felici, Claudia, Tucci, Marco, Doronzo, Antonio, Silvestris, Franco, Ferretta, Anna, Guida, Stefania, Maida, Imma, Cocco, Tiziana, Passarelli, Anna, Quaresmini, Davide, Franzese, Ornella, Palermo, Belinda, Di Donna, Cosmo, Sperduti, Isabella, Foddai, MariaLaura, Stabile, Helena, Gismondi, Angela, Santoni, Angela, Nisticò, Paola, Sponghini, Andrea P., Platini, Francesca, Marra, Elena, Rondonotti, David, Alabiso, Oscar, Fierro, Maria T., Savoia, Paola, Stratica, Florian, Quaglino, Pietro, Di Monta, Gianluca, Corrado, Caracò, Di Marzo, Massimiliano, Ugo, Marone, Di Cecilia, Maria Luisa, Nicola, Mozzillo, Fusciello, Celeste, Marra, Antonio, Guarrasi, Rosario, Baldi, Carlo, Russo, Rosa, Di Giulio, Giovanni, Faiola, Vincenzo, Zeppa, Pio, Pepe, Stefano, Gambale, Elisabetta, Carella, Consiglia, Di Paolo, Alessandra, De Tursi, Michele, Marra, Laura, De Murtas, Fara, Sorrentino, Valeria, Voinea, Silviu, Panaitescu, Eugenia, Bolovan, Madalina, Stanciu, Adina, Cinca, Sabin, Botti, Chiara, Aquino, Gabriella, Anniciello, Annamaria, Fortes, Cristina, Mastroeni, Simona, Caggiati, Alessio, Passarelli, Francesca, Zappalà, Alba, Capuano, Maria, Bono, Riccardo, Nudo, Maurizio, Marino, Claudia, Michelozzi, Paola, De Biasio, Valeria, Battarra, Vincenzo C., Formenti, Silvia, Ascierto, Maria Libera, McMiller, Tracee L., Berger, Alan E., Danilova, Ludmila, Anders, Robert A., Netto, George J., Xu, Haiying, Pritchard, Theresa S., Fan, Jinshui, Cheadle, Chris, Cope, Leslie, Drake, Charles G., Pardoll, Drew M., Taube, Janis M., Topalian, Suzanne L., Gnjatic, Sacha, Nataraj, Sarah, Imai, Naoko, Rahman, Adeeb, Jungbluth, Achim A., Pan, Linda, Venhaus, Ralph, Park, Andrew, Lehmann, Frédéric F., Lendvai, Nikoletta, Cohen, Adam D., Cho, Hearn J., Daniel, Speiser, and Hirsh, Vera
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Medicine(all) ,Biochemistry, Genetics and Molecular Biology(all) ,Meeting Abstracts - Abstract
Table of contents MELANOMA BRIDGE 2015 KEYNOTE SPEAKER PRESENTATIONS Molecular and immuno-advances K1 Immunologic and metabolic consequences of PI3K/AKT/mTOR activation in melanoma Vashisht G. Y. Nanda, Weiyi Peng, Patrick Hwu, Michael A. Davies K2 Non-mutational adaptive changes in melanoma cells exposed to BRAF and MEK inhibitors help the establishment of drug resistance Gennaro Ciliberto, Luigi Fattore, Debora Malpicci, Luigi Aurisicchio, Paolo Antonio Ascierto, Carlo M. Croce, Rita Mancini K3 Tumor-intrinsic beta-catenin signaling mediates tumor-immune avoidance Stefani Spranger, Thomas F. Gajewski K4 Intracellular tumor antigens as a source of targets of antibody-based immunotherapy of melanoma Yangyang Wang, Soldano Ferrone Combination therapies K5 Harnessing radiotherapy to improve responses to immunotherapy in cancer Claire Vanpouille-Box, Erik Wennerberg, Karsten A. Pilones, Silvia C. Formenti, Sandra Demaria K6 Creating a T cell-inflamed tumor microenvironment overcomes resistance to checkpoint blockade Haidong Tang, Yang Wang, Yang-Xin Fu K7 Biomarkers for treatment decisions? Reinhard Dummer K8 Combining oncolytic therapies in the era of checkpoint inhibitors Igor Puzanov K9 Immune checkpoint blockade for melanoma: should we combine or sequence ipilimumab and PD-1 antibody therapy? Michael A. Postow News in immunotherapy K10 An update on adjuvant and neoadjuvant therapy for melanom Ahmad Tarhini K11 Targeting multiple inhibitory receptors in melanoma Joe-Marc Chauvin, Ornella Pagliano, Julien Fourcade, Zhaojun Sun, Hong Wang, Cindy Sanders, John M. Kirkwood, Tseng-hui Timothy Chen, Mark Maurer, Alan J. Korman, Hassane M. Zarour K12 Improving adoptive immune therapy using genetically engineered T cells David F. Stroncek Tumor microenvironment and biomarkers K13 Myeloid cells and tumor exosomes: a crosstalk for assessing immunosuppression? Veronica Huber, Licia Rivoltini K14 Update on the SITC biomarker taskforce: progress and challenges Magdalena Thurin World-wide immunoscore task force: an update K15 The immunoscore in colorectal cancer highlights the importance of digital scoring systems in surgical pathology Tilman Rau, Alessandro Lugli K16 The immunoscore: toward an integrated immunomonitoring from the diagnosis to the follow up of cancer’s patients Franck Pagès Economic sustainability of melanoma treatments: regulatory, health technology assessment and market access issues K17 Nivolumab, the regulatory experience in immunotherapy Jorge Camarero, Arantxa Sancho K18 Evidence to optimize access for immunotherapies Claudio Jommi ORAL PRESENTATIONS Molecular and immuno-advances O1 Ipilimumab treatment results in CD4 T cell activation that is concomitant with a reduction in Tregs and MDSCs Yago Pico de Coaña, Maria Wolodarski, Yuya Yoshimoto, Giusy Gentilcore, Isabel Poschke, Giuseppe V. Masucci, Johan Hansson, Rolf Kiessling O2 Evaluation of prognostic and therapeutic potential of COX-2 and PD-L1 in primary and metastatic melanoma Giosuè Scognamiglio, Francesco Sabbatino, Federica Zito Marino, Anna Maria Anniciello, Monica Cantile, Margherita Cerrone, Stefania Scala, Crescenzo D’alterio, Angela Ianaro, Giuseppe Cirino, Paolo Antonio Ascierto, Giuseppina Liguori, Gerardo Botti O3 Vemurafenib in patients with BRAFV600 mutation–positive metastatic melanoma: final overall survival results of the BRIM-3 study Paul B. Chapman, Caroline Robert, James Larkin, John B. Haanen, Antoni Ribas, David Hogg, Omid Hamid, Paolo Antonio Ascierto, Alessandro Testori, Paul Lorigan, Reinhard Dummer, Jeffrey A. Sosman, Keith T. Flaherty, Huibin Yue, Shelley Coleman, Ivor Caro, Axel Hauschild, Grant A. McArthur O4 Updated survival, response and safety data in a phase 1 dose-finding study (CA209-004) of concurrent nivolumab (NIVO) and ipilimumab (IPI) in advanced melanoma Mario Sznol, Margaret K. Callahan, Harriet Kluger, Michael A. Postow, RuthAnn Gordan, Neil H. Segal, Naiyer A. Rizvi, Alexander Lesokhin, Michael B. Atkins, John M. Kirkwood, Matthew M. Burke, Amanda Ralabate, Angel Rivera, Stephanie A. Kronenberg, Blessing Agunwamba, Mary Ruisi, Christine Horak, Joel Jiang, Jedd Wolchok Combination therapies O5 Efficacy and correlative biomarker analysis of the coBRIM study comparing cobimetinib (COBI) + vemurafenib (VEM) vs placebo (PBO) + VEM in advanced BRAF-mutated melanoma patients (pts) Paolo A. Ascierto, Grant A. McArthur, James Larkin, Gabriella Liszkay, Michele Maio, Mario Mandalà, Lev Demidov, Daniil Stoyakovskiy, Luc Thomas, Luis de la Cruz-Merino, Victoria Atkinson, Caroline Dutriaux, Claus Garbe, Matthew Wongchenko, Ilsung Chang, Daniel O. Koralek, Isabelle Rooney, Yibing Yan, Antoni Ribas, Brigitte Dréno O6 Preliminary clinical safety, tolerability and activity results from a Phase Ib study of atezolizumab (anti-PDL1) combined with vemurafenib in BRAFV600-mutant metastatic melanoma Ryan Sullivan, Omid Hamid, Manish Patel, Stephen Hodi, Rodabe Amaria, Peter Boasberg, Jeffrey Wallin, Xian He, Edward Cha, Nicole Richie, Marcus Ballinger, Patrick Hwu O7 Preliminary safety and efficacy data from a phase 1/2 study of epacadostat (INCB024360) in combination with pembrolizumab in patients with advanced/metastatic melanoma Thomas F. Gajewski, Omid Hamid, David C. Smith, Todd M. Bauer, Jeffrey S. Wasser, Jason J. Luke, Ani S. Balmanoukian, David R. Kaufman, Yufan Zhao, Janet Maleski, Lance Leopold, Tara C. Gangadhar O8 Primary analysis of MASTERKEY-265 phase 1b study of talimogene laherparepvec (T-VEC) and pembrolizumab (pembro) for unresectable stage IIIB-IV melanoma Reinhard Dummer, Georgina V. Long, Antoni Ribas, Igor Puzanov, Olivier Michielin, Ari VanderWalde, Robert H.I. Andtbacka, Jonathan Cebon, Eugenio Fernandez, Josep Malvehy, Anthony J. Olszanski, Thomas F. Gajewski, John M. Kirkwood, Christine Gause, Lisa Chen, David R. Kaufman, Jeffrey Chou, F. Stephen Hodi News in immunotherapy O9 Two-year survival and safety update in patients (pts) with treatment-naïve advanced melanoma (MEL) receiving nivolumab (NIVO) or dacarbazine (DTIC) in CheckMate 066 Victoria Atkinson, Paolo A. Ascierto, Georgina V. Long, Benjamin Brady, Caroline Dutriaux, Michele Maio, Laurent Mortier, Jessica C. Hassel, Piotr Rutkowski, Catriona McNeil, Ewa Kalinka-Warzocha, Celeste Lebbé, Lars Ny, Matias Chacon, Paola Queirolo, Carmen Loquai, Parneet Cheema, Alfonso Berrocal, Karmele Mujika Eizmendi, Luis De La Cruz-Merino, Gil Bar-Sela, Christine Horak, Joel Jiang, Helene Hardy, Caroline Robert O10 Efficacy and safety of nivolumab (NIVO) in patients (pts) with advanced melanoma (MEL) who were treated beyond progression in CheckMate 066/067 Georgina V. Long, Jeffrey S. Weber, James Larkin, Victoria Atkinson, Jean-Jacques Grob, Reinhard Dummer, Caroline Robert, Ivan Marquez-Rodas, Catriona McNeil, Henrik Schmidt, Karen Briscoe, Jean-François Baurain, F. Stephen Hodi, Jedd D. Wolchok Tumor microenvironment and biomarkers O11 New biomarkers for response/resistance to BRAF inhibitor therapy in metastatic melanoma Rosamaria Pinto, Simona De Summa, Vito Michele Garrisi, Sabino Strippoli, Amalia Azzariti, Gabriella Guida, Michele Guida, Stefania Tommasi O12 Chemokine receptor patterns in lymphocytes mirror metastatic spreading in melanoma and response to ipilimumab Nicolas Jacquelot, David Enot, Caroline Flament, Jonathan M. Pitt, Nadège Vimond, Carolin Blattner, Takahiro Yamazaki, Maria-Paula Roberti, Marie Vetizou, Romain Daillere, Vichnou Poirier-Colame, Michaëla Semeraro, Anne Caignard, Craig L Slingluff Jr, Federica Sallusto, Sylvie Rusakiewicz, Benjamin Weide, Aurélien Marabelle, Holbrook Kohrt, Stéphane Dalle, Andréa Cavalcanti, Guido Kroemer, Anna Maria Di Giacomo, Michaele Maio, Phillip Wong, Jianda Yuan, Jedd Wolchok, Viktor Umansky, Alexander Eggermont, Laurence Zitvogel O13 Serum levels of PD1- and CD28-positive exosomes before Ipilimumab correlate with therapeutic response in metastatic melanoma patients Passarelli Anna, Tucci Marco, Stucci Stefania, Mannavola Francesco, Capone Mariaelena, Madonna Gabriele, Ascierto Paolo Antonio, Silvestris Franco O14 Immunological prognostic factors in stage III melanomas María Paula Roberti, Nicolas Jacquelot, David P Enot, Sylvie Rusakiewicz, Michaela Semeraro, Sarah Jégou, Camila Flores, Lieping Chen, Byoung S. Kwon, Ana Carrizossa Anderson, Caroline Robert, Christophe Borg, Benjamin Weide, François Aubin, Stéphane Dalle, Michele Maio, Jedd D. Wolchok, Holbrook Kohrt, Maha Ayyoub, Guido Kroemer, Aurélien Marabelle, Andréa Cavalcanti, Alexander Eggermont, Laurence Zitvogel POSTER PRESENTATIONS Molecular and immuno-advances P1 Human melanoma cells resistant to B-RAF and MEK inhibition exhibit mesenchymal-like features Anna Lisa De Presbiteris, Fabiola Gilda Cordaro, Rosa Camerlingo, Federica Fratangelo, Nicola Mozzillo, Giuseppe Pirozzi, Eduardo J. Patriarca, Paolo A. Ascierto, Emilia Caputo P2 Anti-proliferative and pro-apoptotic effect of ABT888 on melanoma cell lines and its potential role in the treatment of melanoma resistant to B-RAF inhibitors Federica Fratangelo, Rosa Camerlingo, Emilia Caputo, Maria Letizia Motti, Rosaria Falcone, Roberta Miceli, Mariaelena Capone, Gabriele Madonna, Domenico Mallardo, Maria Vincenza Carriero, Giuseppe Pirozzi and Paolo Antonio Ascierto P3 Involvement of the L-cysteine/CSE/H2S pathway in human melanoma progression Elisabetta Panza, Paola De Cicco, Chiara Armogida, Giuseppe Ercolano, Rosa Camerlingo, Giuseppe Pirozzi, Giosuè Scognamiglio, Gerardo Botti, Giuseppe Cirino, Angela Ianaro P4 Cancer stem cell antigen revealing pattern of antibody variable region genes were defined by immunoglobulin repertoire analysis in patients with malignant melanoma Beatrix Kotlan, Gabriella Liszkay, Miri Blank, Timea Balatoni, Judit Olasz, Emil Farkas, Andras Szollar, Akos Savolt, Maria Godeny, Orsolya Csuka, Szabolcs Horvath, Klara Eles, Yehuda Shoenfeld and Miklos Kasler P5 Upregulation of Neuregulin-1 expression is a hallmark of adaptive response to BRAF/MEK inhibitors in melanoma Debora Malpicci, Luigi Fattore, Susan Costantini, Francesca Capone, Paolo Antonio Ascierto, Rita Mancini, Gennaro Ciliberto P6 HuR positively regulates migration of HTB63 melanoma cells Farnaz Moradi, Pontus Berglund, Karin Leandersson, Rickard Linnskog, Tommy Andersson, Chandra Prakash Prasad P7 Prolyl 4- (C-P4H) hydroxylases have opposing effects in malignant melanoma: implication in prognosis and therapy Cristiana Lo Nigro, Laura Lattanzio, Hexiao Wang, Charlotte Proby, Nelofer Syed, Marcella Occelli, Carolina Cauchi, Marco Merlano, Catherine Harwood, Alastair Thompson, Tim Crook P8 Urokinase receptor antagonists: novel agents for the treatment of melanoma Maria Letizia Motti, Katia Bifulco, Vincenzo Ingangi, Michele Minopoli, Concetta Ragone, Federica Fratangelo, Antonello Pessi, Gennaro Ciliberto, Paolo Antonio Ascierto, Maria Vincenza Carriero P9 Exosomes released by melanoma cell lines enhance chemotaxis of primary tumor cells Francesco Mannavola, Stella D’Oronzo, Claudia Felici, Marco Tucci, Antonio Doronzo, Franco Silvestris P10 New insights in mitochondrial metabolic reprogramming in melanoma Anna Ferretta, Gabriella Guida, Stefania Guida, Imma Maida, Tiziana Cocco, Sabino Strippoli, Stefania Tommasi, Amalia Azzariti, Michele Guida P11 Lenalidomide restrains the proliferation in melanoma cells through a negative regulation of their cell cycle Stella D’Oronzo, Anna Passarelli, Claudia Felici, Marco Tucci, Davide Quaresmini, Franco Silvestris Combination therapies P12 Chemoimmunotherapy elicits polyfunctional anti-tumor CD8 + T cells depending on the activation of an AKT pathway sustained by ICOS Ornella Franzese, Belinda Palermo, Cosmo Di Donna, Isabella Sperduti, MariaLaura Foddai, Helena Stabile, Angela Gismondi, Angela Santoni, Paola Nisticò P13 Favourable toxicity profile of combined BRAF and MEK inhibitors in metastatic melanoma patients Andrea P. Sponghini, Francesca Platini, Elena Marra, David Rondonotti, Oscar Alabiso, Maria T. Fierro, Paola Savoia, Florian Stratica, Pietro Quaglino P14 Electrothermal bipolar vessel sealing system dissection reduces seroma output or time to drain removal following axillary and ilio-inguinal node dissection in melanoma patients: a pilot study Di Monta Gianluca, Caracò Corrado, Di Marzo Massimiliano, Marone Ugo, Di Cecilia Maria Luisa, Mozzillo Nicola News in immunotherapy P15 Clinical and immunological response to ipilimumab in a metastatic melanoma patient with HIV infection Francesco Sabbatino, Celeste Fusciello1, Antonio Marra, Rosario Guarrasi, Carlo Baldi, Rosa Russo, Di Giulio Giovanni, Vincenzo Faiola, Pio Zeppa, Stefano Pepe P16 Immunotherapy and hypophysitis: a case report Elisabetta Gambale, Consiglia Carella, Alessandra Di Paolo, Michele De Tursi Tumor microenvironment and biomarkers P17 New immuno- histochemical markers for the differential diagnosis of atypical melanocytic lesions with uncertain malignant potential Laura Marra, Giosuè Scognamiglio, Monica Cantile, Margherita Cerrone, Fara De Murtas, Valeria Sorrentino, Anna Maria Anniciello, Gerardo Botti P18 Utility of simultaneous measurement of three serum tumor markers in melanoma patients Angela Sandru, Silviu Voinea, Eugenia Panaitescu, Madalina Bolovan, Adina Stanciu, Sabin Cinca P19 The significance of various cut-off levels of melanoma inhibitory activity in evaluation of cutaneous melanoma patients Angela Sandru, Silviu Voinea, Eugenia Panaitescu, Madalina Bolovan, Adina Stanciu, Sabin Cinca P20 The long noncoding RNA HOTAIR is associated to metastatic progression of melanoma and it can be identified in the blood of patients with advanced disease Chiara Botti, Giosuè Scognamiglio, Laura Marra, Gabriella Aquino, Rosaria Falcone, Annamaria Anniciello, Paolo Antonio Ascierto, Gerardo Botti, Monica Cantile Other P21 The effect of Sentinel Lymph Node Biopsy in melanoma mortality: timing of dissection Cristina Fortes, Simona Mastroeni, Alessio Caggiati, Francesca Passarelli, Alba Zappalà, Maria Capuano, Riccardo Bono, Maurizio Nudo, Claudia Marino, Paola Michelozzi P22 Epidemiological survey on related psychopathology in melanoma Valeria De Biasio, Vincenzo C. Battarra IMMUNOTHERAPY BRIDGE KEYNOTE SPEAKER PRESENTATIONS Immunotherapy beyond melanoma K19 Predictor of response to radiation and immunotherapy Silvia Formenti K20 Response and resistance to PD-1 pathway blockade: clues from the tumor microenvironment Maria Libera Ascierto, Tracee L. McMiller, Alan E. Berger, Ludmila Danilova, Robert A. Anders, George J. Netto, Haiying Xu, Theresa S. Pritchard, Jinshui Fan, Chris Cheadle, Leslie Cope, Charles G. Drake, Drew M. Pardoll, Janis M. Taube and Suzanne L. Topalian K21 Combination immunotherapy with autologous stem cell transplantation, protein immunization, and PBMC reinfusion in myeloma patients Sacha Gnjatic, Sarah Nataraj, Naoko Imai, Adeeb Rahman, Achim A. Jungbluth, Linda Pan, Ralph Venhaus, Andrew Park, Frédéric F. Lehmann, Nikoletta Lendvai, Adam D. Cohen, and Hearn J. Cho K22 Anti-cancer immunity despite T cell “exhaustion” Speiser Daniel Immunotherapy in oncology (I-O): data from clinical trial K23 The Checkpoint Inhibitors for the Treatment of Metastatic Non-small Cell Lung Cancer (NSCLC) Vera Hirsh
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48. The effect of time to sentinel lymph node biopsy on cutaneous melanoma survival
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Fortes, Cristina, primary, Mastroeni, Simona, additional, Caggiati, Alessio, additional, Passarelli, Francesca, additional, Zappalà, Alba, additional, Capuano, Maria, additional, Bono, Riccardo, additional, Nudo, Maurizio, additional, Marino, Claudia, additional, and Michelozzi, Paola, additional
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- 2016
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49. Ion channels expression and function are strongly modified in solid tumors and vascular malformations
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Biasiotta, Antonella, primary, D’Arcangelo, Daniela, additional, Passarelli, Francesca, additional, Nicodemi, Ezio Maria, additional, and Facchiano, Antonio, additional
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- 2016
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50. Abstract 936: Skin microenvironment enhances proliferation index and activates mTORC 1 signaling in sezary syndrome
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Cristofoletti, Cristina, primary, Picozza, Mario, additional, Bresin, Antonella, additional, Picchio, Maria Cristina, additional, Scala, Enrico, additional, Lombardo, Giuseppe A., additional, Passarelli, Francesca, additional, Caprini, Elisabetta, additional, Russo, Giandomenico, additional, and Narducci, Maria Grazia, additional
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- 2016
- Full Text
- View/download PDF
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