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1. Opioids Switching with Transdermal Systems in Chronic Cancer Pain

Author

Barbarisi M, Sansone P, Pota V, Pace MC, Aurilio C, Grella E, and Passavanti MB

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Due to tolerance development and adverse side effects, chronic pain patients frequently need to be switched to alternative opioid therapy Objective To assess the efficacy and tolerability of an alternative transdermally applied (TDS) opioid in patients with chronic cancer pain receiving insufficient analgesia using their present treatment. Methods A total of 32 patients received alternative opioid therapy, 16 were switched from buprenorphine to fentanyl and 16 were switched from fentanyl to buprenorphine. The dosage used was 50% of that indicated in equipotency conversion tables. Pain relief was assessed at weekly intervals for the next 3 weeks Results Pain relief as assessed by VAS, PPI, and PRI significantly improved (p < 0.0001) in all patients at all 3 follow up visits. After 3 weeks of treatment, the reduction in the mean VAS, PPI, and PRI scores in the fentanyl and buprenorphine groups was 68, 77, 74, and 69, 79, and 62%, respectively. Over the same time period the use of oral morphine as rescue medication was reduced from 27.5 ± 20.5 (mean ± SD) to 3.75 ± 8.06, and 33.8 ± 18.9 to 3.75 ± 10.9 mg/day in the fentanyl and buprenorphine groups, respectively. There was no significant difference in either pain relief or rescue medication use between the two patient groups The number of patient with adverse events fell during the study. After the third week of the treatment the number of patients with constipation was reduced from 11 to 5, and 10 to 4 patients in the fentanyl and buprenorphine groups, respectively. There was a similar reduction in the incidence of nausea and vomiting. No sedation was seen in any patient after one week of treatment. Conclusion Opioid switching at 50% of the calculated equianalgesic dose produced a significant reduction in pain levels and rescue medication. The incidence of side effects decreased and no new side effects were noted. Further studies are required to provide individualized treatment for patients according to their different types of cancer.

Published
2009
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2. Effect of Intraoperative High Positive End-Expiratory Pressure (PEEP) with Recruitment Maneuvers vs Low PEEP on Postoperative Pulmonary Complications in Obese Patients: A Randomized Clinical Trial

Author

Bluth, T, Neto, As, Schultz, Mj, Pelosi, P, de Abreu MG, Bobek, I, Canet, Jc, de Baerdemaeker, L, Gregoretti, C, Hedenstierna, G, Hemmes, Snt, Hiesmayr, M, Hollmann, M, Jaber, S, Laffey, J, Licker, Mj, Markstaller, K, Matot, I, Mills, G, Mulier, Jp, Putensen, C, Rossaint, R, Schmitt, J, Senturk, M, Severgnini, P, Sprung, J, Melo, Mfv, Wrigge, H, Abelha, F, Abitagaoglu, S, Achilles, M, Adebesin, A, Adriaensens, I, Ahene, C, Akbar, F, Al Harbi, M, al Kallab RA, Albanel, X, Aldenkortt, F, Alfouzan, Ras, Alruqaie, R, Altermatt, F, Araujo, Bld, Arbesu, G, Artsi, H, Aurilio, C, Ayanoglu, Oh, Bacuzzi, A, Baig, H, Baird, Y, Balonov, K, Balust, J, Banks, S, Bao, Xd, Baumgartner, M, Tortosa, Ib, Bergamaschi, A, Bergmann, L, Bigatello, L, Perez, Eb, Birr, K, Bojaxhi, E, Bonenti, C, Bonney, I, Bos, Ee, Bowman, S, Braz, Lg, Brugnoni, E, Brunetti, I, Bruni, A, Buenvenida, Sl, Camerini, Cj, Canet, J, Capatti, B, Carmona, J, Carungcong, J, Carvalho, M, Cattan, A, Cavaleiro, C, Chiumello, D, Ciardo, S, Coburn, M, Colella, U, Contreras, V, Dincer, Pc, Cotter, E, Crovetto, M, Crovetto, W, Darrah, W, Davies, S, De Hert, S, Peces, Ed, Delphin, E, Diaper, J, do Nascimento, P, Donatiello, V, Dong, J, Dourado, Md, Dullenkopf, A, Ebner, F, Elgendy, H, Ellenberger, C, Ari, De, Ermert, T, Farah, F, Fernandez-Bustamante, A, Ferreira, C, Fiore, M, Fonte, A, Palahi, Cf, Galimberti, A, Garofano, N, Giaccari, Lg, Gilsanz, F, Girrbach, F, Gobbi, L, Godfried, Mb, Goettel, N, Goldstein, Pa, Goren, O, Gorlin, A, Gil, Mg, Gratarola, A, Graterol, J, Guyon, P, Haire, K, Harou, P, Helf, A, Hempel, G, Cadiz, Mjh, Heyse, B, Hollmann, Mw, Huercio, I, Ilievska, J, Jakus, L, Jeganath, V, Jelting, Y, Jung, M, Kabon, B, Kacha, A, Ilic, Mk, Karuppiah, A, Kavas, Ad, Barcelos, Gk, Kellogg, Ta, Kemper, J, Kerbrat, R, Khodr, S, Kienbaum, P, Kir, B, Kiss, T, Kivrak, S, Klaric, V, Koch, T, Koksal, C, Kowark, A, Kranke, P, Kuvaki, B, Kuzmanovska, B, Lange, M, de Lemos MF, Lopez-Baamonde, M, Lopez-Hernandez, A, Lopez-Martinez, M, Luise, S, Macgregor, M, Magalhaes, D, Maillard, J, Malerbi, P, Manimekalai, N, Margarson, M, Martin, Dp, Martin, Yn, Martinez-Ocon, J, Martin-Loeches, I, Maseda, E, Mcauliffe, N, Mckenzie, Tj, Medina, P, Meersch, M, Menzen, A, Mertens, E, Meurer, B, Meyer-Treschan, T, Miao, Ch, Micalizzi, C, Milic, M, Modolo, Nsp, Moine, P, Molders, P, Montero-Feijoo, A, Moret, E, Muller, Mk, Murphy, Z, Nalwaya, P, Naumovski, F, Navalesi, P, Lima, Lhne, Adam, Vn, Neumann, C, Newell, C, Nisnevitch, Z, Nizamuddin, J, Novazzi, C, O'Connor, M, Oprea, G, Sungur, Mo, Ozbilgin, S, Pace, Mc, Pacheco, M, Packianathaswamy, B, Gonzalez, Ep, Papaspyros, F, Paredes, S, Passavanti, Mb, Pedemonte, Jc, Peremin, S, Philipsenburg, C, Pinho, D, Pinho, S, Posthuma, Lm, Pota, V, Preckel, B, Priani, P, Rached, Ma, Radoeshki, A, Ragazzi, R, Rajamanickam, T, Rajamohan, A, Ramakrishna, H, Rangarajan, D, Reiterer, C, Renew, Jr, Reynaud, T, Rhys, R, Rivas, E, Robitzky, L, Rubulotta, F, Machado, Hs, Nunes, Cs, Sabbatini, G, Sanahuja, Jm, Sansone, P, Santos, A, Sayedalahl, M, Schaefer, Ms, Scharffenberg, E, Scharffenberg, M, Schiffer, E, Schliewe, N, Schorer, R, Schumann, R, Selmo, G, Sendra, M, Shaw, K, Shosholcheva, M, Sibai, A, Simon, P, Simonassi, F, Sinno, C, Sivrikoz, N, Skandalou, V, Smith, N, Soares, M, Artiles, Ts, Castro, Ds, Sousa, M, Spadaro, S, Stamatakis, E, Steiner, La, Stevenazzi, A, Suarez-de-la-Rica, A, Suppan, M, Teichmann, R, Guerrero, Jmt, Thiel, B, Tolos, R, Altun, Gt, Tucci, M, Turnbull, Za, Turudic, Z, Unterberg, M, Van Limmen, J, Van Nieuwenhove, Y, Van Waesberghe, J, Francisco, M, Melo, V, Vitkovic, B, Vivona, L, Vizcaychipi, M, Volta, Ca, Weber, A, Weingarten, Tn, Wittenstein, J, Wyffels, P, Yague, J, Yates, D, Yavru, A, Zac, L, Zhong, J, Intensive Care Medicine, ACS - Heart failure & arrhythmias, Anesthesiology, ACS - Diabetes & metabolism, APH - Quality of Care, ACS - Pulmonary hypertension & thrombosis, ACS - Microcirculation, Bluth T., Serpa Neto A., Schultz M.J., Pelosi P., Gama de Abreu M., Bobek I., Canet J.C., Cinella G., de Baerdemaeker L., Gregoretti C., Hedenstierna G., Hemmes S.N.T., Hiesmayr M., Hollmann M.W., Jaber S., Laffey J., Licker M.-J., Markstaller K., Matot I., Mills G.H., Mulier J.P., Putensen C., Rossaint R., Schmitt J., Senturk M., Severgnini P., Sprung J., Vidal Melo M.F., Wrigge H., Abelha F., Abitagaoglu S., Achilles M., Adebesin A., Adriaensens I., Ahene C., Akbar F., Harbi M.A., Al Kallab R.A.K., Albanel X., Aldenkortt F., Alfouzan R.A.S., Alruqaie R., Altermatt F., de Castro Araujo B.L., Arbesu G., Artsi H., Aurilio C., Ayanoglu O.H., Bacuzzi A., Baig H., Baird Y., Balonov K., Balust J., Banks S., Bao X., Baumgartner M., Tortosa I.B., Bergamaschi A., Bergmann L., Bigatello L., Perez E.B., Birr K., Bojaxhi E., Bonenti C., Bonney I., Bos E.M.E., Bowman S., Braz L.G., Brugnoni E., Brull S.J., Brunetti I., Bruni A., Buenvenida S.L., Busch C.J., Camerini G., Capatti B., Carmona J., Carungcong J., Carvalho M., Cattan A., Cavaleiro C., Chiumello D., Ciardo S., Coburn M., Colella U., Contreras V., Dincer P.C., Cotter E., Crovetto M., Darrah W., Davies S., De Hert S., Peces E.D.C., Delphin E., Diaper J., Do Nascimento Junior P., Donatiello V., Dong J., Dourado M.D.S., Dullenkopf A., Ebner F., Elgendy H., Ellenberger C., Erdogan Ari D., Ermert T., Farah F., Fernandez-Bustamante A., Ferreira C., Fiore M., Fonte A., Palahi C.F., Galimberti A., Garofano N., Giaccari L.G., Gilsanz F., Girrbach F., Gobbi L., Godfried M.B., Goettel N., Goldstein P.A., Goren O., Gorlin A., Gil M.G., Gratarola A., Graterol J., Guyon P., Haire K., Harou P., Helf A., Hempel G., Cadiz M.J.H., Heyse B., Huercio I., Ilievska J., Jakus L., Jeganath V., Jelting Y., Jung M., Kabon B., Kacha A., Ilic M.K., Karuppiah A., Kavas A.D., Barcelos G.K., Kellogg T.A., Kemper J., Kerbrat R., Khodr S., Kienbaum P., Kir B., Kiss T., Kivrak S., Klaric V., Koch T., Koksal C., Kowark A., Kranke P., Kuvaki B., Kuzmanovska B., Lange M., de Lemos M.F., Lopez-Baamonde M., Lopez-Hernandez A., Lopez-Martinez M., Luise S., Macgregor M., Magalhaes D., Maillard J., Malerbi P., Manimekalai N., Margarson M., Martin A.K., Martin D.P., Martin Y.N., Martinez-Ocon J., Martin-Loeches I., Maseda E., McAuliffe N., McKenzie T.J., Medina P., Meersch M., Menzen A., Mertens E., Meurer B., Meyer-Treschan T., Miao C., Micalizzi C., Milic M., Modolo N.S.P., Moine P., Molders P., Montero-Feijoo A., Moret E., Muller M.K., Murphy Z., Nalwaya P., Naumovski F., Navalesi P., Navarro E Lima L.H., Adam V.N., Neumann C., Newell C., Nisnevitch Z., Nizamuddin J., Novazzi C., O'connor M., Oprea G., Sungur M.O., Ozbilgin S., Pace M.C., Pacheco M., Packianathaswamy B., Gonzalez E.P., Papaspyros F., Paredes S., Passavanti M.B., Pedemonte J.C., Peremin S., Philipsenburg C., Pinho D., Pinho S., Posthuma L.M., Pota V., Preckel B., Priani P., Rached M.A., Radoeshki A., Ragazzi R., Rajamanickam T., Rajamohan A., Ramakrishna H., Rangarajan D., Reiterer C., Ross Renew J., Reynaud T., Rhys R., Rivas E., Robitzky L., Rubulotta F., Machado H.S., Nunes C.S., Sabbatini G., Samuels J.D., Sanahuja J.M., Sansone P., Santos A., Sayedalahl M., Schaefer M.S., Scharffenberg M., Schiffer E., Schliewe N., Schorer R., Schumann R., Selmo G., Sendra M., Shaw K., Shosholcheva M., Sibai A., Simon P., Simonassi F., Sinno C., Sivrikoz N., Skandalou V., Smith N., Soares M., Artiles T.S., Castro D.S., Sousa M., Spadaro S., Stamatakis E., Steiner L.A., Stevenazzi A., Suarez-De-la-rica A., Suppan M., Teichmann R., Guerrero J.M.T., Thiel B., Tolos R., Altun G.T., Tucci M., Turnbull Z.A., Turudic Z., Unterberg M., Van Limmen J., Van Nieuwenhove Y., Van Waesberghe J., Vitkovic B., Vivona L., Vizcaychipi M., Volta C.A., Weber A., Weingarten T.N., Wittenstein J., Wyffels P., Yague J., Yates D., Yavru A., Zac L., Zhong J., Bluth, T., Serpa Neto, A., Schultz, M. J., Pelosi, P., Gama De Abreu, M., Aurilio, C., Pace, M. C., Passavanti, M. B., Pota, V., and Sansone, P.

Subjects
Lung Diseases, Male, medicine.medical_treatment, Atelectasis, Lung Disease, 01 natural sciences, Body Mass Index, Hypoxemia, Positive-Pressure Respiration, Postoperative Complications, 0302 clinical medicine, PEEP, postoperative complications, obese patients, Anesthesia, Respiratory function, 030212 general & internal medicine, Tidal volume, General Medicine, Middle Aged, Pleural Diseases, respiratory system, Adult, Anesthesia, General, Female, Humans, Obesity, Pulmonary Atelectasis, Respiratory Insufficiency, Surgical Procedures, Operative, Tidal Volume, Treatment Outcome, Intraoperative Care, Operative, 3. Good health, Pneumothorax, medicine.symptom, psychological phenomena and processes, Human, circulatory and respiratory physiology, NO, 03 medical and health sciences, mental disorders, medicine, Pleural Disease, 0101 mathematics, General, Positive end-expiratory pressure, Mechanical ventilation, Surgical Procedures, Pulmonary Atelectasi, business.industry, 010102 general mathematics, medicine.disease, respiratory tract diseases, Respiratory failure, Postoperative Complication, business
Abstract

Importance: An intraoperative higher level of positive end-expiratory positive pressure (PEEP) with alveolar recruitment maneuvers improves respiratory function in obese patients undergoing surgery, but the effect on clinical outcomes is uncertain. Objective: To determine whether a higher level of PEEP with alveolar recruitment maneuvers decreases postoperative pulmonary complications in obese patients undergoing surgery compared with a lower level of PEEP. Design, Setting, and Participants: Randomized clinical trial of 2013 adults with body mass indices of 35 or greater and substantial risk for postoperative pulmonary complications who were undergoing noncardiac, nonneurological surgery under general anesthesia. The trial was conducted at 77 sites in 23 countries from July 2014-February 2018; final follow-up: May 2018. Interventions: Patients were randomized to the high level of PEEP group (n = 989), consisting of a PEEP level of 12 cm H2O with alveolar recruitment maneuvers (a stepwise increase of tidal volume and eventually PEEP) or to the low level of PEEP group (n = 987), consisting of a PEEP level of 4 cm H2O. All patients received volume-controlled ventilation with a tidal volume of 7 mL/kg of predicted body weight. Main Outcomes and Measures: The primary outcome was a composite of pulmonary complications within the first 5 postoperative days, including respiratory failure, acute respiratory distress syndrome, bronchospasm, new pulmonary infiltrates, pulmonary infection, aspiration pneumonitis, pleural effusion, atelectasis, cardiopulmonary edema, and pneumothorax. Among the 9 prespecified secondary outcomes, 3 were intraoperative complications, including hypoxemia (oxygen desaturation with Spo2 ≤92% for >1 minute). Results: Among 2013 adults who were randomized, 1976 (98.2%) completed the trial (mean age, 48.8 years; 1381 [69.9%] women; 1778 [90.1%] underwent abdominal operations). In the intention-to-treat analysis, the primary outcome occurred in 211 of 989 patients (21.3%) in the high level of PEEP group compared with 233 of 987 patients (23.6%) in the low level of PEEP group (difference, -2.3% [95% CI, -5.9% to 1.4%]; risk ratio, 0.93 [95% CI, 0.83 to 1.04]; P =.23). Among the 9 prespecified secondary outcomes, 6 were not significantly different between the high and low level of PEEP groups, and 3 were significantly different, including fewer patients with hypoxemia (5.0% in the high level of PEEP group vs 13.6% in the low level of PEEP group; difference, -8.6% [95% CI, -11.1% to 6.1%]; P

Published
2019

8. Opioids switching with transdermal systems in chronic cancer pain

Author

AURILIO, Caterina, PACE, Maria Caterina, POTA V, SANSONE, Pasquale, BARBARISI, Manlio, GRELLA, Elisa, PASSAVANTI MB, PASSAVANTI, Maria Beatrice, Aurilio, Caterina, Pace, Maria Caterina, Pota, V, Sansone, Pasquale, Barbarisi, Manlio, Grella, Elisa, Passavanti, Mb, and Passavanti, Maria Beatrice

Subjects
Adult, Male, Cancer Research, Palliative care, Chronic Cancer Pain, Sedation, Pain, Opioid, lcsh:RC254-282, Fentanyl, Neoplasms, medicine, Humans, Aged, business.industry, Research, Palliative Care, Chronic pain, Middle Aged, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Equianalgesic, Buprenorphine, Analgesics, Opioid, Oncology, Tolerability, Anesthesia, Chronic Disease, Female, medicine.symptom, Analgesia, business, medicine.drug
Abstract

Background Due to tolerance development and adverse side effects, chronic pain patients frequently need to be switched to alternative opioid therapy Objective To assess the efficacy and tolerability of an alternative transdermally applied (TDS) opioid in patients with chronic cancer pain receiving insufficient analgesia using their present treatment. Methods A total of 32 patients received alternative opioid therapy, 16 were switched from buprenorphine to fentanyl and 16 were switched from fentanyl to buprenorphine. The dosage used was 50% of that indicated in equipotency conversion tables. Pain relief was assessed at weekly intervals for the next 3 weeks Results Pain relief as assessed by VAS, PPI, and PRI significantly improved (p < 0.0001) in all patients at all 3 follow up visits. After 3 weeks of treatment, the reduction in the mean VAS, PPI, and PRI scores in the fentanyl and buprenorphine groups was 68, 77, 74, and 69, 79, and 62%, respectively. Over the same time period the use of oral morphine as rescue medication was reduced from 27.5 ± 20.5 (mean ± SD) to 3.75 ± 8.06, and 33.8 ± 18.9 to 3.75 ± 10.9 mg/day in the fentanyl and buprenorphine groups, respectively. There was no significant difference in either pain relief or rescue medication use between the two patient groups The number of patient with adverse events fell during the study. After the third week of the treatment the number of patients with constipation was reduced from 11 to 5, and 10 to 4 patients in the fentanyl and buprenorphine groups, respectively. There was a similar reduction in the incidence of nausea and vomiting. No sedation was seen in any patient after one week of treatment. Conclusion Opioid switching at 50% of the calculated equianalgesic dose produced a significant reduction in pain levels and rescue medication. The incidence of side effects decreased and no new side effects were noted. Further studies are required to provide individualized treatment for patients according to their different types of cancer.

Published
2009

14. Neurometer CPT per la valutazione delle nevralgie del trigemino

Author

SANSONE, Pasquale, Passavanti MB, Argenzio F, Pota V, Carfora P, Spirk R, De Lucia Sposito L, Aurilio C., PACE, Maria Caterina, Sansone, Pasquale, Passavanti, Mb, Argenzio, F, Pace, Maria Caterina, Pota, V, Carfora, P, Spirk, R, De Lucia Sposito, L, and Aurilio, C.

Published
2008

16. Gonodal hormones influence pain perception

Author

SANSONE, Pasquale, Passavanti MB, Palagiano A, Iannotti M, Pota V, AURILIO, Caterina, PACE, Maria Caterina, Sansone, Pasquale, Passavanti, Mb, Pace, Maria Caterina, Palagiano, A, Iannotti, M, Pota, V, and Aurilio, Caterina

Published
2008

26. Pregabalin in post-mastectomy patients: Neurometer CPT evaluation

Author

Passavanti MB, PACE, Maria Caterina, SANSONE, Pasquale, Barbato E, Maisto M, Russo T, Zagaria N, AURILIO, Caterina, Passavanti, Mb, Pace, Maria Caterina, Sansone, Pasquale, Barbato, E, Maisto, M, Russo, T, Zagaria, N, and Aurilio, Caterina

Published
2006

29. Pregabalin e TENS nel trattamento della nevralgia posterpetica

Author

Mazzariello L, Maisto M, Pota V, Passavanti MB, Vestini R, SANSONE, Pasquale, Aurilio C., PACE, Maria Caterina, Mazzariello, L, Maisto, M, Pota, V, Pace, Maria Caterina, Passavanti, Mb, Vestini, R, Sansone, Pasquale, and Aurilio, C.

Published
2006

32. A pocket computerized algometer

Author

Viggiano A, Baccari ME, Zagaria N, Aurilio C, Passavanti MB, Chiefari M. De Luca B., PACE, Maria Caterina, Viggiano, A, Baccari, Me, Zagaria, N, Aurilio, C, Passavanti, Mb, Pace, Maria Caterina, and Chiefari, M. De Luca B.

Published
2005

38. Control of post-thoracotomy pain by transcutaneous electrical nerve stimulation: effect on serum cytokine levels, visual analogue scale, pulmonary function and medication

Author

Fiorelli A, Morgillo F, Milione R, Pace MC, Passavanti MB, Laperuta P, Aurilio C, and Santini M

Abstract

"OBJECTIVES: Transcutaneous electrical nerve stimulation (TENS) has been used to control post-thoracotomy pain with contrasting results. We aimed to assess the efficacy of TENS on post-thoracotomy pain in relation of four criterion measurements as: (i) cytokines; (ii) pain; (iii) respiratory function and (iv) intake of narcotic medication.. . METHODS: Between January 2008 and October 2010, 58 patients underwent standard posterolateral thoracotomy for resectable lung cancer. Fifty patients were enrolled in the present study and randomized in two groups: TENS group (25 patients) who received postoperatively TENS for 5 days and placebo group (25 patients) without TENS. In both groups (i) serum cytokines (IL-6, IL-10, TNF-α) were measured by ELISA before surgery and at 6, 12, 24, 48, 72, 96 and 120 postoperative hours (POHs); (ii) at the same POHs, the pain score was measured using visual analogue scale (VAS) ranging from 0 to 10 levels; (iii) respiratory function (FEV 1% and FVC % of predicted value) were valuated on 72, 96 and 120 POHs; (iv) the total intake of narcotic medication given during postoperative period of 5 days was recorded. Repeated measures of analysis of variance assess the difference between two study groups. A value of P < 0.05 was considered statistically significant.. . RESULTS: Of the 50 patients enrolled, two patients of TENS group and two patients of the placebo group were lost to follow-up. (i) Serum IL-6 (P = 0.001), IL-10 (P = 0.001) and TNF-α (P = 0.001) levels in TENS group were significantly lower than in the control group; (ii) VAS score in TENS group was significantly lower than in the control group (P < 0.001); (iii) recovery of FEV 1 (P = 0.02) and of FVC (P = 0.02) was statistically better in the TENS group than in control group; (iv) morphine requirement was lower in the TENS group with respect to placebo TENS (P = 0.004). After 48 POHs, no patient required supplementary dose of morphine. TENS group compared with placebo-group presented a significant reduction of non-opioid consumption (P = 0.002).. . CONCLUSIONS: TENS is a valuable strategy to alleviate post-thoracotomy pain with reduction of cytokine production and of analgesic consumption, and with positive effects on pulmonary ventilation function. "

Published
2012

41. [Emergencies in alcoholism]

Author

IANNOTTI M, ARGENZIO F, AURILIO, Caterina, GEMINI D, MACCHI G, PACE MC, PASSAVANTI MB, ACCARDO R., Iannotti, M, Argenzio, F, Aurilio, Caterina, Gemini, D, Macchi, G, Pace, Mc, Passavanti, Mb, and Accardo, R.

Subjects
Alcoholism, Humans, Emergencies, Human
Published
1991

46. Metabolic syndrome is associated with a poor outcome in patients affected by outflow tract premature ventricular contractions treated by catheter ablation

Author

Sardu, Celestino, Carreras, Giovanni, Katsanos, Spyridon, Kamperidis, Vasileios, Pace, Maria Caterina, Passavanti, Maria Beatrice, Fava, Ilaria, Paolisso, Pasquale, Pieretti, Gorizio, Nicoletti, Giovanni Francesco, Paolisso, Giuseppe Marfella, Raffaele, SANTULLI, GAETANO, Sardu, Celestino, Carreras, Giovanni, Katsanos, Spyridon, Kamperidis, Vasileio, Pace, Maria Caterina, Passavanti, Maria Beatrice, Fava, Ilaria, Paolisso, Pasquale, Pieretti, Gorizio, Nicoletti, Giovanni Francesco, Santulli, Gaetano, Paolisso, Giuseppe, Marfella, Raffaele, Sardu, C, Carreras, G, Katsanos, S, Kamperidis, V, Pace, Mc, Passavanti, Mb, Fava, I, Paolisso, P, Pieretti, G, Nicoletti, Gf, Santulli, G, Paolisso, G, and Marfella, R.

Subjects
medicine.medical_specialty, Heart disease, medicine.medical_treatment, Biophysics, Catheter ablation, Recurrence, Internal medicine, medicine, Humans, Ventricular outflow tract, Prospective Studies, cardiovascular diseases, Prospective cohort study, Angiology, Metabolic Syndrome, business.industry, Proportional hazards model, Metabolic Syndrome X, medicine.disease, Ventricular Premature Complexes, Ventricular Premature Complexe, Cardiac surgery, Prospective Studie, Treatment Outcome, Catheter Ablation, cardiovascular system, Cardiology, Medicine, Metabolic syndrome, Cardiology and Cardiovascular Medicine, business, Research Article, Human
Abstract

Background The purpose of this study was to investigate the impact of metabolic syndrome (MS) on outcome of catheter ablation (CA) for treatment of frequent premature ventricular contraction beats (PVCs) originating from right ventricular outflow tract (RVOT), left ventricular outflow tract (LVOT) or coronary cusps (CUSPs), in patients with normal ventricular systolic function and absence of cardiac structural disease. Methods In this multicentre prospective study we evaluated 90 patients with frequent PVCs originating from RVOT (n = 68), LVOT (n = 19) or CUSPs (n = 3), treated with CA. According to baseline diagnosis they were divided in patients with MS (n = 24) or without MS (n = 66). The study endpoint was a composite of recurrence of acute or delayed outflow tract ventricular arrhythmia: acute spontaneous or inducible outflow tract ventricular arrhythmia recurrence or recurrence of outflow tract PVCs in holter monitoring at follow up. Results Patients with MS compared to patients without MS showed a higher acute post-procedural recurrence of outflow tract PVCs (n = 8, 66.6%, vs. n = 6, 9.0%, p = 0.005). At a mean follow up of 35 (17-43) months survival free of recurrence of outflow tract PVCs was lower in patients with baseline MS compared to patients without MS diagnosis (log-rank test, p

Published
2014

49. NEUROMETER CPT ED IMPLICAZIONI DOLOROSE A CONFRONTO IN PAZIENTI SOTTOPOSTE A INTERVENTO RICOSTRUTTIVO CON PROTESI IN SILICONE E NON

Author

PASSAVANTI, Maria Beatrice, TARALLO F., NICOLETTI, Giovanni Francesco, GRELLA E., MAZZARIELLO L., PACE, Maria Caterina, DE MARTINO C., AURILIO, Caterina, Passavanti, Mb, Tarallo, F, Nicoletti, Giovanni Francesco, Grella, E, Mazzariello, L, Pace, Maria Caterina, DE MARTINO, C, Aurilio, Caterina, Passavanti, M, Pace, M, De Martino, C, Di Martino, L, Passavanti, Maria Beatrice, Tarallo, F., Grella, E., Mazzariello, L., and DE MARTINO, C.

Published
2003

50. [Hemodynamic changes after endotoxin infusion]

Author

C, Aurilio, F, Argenzio, B, Lettieri, D, Gemini, M B, Passavanti, G, Macchi, R, Accardo, Aurilio, Caterina, Argenzio, Filomena, Lettieri, Biagio, Gemini, D, Passavanti, Mb, Macchi, G, and Accardo, R.

Subjects
Endotoxins, Time Factors, Endotoxin, Animal, Swine, Hemodynamics, Animals, Hemodynamic
Published
1991

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