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61 results on '"Pastore, B"'

1. Emergenza pandemica, decisioni, bilanciamento

Author

Pastore, B.

Subjects
Law and politics, Covid-19, Vulnerability, Solidarity, Law and politics, Balancing, Vulnerability, Socio-culturale, SH2_8, Covid-19, Balancing, Solidarity
Published
2021

4. Pluralismi giuridici e trasformazioni del diritto contemporaneo

Author

Pastore, B.

Subjects
fonti del diritto, ordinamento giuridico, internormatività, Pluralismo giuridico, Socio-culturale, pluralismo giudiziario transnazionale, Pluralismo giuridico, fonti del diritto, ordinamento giuridico, internormatività, pluralismo giudiziario transnazionale, SH2_8
Published
2021

5. Semantica della vulnerabilità, soggetto, cultura giuridica

Author

Pastore, B.

Subjects
diritti umani, costituzionalismo, giustizia, Socio-culturale, solidarietà, SH2_8, diritto, Vulnerabilità, diritto, giustizia, costituzionalismo, solidarietà, diritti umani, Vulnerabilità
Published
2021

6. Su Ferrajoli e il 'creazionismo giudiziario' di Kelsen

Author

Pastore, B

Subjects
interpretazione, Hans Kelsen, Luigi Ferrajoli, Socio-culturale, giurisdizione, costruttivismo, Hans Kelsen, Luigi Ferrajoli, giurisdizione, interpretazione, costruttivismo
Published
2020

7. Vulnerabilità

Author

Pastore, B.

Subjects
Discrimination, Socio-culturale, Human Fragility, Human Fragility, Discrimination, Law, Rights, SH2_8, Rights, Law
Published
2020

8. Introduzione [Ars Interpretandi]

Author

Pastore, B.

Subjects
interpretazione giuridica, Socio-culturale, Diritto internazionale, interpretazione giuridica, giurisdizione, positivizzazione, Diritto internazionale, giurisdizione, positivizzazione, SH2_8
Published
2020

10. L'aporia del concetto kelseniano di 'norma'

Author

Ferrajoli, L, Di Lucia, P, Passerini Glazel, L, Losano, MG, Barberis, M, Chiassoni, P, Itzcovich, G, Bisogni, G, Manero, JR, Luzzati, C, Baccelli, L, Moreso, JJ, Mazzarese, T, Scalone, A, Tuzet, G, Tedesco, F, Mastromartino, F, Pino, G, Ippolito, D, Pastore, B, Spuntarelli, S, Bersier Ladavac, N, Carrino, A, Nitsch, C, Zanichelli, M, Lozada, A, Volpi, M, Ferrajoli, L, Di Lucia, P, Passerini Glazel, L, Losano, MG, Barberis, M, Chiassoni, P, Itzcovich, G, Bisogni, G, Manero, JR, Luzzati, C, Baccelli, L, Moreso, JJ, Mazzarese, T, Scalone, A, Tuzet, G, Tedesco, F, Mastromartino, F, Pino, G, Ippolito, D, Pastore, B, Spuntarelli, S, Bersier Ladavac, N, Carrino, A, Nitsch, C, Zanichelli, M, Lozada, A, and Volpi, M

Abstract

Luigi Ferrajoli, in his work La logica del diritto. Dieci aporie nell’opera di Hans Kelsen (2016), pointed out ten aporias in Hans Kelsen’s pure theory of law. This paper deals with the fifth aporia, that is the of Kelsen’s concept of a “norm”. The paper firstly distinguishes two different questions on the concept of a norm underlying the pure theory of law: the question “What is a norm?”, and the question “What has the meaning of a norm within a legal system?”; it secondly distinguishes three different levels of interpretation of a norm: (i) interpretation of the semantic meaning of norm sentences, (ii) interpretation of the subjective intrinsic pragmatic meaning of the norm creating act; (iii) interpretation of the extrinsic objective normative meaning of the norm creating act; it thirdly suggests that the existence of a norm is the ideal (ideel) existence of a meaning, not the empirical existence of an act.

Published
2020

11. Non sola auctoritas facit legem. Il costituzionalismo logico di Luigi Ferrajoli

Author

Ferrajoli, L, Di Lucia, P, Passerini Glazel, L, Losano, MG, Barberis, M, Chiassoni, P, Itzcovich, G, Bisogni, G, Manero, JR, Luzzati, C, Baccelli, L, Moreso, JJ, Mazzarese, T, Scalone, A, Tuzet, G, Tedesco, F, Mastromartino, F, Pino, G, Ippolito, D, Pastore, B, Spuntarelli, S, Bersier Ladavac, N, Carrino, A, Nitsch, C, Zanichelli, M, Lozada, A, Volpi, M, Di Lucia,P, Ferrajoli, L, Di Lucia, P, Passerini Glazel, L, Losano, MG, Barberis, M, Chiassoni, P, Itzcovich, G, Bisogni, G, Manero, JR, Luzzati, C, Baccelli, L, Moreso, JJ, Mazzarese, T, Scalone, A, Tuzet, G, Tedesco, F, Mastromartino, F, Pino, G, Ippolito, D, Pastore, B, Spuntarelli, S, Bersier Ladavac, N, Carrino, A, Nitsch, C, Zanichelli, M, Lozada, A, Volpi, M, and Di Lucia,P

Abstract

Per il positivismo giuridico tradizionale, l’idea che alcune norme create dal legislatore attraverso atti di normazione formalmente validi possano costituire “diritto illegittimo” sembra essere una contraddizione in termini. Questa tesi viene tuttavia messa esplicitamente in discussione nella teoria assiomatizzata del diritto di Luigi Ferrajoli, che pur si propone come uno sviluppo della teoria pura del diritto di Hans Kelsen. Il dissenso da Kelsen si incentra sul problema dell’applicazione dei principi logici di contraddizione e di implicazione al diritto, applicazione impossibile per Kelsen, necessaria invece per Ferrajoli per l’identificazione del diritto illegittimo. Gli autori della prefazione ricostruiscono i nodi teorici fondamentali della critica di Ferrajoli a Kelsen, e mostrano come Ferrajoli proponga di superare i limiti della teoria pura kelseninana attraverso l'elaborazione di un costituzionalismo logico., For traditional legal positivism, the idea that certain legal norms created through valid enactments can be "unlawful law" seems to be self-contradictory. This view is explicitly disputed by Luigi Ferrajoli's axiomatized theory of law, which is nonetheless presented as a development of Hans Kelsen's pure theory of law. The dispute focus on the problem of the application of the logical principles of contradiction and implication to legal systems: an impossible application for Kelsen, a necessary one for Ferrajoli, since the theory of law should identify "unlawful norms" within the legal system. The authors of this preface reconstruct the main theoretical claims of Ferrajoli's critique to Kelsen, and show how he suggests to overcome the theoretical limits of the pure theory of law through the delieation of a logical constitutionalism.

Published
2020

12. Comparazione, interpretazione, positivizzazione

Author

Pastore, B.

Subjects
argomentazione giuridica, Diritto positivo, Diritto positivo, uso del diritto straniero, applicabilità, argomentazione giuridica, armonizzazione giuridica, uso del diritto straniero, Socio-culturale, armonizzazione giuridica, SH2_8, applicabilità
Published
2019

16. Teoria del diritto e riabilitazione della filosofia pratica

Author

Pastore, B.

Subjects
giurisprudenza, filosofia pratica, Socio-culturale, Teoria del diritto, SH2_8, Teoria del diritto, filosofia pratica, ermeneutica, positivizzazione giuridica, giurisprudenza, positivizzazione giuridica, ermeneutica
Published
2019

18. Casi, microsistemi, princìpi nel disordine delle fonti

Author

Pastore, B.

Subjects
caso giuridico, Interpretazione, princìpi, Socio-culturale, Interpretazione, Fonti del diritto, microsistema, caso giuridico, princìpi, SH2_8, Fonti del diritto, microsistema
Published
2019

19. Complessità del diritto e autonomia privata

Author

Pastore, B.

Subjects
interpretazione, Fonti del diritto, positivizzazione giuridica, interpretazione, prassi notarile, soft law, Socio-culturale, soft law, prassi notarile, SH2_8, Fonti del diritto, positivizzazione giuridica
Published
2019

20. Tecnologie emergenti, incertezze della scienza, regolamentazione giuridica

Author

Pastore, B.

Subjects
precautionary principle, forms of regulation, SH2_11, transformation of legal concepts, Socio-culturale, Law and technoscience, transformation of legal concepts, responsibility, precautionary principle, forms of regulation, responsibility, SH2_8, Law and technoscience
Published
2018

22. Vulnerabilità

Author

Pastore, B.

Subjects
Eguaglianza, dignità umana, Socio-culturale, migrazioni, diritto, discriminazione, Eguaglianza, discriminazione, migrazioni, diritto, dignità umana
Published
2018

23. Introduzione [Vulnerabilità e interpretazione giudiziale]

Author

Pastore, B.

Subjects
interpretazione giuridica, Corte europea del diritti umani, Socio-culturale, giustificazione della decisione giudiziale, vulnerabilità, interpretazione giuridica, giustificazione della decisione giudiziale, Corte europea del diritti umani, vulnerabilità
Published
2018

24. Pluralismo, religione, sfera pubblica

Author

Pastore, B.

Subjects
riconoscimento, Pluralismo culturale, Pluralismo culturale, religione, sfera pubblica, riconoscimento, Stato costituzionale, religione, Socio-culturale, Stato costituzionale, SH2_8, sfera pubblica
Published
2018

25. Conflictos identitarios [Identity Conflicts]

Author

Pastore, B.

Subjects
inclusión social, multiculturalismo, Derecho y conflicto, identidad, multiculturalismo, reconocimiento, inclusión social, reconocimiento, Socio-culturale, Derecho y conflicto, identidad
Published
2018

26. Storicità del diritto e interpretazione

Author

Pastore, B.

Subjects
Diritto positivo, interpretazione, esperienza giuridica, ermeneutica, tradizione giuridica, interpretazione, esperienza giuridica, Diritto positivo, Socio-culturale, tradizione giuridica, ermeneutica
Published
2018

27. Poder de gracia, legalidad, justicia

Author

Pastore, B.

Subjects
iluminismo jurídico, equidad, Socio-culturale, legalidad, Gracia, soberanía, legalidad, iluminismo jurídico, equidad, Gracia, soberanía
Published
2018

28. Physiological postural stabilization with rugran plantar in athletes

Author

Monda, V., Anna, V., Ruberto, M., Villano, I., Russo, V., Marra, M. L., Pastore, B., Giuseppe, C., Salerno, M., Albano, G. D., Sessa, F., Marsala, G., Messina, A., Monda, Vincenzo, Anna, Valenzano, Ruberto, Maria, Villano, Ine, Russo, Vincenzo, LA MARRA, Marco, Pastore, Bianca, Giuseppe, Cibelli, Salerno, Monica, Albano, GISEPPE D., Sessa, Francesco, Marsala, Gabriella, and Messina, Antonietta

Subjects
Foot, Medicine (all), Posture, Plantar, Static pedobarographic
Published
2017

29. Activity-independent intracellular calcium signals are spontaneously generated in ventral spinal neurons during development in vitro

Author

FABBRO, ALESSANDRA, BALLERINI, Laura, PASTORE B., NISTRI A., Fabbro, Alessandra, Pastore, B., Nistri, A., and Ballerini, Laura

Subjects
network development, motor circuit maturation, caclium imaging, calcium signaling, spinal interneuron
Abstract

The present report is the first description of repetitive calcium events generated by discrete ventral spinal neurons maintained in organotypic culture during in vitro maturation stages crucial for network evolution. Ventral interneurons in one-third of slices displayed spontaneous intracellular calcium transients suppressed by calcium-free extracellular solution or by application of cobalt, and resistant to blockers of network activity like TTX, CNQX, APV, strychnine or bicuculline. Our data suggest a primary role for mitochondria in intracellular calcium oscillations, because CCCP, that selectively collapses the mitochondrial electrochemical gradient, eliminated the ability of these neurons to show activity-independent calcium oscillations. Likewise, CGP-37157, a blocker of mitochondrial Na+/Ca2+ exchanger, inhibited oscillations in the majority of neurons. We propose that spontaneous Ca2+ transients, dynamically regulated by mitochondria, occurred in a discrete cluster of interneurons possibly to guide the development of synaptic connections.

Published
2007

30. Il paradosso di una religione senza dio. Hans Kelsen antropologo della modernità

Author

Lombardi Vallauri, L, Fiorelli, P, Adinolfi, A, Amato, S, Amato Mangiameli, A C, Barberis, M, Bartoli, R, Becchi, P, Bellavista, M, Bernardini, P L, Bianchi, A, Borsellino, P, Cabiddu, M A, Caretti, P, Casavola, F P, Castignone, S, Castrucci, E, Chiassoni, P, Corbetta, S, Corongiu, S, Corsi, C, Cosi, G, Croce, M, D'Agostino, F, De Sanctis, F M, Di Cagno, V, Di Lucia, P, Passerini Glazel, L, Di Mario, A, Diciotti, E, Dilcher, G, Eusebi, L, Faralli, C, Faro, S, Lettieri, N, Fioravanti, M, Flora, G, Foddai, M A, Francavilla, D, Franchini, L, Franza, T, Gaja, G, Galvan, S, Di Florio, C, Gazzolo, T, Ghezzi, M L, Giachery, E, Giachi, C, Grisolia, M C, Guastini, R, Incampo, A, Irti, N, La Torre, M, Lombardi Vallauri, Edoardo, Lombardi Vallauri, Elena, Lombardi Vallauri, M, Lombardi Vallauri, S, Lucarelli, P, Luzzati, C, Mannozzi, G, Mannucci, A, Mantovani, F, Marini, R, Marotta, V, Mazzoni, C M, Meschiari, M, Migliorini, M, Montanari, B, Neumann, U, Onida, P P, Orrù, G, Palavera, R, Palazzani, L, Palazzo, F, Papa, M, Parenti, C, Pastore, B, Perfetti, L R, Rescigno, F, Righi, R, Rodotà, S, Roselli, O, Ruschi, F, Santalucia, B, Savarese, P, Scerbo, A, Scillitani, L, Siciliano, D, Simoni, A, Romoli, F, Stolfi, E, Taddei Elmi, G, Tallacchini, M, Tarantino, A, Trautteur, G, Troje, H E, Trujillo, I, Valastro, A, Vallini, A, Vettori, G, Villa, M L, Viola, F, Zaccaria, G, Zamperetti, G M, Zanotti, L, Luderssen, K, Lombardi Vallauri, L, Fiorelli, P, Adinolfi, A, Amato, S, Amato Mangiameli, A C, Barberis, M, Bartoli, R, Becchi, P, Bellavista, M, Bernardini, P L, Bianchi, A, Borsellino, P, Cabiddu, M A, Caretti, P, Casavola, F P, Castignone, S, Castrucci, E, Chiassoni, P, Corbetta, S, Corongiu, S, Corsi, C, Cosi, G, Croce, M, D'Agostino, F, De Sanctis, F M, Di Cagno, V, Di Lucia, P, Passerini Glazel, L, Di Mario, A, Diciotti, E, Dilcher, G, Eusebi, L, Faralli, C, Faro, S, Lettieri, N, Fioravanti, M, Flora, G, Foddai, M A, Francavilla, D, Franchini, L, Franza, T, Gaja, G, Galvan, S, Di Florio, C, Gazzolo, T, Ghezzi, M L, Giachery, E, Giachi, C, Grisolia, M C, Guastini, R, Incampo, A, Irti, N, La Torre, M, Lombardi Vallauri, Edoardo, Lombardi Vallauri, Elena, Lombardi Vallauri, M, Lombardi Vallauri, S, Lucarelli, P, Luzzati, C, Mannozzi, G, Mannucci, A, Mantovani, F, Marini, R, Marotta, V, Mazzoni, C M, Meschiari, M, Migliorini, M, Montanari, B, Neumann, U, Onida, P P, Orrù, G, Palavera, R, Palazzani, L, Palazzo, F, Papa, M, Parenti, C, Pastore, B, Perfetti, L R, Rescigno, F, Righi, R, Rodotà, S, Roselli, O, Ruschi, F, Santalucia, B, Savarese, P, Scerbo, A, Scillitani, L, Siciliano, D, Simoni, A, Romoli, F, Stolfi, E, Taddei Elmi, G, Tallacchini, M, Tarantino, A, Trautteur, G, Troje, H E, Trujillo, I, Valastro, A, Vallini, A, Vettori, G, Villa, M L, Viola, F, Zaccaria, G, Zamperetti, G M, Zanotti, L, and Luderssen, K

Abstract

In 2012 an unpublished book by the Austrian legal philosopher Hans Kelsen, Secular Religion, has been posthumously published. This book, written by Kelsen between 1952 and 1964 in the United States, severely criticizes those theories of politics and culture that misinterpret modern social philosophy, science and politics as new religions, mainly adopting the controversial concept of “secular religión.” In the first part of the paper, we reconstruct the genesis of the book and the complex events that led to its final version, and we underline the motives that led Kelsen to write this vehement polemic in defense of the spirit of modernity, and eventually to withdraw it. In the second part of the paper, we investigate some of the main methodological and theoretical contributions that this work, albeit its critical tenor, is able to give to an anthropology of modernity.

Published
2016

34. Prefazione. Un binomio che stride

Author

Pastore, B, Lanza, L, Ubertis, G, UBERTIS, GIULIO, Pastore, B, Lanza, L, Ubertis, G, and UBERTIS, GIULIO

Published
2008

35. Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Author

Labeau, Sonia O, Afonso, Elsa, Benbenishty, Julie, Blackwood, Bronagh, Boulanger, Carole, Brett, Stephen J, Calvino-Gunther, Silvia, Chaboyer, Wendy, Coyer, Fiona, Deschepper, Mieke, François, Guy, Honore, Patrick M, Jankovic, Radmilo, Khanna, Ashish K, Llaurado-Serra, Mireia, Lin, Frances, Rose, Louise, Rubulotta, Francesca, Saager, Leif, Williams, Ged, Blot, Stijn I, Dritan, Muzha, Antoni Margarit Ribas, Fernando, Lipovesty, Cecilia, Loudet, Fiona, Coyer, Philipp, Eller, Nafseen, Mostafa, Patrick, M Honoré, Vanesa Mercado Telleria, Jasmina, Smajic, Paula Cristina Nogueira, Khalid Mahmood Khan Nafees, Romuald, Hentchoya, Louise, Rose, Javiera, Soledad, Frances, Lin, Yenny, Cardenas, Amylkar Garay Reyes, Alan, Sustic, Meropi, Mpouzika, Tamas, Vymazal, Hanne Irene Jensen, Hernan, Aguirre-Bermeo, Liivi, Maddison, Maija, Valta, Silvia, Calvino-Gunther, Frank, Bloos, Faustina Excel Adipa, Vasilios, Koulouras, Judy, Enamorado, Zsuzsann, Ágoston, Hrönn, Birgisdóttir, Amit, Gupta, Mohan, Gurjar, Bram, Kilapong, Seyed Mohammadreza Hashemian, Ignacio, Martin-Loeches, Julie, Benbenishty, Andrea, Cortegiani, Kelly, Fletcher, Yoshiro, Hayashi, Wangari, Waweru-Siika, Khalid, Abidi, Sang-Min, Lee, Burhan, Hadri, Mihails, Dolgusevs, Fayez François Abillama, Tomas, Jovaisa, Cyril, Thix, Muhammed, Elhadi, Basri Mat Nor, Shanti, Ratnam, Mohd Zulfakar Mazlan, Sundaresan, Maiyalagan, Luis, Sánchez-Hurtado, Adrian, Belii, Mendsaikhan, Naranpurev, Prabha, Gautam, Dylan De Lange, Rachael, Parke, Rose Ekama Ilesanmi, Mirjana, Shosholcheva, Antonija, Petosic, Ranveig, Lind, Madiha Hashmi Ffarcsi, Javier, Bogarin, Aaron Mark Hernandez, Malgorzata, Mikaszewska-Sokolewicz, Bruno, Sousa, Dana, Tomescu, Dorel, Sandesc, Theogene, Twagirumugabe, Vitaly, Gusarov, Maie, Ebaid, Radmilo, Jankovic, Gari, Slobodianiuk, Andrea, Martonova, Rihard, Knafelj, Mervyn, Mer, Emilio, Maseda, Bernardo, Panka, Joerg, C Schefold, Eva, Joelsson-Alm, Konlawij, Trongtrakul, Lorna, Merritt-Charles, Lamia Ouanes Besbes, Yalım, Dikmen, Lesia, Zgrzheblovska, Mark, Fielding, Francesca, Rubulotta, Ashish, K Khanna, Leif, Saager, Ingrid von der Osten, Alban, Greca, Alma, Cani, Nordian, Xhindi, Genci, Hyska, Antonio Margarit Ribas, Susana, Pinto, Paulo, Alves, Romina, Esposito, Emanuel, Valgolio, John Thomas Sanchez Minope, Antonio, Abdala, Maria, Ayala, Silvina, Bravo, Ana, Bantar, Patricia, Delgado, Gustavo, Badariotti, Fernando, Lipovestky, Ana, Diaz, Pablo, Saul, Mariano, Setten, Alejandra, Aucapina, Ysica, Acosta, Victor, Gonzalez, Luis, Camputaro, Fernando, Baccaro, Robert, Villa, Marcela, Mastantuono, Emiliano, Dean, Oscar Fernández Rostello, Patricia, Brizuela, Julio Ricardo Bartoli, Matias, Guereschi, Cristian, Quiroga, Sofia, Putruele, Paula, Villegas, Veronica, Curilen, Ruben, Fernandez, Mariangeles Gabriela Nocheretti, Rosana Gabriela Escalante, Cecilia Inés Loudet, Silvia, Fernandez, Ana Laura Gonzalez, Gustavo Andres Alvarez, Federico, Iglesias, Silvia, Chaparro, Graciela, Zakalik, Gonzalo, Pagella, Matías, Baini, Pierina Arias Campos, Ignacio, Sabbag, Armando, Schmukler, Imelda Perdomo Fonseca, Gonzalo Martín Alvarez, Mario, Ramirez, Fernando, Tapia, Carlos Alejandro Bascary, Graciela Del Valle Gimenez, Fernando Pablo Bertoletti, Esteban, Milioto, Pablo Julio Maldonaldo Bonsignore, Maria Alejandra Fernandez, Julie, Smith, Tim, Chimunda, Lorraine, Thompson, Teena, Maguire, Wendy, Chaboyer, Stacey, Watts, Marion, Mitchell, Madeleine, Powell, India, Lye, Leanne, Parsons, Nerilee, Baker, Claire, Reynolds, Amy, Thompson, Kristy, Masters, Kellie, Sosnowski, Lynette, Morrison, Gavin, D Leslie, Ramanathan, Lakshmanan, Alexis, Tabah, Wendy, Brown, Sharon, McDowell-Skaines, Andrea, Mclucas, Chris, Smith, Mandy, Tallot, Sarah, Jones, Michelle, Barakat-Johnson, Thomas, Leong, Rand, Butcher, Kerrie, Martin, Philipp, Douschan, Dirk von Lewinski, René, Schmutz, Uta, Kolussi, Fatema, Salman, Zainab, Ateya, Koen De Decker, Niels Van Regenmortel, Anita, Jans, Patricia, Wijnands, Stefano, Coremans, Patrick, M Honore, David De Bels, Tanja, Depuydt, Caroline, Paillet, Luc-Marie, Jacquet, Walter, Swinnen, Francis, Hannes, Matthia, Mergeay, Stijn Van de Velde, Silvie, Allaert, Pieter, Hoste, Christophe, Borin, Sandrine, Balon, Vincent, Fraipont, Patrick, Biston, Nicolas De Schryver, Thierry, Dugernier, Ilse Van Cotthem, Angelica Olivetto de Almeida, Silvia Angelica Jorge, Delmiro, Becker, Raysa Cristina Schmidt, Evellyn, Oliveira, Aline, Ramalho, Eliane, Mazocoli, Audrey, Fioretti, Elaine, Barros, Leticia, Serpa, Suzana, Bianchini, Ticiane, Campanili, Taís, Pantaleao, Paulo Carlos Garcia, Ana Lucia Vitti Ronchini, Rayanne, Santos, Nurulhuda Binti, A Manap, Sean, Bagshaw, Dominic, Carney, Jon, Davidow, Ella, Rokosh, Andréa Maria Laizner, Samantha, Smith, Megan, Mcquirter, Betty Star Kampayana, René, Favre, Martin, Sills, Julie, Dallaire, Cathy, Becker, Sherissa, Microys, Bonnie, Bowes, Jennifer, Lajeunesse, Rishi, Ghosh, Jacqueline, Baptiste-Savoie, Rose, Raizman, Gabriel, Suen, Noushin, Taghavi, Orla, Smith, Clare, Fielding, Julieta, Canales, Pia, Molina, Javiera, Chaparro, Maria Idalia Sepulveda, Matias Jesús Flamm Zamorano, Pamela, Rocha, Ximena, Villanueva, Paola, Araya, Meneses, Dayan, Fernando, Avalos, Xiaohan, Li, Liu, Yu, Xinxia, Li, Xiaoyan, Chen, Zhixia, Jiang, Jing, Yang, Jingfang, Chen, Lei, Yang, Kefang, Wang, Jie, Gao, Xiuhua, Fang, Ronghua, Zhao, Xinhua, Xia, Hongmei, Liu, Jing, Li, Haiyan, Wang, Gen, Meng, Yanhong, Di, Damei, Wang, Rong Hua Zhao, Li Ping Hu, Peipei, Xu, Qing Feng Jiao, Hai Yun Wang, Chun Jie Xia, Yan, Liu, Mei, Ye, Yan, Wan, Wenmei, Wang, Yajun, Ding, Aiua, Ren, Yan, Gao, Qi, Li, Guifang, Du, Yanling, Shen, Yanming, Ding, Ning, Li, Cui, Yuan, Lei, Tan, Qiang, Lin, Hailing, Guo, Howe, Yan, Xiao, Xu, Wei, Zhang, Jinxian, Liang, Libing, Zhang, Eryun, Tian, Qian, Zhao, Lin, Insu, Jingwen, Dong, Yanmei, Gu, Ying, Liu, Lina, Zhao, Wei, Wang, Hongmei, Qiao, Lili, Tuo, Mengmeng, Lv, Jin Yu Zhu, Jifen, Zhu, Ying, Wei, Man, Liu, Yin, He, Jiyin, Cheng, Jin, Liu, Jia, Na, Dongfang, Wei, Qing, Li, Xiaoying, Wu, Huan, Duan, Dongliang, Lin, Qiong, Liang, Xiaofang, Luo, Yunfeng, Xiong, Rong Fen Huang, Jing, Fu, Tao, Zan, Man, Ye, Zeya, Shi, Yanfei, Long, Yang, Lei, Xiaodi, Liu, Chen, Yumei, Lingling, Wang, Yali, Zhang, Yan, Xu, Cheng, Wang, Zhijuan, Chengxia, Sun, Jinhui, Song, Yingli, Wang, Xiumei, Liu, Yupeng, Liu, Yuxia, Yuan, Qingping, Huang, Fengling, Yang, Yun, Wu, Xianping, Luo, Xiaowu, Bai, Hong, Zheng, Min, Song, Yue, Sun, Zhangshuangzi, Li, Feifei, Luo, Miao, Liu, Li Chuntang Li, Xinjian, Li, Guiping, Zhang, Lina, Xiao, Tingting, Yu, Guangyuan, Gao, Wei, Wei, Fanglan, Wang, Ting, Han, Tingting, Li, Zeng, Qi, Jing Mei Zeng, Yan, Long, Fuqun, Pan, Jing, Wang, Guoxue, He, Haiyan, Chen, Feifei, Zhang, Chao, Yu, Gao, Chunhua, Xiuying, Yao, Dongmei, Bai, Liu, Lu, Xuelian, Xu, Yan, Wang, Xuejuan, Liang, Zhang, Na, Aizhi, Zhang, Xiaochun, Hu, Hui, Zhang, Ruixia, Wang, Poon Shing Tak, Sung Wai Ho, Qun Xia 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Mar Diaz Salcedo, Javier, Ripolles-Melchor, Eugenio, Martinez-Hurtado, Jorge Duerto Alvarez, María Luisa Bravo Arcas, Juan Ignacio Torres Gonzalez, Ana Belén Sánchez de la Ventana, Pablo Lopez-Arcas Calleja, Raquel Garcia Alvarez, Purificacion Sanchez Zamora, Alvaro Ortega Guerrero, Rosario, Cosano, Jonathan, Perez-Vacas, Margarita, Campos-Perez, Emma Moreno Barreiro, Losune Cano Sanchez, Monica Garcia Diaz, Raquel, Jimenez, Lorena Del Rio Cabajo, Daniel Sancho Muriel, Helena Fernandez Alonso, Ana Wensell Fernández, Isabel Santín Piñan, Guillermo Muñiz Albaiceta, Maria Cristina Iglesias Fernandez, Francisco Javier Saenz Abos, Pablo, Monedero, Ramon Molina Chueca, Lydia Gallego Aguirre, Silvia Call Manosa, Carmen Partera Luque, Neus, Calpe, Monica Recio Losilla, Meritxell Tapia Fores, Olga, Farre, Oscar, Fernandez, M Del Rosario Villar Redondo, Donaldo, S Arteta Arteta, Maria Angeles Hurtado Sanchez, Cristina Paños Espinosa, Laura Martinez Reyes, Laura Claramunt Domenech, Carmen Velasco Guillén, Josep Trenado Alvarez, Mercedes Del Cotillo, Jesus Emilio Barrueco-Francioni, Belen Burgos Conde, Maria Pilar Sogues Blanco, Maria Luisa Blasco, Ana Isabel Clement, Clara, Hurtado, Luz Coronado Sanz, David, Perez-Torres, Estefanía, Prol-Silva, Jorge, Pereira, Iván Areán González, Anastasio Espejo Cano, Cesar Rodriguez Nuñez, Inmaculada Lorenzo Fernadez, Alejandra Azahara Marguello Fernandez, Rosa Del Bosque Diez, Badiola, Hilario, Begoña, Zalba-Etayo, Ana, Pascual-Bielsa, Preveen, Banwarie, Dick, Nahar, Alisha van Axel, Naraindath, N Boedjawan, Erika Backlund Jansson, Ann-Sofie, Malvemyr, Lotta, Johansson, Ulla, Sandberg, Catarina, Tingsvik, Gunilla, Mattsson, Gun, Löf, Martin, Spångfors, Mona, Ringdal, Sebastian, Geijer, Lotti, Orvelius, Mia, Hylen, Caroline, Lagerhäll, Eva, Åkerman, Viveca Hamback Hellkvist, Ulrica, Mickelsson, Ewa, Wahlbom, Ing-Marie, Larsson, Ewa, Wallin, Filippo, Boroli, Solenne, Ory, Margaret Lynn Jong, Alexander, Dullenkopf, Martin, Lang, Yvan, Fleury, 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Bielskute E., Horrigan N., Jacob R., Habgood K., Zaki A., Collins A., Lord J., Ramiro C., Kubisz-Pudelko A., Kotze M., Williams H., Iovenko I., Tsarev A., Briva A., Mendez G., Napolitano L., Teig M., Rodriguez G.E., Ben-Jacob T., Potestio C., Eng T., Mahanes D., Khanna A., Duggal A., Nananmori M., Lois M., Karamchandani K., Bealer C., Barefield C., Terry D., Fivecoat P., Idowu O., Cata J., Clesi T., Peterson J., Hatton K., Dhaliwal J., Mueller D., Tao J., Eltorai A.S., Pastores S.M., Remor N., Salazar J., Barkas D., Joffe A., Barnes C., Sona C., Schallom M., Short J., Lorenzo J., Von Der Osten I., Borkowska M., Demarre L., Pleitinckx V., Xing C., Debue A.-S., Goller S., Larina E., Labeau, S. O., Blackwood, B., Brett, S. J., Deschepper, M., Francois, G., Honore, P. M., Khanna, A. K., Williams, G., Blot, S. I., Ribas, A. M., Telleria, V. M., Nogueira, P. C., Nafees, K. M. K., Reyes, A. G., Jensen, H. I., Adipa, F. E., Agoston, Z., Hashemian, S. M., Lee, S. -M., Abillama, F. F., Nor, B. M., Mazlan, M. Z., Sanchez-Hurtado, L., De lange, D., Ilesanmi, R. E., Ffarcsi, M. H., Hernandez, A. M., Schefold, J. C., Besbes, L. O., Minope, J. T. S., Rostello, O. F., Bartoli, J. R., Nocheretti, M. G., Escalante, R. G., Loudet, C. I., Gonzalez, A. L., Alvarez, G. A., Campos, P. A., Fonseca, I. P., Alvarez, G. M., Bascary, C. A., del Valle Gimenez, G., Bertoletti, F. P., Bonsignore, P. J. M., Fernandez, M. A., Leslie, G. D., Mclucas, A., Jacquet, L. -M., de Almeida, A. O., Jorge, S. A., Schmidt, R. C., Garcia, P. C., Ronchini, A. L. V., Manap, N. B. A., Laizner, A. M., Mcquirter, M., Kampayana, B. S., Sepulveda, M. I., Zamorano, M. J. F., Zhao, R. H., Hu, L. P., Jiao, Q. F., Wang, H. Y., Xia, C. J., Insu, L., Zhu, J. Y., Zhu, J. F., Huang, R. F., Wang, L. L., Song, J. H., Liu, X. M., Li, Z. S., Li, L. C., Zeng, J. M., Hu, X. C., Wang, R. X., Tak, P. S., Ho, S. W., Jiang, Q. X., Huang, L. P., Liu, X. L., Jiang, J. H., Gong, Y. Y., Lei, D. H., Bi, A. P., Zhao, H. M., Cao, Z. Q., Wu, S. F., Tian, X. F., Feng, Z. X., Liu, X. Z., Jiang, Z. X., Wang, G. X., Hu, R. L., Li, X. Q., Yu, Z. J., Yang, Y. X., Gama, L. M. S., Hernandez, J. S., Ochoa, M. -E., Reyes, A. J. G., Filipovic-Grcic, I., Vukovic, A., Pecenkovic, S., Suput, A., Radivojevic, R. C., Culjak, H., Adam, V. N., Pedersen, K. R., Kjaergard, I. E., Kodal, A. M., Hansen, T. C. B., Pedersen, A. S. B., Thomsen, T. D., Frandsen, T. M., Bliksted, I. A., Tamayo, L. M., Tutillo, D. R. M., Hurtado, C. V., Garcia, M. F., Kutimets, M., Lofqvist, C., Sakki, J. -K., Valta, M. A., Plantefeve, G., Deserts, M. D., Gunther, S. C., Timsit, J. -F., Farkas, J. -C., Bosl, K., Schuppel, S., Stubner, A., Osei, I. P., Kusi-Appiah, A. -C., Yakubu, Y. H., Patsiou, E. -C., Stalika, K. M. M., Enamorado, J. E., Jonasdottir, R. J., Lestari, M. I., Finn, D. O. C. R., Mcpherson, S., Ghioldi, D. M., Bruno, A. V., Maggiore, S. M., Volta, C. A., Taibi, M. R., Tranello, F. P., Giusti, G. D., Martin, M. A., Correia, M. C., Kim, J. H., Kim, K. C., Bae, J. -M., Park, S. Y., Park, T. S., Lee, H. B., Kim, S. C., Chee, H. K., Huh, J. W., Sim, Y. S., Ahn, J. -J., Kang, B. J., Lee, W. -Y., Lee, S. J., Feghaly, M. E., Belkhair, W. A., Tababa, O. W. E., Alkhumsi, S. I. R., Alshrif, A. I., Aboufray, A. A., Triki, A. R., Zahra, H. B., Al-Alawi, M. M. S., Ghula, M. A. A., Bahrin, L. K. K., Deva, S. R., Rahim, A. H. A., Hassan, W. N. W., Ismail, W. N. W., Ali, M. N., Khoo, T. M., Samat, N. M., Tong, J. M. G., Adib, N. A. N., Nor, M. B. M., Sulaiman, S. R., Foong, K. W., Hua, N. P., Zermeno, J. M., Nava, C. L. L., Nandyelly, S. J. R., Sanchez-Hurtado, L. A., Nava, L. P. A., Herrera, J. G., de Anda, G. F. V., Namendys-Silva, S. A., Romero-Gonzalez, J. P., Sosa, M. A., de Molina Serrano, J. I. R., Iburrigarro, S. R., Padilla, N. R. C., Pineda, A. A. V., Villafuerte, M. V. E., Herrera, M. O. G., Subedi, N. B., Pathak, S. D., Vermeijden, J. W., Gerritsen, R. T., Fijen, J. -W., Adejumo, P. O., Sankey, B. J., Olsen, B. F., Jensen, K. D., Johansen, B. F., Finnstrom, I. J., Skorstad, E. M., Lunde, G. A., Akselsen, G. R., Monstad, K. R., Hogvall, L., Malmin, S. K., Andersen, M. H., Hargott, R. F., de Jesus Ortiz, A., Cabral, D. M. B., Rivas, J. C., Moreira, M. L., Ellazar, C. G., Cerezo, F. D., Palo, J. E., Aperocho, C. A. J., Figueiredo, M. F., Pinheiro, C. M., Rita, C. S., Feranandes, A. M., Pinto, V. M. V., Bispo, B. M., Lima, A., Alsheikhly, A. S., Guran, C. T., Filipescu, D. C., Scutariu, M. A., Ebaid, M. S., Velickovic, D., Rajkovic, M., Stanojevic, M., Turcan, A., Lancaricova, D., Yeni, N. P., Syed, M. R., Navarro, J. A., De Pablo, A. M., Llinas, A. A., Lajara, M. A. G., Nieto, M. V., Pena, J. M. G., Gorgolas, M. C., Isasi, M. A., Salva-Costa, V., Garzon-Tovar, C., Olivares, P. G., de Ceballos, J. P. G., Polo, A. B. C., del Mar Diaz Salcedo, M., Alvarez, J. D., Arcas, M. L. B., Gonzalez, J. I. T., de la Ventana, A. B. S., Calleja, P. L. -A., Alvarez, R. G., Zamora, P. S., Guerrero, A. O., Barreiro, E. M., Sanchez, L. C., Diaz, M. G., Muriel, D. S., Alonso, H. F., Fernandez, A. W., Pinan, I. S., Albaiceta, G. M., Fernandez, M. C. I., Abos, F. J. S., Chueca, R. M., Aguirre, L. G., Manosa, S. C., Luque, C. P., Losilla, M. R., Fores, M. T., del Rosario Villar Redondo, M., Arteta Arteta, D. S., Sanchez, M. A. H., Espinosa, C. P., Reyes, L. M., Domenech, L. C., Guillen, C. V., Alvarez, J. T., del Cotillo, M., Barrueco-Francioni, J. E., Conde, B. B., Blanco, M. P. S., Blasco, M. L., Clement, A. I., Sanz, L. C., Gonzalez, I. A., Cano, A. E., Nunez, C. R., Fernadez, I. L., Fernandez, A. A. M., Boedjawan, N. N., Jansson, E. B., Malvemyr, A. -S., Lof, G., Spangfors, M., Lagerhall, C., Akerman, E., Hellkvist, V. H., Larsson, I. -M., Jong, M. L., Hsu, M. Y., Chang, S. C., Mebazaa, M. S., Elhechmi, Y. Z., Kuscu, O. O., Dal, H. C., Calili, D. K., Izdes, S., Gumus, A., Tasdemir, B., Kagnici, A., Ay, S. A., Balbay, A. O., Ozserezli, B., Senturk, E., Serin, S. O., Gul, F., Cinel, I., Undar, H. N., Bayraktar, Y. S., Celik, J. B., Tokur, M. E., Aydin, D. T., Yildiz, I., Ozcan, B., Akdag, D., Unlu, N., Reyes, P. E., Ahmad, F. K. E., Smiley, K. A., Miller, M. T., Antonio, M. G. S., Qawasmeh, K. A., Shawish, S. A., Groba, C. B., Raj, A. S., Ei, P. P., Legorburo, M. S., Welters, I. D., Mcmullen, J., Mcdonnell, A., Rose, B. O., Delgado, C. C., Mccann, N., Turner, S. J., Rodriguez, G. E., Eltorai, A. S., Pastores, S. M., Demarre, L., and Debue, A. -S.

Subjects
Male, Original, medicine.medical_treatment, artificial, Critical Care and Intensive Care Medicine, Medical and Health Sciences, Pressure ulcer, law.invention, Decubitus epidemiology, ICU, Morbidity, Mortality, Outcome, Pressure injury, Risk factors, Adult, Aged, Hospital Mortality, Humans, Patient Discharge, Prevalence, Risk Factors, Intensive Care Units, Respiration, Artificial, 0302 clinical medicine, decubitus epidemiology, pressure injury, pressure ulcer, outcome, risk factors, morbidity, mortality, law, Medicine and Health Sciences, adults, Medicine, Simplified Acute Physiology Score, icu, ziekenhuissterfte, Immunodeficiency, intensive care, European Society of Intensive Care Medicine (ESICM) Trials Group Collaborators, mannen, volwassenen, COST, Intensive care unit, STATE, ULCERS, Underweight, medicine.symptom, Life Sciences & Biomedicine, Human, medicine.medical_specialty, risicofactoren, Decubitus epidemiology, ICU, Pressure injury, Pressure ulcer, Outcome, Risk factors, Morbidity, Mortality, pressure injuries, Intensive Care Unit, prevalentie, NO, 1117 Public Health and Health Services, DecubICUs Study Team, 03 medical and health sciences, Critical Care Medicine, Anesthesiology, General & Internal Medicine, Health Sciences, ouderen, Mechanical ventilation, Science & Technology, business.industry, decubitus, Risk Factor, 030208 emergency & critical care medicine, 1103 Clinical Sciences, Odds ratio, medicine.disease, Emergency & Critical Care Medicine, Confidence interval, 030228 respiratory system, Emergency medicine, kunstmatige ademhaling, RISK-FACTORS, business, respiration
Abstract

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347, Funder: Flemish Society for Critical Care Nurses, Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score < 19, ICU stay > 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat.

Published
2021
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36. Non sola auctoritas facit legem. Il costituzionalismo logico di Luigi Ferrajoli

Author

Di Lucia,P, Passerini Glazel, L, Ferrajoli, L, Di Lucia, P, Passerini Glazel, L, Losano, MG, Barberis, M, Chiassoni, P, Itzcovich, G, Bisogni, G, Manero, JR, Luzzati, C, Baccelli, L, Moreso, JJ, Mazzarese, T, Scalone, A, Tuzet, G, Tedesco, F, Mastromartino, F, Pino, G, Ippolito, D, Pastore, B, Spuntarelli, S, Bersier Ladavac, N, Carrino, A, Nitsch, C, Zanichelli, M, Lozada, A, and Volpi, M

Subjects
Diritto illegittimo, Unlawful law, Hans Kelsen, Luigi Ferrajoli, logical constitutionalism, IUS/20 - FILOSOFIA DEL DIRITTO, diritto e logica, costituzionalismo logico, law and logic
Abstract

Per il positivismo giuridico tradizionale, l’idea che alcune norme create dal legislatore attraverso atti di normazione formalmente validi possano costituire “diritto illegittimo” sembra essere una contraddizione in termini. Questa tesi viene tuttavia messa esplicitamente in discussione nella teoria assiomatizzata del diritto di Luigi Ferrajoli, che pur si propone come uno sviluppo della teoria pura del diritto di Hans Kelsen. Il dissenso da Kelsen si incentra sul problema dell’applicazione dei principi logici di contraddizione e di implicazione al diritto, applicazione impossibile per Kelsen, necessaria invece per Ferrajoli per l’identificazione del diritto illegittimo. Gli autori della prefazione ricostruiscono i nodi teorici fondamentali della critica di Ferrajoli a Kelsen, e mostrano come Ferrajoli proponga di superare i limiti della teoria pura kelseninana attraverso l'elaborazione di un costituzionalismo logico. For traditional legal positivism, the idea that certain legal norms created through valid enactments can be "unlawful law" seems to be self-contradictory. This view is explicitly disputed by Luigi Ferrajoli's axiomatized theory of law, which is nonetheless presented as a development of Hans Kelsen's pure theory of law. The dispute focus on the problem of the application of the logical principles of contradiction and implication to legal systems: an impossible application for Kelsen, a necessary one for Ferrajoli, since the theory of law should identify "unlawful norms" within the legal system. The authors of this preface reconstruct the main theoretical claims of Ferrajoli's critique to Kelsen, and show how he suggests to overcome the theoretical limits of the pure theory of law through the delieation of a logical constitutionalism.

Published
2020

37. L'aporia del concetto kelseniano di 'norma'

Author

Passerini Glazel, L, Ferrajoli, L, Di Lucia, P, Passerini Glazel, L, Losano, MG, Barberis, M, Chiassoni, P, Itzcovich, G, Bisogni, G, Manero, JR, Luzzati, C, Baccelli, L, Moreso, JJ, Mazzarese, T, Scalone, A, Tuzet, G, Tedesco, F, Mastromartino, F, Pino, G, Ippolito, D, Pastore, B, Spuntarelli, S, Bersier Ladavac, N, Carrino, A, Nitsch, C, Zanichelli, M, Lozada, A, and Volpi, M

Subjects
Norma, Norm, Hans Kelsen, Luigi Ferrajoli, livelli di interpretazione della norma, senso di norma, IUS/20 - FILOSOFIA DEL DIRITTO, norm as meaning, levels of interpretation of a norm
Abstract

Luigi Ferrajoli, in his work La logica del diritto. Dieci aporie nell’opera di Hans Kelsen (2016), pointed out ten aporias in Hans Kelsen’s pure theory of law. This paper deals with the fifth aporia, that is the of Kelsen’s concept of a “norm”. The paper firstly distinguishes two different questions on the concept of a norm underlying the pure theory of law: the question “What is a norm?”, and the question “What has the meaning of a norm within a legal system?”; it secondly distinguishes three different levels of interpretation of a norm: (i) interpretation of the semantic meaning of norm sentences, (ii) interpretation of the subjective intrinsic pragmatic meaning of the norm creating act; (iii) interpretation of the extrinsic objective normative meaning of the norm creating act; it thirdly suggests that the existence of a norm is the ideal (ideel) existence of a meaning, not the empirical existence of an act.

Published
2020

38. Interpretazione cognitiva, decisoria, creativa. La teoria delle due cornici

Author

maniaci, giorgio, Chiassoni, P, Comanducci, P, Battista Ratti, G, Muffato, N, Celano, B, Lifante Vidal, I, Caballaro Elbersci, P, Papayannis, D, Viggiani, G, Canale D, Reyes Molina S, Rapetti, P, Tuzet, G, Ratti, G, Luzzati, C, Huerta, C, Perea Bonilla, H, Pastore, B, Castignone, S, Marra, R, Redondo, M, Pino, G, Barberis, M, Rodenas, A., Villalojasana, J, Sampedro, A, Agiero, S, Champeil- despalts, V, Tusseau, g, Zaccaria, G, Minuche, J, Cherot, J, Alday R, Ladavac, N, Maestri, E, Parodi, G, Fanlo, I, and maniaci, giorgio

Subjects
Settore IUS/20 - Filosofia Del Diritto, guastini, cognitive interpretation, context
Abstract

In this article I discuss the concepts elaborated by riccardo guastini of cognitive and creative interpretation

Published
2019

39. Il paradosso di una religione senza dio. Hans Kelsen antropologo della modernità

Author

Di Lucia, P, Passerini Glazel, L, Lombardi Vallauri, L, Fiorelli, P, Adinolfi, A, Amato, S, Amato Mangiameli, A C, Barberis, M, Bartoli, R, Becchi, P, Bellavista, M, Bernardini, P L, Bianchi, A, Borsellino, P, Cabiddu, M A, Caretti, P, Casavola, F P, Castignone, S, Castrucci, E, Chiassoni, P, Corbetta, S, Corongiu, S, Corsi, C, Cosi, G, Croce, M, D'Agostino, F, De Sanctis, F M, Di Cagno, V, Di Lucia, P, Passerini Glazel, L, Di Mario, A, Diciotti, E, Dilcher, G, Eusebi, L, Faralli, C, Faro, S, Lettieri, N, Fioravanti, M, Flora, G, Foddai, M A, Francavilla, D, Franchini, L, Franza, T, Gaja, G, Galvan, S, Di Florio, C, Gazzolo, T, Ghezzi, M L, Giachery, E, Giachi, C, Grisolia, M C, Guastini, R, Incampo, A, Irti, N, La Torre, M, Lombardi Vallauri, Edoardo, Lombardi Vallauri, Elena, Lombardi Vallauri, M, Lombardi Vallauri, S, Lucarelli, P, Luzzati, C, Mannozzi, G, Mannucci, A, Mantovani, F, Marini, R, Marotta, V, Mazzoni, C M, Meschiari, M, Migliorini, M, Montanari, B, Neumann, U, Onida, P P, Orrù, G, Palavera, R, Palazzani, L, Palazzo, F, Papa, M, Parenti, C, Pastore, B, Perfetti, L R, Rescigno, F, Righi, R, Rodotà, S, Roselli, O, Ruschi, F, Santalucia, B, Savarese, P, Scerbo, A, Scillitani, L, Siciliano, D, Simoni, A, Romoli, F, Stolfi, E, Taddei Elmi, G, Tallacchini, M, Tarantino, A, Trautteur, G, Troje, H E, Trujillo, I, Valastro, A, Vallini, A, Vettori, G, Villa, M L, Viola, F, Zaccaria, G, Zamperetti, G M, Zanotti, L, and Luderssen, K

Subjects
Hans Kelsen, IUS/20 - FILOSOFIA DEL DIRITTO, religione secolare, modern times, modernità, secular religion, M-FIL/06 - STORIA DELLA FILOSOFIA
Abstract

In 2012 an unpublished book by the Austrian legal philosopher Hans Kelsen, Secular Religion, has been posthumously published. This book, written by Kelsen between 1952 and 1964 in the United States, severely criticizes those theories of politics and culture that misinterpret modern social philosophy, science and politics as new religions, mainly adopting the controversial concept of “secular religión.” In the first part of the paper, we reconstruct the genesis of the book and the complex events that led to its final version, and we underline the motives that led Kelsen to write this vehement polemic in defense of the spirit of modernity, and eventually to withdraw it. In the second part of the paper, we investigate some of the main methodological and theoretical contributions that this work, albeit its critical tenor, is able to give to an anthropology of modernity.

Published
2016

40. Pin1 Modulates the Synaptic Content of NMDA Receptors via Prolyl-Isomerization of PSD-95

Author

Paola Zacchi, Beatrice Pastore, Andrea Barberis, Roberto De Filippo, Silvia Middei, Stefka Stancheva, Martine Ammassari-Teule, Roberta Antonelli, Enrico Cherubini, Antonelli, Roberta, De Filippo, Roberto, Middei, Silvia, Stancheva, Stefka, Pastore, Beatrice, Ammassari Teule, Martine, Barberis, Andrea, Cherubini, Enrico, Zacchi, Paola, Antonelli, R, De Filippo, R, Middei, S, Pastore, B, Ammassari-Teule, M, Cherubini, E, and Zacchi, P

Subjects
0301 basic medicine, Male, Dendritic spine, hippocampus, Long-Term Potentiation, Synaptic Transmission, Mice, HEK293 Cell, Postsynaptic potential, Receptors, Hippocampal, Membrane Protein, Cells, Cultured, Cultured, dendritic spine, musculoskeletal, neural, and ocular physiology, General Neuroscience, CA1 Region, Long-term potentiation, Articles, glutamatergic transmission, Guanylate Kinase, Synapse, Cell biology, medicine.anatomical_structure, Excitatory postsynaptic potential, Female, Disks Large Homolog 4 Protein, psychological phenomena and processes, Human, Receptor, NMDA receptors, PSD-95, Pin1, dendritic spines, Animals, Cells, Guanylate Kinases, HEK293 Cells, Humans, Isomerism, Membrane Proteins, NIMA-Interacting Peptidylprolyl Isomerase, Protein Binding, N-Methyl-D-Aspartate, Synapses, Biology, Neurotransmission, Receptors, N-Methyl-D-Aspartate, 03 medical and health sciences, mental disorders, medicine, CA1 Region, Hippocampal, hippocampu, Animal, NMDA receptor, 030104 developmental biology, nervous system, Schaffer collateral, Synaptic plasticity, Cell, Postsynaptic density
Abstract

Phosphorylation of serine/threonine residues preceding a proline regulates the fate of its targets through postphosphorylation conformational changes catalyzed by the peptidyl-prolylcis-/transisomerase Pin1. By flipping the substrate between two different functional conformations, this enzyme exerts a fine-tuning of phosphorylation signals. Pin1 has been detected in dendritic spines and shafts where it regulates protein synthesis required to sustain the late phase of long-term potentiation (LTP). Here, we demonstrate that Pin1 residing in postsynaptic structures can interact with postsynaptic density protein-95 (PSD-95), a key scaffold protein that anchors NMDA receptors (NMDARs) in PSD via GluN2-type receptor subunits. Pin1 recruitment by PSD-95 occurs at specific serine-threonine/proline consensus motifs localized in the linker region connecting PDZ2 to PDZ3 domains. Upon binding, Pin1 triggers structural changes in PSD-95, thus negatively affecting its ability to interact with NMDARs. In electrophysiological experiments, larger NMDA-mediated synaptic currents, evoked in CA1 principal cells by Schaffer collateral stimulation, were detected in hippocampal slices obtained from Pin1−/−mice compared with controls. Similar results were obtained in cultured hippocampal cells expressing a PSD-95 mutant unable to undergo prolyl-isomerization, thus indicating that the action of Pin1 on PSD-95 is critical for this effect. In addition, an enhancement in spine density and size was detected in CA1 principal cells of Pin1−/−or in Thy-1GFP mice treated with the pharmacological inhibitor of Pin1 catalytic activity PiB.Our data indicate that Pin1 controls synaptic content of NMDARs via PSD-95 prolyl-isomerization and the expression of dendritic spines, both required for LTP maintenance.SIGNIFICANCE STATEMENTPSD-95, a membrane-associated guanylate kinase, is the major scaffolding protein at excitatory postsynaptic densities and a potent regulator of synaptic strength and plasticity. The activity of PSD-95 is tightly controlled by several post-translational mechanisms including proline-directed phosphorylation. This signaling cascade regulates the fate of its targets through postphosphorylation conformational modifications catalyzed by the peptidyl-prolylcis-/transisomerase Pin1. Here, we uncover a new role of Pin1 in glutamatergic signaling. By interacting with PSD-95, Pin1 dampens PSD-95 ability to complex with NMDARs, thus negatively affecting NMDAR signaling and spine morphology. Our findings further emphasize the emerging role of Pin1 as a key modulator of synaptic transmission.

Published
2016
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41. An AT-hook transcription factor promotes transcription of histone, spliced-leader, and piRNA clusters.

Author

Wang YH, Hertz HL, Pastore B, and Tang W

Subjects
Animals, DNA, Ribosomal genetics, DNA, Ribosomal metabolism, Transcription Factors metabolism, Transcription Factors genetics, RNA, Ribosomal, 5S genetics, RNA, Ribosomal, 5S metabolism, Piwi-Interacting RNA, Histones metabolism, Histones genetics, Caenorhabditis elegans genetics, Caenorhabditis elegans metabolism, RNA, Small Interfering metabolism, RNA, Small Interfering genetics, Caenorhabditis elegans Proteins genetics, Caenorhabditis elegans Proteins metabolism, Transcription, Genetic, Multigene Family
Abstract

In all three domains of life, genes with related functions can be organized into specific genomic regions known as gene clusters. In eukaryotes, histone, piRNA (Piwi-interacting RNA), and rDNA (ribosomal DNA) clusters are among the most notable clusters which play fundamental roles in chromatin formation, genome integrity, and translation, respectively. These clusters have long been thought to be regulated by distinct transcriptional mechanisms. In this study, using Caenorhabditis elegans as a model system we identify ATTF-6, a member of the AT-hook family, as a key factor for the expression of histone, piRNA, and 5S rDNA-SL1 (spliced leader 1) clusters. ATTF-6 is essential for C. elegans viability. It forms distinct nuclear foci at both piRNA and 5S rDNA-SL1 clusters. Loss of ATTF-6 leads to a depletion of histone mRNAs, SL1 transcripts, and piRNAs. Additionally, we demonstrate that ATTF-6 is required for the recruitment of USTC (Upstream Sequence Transcription Complex) to piRNA clusters, which is necessary for piRNA production. Collectively, our findings reveal a unifying role for an AT-hook transcription factor in promoting the expression of fundamental gene clusters., (© The Author(s) 2025. Published by Oxford University Press on behalf of Nucleic Acids Research.)

Published
2025
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42. Target cleavage and gene silencing by Argonautes with cityRNAs.

Author

Zhang H, Sim G, Kehling AC, Adhav VA, Savidge A, Pastore B, Tang W, and Nakanishi K

Subjects
Humans, MicroRNAs metabolism, MicroRNAs genetics, Argonaute Proteins metabolism, Argonaute Proteins genetics, Gene Silencing
Abstract

TinyRNAs (tyRNAs) are ≤17-nt guide RNAs associated with Argonaute proteins (AGOs), and certain 14-nt cleavage-inducing tyRNAs (cityRNAs) catalytically activate human Argonaute3 (AGO3). We present the crystal structure of AGO3 in complex with a cityRNA, 14-nt miR-20a, and its complementary target, revealing a different trajectory for the guide-target duplex from that of its ∼22-nt microRNA-associated AGO counterpart. cityRNA-loaded Argonaute2 (AGO2) and AGO3 enhance their endonuclease activity when the immediate 5' upstream region of the tyRNA target site (UTy) includes sequences with low affinity for AGO. We propose a model where cityRNA-loaded AGO2 and AGO3 efficiently cleave fully complementary tyRNA target sites unless they directly recognize the UTy. To investigate their gene silencing, we devised systems for loading endogenous AGOs with specific tyRNAs and demonstrated that, unlike microRNAs, cityRNA-mediated silencing heavily relies on target cleavage. Our study uncovered that AGO exploits cityRNAs for target recognition differently from microRNAs and alters gene silencing., Competing Interests: Declaration of interests K.N. has patents related to this work and a financial interest with City Therapeutics, Inc., (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)

Published
2024
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43. Sm-site containing mRNAs can accept Sm-rings and are downregulated in Spinal Muscular Atrophy.

Author

Blatnik AJ, Sanjeev M, Slivka J, Pastore B, Embree CM, Tang W, Singh G, and Burghes AHM

Abstract

Sm-ring assembly is important for the biogenesis, stability, and function of uridine-rich small nuclear RNAs (U snRNAs) involved in pre-mRNA splicing and histone pre-mRNA processing. Sm-ring assembly is cytoplasmic and dependent upon the Sm-site sequence and structural motif, ATP, and Survival motor neuron (SMN) protein complex. While RNAs other than U snRNAs were previously shown to associate with Sm proteins, whether this association follows Sm-ring assembly requirements is unknown. We systematically identified Sm-sites within the human and mouse transcriptomes and assessed whether these sites can accept Sm-rings. In addition to snRNAs, Sm-sites are highly prevalent in the 3' untranslated regions of long messenger RNAs. RNA immunoprecipitation experiments confirm that Sm-site containing mRNAs associate with Sm proteins in the cytoplasm. In modified Sm-ring assembly assays, Sm-site containing RNAs, from either bulk polyadenylated RNAs or those transcribed in vitro , specifically associate with Sm proteins in an Sm-site and ATP-dependent manner. In cell and animal models of Spinal Muscular Atrophy (SMA), mRNAs containing Sm-sites are downregulated, suggesting reduced Sm-ring assembly on these mRNAs may contribute to SMA pathogenesis. Together, this study establishes that Sm-site containing mRNAs can accept Sm-rings and identifies a novel mechanism for Sm proteins in regulation of cytoplasmic mRNAs.

Published
2024
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44. Characterization of ribosome stalling and no-go mRNA decay stimulated by the fragile X protein, FMRP.

Author

Scarpitti MR, Pastore B, Tang W, and Kearse MG

Subjects
Humans, Fragile X Syndrome metabolism, Fragile X Syndrome genetics, Cell Line, Tumor, Protein Biosynthesis, Fragile X Mental Retardation Protein metabolism, Fragile X Mental Retardation Protein genetics, RNA Stability, Ribosomes metabolism, RNA, Messenger metabolism, RNA, Messenger genetics
Abstract

Loss of functional fragile X mental retardation protein (FMRP) causes fragile X syndrome and is the leading monogenic cause of autism spectrum disorders and intellectual disability. FMRP is most notably a translational repressor and is thought to inhibit translation elongation by stalling ribosomes as FMRP-bound polyribosomes from brain tissue are resistant to puromycin and nuclease treatment. Here, we present data showing that the C-terminal noncanonical RNA-binding domain of FMRP is essential and sufficient to induce puromycin-resistant mRNA•ribosome complexes. Given that stalled ribosomes can stimulate ribosome collisions and no-go mRNA decay (NGD), we tested the ability of FMRP to drive NGD of its target transcripts in neuroblastoma cells. Indeed, FMRP and ribosomal proteins, but not poly(A)-binding protein, were enriched in isolated nuclease-resistant disomes compared to controls. Using siRNA knockdown and RNA-seq, we identified 16 putative FMRP-mediated NGD substrates, many of which encode proteins involved in neuronal development and function. Increased mRNA stability of four putative substrates was also observed when either FMRP was depleted or NGD was prevented via RNAi. Taken together, these data support that FMRP stalls ribosomes but only stimulates NGD of a small select set of transcripts, revealing a minor role of FMRP that would be misregulated in fragile X syndrome., Competing Interests: Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

Published
2024
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45. Pre-piRNA trimming safeguards piRNAs against erroneous targeting by RNA-dependent RNA polymerase.

Author

Pastore B, Hertz HL, and Tang W

Subjects
Animals, Piwi-Interacting RNA, Caenorhabditis elegans genetics, RNA, Nucleotidyltransferases, Nucleotides, Ribonucleases, Mammals, RNA-Dependent RNA Polymerase, Caenorhabditis elegans Proteins genetics
Abstract

The Piwi/Piwi-interacting RNA (piRNA) pathway protects genome integrity in animal germ lines. Maturation of piRNAs involves nucleolytic processing at both 5' and 3' ends. The ribonuclease PARN-1 and its orthologs mediate piRNA 3' trimming in worms, insects, and mammals. However, the significance of this evolutionarily conserved processing step is not fully understood. Employing C. elegans as a model, we recently discovered that 3' trimming protects piRNAs against non-templated nucleotide additions and degradation. Here, we find that worms lacking PARN-1 accumulate an uncharacterized RNA species termed anti-piRNAs, which are antisense to piRNAs. Anti-piRNAs associate with Piwi proteins, are 17-19 nucleotides long, and begin with 5' guanine or adenine. Untrimmed pre-piRNAs are misdirected by the terminal nucleotidyltransferase RDE-3 and RNA-dependent RNA polymerase EGO-1, leading to the formation of anti-piRNAs. This work identifies a class of small RNAs in parn-1 mutants and provides insight into the activities of RDE-3, EGO-1, and Piwi proteins., Competing Interests: Declaration of interests The authors declare no competing interests., (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)

Published
2024
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46. Pre-piRNA trimming safeguards piRNAs against erroneous targeting by RNA-dependent RNA Polymerase.

Author

Pastore B, Hertz HL, and Tang W

Abstract

In animal germ lines, The Piwi/piRNA pathway plays a crucial role in safeguarding genome integrity and promoting fertility. Following transcription from discrete genomic loci, piRNA precursors undergo nucleolytic processing at both 5' and 3' ends. The ribonuclease PARN-1 and its orthologs mediate piRNA 3' trimming in worms, insects and mammals. Yet, the significance of this evolutionarily conserved processing step is not well understood. Employing C. elegans as a model organism, our recent work has demonstrated that 3' trimming protects piRNAs against non-templated nucleotide additions and degradation. In this study, we present an unexpected finding that C. elegans deficient for PARN-1 accumulate a heretofore uncharacterized RNA species termed anti-piRNAs, which are antisense to piRNAs. These anti-piRNAs associate with Piwi proteins and display the propensity for a length of 17-19 nucleotides and 5' guanine and adenine residues. We show that untrimmed pre-piRNAs in parn-1 mutants are modified by the terminal nucleotidyltransferase RDE-3 and erroneously targeted by the RNA-dependent RNA polymerase EGO-1, thereby giving rise to anti-piRNAs. Taken together, our work identifies a previously unknown class of small RNAs upon loss of parn-1 and provides mechanistic insight to activities of RDE-3, EGO-1 and Piwi proteins.

Published
2023
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47. C. elegans germ granules sculpt both germline and somatic RNAome.

Author

Price IF, Wagner JA, Pastore B, Hertz HL, and Tang W

Subjects
Animals, Germ Cell Ribonucleoprotein Granules, Cell Body, Communication, Germ Cells, Basic Helix-Loop-Helix Transcription Factors, Caenorhabditis elegans genetics, Caenorhabditis elegans Proteins genetics
Abstract

Germ granules are membrane-less organelles essential for small RNA biogenesis and germline development. Among the conserved properties of germ granules is their association with the nuclear membrane. Recent studies demonstrated that LOTUS domain proteins, EGGD-1 and EGGD-2 (also known as MIP-1 and MIP-2 respectively), promote the formation of perinuclear germ granules in C. elegans. This finding presents a unique opportunity to evaluate the significance of perinuclear localization of germ granules. Here we show that loss of eggd-1 causes the coalescence of germ granules and formation of abnormal cytoplasmic aggregates. Impairment of perinuclear granules affects certain germline classes of small RNAs including Piwi-interacting RNAs. Transcriptome profiling reveals overexpression of spermatogenic and cuticle-related genes in eggd-1 hermaphrodites. We further demonstrate that disruption of germ granules activates HLH-30-mediated transcriptional program in somatic tissues. Collectively, our findings underscore the essential role of EGGD-1 in germ granule organization and reveal an unexpected germ granule-to-soma communication., (© 2023. Springer Nature Limited.)

Published
2023
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48. 2D MXene interfaces preserve the basal electrophysiology of targeted neural circuits.

Author

Xiao M, Li X, Pifferi S, Pastore B, Liu Y, Lazzarino M, Torre V, Yang X, Menini A, and Tang M

Subjects
Electric Conductivity, Electrodes, Neurons metabolism
Abstract

Neural interfaces enable the monitoring of the state of the brain and its composite cell networks, as well as stimulate them to treat nervous disorders. In addition to their highly efficient charge transduction and stability during operation, the neural electrodes should avoid altering the physiological properties of targeted neuronal tissues. Two-dimensional (2D) MXene materials integrate the advantages of metallic conductivity, high specific-surface area and surface functionality in aqueous dispersions, showing promising potential in neural interface applications. Here, we apply uncoated Ti 3 C 2 T x MXene to interface neuronal development. The impacts of the uncoated Ti 3 C 2 T x MXene interface on neuronal development and neuronal microcircuit activity were tested for the first time. Compared to the standard neuronal culture with a poly-L-ornithine coated coverslip, uncoated Ti 3 C 2 T x MXene surfaces did not affect the cell morphology, density, neuron ratios, maturation or the compositions of the neuronal network. Moreover, calcium imaging, spontaneous postsynaptic currents (sPSCs) and also miniature postsynaptic currents (mPSCs) were recorded to demonstrate that Ti 3 C 2 T x MXene interfaces preserved the basal physiology of neuronal activity. The ability to interface neuronal circuit development without altering neuronal signaling properties enables the construction of MXene-based neural prosthetic devices for neuroscience research, diagnosis, and therapies.

Published
2022
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49. Comparative analysis of piRNA sequences, targets and functions in nematodes.

Author

Pastore B, Hertz HL, and Tang W

Subjects
Animals, RNA, Small Interfering genetics, Fertility, Genomics, Caenorhabditis elegans genetics, RNA, Ribosomal
Abstract

Piwi proteins and Piwi-interacting RNAs (piRNAs) are best known for their roles in suppressing transposons and promoting fertility. Yet piRNA biogenesis and its mechanisms of action differ widely between distantly related species. To better understand the evolution of piRNAs, we characterized the piRNA pathway in C. briggsae , a sibling species of the model organism C. elegans . Our analyses define 25,883 piRNA producing-loci in C. briggsae . piRNA sequences in C. briggsae are extremely divergent from their counterparts in C. elegans , yet both species adopt similar genomic organization that drive piRNA expression. By examining production of Piwi-mediated secondary small RNAs, we identified a set of protein-coding genes that are evolutionarily conserved piRNA targets. In contrast to C. elegans , small RNAs targeting ribosomal RNAs or histone transcripts are not hyper-accumulated in C. briggsae Piwi mutants. Instead, we found that transcripts with few introns are prone to small RNA overamplification. Together our work highlights evolutionary conservation and divergence of the nematode piRNA pathway and provides insights into its role in endogenous gene regulation.

Published
2022
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50. Proximity labeling identifies LOTUS domain proteins that promote the formation of perinuclear germ granules in C. elegans .

Author

Price IF, Hertz HL, Pastore B, Wagner J, and Tang W

Subjects
Animals, Caenorhabditis elegans genetics, Caenorhabditis elegans metabolism, Caenorhabditis elegans Proteins genetics, Clustered Regularly Interspaced Short Palindromic Repeats, Gene Editing, Germ Cells growth & development, Protein Domains, RNA Interference, Caenorhabditis elegans Proteins analysis, Germ Cell Ribonucleoprotein Granules chemistry, Germ Cells metabolism
Abstract

The germ line produces gametes that transmit genetic and epigenetic information to the next generation. Maintenance of germ cells and development of gametes require germ granules-well-conserved membraneless and RNA-rich organelles. The composition of germ granules is elusive owing to their dynamic nature and their exclusive expression in the germ line. Using Caenorhabditis elegans germ granule, called P granule, as a model system, we employed a proximity-based labeling method in combination with mass spectrometry to comprehensively define its protein components. This set of experiments identified over 200 proteins, many of which contain intrinsically disordered regions (IDRs). An RNA interference-based screen identified factors that are essential for P granule assembly, notably EGGD-1 and EGGD-2, two putative LOTUS-domain proteins. Loss of eggd-1 and eggd-2 results in separation of P granules from the nuclear envelope, germline atrophy, and reduced fertility. We show that IDRs of EGGD-1 are required to anchor EGGD-1 to the nuclear periphery while its LOTUS domains are required to promote the perinuclear localization of P granules. Taken together, our work expands the repertoire of P granule constituents and provides new insights into the role of LOTUS-domain proteins in germ granule organization., Competing Interests: IP, HH, BP, JW, WT No competing interests declared, (© 2021, Price et al.)

Published
2021
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