1. Kinase inhibitors from marine sponges.
- Author
-
Skropeta D, Pastro N, and Zivanovic A
- Subjects
- Animals, Biological Products chemistry, Biological Products isolation & purification, Biological Products pharmacology, Cyclin-Dependent Kinases chemistry, Cyclin-Dependent Kinases isolation & purification, Cyclin-Dependent Kinases pharmacology, ErbB Receptors antagonists & inhibitors, Glycogen Synthase Kinase 3 antagonists & inhibitors, Mitogen-Activated Protein Kinases antagonists & inhibitors, Protein Kinase C antagonists & inhibitors, Protein Kinase Inhibitors chemistry, Protein Kinase Inhibitors pharmacology, Protein-Tyrosine Kinases antagonists & inhibitors, Porifera chemistry, Protein Kinase Inhibitors isolation & purification
- Abstract
Protein kinases play a critical role in cell regulation and their deregulation is a contributing factor in an increasing list of diseases including cancer. Marine sponges have yielded over 70 novel compounds to date that exhibit significant inhibitory activity towards a range of protein kinases. These compounds, which belong to diverse structural classes, are reviewed herein, and ordered based upon the kinase that they inhibit. Relevant synthetic studies on the marine natural product kinase inhibitors have also been included.
- Published
- 2011
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