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12 results on '"Pasu, Saruban"'

1. Macular hole : imaging and post operative positioning studies

Author

Pasu, Saruban

Subjects
617.7
Abstract

Since 1991 when Kelly and Wendel published the first case series of a surgical technique to repair macular holes, both the closure rates and functional outcomes have improved. The four novel studies presented in this thesis all have the subject of macular hole as a common theme running throughout. A comprehensive review of the pathophysiology, imaging and surgical reparative techniques is described in Chapter 1 which concludes with the results of a Cochrane review undertaken to determine the value of post-operative face down positioning. Chapter 2 focuses on a previously unreported method of imaging a macular hole using the Shadowgram overlay tool on the Topcon 3D - OCT 2000 (Topcon, Tokyo, Japan). This technique while offering no significant benefit over traditional linear OCT measurements may be of interest in other causes of macula pathology. Another aspect of macula imaging is explored in Chapter 3, which concentrates on assessing the reproducibility and reliability of the caliper tool on three different OCT devices. This original piece of work is the first of its kind to look in detail at the varies aspects of macular hole geometry. Chapters 4 and 5 offer an extensive explanation of the PIMS (positioning in macular hole study) trial. This NIHR funded trial is to date the largest multi-centre randomised controlled trial to determine whether advice to position face down improves the surgical success rate of closure of large (≥400 μm) macular holes.

Published
2019

6. PIMS (Positioning In Macular hole Surgery) trial – a multicentre interventional comparative randomised controlled clinical trial comparing face-down positioning, with an inactive face-forward position on the outcome of surgery for large macular holes: study protocol for a randomised controlled trial

Author

Pasu, Saruban, Bunce, Catey, Hooper, Richard, Thomson, Ann, and Bainbridge, James

Subjects
Male, Time Factors, genetic structures, Medicine (miscellaneous), Ophthalmologic Surgical Procedures, Diagnostic Techniques, Ophthalmological, Retinal Perforations, Patient Positioning, United Kingdom, Study Protocol, Treatment Outcome, Clinical Protocols, Research Design, Prone Position, Supine Position, Humans, Pharmacology (medical), Female
Abstract

Background Idiopathic macular holes are an important cause of blindness. They have an annual incidence of 8 per 100,000 individuals, and prevalence of 0.2 to 3.3 per 1000 individuals with visual impairment. The condition occurs more frequently in adults aged 75 years or older. Macular holes can be repaired by surgery in which the causative tractional forces in the eye are released and a temporary bubble of gas is injected. To promote successful hole closure individuals may be advised to maintain a face-down position for up to 10 days following surgery. The aim of this study is to determine whether advice to position face-down improves the surgical success rate of closure of large (>400 μm) macular holes, and thereby reduces the need for further surgery. Methods/Design This will be a multicentre interventional, comparative randomised controlled clinical trial comparing face-down positioning with face-forward positioning. At the conclusion of standardised surgery across all sites, participants still eligible for inclusion will be allocated randomly 1:1 to 1 of the 2 treatment arms stratified by site, using random permuted blocks of size 4 or 6 in equal proportions. We will recruit 192 participants having surgery for large macular holes (>400 μm); 96 in each of the 2 arms of the study. The primary objective is to determine the impact of face-down positioning on the likelihood of closure of large (≥400 μm) full-thickness macular holes following surgery. Discussion This will be the first multicentre randomised control trial to investigate the value of face-down positioning following macular hole standardised surgery. Trial registration UK CRN: 17966 (date of registration 26 November 2014). Electronic supplementary material The online version of this article (doi:10.1186/s13063-015-1048-8) contains supplementary material, which is available to authorized users.

Published
2015

9. Anti-VEGF Therapy and the Retina: An Update

Author

Tah, Vikas, primary, Orlans, Harry O., additional, Hyer, Jonathan, additional, Casswell, Edward, additional, Din, Nizar, additional, Sri Shanmuganathan, Vishnu, additional, Ramskold, Louise, additional, and Pasu, Saruban, additional

Published
2015
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12. The Development of New Tests of Source Memory and a New Approach to the Testing of Equivalence of Parallel Versions.

Author

van Niekerk, Jan K., Nielsen, Tom A., Pasu, Saruban, Shore, Sarah, and Huppert, Felicia A.

Subjects
MEMORY testing, COGNITIVE ability, LONGITUDINAL method, PSYCHOMETRICS, DEMENTIA, NEUROBEHAVIORAL disorders, MEDICAL research
Abstract

The principal aim of this study was to develop tests of source memory in both the verbal and visuo-spatial domains, which would be brief and easy to use in clinical and population settings. Source memory, that is, memory for context or attributes, is very vulnerable to the effects of ageing and to the early stages of dementia. Because longitudinal studies of cognitive function, including clinical trials, involve repeat testing, practice effects may hamper interpretation when identical tests are administered on each occasion. Accordingly, we developed parallel versions of each of the source memory tests. Rather than assuming equivalence by design, we tested the parallel versions to determine whether they were in fact equivalent in difficulty. We also explored the use of different analytic approaches to establishing equivalence. We report the results of a study in which we compared within- and between-subject performance on three parallel versions of visuo-spatial and verbal source memory tests, as well as three parallel versions of standard tests of episodic memory (word list recall) and executive function (letter fluency, category fluency, ideational fluency) in a sample of healthy elderly volunteers. Participants were tested on three occasions separated by 1 week, and test versions were counterbalanced across test sessions. We also examined performance in a group of participants tested on one occasion only, with test versions being allocated at random. We found that for a number of tests, versions which were designed to be parallel, failed to produce equivalent performance in our sample. We show how the results of this study may be of general use to researchers wishing to select particular versions of the tests in our battery. We also urge researchers to be cautious when using parallel versions of other tests. The careful matching or random allocation of items to parallel versions of a test is no guarantee that performance on the different versions will be equivalent. [ABSTRACT FROM AUTHOR]

Published
2004
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