Search

Your search keyword '"Patel, Chetan P."' showing total 285 results
Start Over Author "Patel, Chetan P."
285 results on '"Patel, Chetan P."'

2. A Carrier Female Manifesting an Unusual X-Linked Retinoschisis Phenotype Associated with the Pathogenic Variant c.266delA, p.(Tyr89LeufsTer37) in RS1, and Skewed X-Inactivation.

Author

Gait, Anthony, Jenkins, Lucy, Clouston, Penny, Patel, Chetan, Downes, Susan, Kirkby, Jennifer, Halford, Stephanie, Shanks, Morag, and Moore, Anthony

Subjects
X-inactivation, X-linked retinoschisis, carrier, female, heterozygous, Female, Humans, Eye Proteins, Phenotype, Retina, Retinoschisis, X Chromosome Inactivation, Child, Preschool
Abstract

X-linked retinoschisis (XLRS) is the most common juvenile macular degeneration in males. Unlike most other X-linked retinal dystrophies, carrier heterozygous females are very rarely reported to show clinical features of the disease. Herein, we describe unusual retinal features in a 2-year-old female infant with family history and genetic testing consistent with XLRS.

Published
2023

16. Reproducibility of global LV function and dyssynchrony parameters derived from phase analysis of gated myocardial perfusion SPECT: A multicenter comparison with core laboratory setting

Author

de Amorim Fernandes, Fernando, Peix, Amalia, Giubbini, Raffaele, Karthikeyan, Ganesan, Massardo, Teresa, Patel, Chetan, Pabon, Luz M., Jimenez-Heffernan, Amelia, Alexanderson, Erick, Butt, Sadaf, Kumar, Alka, Marin, Victor, Morozova, Olga, Paez, Diana, Mesquita, Claudio T., and Garcia, Ernest V.

Published
2022
Full Text
View/download PDF

20. Regional variation in donation after circulatory death heart allograft utilization

Author

Jawitz, Oliver K., Devore, Adam D., Patel, Chetan B., Keenan, Jeffrey E., Milano, Carmelo A., and Schroder, Jacob N.

Abstract

Randomized data support transplantation of hearts from donors after circulatory death. This may lead to a sizeable increase in the donor pool. Regional variations in donors after circulatory death heart use were examined to help elucidate barriers to donor pool expansion.

Published
2024
Full Text
View/download PDF

21. Diastolic dyssynchrony assessment by gated myocardial perfusion-SPECT in subjects who underwent cardiac resynchronization therapy

Author

Alexanderson-Rosas, Erick, Espinola-Zavaleta, Nilda, Garcia, Ernest V., Peix, Amalia, Massardo, Teresa, Pabon, Luz M., Antonio-Villa, Neftali Eduardo, Carvajal-Juarez, Isabel, Mesquita, Claudio T., Jimenez-Heffernan, Amelia, Patel, Chetan, Karthikeyan, Ganesan, Kumar, Alka, Butt, Sadaf, Kalaivani, Mani, Marin, Victor, Morozova, Olga, and Paez, Diana

Published
2021
Full Text
View/download PDF

26. Value of intraventricular dyssynchrony assessment by gated-SPECT myocardial perfusion imaging in the management of heart failure patients undergoing cardiac resynchronization therapy (VISION-CRT)

Author

Peix, Amalia, Karthikeyan, Ganesan, Massardo, Teresa, Kalaivani, Mani, Patel, Chetan, Pabon, Luz M., Jiménez-Heffernan, Amelia, Alexanderson, Erick, Butt, Sadaf, Kumar, Alka, Marin, Victor, Mesquita, Claudio T., Morozova, Olga, Paez, Diana, and Garcia, Ernest V.

Published
2021
Full Text
View/download PDF

28. Early Outcomes in Patients With LVAD Undergoing Heart Transplant via Use of the SherpaPak Cardiac Transport System.

Author

Lerman, Joseph B., Patel, Chetan B., Casalinova, Sarah, Nicoara, Alina, Holley, Christopher L., Leacche, Marzia, Silvestry, Scott, Zuckermann, Andreas, D'Alessandro, David A., Milano, Carmelo A., Schroder, Jacob N., and DeVore, Adam D.

Abstract

BACKGROUND: Heart transplant (HT) in recipients with left ventricular assist devices (LVADs) is associated with poor early post-HT outcomes, including primary graft dysfunction (PGD). As complicated heart explants in recipients with LVADs may produce longer ischemic times, innovations in donor heart preservation may yield improved post-HT outcomes. The SherpaPak Cardiac Transport System is an organ preservation technology that maintains donor heart temperatures between 4 °C and 8 °C, which may minimize ischemic and cold-induced graft injuries. This analysis sought to identify whether the use of SherpaPak versus traditional cold storage was associated with differential outcomes among patients with durable LVAD undergoing HT. METHODS: Global Utilization and Registry Database for Improved Heart Preservation-Heart (NCT04141605) is a multicenter registry assessing post-HT outcomes comparing 2 methods of donor heart preservation: SherpaPak versus traditional cold storage. A retrospective review of all patients with durable LVAD who underwent HT was performed. Outcomes assessed included rates of PGD, post-HT mechanical circulatory support use, and 30-day and 1-year survival. RESULTS: SherpaPak (n=149) and traditional cold storage (n=178) patients had similar baseline characteristics. SherpaPak use was associated with reduced PGD (adjusted odds ratio, 0.56 [95% CI, 0.32--0.99]; P=0.045) and severe PGD (adjusted odds ratio, 0.31 [95% CI, 0.13--0.75]; P=0.009), despite an increased total ischemic time in the SherpaPak group. Propensity matched analysis also noted a trend toward reduced intensive care unit (SherpaPak 7.5±6.4 days versus traditional cold storage 11.3±18.8 days; P=0.09) and hospital (SherpaPak 20.5±11.9 days versus traditional cold storage 28.7±37.0 days; P=0.06) lengths of stay. The 30-day and 1-year survival was similar between groups. CONCLUSIONS: SherpaPak use was associated with improved early post-HT outcomes among patients with LVAD undergoing HT. This innovation in preservation technology may be an option for HT candidates at increased risk for PGD. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT04141605. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

31. Comparison of Lipid Deposition at Coronary Bifurcations Versus at Nonbifurcation Portions of Coronary Arteries as Determined by Near-Infrared Spectroscopy

Author

Townsend, Jacob C, Steinberg, Daniel H, Nielsen, Christopher D, Todoran, Thomas M, Patel, Chetan P, Leonardi, Robert A, Wolf, Bethany J, Brilakis, Emmanouil S, Shunk, Kendrick A, Goldstein, James A, Kern, Morton J, and Powers, Eric R

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Cardiovascular, Atherosclerosis, Heart Disease, Heart Disease - Coronary Heart Disease, Aged, Angina Pectoris, Body Mass Index, Cardiac Catheterization, Coronary Angiography, Coronary Artery Disease, Coronary Stenosis, Coronary Vessels, Female, Heart Failure, Humans, Lipids, Male, Middle Aged, Myocardial Infarction, Myocardial Ischemia, Risk Factors, Spectroscopy, Near-Infrared, Statistics as Topic, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

Atherosclerosis has been shown to develop preferentially at sites of coronary bifurcation, yet culprit lesions resulting in ST-elevation myocardial infarction do not occur more frequently at these sites. We hypothesized that these findings can be explained by similarities in intracoronary lipid and that lipid and lipid core plaque would be found with similar frequency in coronary bifurcation and nonbifurcation segments. One hundred seventy bifurcations were identified, 156 of which had comparative nonbifurcation segments proximal and/or distal to the bifurcation. We compared lipid deposition at bifurcation and nonbifurcation segments in coronary arteries using near-infrared spectroscopy (NIRS), a novel method for the in vivo detection of coronary lipid. Any NIRS signal for the presence of lipid was found with similar frequency in bifurcation and nonbifurcation segments (79% vs 74%, p = NS). Lipid core burden index, a measure of total lipid quantity indexed to segment length, was similar across bifurcation segments as well as their proximal and distal controls (lipid core burden index 66.3 ± 106, 67.1 ± 116, and 66.6 ± 104, p = NS). Lipid core plaque, identified as a high-intensity focal NIRS signal, was found in 21% of bifurcation segments, and 20% of distal nonbifurcation segments (p = NS). In conclusion, coronary bifurcations do not appear to have higher levels of intracoronary lipid or lipid core plaque than their comparative nonbifurcation regions.

Published
2013

34. Endomyocardial fibrosis regression

Author

Karishma Landge, Vineeta Ojha, Kartik P Ganga, Prateek Kaushik, Pooja Sharma, Priya Jagia, Sudheer Arava, Patel Chetan, Gurpreet Gulati, Ruma Ray, and Sandeep Seth

Subjects
dotanoc, endomyocardial fibrosis, emf, imaging, mri, regression, Medicine, Surgery, RD1-811, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Endomyocardial fibrosis usually is an end-stage cardiomyopathy. We present a case which was picked up early in a stage with active thrombosis and inflammation using magnetic resonance imaging and DOTANOC scans and treated leading to regression of inflammation and thrombus. We advocate aggressive investigation of all cardiomyopathies to look for treatable causes.

Published
2019
Full Text
View/download PDF

35. Donor Heart Recovery and Preservation Modalities in 2024

Author

Lerman, Joseph B., Agarwal, Richa, Patel, Chetan B., Keenan, Jeffrey E., Casalinova, Sarah, Milano, Carmelo A., Schroder, Jacob N., and DeVore, Adam D.

Abstract

Historically, heart transplantation (HT) has relied on the use of traditional cold storage for donor heart preservation. This organ preservation modality has several limitations, including the risk for ischemic and cold-induced graft injuries that may contribute to primary graft dysfunction and poor post-HT outcomes. In recent years, several novel donor heart preservation modalities have entered clinical practice, including the SherpaPak Cardiac Transport System of controlled hypothermic preservation, and the Transmedics Organ Care System of ex vivo perfusion. Such technologies are altering the landscape of HT by expanding the geographic reach of procurement teams and enabling both donation after cardiac death and the use of expanded criteria donor hearts. This paper will review the emerging evidence on the association of these modalities with improved post-HT outcomes, and will also suggest best practices for selecting between donor heart preservation techniques.

Published
2024
Full Text
View/download PDF

36. Increasing Utilization of Extended Criteria Donor Hearts for Transplantation

Author

Schroder, Jacob N., Patel, Chetan B., DeVore, Adam D., Casalinova, Sarah, Koomalsingh, Kevin J., Shah, Ashish S., Anyanwu, Anelechi C., D’Alessandro, David A., Mudy, Karol, Sun, Benjamin, Strueber, Martin, Khaghani, Asghar, Shudo, Yasuhiro, Esmailian, Fardad, Liao, Kenneth, Pagani, Francis D., Silvestry, Scott, Wang, I-wen, Salerno, Christopher T., Absi, Tarek S., Madsen, Joren C., Mancini, Donna, Fiedler, Amy G., Milano, Carmelo A., and Smith, Jason W.

Abstract

Extended criteria donor (ECD) hearts available with donation after brain death (DBD) are underutilized for transplantation due to limitations of cold storage.

Published
2024
Full Text
View/download PDF

42. The Role of Recipient Thyroid Hormone Supplementation in Primary Graft Dysfunction After Heart Transplantation: A Propensity-Adjusted Analysis.

Author

Gosling, Andre F., Wright, Mary C., Cherry, Anne, Milano, Carmelo A., Patel, Chetan B., Schroder, Jacob N., DeVore, Adam, McCartney, Sharon, Kerr, Daryl, Bryner, Benjamin, Podgoreanu, Mihai, and Nicoara, Alina

Abstract

To investigate whether recipient administration of thyroid hormone (liothyronine [T3]) is associated with reduced rates of primary graft dysfunction (PGD) after orthotopic heart transplantation. Retrospective cohort study. Single-center, university hospital. Adult patients undergoing orthotopic heart transplantation. A total of 609 adult heart transplant recipients were divided into 2 cohorts: patients who did not receive T3 (no T3 group, from 2009 to 2014), and patients who received T3 (T3 group, from 2015 to 2019). Propensity-adjusted logistic regression was performed to assess the association between T3 supplementation and PGD. After applying exclusion criteria and propensity-score analysis, the final cohort included 461 patients. The incidence of PGD was not significantly different between the groups (33.9% no T3 group v 40.8% T3 group; p = 0.32). Mortality at 30 days (3% no T3 group v 2% T3 group; p = 0.53) and 1 year (10% no T3 group v 12% T3 group; p = 0.26) were also not significantly different. When assessing the severity of PGD, there were no differences in the groups' rates of moderate PGD (not requiring mechanical circulatory support other than an intra-aortic balloon pump) or severe PGD (requiring mechanical circulatory support other than an intra-aortic balloon pump). However, segmented time regression analysis revealed that patients in the T3 group were less likely to develop severe PGD. These findings indicated that recipient single-dose thyroid hormone administration may not protect against the development of PGD, but may attenuate the severity of PGD. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

45. Functional compared to anatomical imaging in the initial evaluation of patients with suspected coronary artery disease: An international, multi-center, randomized controlled trial (IAEA-SPECT/CTA study)

Author

Karthikeyan, Ganesan, Guzic Salobir, Barbara, Jug, Borut, Devasenapathy, Niveditha, Alexanderson, Erick, Vitola, Joao, Kraft, Otakar, Ozkan, Elgin, Sharma, Saket, Purohit, Gaurav, Dolenc Novak, Maja, Meave, Aloha, Trevethan, Sergio, Cerci, Rodrigo, Zier, Sandra, Gotthardtová, Lucia, Jonszta, Tomáš, Altin, Timucin, Soydal, Cigdem, Patel, Chetan, Gulati, Gurpreet, Paez, Diana, Dondi, Maurizio, and Kashyap, Ravi

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results