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Byline: Sachin. Gupta, Varniraj. Patel, Shivangi. Garg, Nikhil. Mehta Sir, GM1-gangliosidosis is a rare autosomal recessive lysosomal storage disorder characterized by a deficiency of the ß-galactosidase enzyme. Patients with GM1-gangliosidosis [...]

This article discusses a case of anaplastic large cell lymphoma (ALCL) presenting as zosteriform skin nodules. ALCL is a type of lymphoproliferative disorder that can appear on the skin or throughout the body. In this case, a 48-year-old man had red nodules on his arm and chest, along with other symptoms. Biopsy results confirmed ALCL, and the patient received chemotherapy. The article also mentions prurigo nodularis, a chronic skin condition characterized by itchy nodules. [Extracted from the article]

The article discusses the "hypopyon sign," a clinical manifestation characterized by the presence of small vesicles that contain clear fluid that later becomes turbid and pustular due to inflammation or bacterial infection. The sign is commonly observed in pyodermas and vesiculobullous disorders such as pemphigus and bullous pemphigoid. The presence of the hypopyon sign indicates the severity of infection and inflammation and aids in diagnosis and treatment. The article provides a comprehensive list of dermatological conditions associated with the hypopyon sign, including autoimmune/inflammatory dermatoses and infectious dermatoses. [Extracted from the article]

This article discusses a case of a 42-year-old man with Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL) who developed a rare adverse event called ponatinib-induced desquamation. The patient experienced diffuse brownish hyperpigmented desquamation of the skin, primarily on the lower trunk, buttocks, and extremities. The skin lesions progressed rapidly but improved after treatment with topical emollients. Ponatinib is a tyrosine kinase inhibitor used to treat Ph+ ALL and chronic myeloid leukemia (CML), and while cutaneous adverse events are rare, they have been increasingly reported in recent years. The article suggests that these skin changes should not lead to the discontinuation of treatment for the primary malignancy. [Extracted from the article]

Nevus comedonicus, an uncommon skin condition, was originally termed "comedo nevus" by Kofmann in 1895. It is characterized by the clusters of pits-containing black keratinous plugs resembling blackheads. Conventionally, nevus comedonicus manifests at birth (in 50% of cases) or during the first decade of life. The commonly affected areas include the head, neck, chest, upper, and lower limbs, with patterns ranging from unilateral, bilateral, linear, interrupted, segmental, to blaschkoid. While genital nevus comedonicus is rare, some cases have been reported. In this report, we present a case of nevus comedonicus on the glans, underscoring the importance of considering nonsexually transmitted disease-related causes for genital lesions., Competing Interests: There are no conflicts of interest., (Copyright: © 2024 Indian Journal of Sexually Transmitted Diseases and AIDS.)

Syphilitic balanitis is an uncommon rather underreported manifestation of primary syphilis initially described by Eugene Follmann and subsequently named after him. It is characterized by balanitis with or without a primary chancre and inguinal lymphadenopathy. Given its rarity, Follmann balanitis may be misdiagnosed with other causes of balanitis. Therefore, a strong clinical suspicion and awareness are crucial, particularly in the current resurgence of syphilis. With this background, we hereby report a case of Follmann balanitis in secondary syphilis, diagnosed based on clinical features, positive syphilis serology, and response to benzathine penicillin treatment., Competing Interests: There are no conflicts of interest., (Copyright: © 2024 Indian Journal of Sexually Transmitted Diseases and AIDS.)