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16 results on '"Patetko, Liene"'

7. Discovery of SARS-CoV-2 Nsp14 and Nsp16 Methyltransferase Inhibitors by High-Throughput Virtual Screening

Author

Bobrovs, Raitis, primary, Kanepe, Iveta, additional, Narvaiss, Nauris, additional, Patetko, Liene, additional, Kalnins, Gints, additional, Sisovs, Mihails, additional, Bula, Anna L., additional, Grinberga, Solveiga, additional, Boroduskis, Martins, additional, Ramata-Stunda, Anna, additional, Rostoks, Nils, additional, Jirgensons, Aigars, additional, Tars, Kaspars, additional, and Jaudzems, Kristaps, additional

Published
2021
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9. Potent SARS-CoV-2 mRNA Cap Methyltransferase Inhibitors by Bioisosteric Replacement of Methionine in SAM Cosubstrate

Author

Bobiļeva, Olga, primary, Bobrovs, Raitis, additional, Kaņepe, Iveta, additional, Patetko, Liene, additional, Kalniņš, Gints, additional, Šišovs, Mihails, additional, Bula, Anna L., additional, Gri̅nberga, Solveiga, additional, Borodušķis, Ma̅rtiņš, additional, Ramata-Stunda, Anna, additional, Rostoks, Nils, additional, Jirgensons, Aigars, additional, Ta̅rs, Kaspars, additional, and Jaudzems, Kristaps, additional

Published
2021
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11. Cultivation of 3D Dermal Tissue by Application of Autologous Matrix

Author

Jakobsons, Ēriks, primary, Ērglis, Kristaps, additional, Ramata-Stunda, Anna, additional, Blāķe, Ilze, additional, Patetko, Liene, additional, Tīcmane, Simona, additional, Rupaine, Beatrise Lūcija, additional, Ērglis, Mārtiņš, additional, Ērgle, Māra, additional, Strīķe, Eva, additional, Strazdiņš, Uldis, additional, Rubīns, Silvesters, additional, Rubīns, Andris, additional, and Ērglis, Andrejs, additional

Published
2020
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15. Treatment of Knee Osteoarthritis with Bone Marrow–Derived Mononuclear Cell Injection: 12-Month Follow-up

Author

Goncars, Valdis, Kalnberzs, Konstantins, Jakobsons, Eriks, Enģele, Ilze, Briede, Ieva, Blums, Kristaps, Erglis, Kristaps, Erglis, Martins, Patetko, Liene, Muiznieks, Indrikis, and Erglis, Andrejs

Abstract

Objectives To evaluate the main symptoms of knee osteoarthritis (OA) and tissue structure changes after a single dose bone marrow–derived mononuclear cell (BM MNC) intra articular injection. Case series study. Patients with knee OA Kellgren Lawrence (K-L) grade II and III received 1 injection of BM MNC. The clinical results were analyzed with the Knee injury and Osteoarthritis Outcome Score (KOOS) and Knee Society Score (KSS) before, 3, 6, and 12 months after injection. Radiological evaluation was performed with a calibrated x-ray and the magnetic resonance (MR) imaging before and 6 to 7 months postinjection.Results A total of 34 knees were treated with BM MNC injections. Mean (±SD) age of patient group was 53.96 ± 14.15 years; there were 16 males, 16 females, KL grade II, 16; KL grade III, 18. The average injected count of BM MNCs was 45.56 ± 34.94 × 106cells. At the endpoint of 12 months 65% of patients still had minimal perceptible clinical improvement of the KOOS total score. The mean improvement of KOOS total score was +15.3 and of the KSS knee score was +21.45 and the function subscale +27.08 (P< 0.05) points. The Whole Organ Magnetic Resonance Imaging Score (WORMS) improved from 44.31 to 42.93 points (P< 0.05). No adverse effects after the BM-MNC injection were observed.Conclusions The single dose BM MNC partially reduces clinical signs of the knee osteoarthritis stage II/III and in some cases, decreases degenerative changes in the joint building tissue over 12-month period.

Published
2019
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16. Penicillium lanoso-viride AMP dezamināzi atpazīstošo receptoru klāsta detektēšana perifēro asiņu mononukleārajās šūnās

Author

Livkiša, Dora, Patetko, Liene, and Latvijas Universitāte. Bioloģijas fakultāte

Subjects
citokīni, PRR, AMPD, TLR4, Bioloģija, imūnmodulatori
Abstract

Šajā darbā salīdzināta Penicillium lanoso-viride sintezētās AMPD un citu sēņu izcelsmes imūnmodulatoru un standartvielu iedarbība uz iekaisuma reakcijās iesaistītu molekulu gēnu ekspresiju un sekrēciju asins imūnsistēmas šūnās, un, balstoties uz rezultātos iegūto informāciju, veikta AMPD atpazīstošo PRR analīze. Ar RT-PCR metodi veiktās analīzes uzrāda, ka AMPD stimulētās asins imūnajās šūnās ir paaugstināta iekaisuma citokīnu, kā arī TLR4 signālceļā iesaistīto molekulu gēnu ekspresija, kas norāda uz tās iekaisumu veicinošo ietekmi. Ar receptoru bloķēšanas un ELISA proteīnu koncentrācijas noteikšanas metodes palīdzību noskaidrots, ka AMPD savu imūnmodulatoro darbību asins mononukleārajās šūnās veic caur TLR4, In this study the effects of Penicillium lanoso-viride AMPD, other fungal immunomodulators and standart substances on gene expression and secretion of inflammatory cytokines in peripheral blood immunity cells were analysed. Along with these experiments, analysis of the PRRs associated with the AMPD recognition was performed. The results from RT-PCR gene expression analysis showed elevated expression levels of main inflammatory cytokines and molecules associated with TLR4 signaling pathway in AMPD stimulated blood immune cells, suggesting its pro-inflammatory effect. Using receptor blocking and ELISA protein concentration determining method, it has been ascertained that AMPD evokes immune response by binding to TLR4.

Published
2016

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