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407 results on '"Patil, Chirag G."'

2. Transplantation of human neural progenitor cells secreting GDNF into the spinal cord of patients with ALS: a phase 1/2a trial

Author

Baloh, Robert H., Johnson, J. Patrick, Avalos, Pablo, Allred, Peggy, Svendsen, Soshana, Gowing, Genevieve, Roxas, Kristina, Wu, Amanda, Donahue, Becky, Osborne, Sheryl, Lawless, George, Shelley, Brandon, Wheeler, Koral, Prina, Carolyn, Fine, Dana, Kendra-Romito, Tami, Stokes, Haniah, Manoukian, Vicki, Muthukumaran, Abirami, Garcia, Leslie, Bañuelos, Maria G., Godoy, Marlesa, Bresee, Catherine, Yu, Hong, Drazin, Doniel, Ross, Lindsey, Naruse, Robert, Babu, Harish, Macklin, Eric A., Vo, Ashley, Elsayegh, Ashraf, Tourtellotte, Warren, Maya, Marcel, Burford, Matthew, Diaz, Frank, Patil, Chirag G., Lewis, Richard A., and Svendsen, Clive N.

Published
2022
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3. Blockade of a laminin-411 - Notch axis with CRISPR/Cas9 or a nanobioconjugate inhibits glioblastoma growth through tumor-microenvironment crosstalk

Author

Sun, Tao, Patil, Rameshwar, Galstyan, Anna, Klymyshyn, Dmytro, Ding, Hui, Chesnokova, Alexandra, Cavenee, Webster K, Furnari, Frank B, Ljubimov, Vladimir A, Shatalova, Ekaterina S, Wagner, Shawn, Li, Debiao, Mamelak, Adam N, Bannykh, Serguei I, Patil, Chirag G, Rudnick, Jeremy D, Hu, Jethro, Grodzinski, Zachary B, Rekechenetskiy, Arthur, Falahatian, Vida, Lyubimov, Alexander V, Chen, Yongmei L, Leoh, Lai S, Daniels-Wells, Tracy R, Penichet, Manuel L, Holler, Eggehard, Ljubimov, Alexander V, Black, Keith L, and Ljubimova, Julia Y

Subjects
Brain Cancer, Cancer, Neurosciences, Rare Diseases, Brain Disorders, Stem Cell Research, Biotechnology, Stem Cell Research - Nonembryonic - Human, Animals, Apoptosis, Biomarkers, Tumor, Brain, CRISPR-Cas Systems, Cell Proliferation, Gene Expression Regulation, Neoplastic, Glioblastoma, Humans, Laminin, Mice, Mice, Nude, Nanoparticles, Neoplastic Stem Cells, Prognosis, Receptors, Notch, Signal Transduction, Survival Rate, Tumor Cells, Cultured, Tumor Microenvironment, Xenograft Model Antitumor Assays, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

There is an unmet need for the treatment of glioblastoma multiforme (GBM). The extracellular matrix, including laminins, in the tumor microenvironment is important for tumor invasion and progression. In a panel of 226 patient brain glioma samples, we found a clinical correlation between the expression of tumor vascular laminin-411 (α4β1γ1) with higher tumor grade and with expression of cancer stem cell (CSC) markers, including Notch pathway members, CD133, Nestin, and c-Myc. Laminin-411 overexpression also correlated with higher recurrence rate and shorter survival of GBM patients. We also showed that depletion of laminin-411 α4 and β1 chains with CRISPR/Cas9 in human GBM cells led to reduced growth of resultant intracranial tumors in mice and significantly increased survival of host animals compared with mice with untreated cells. Inhibition of laminin-411 suppressed Notch pathway in normal and malignant human brain cell types. A nanobioconjugate potentially suitable for clinical use and capable of crossing blood-brain barrier was designed to block laminin-411 expression. Nanobioconjugate treatment of mice carrying intracranial GBM significantly increased animal survival and inhibited multiple CSC markers, including the Notch axis. This study describes an efficient strategy for GBM treatment via targeting a critical component of the tumor microenvironment largely independent of heterogeneous genetic mutations in glioblastoma.Significance: Laminin-411 expression in the glioma microenvironment correlates with Notch and other cancer stem cell markers and can be targeted by a novel, clinically translatable nanobioconjugate to inhibit glioma growth.

Published
2019

7. Supplementary Data 5 from Blockade of a Laminin-411–Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk

Author

Sun, Tao, primary, Patil, Rameshwar, primary, Galstyan, Anna, primary, Klymyshyn, Dmytro, primary, Ding, Hui, primary, Chesnokova, Alexandra, primary, Cavenee, Webster K., primary, Furnari, Frank B., primary, Ljubimov, Vladimir A., primary, Shatalova, Ekaterina S., primary, Wagner, Shawn, primary, Li, Debiao, primary, Mamelak, Adam N., primary, Bannykh, Serguei I., primary, Patil, Chirag G., primary, Rudnick, Jeremy D., primary, Hu, Jethro, primary, Grodzinski, Zachary B., primary, Rekechenetskiy, Arthur, primary, Falahatian, Vida, primary, Lyubimov, Alexander V., primary, Chen, Yongmei L., primary, Leoh, Lai S., primary, Daniels-Wells, Tracy R., primary, Penichet, Manuel L., primary, Holler, Eggehard, primary, Ljubimov, Alexander V., primary, Black, Keith L., primary, and Ljubimova, Julia Y., primary

Published
2023
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8. Data from Blockade of a Laminin-411–Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk

Author

Sun, Tao, primary, Patil, Rameshwar, primary, Galstyan, Anna, primary, Klymyshyn, Dmytro, primary, Ding, Hui, primary, Chesnokova, Alexandra, primary, Cavenee, Webster K., primary, Furnari, Frank B., primary, Ljubimov, Vladimir A., primary, Shatalova, Ekaterina S., primary, Wagner, Shawn, primary, Li, Debiao, primary, Mamelak, Adam N., primary, Bannykh, Serguei I., primary, Patil, Chirag G., primary, Rudnick, Jeremy D., primary, Hu, Jethro, primary, Grodzinski, Zachary B., primary, Rekechenetskiy, Arthur, primary, Falahatian, Vida, primary, Lyubimov, Alexander V., primary, Chen, Yongmei L., primary, Leoh, Lai S., primary, Daniels-Wells, Tracy R., primary, Penichet, Manuel L., primary, Holler, Eggehard, primary, Ljubimov, Alexander V., primary, Black, Keith L., primary, and Ljubimova, Julia Y., primary

Published
2023
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9. Supplementary Data 8 from Blockade of a Laminin-411–Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk

Author

Sun, Tao, primary, Patil, Rameshwar, primary, Galstyan, Anna, primary, Klymyshyn, Dmytro, primary, Ding, Hui, primary, Chesnokova, Alexandra, primary, Cavenee, Webster K., primary, Furnari, Frank B., primary, Ljubimov, Vladimir A., primary, Shatalova, Ekaterina S., primary, Wagner, Shawn, primary, Li, Debiao, primary, Mamelak, Adam N., primary, Bannykh, Serguei I., primary, Patil, Chirag G., primary, Rudnick, Jeremy D., primary, Hu, Jethro, primary, Grodzinski, Zachary B., primary, Rekechenetskiy, Arthur, primary, Falahatian, Vida, primary, Lyubimov, Alexander V., primary, Chen, Yongmei L., primary, Leoh, Lai S., primary, Daniels-Wells, Tracy R., primary, Penichet, Manuel L., primary, Holler, Eggehard, primary, Ljubimov, Alexander V., primary, Black, Keith L., primary, and Ljubimova, Julia Y., primary

Published
2023
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10. Supplementary Data 6 from Blockade of a Laminin-411–Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk

Author

Sun, Tao, primary, Patil, Rameshwar, primary, Galstyan, Anna, primary, Klymyshyn, Dmytro, primary, Ding, Hui, primary, Chesnokova, Alexandra, primary, Cavenee, Webster K., primary, Furnari, Frank B., primary, Ljubimov, Vladimir A., primary, Shatalova, Ekaterina S., primary, Wagner, Shawn, primary, Li, Debiao, primary, Mamelak, Adam N., primary, Bannykh, Serguei I., primary, Patil, Chirag G., primary, Rudnick, Jeremy D., primary, Hu, Jethro, primary, Grodzinski, Zachary B., primary, Rekechenetskiy, Arthur, primary, Falahatian, Vida, primary, Lyubimov, Alexander V., primary, Chen, Yongmei L., primary, Leoh, Lai S., primary, Daniels-Wells, Tracy R., primary, Penichet, Manuel L., primary, Holler, Eggehard, primary, Ljubimov, Alexander V., primary, Black, Keith L., primary, and Ljubimova, Julia Y., primary

Published
2023
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11. Supplementary Data from A Phase I Study of Autologous Dendritic Cell Vaccine Pulsed with Allogeneic Stem-like Cell Line Lysate in Patients with Newly Diagnosed or Recurrent Glioblastoma

Author

Hu, Jethro L., primary, Omofoye, Oluwaseun A., primary, Rudnick, Jeremy D., primary, Kim, Sungjin, primary, Tighiouart, Mourad, primary, Phuphanich, Surasak, primary, Wang, Hongqiang, primary, Mazer, Mia, primary, Ganaway, Toni, primary, Chu, Ray M., primary, Patil, Chirag G., primary, Black, Keith L., primary, Shiao, Stephen L., primary, Wang, Rongfu, primary, and Yu, John S., primary

Published
2023
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12. Supplementary Video from Blockade of a Laminin-411–Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk

Author

Sun, Tao, primary, Patil, Rameshwar, primary, Galstyan, Anna, primary, Klymyshyn, Dmytro, primary, Ding, Hui, primary, Chesnokova, Alexandra, primary, Cavenee, Webster K., primary, Furnari, Frank B., primary, Ljubimov, Vladimir A., primary, Shatalova, Ekaterina S., primary, Wagner, Shawn, primary, Li, Debiao, primary, Mamelak, Adam N., primary, Bannykh, Serguei I., primary, Patil, Chirag G., primary, Rudnick, Jeremy D., primary, Hu, Jethro, primary, Grodzinski, Zachary B., primary, Rekechenetskiy, Arthur, primary, Falahatian, Vida, primary, Lyubimov, Alexander V., primary, Chen, Yongmei L., primary, Leoh, Lai S., primary, Daniels-Wells, Tracy R., primary, Penichet, Manuel L., primary, Holler, Eggehard, primary, Ljubimov, Alexander V., primary, Black, Keith L., primary, and Ljubimova, Julia Y., primary

Published
2023
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13. Supplementary Figure from A Phase I Study of Autologous Dendritic Cell Vaccine Pulsed with Allogeneic Stem-like Cell Line Lysate in Patients with Newly Diagnosed or Recurrent Glioblastoma

Author

Hu, Jethro L., primary, Omofoye, Oluwaseun A., primary, Rudnick, Jeremy D., primary, Kim, Sungjin, primary, Tighiouart, Mourad, primary, Phuphanich, Surasak, primary, Wang, Hongqiang, primary, Mazer, Mia, primary, Ganaway, Toni, primary, Chu, Ray M., primary, Patil, Chirag G., primary, Black, Keith L., primary, Shiao, Stephen L., primary, Wang, Rongfu, primary, and Yu, John S., primary

Published
2023
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14. Supplementary Data 2 from Blockade of a Laminin-411–Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk

Author

Sun, Tao, primary, Patil, Rameshwar, primary, Galstyan, Anna, primary, Klymyshyn, Dmytro, primary, Ding, Hui, primary, Chesnokova, Alexandra, primary, Cavenee, Webster K., primary, Furnari, Frank B., primary, Ljubimov, Vladimir A., primary, Shatalova, Ekaterina S., primary, Wagner, Shawn, primary, Li, Debiao, primary, Mamelak, Adam N., primary, Bannykh, Serguei I., primary, Patil, Chirag G., primary, Rudnick, Jeremy D., primary, Hu, Jethro, primary, Grodzinski, Zachary B., primary, Rekechenetskiy, Arthur, primary, Falahatian, Vida, primary, Lyubimov, Alexander V., primary, Chen, Yongmei L., primary, Leoh, Lai S., primary, Daniels-Wells, Tracy R., primary, Penichet, Manuel L., primary, Holler, Eggehard, primary, Ljubimov, Alexander V., primary, Black, Keith L., primary, and Ljubimova, Julia Y., primary

Published
2023
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15. Supplementary Data 7 from Blockade of a Laminin-411–Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk

Author

Sun, Tao, primary, Patil, Rameshwar, primary, Galstyan, Anna, primary, Klymyshyn, Dmytro, primary, Ding, Hui, primary, Chesnokova, Alexandra, primary, Cavenee, Webster K., primary, Furnari, Frank B., primary, Ljubimov, Vladimir A., primary, Shatalova, Ekaterina S., primary, Wagner, Shawn, primary, Li, Debiao, primary, Mamelak, Adam N., primary, Bannykh, Serguei I., primary, Patil, Chirag G., primary, Rudnick, Jeremy D., primary, Hu, Jethro, primary, Grodzinski, Zachary B., primary, Rekechenetskiy, Arthur, primary, Falahatian, Vida, primary, Lyubimov, Alexander V., primary, Chen, Yongmei L., primary, Leoh, Lai S., primary, Daniels-Wells, Tracy R., primary, Penichet, Manuel L., primary, Holler, Eggehard, primary, Ljubimov, Alexander V., primary, Black, Keith L., primary, and Ljubimova, Julia Y., primary

Published
2023
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16. Supplementary Data 3 from Blockade of a Laminin-411–Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk

Author

Sun, Tao, primary, Patil, Rameshwar, primary, Galstyan, Anna, primary, Klymyshyn, Dmytro, primary, Ding, Hui, primary, Chesnokova, Alexandra, primary, Cavenee, Webster K., primary, Furnari, Frank B., primary, Ljubimov, Vladimir A., primary, Shatalova, Ekaterina S., primary, Wagner, Shawn, primary, Li, Debiao, primary, Mamelak, Adam N., primary, Bannykh, Serguei I., primary, Patil, Chirag G., primary, Rudnick, Jeremy D., primary, Hu, Jethro, primary, Grodzinski, Zachary B., primary, Rekechenetskiy, Arthur, primary, Falahatian, Vida, primary, Lyubimov, Alexander V., primary, Chen, Yongmei L., primary, Leoh, Lai S., primary, Daniels-Wells, Tracy R., primary, Penichet, Manuel L., primary, Holler, Eggehard, primary, Ljubimov, Alexander V., primary, Black, Keith L., primary, and Ljubimova, Julia Y., primary

Published
2023
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17. Supplementary Data 4 from Blockade of a Laminin-411–Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk

Author

Sun, Tao, primary, Patil, Rameshwar, primary, Galstyan, Anna, primary, Klymyshyn, Dmytro, primary, Ding, Hui, primary, Chesnokova, Alexandra, primary, Cavenee, Webster K., primary, Furnari, Frank B., primary, Ljubimov, Vladimir A., primary, Shatalova, Ekaterina S., primary, Wagner, Shawn, primary, Li, Debiao, primary, Mamelak, Adam N., primary, Bannykh, Serguei I., primary, Patil, Chirag G., primary, Rudnick, Jeremy D., primary, Hu, Jethro, primary, Grodzinski, Zachary B., primary, Rekechenetskiy, Arthur, primary, Falahatian, Vida, primary, Lyubimov, Alexander V., primary, Chen, Yongmei L., primary, Leoh, Lai S., primary, Daniels-Wells, Tracy R., primary, Penichet, Manuel L., primary, Holler, Eggehard, primary, Ljubimov, Alexander V., primary, Black, Keith L., primary, and Ljubimova, Julia Y., primary

Published
2023
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33. A Phase I Study of Autologous Dendritic Cell Vaccine Pulsed with Allogeneic Stem-like Cell Line Lysate in Patients with Newly Diagnosed or Recurrent Glioblastoma

Author

Hu, Jethro L., primary, Omofoye, Oluwaseun A., additional, Rudnick, Jeremy D., additional, Kim, Sungjin, additional, Tighiouart, Mourad, additional, Phuphanich, Surasak, additional, Wang, Hongqiang, additional, Mazer, Mia, additional, Ganaway, Toni, additional, Chu, Ray M., additional, Patil, Chirag G., additional, Black, Keith L., additional, Shiao, Stephen L., additional, Wang, Rongfu, additional, and Yu, John S., additional

Published
2021
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